Pahlavi medical journal最新文献

A case of cholera admitted to the Pahlavi University Medical Centre is presented and the aetiology, pathophysiology, complications and treatment of the disease are reviewed and discussed.

The duration of systolic time interval in ten anemic, (mean Hb 3.46) and otherwise healthy individuals (mean age 15) was measured from simultaneous recording of electrocardiogram, phonocardiogram and carotid pulsation. The preejection period (PEP); left ventricular ejection time (LVET) and ratio of PEP/LVET from 20 consecutive beats were calculated and averaged. Anemia was corrected slowly and study was repeated (mean 3 1/2 weeks) later and a similar data for comparison was obtained; heart rate decreased, LVET lengthened and the ratio of PEP/LVET remained unchanged. The lengthening of the LVET was due to slower heart rate. LVET before and after correction of anemia could be predicted from regression formula reported for normals. The unchanged PEP/LVET before and after the anemia indicates no significant alteration in myocardial performance at rest.

Three different phosphate buffered saline extracts of Litomosoides carini were prepared and examined by gel diffusion, immunoelectrophoresis and disc polyacrylamide gel electrophoresis using sera from infected cotton rats and antisera from hyperimmunized rabbits. Using disc polyacrylamide gel electrophoresis, up to 22 protein, 6 lipoprotein and 4 glycoprotein bands were identified. A minimum of 8 precipitin lines were detected by gel diffusion and a maximum of 11 precipitin arcs by immunoelectrophoresis when pooled rabbit antiserum was used. Using infected cotton rat sera, fewer number of precipitin lines and arcs were detected. Two precipitin arcs did not have a counterpart on examination against pooled rabbit antiserum. The importance of these two specific antigenic components for use in immunodiagnosis of human filariasis has been discussed.

The so-called pure red cell aplasia or hypoplasia may occur in various instances: 1- Congenital form, usually occuring in childhood; 2-Drug-induced types; 3-The forms associated with thymoma, carcinoma and hypogamma-globulinemia; and 4-As an isolated syndrome. In the etiology of congenital PRCA some immune mechanisms are considered to be important but the role of a genetic factor in producing the syndrome is more acceptable, although the exact pathogenesis of impairment of erythropoiesis is not clear. Disregarding the drug-induced types of the aplasia, acquired PRCA with or without thymoma is produced by immunologic mechanisms. Finding some factors such as antibody against erythroblast nuclei, inhibitor of heme synthesis and recently a cytotoxic factor that are in gamma G-globulin fraction of plasma of PRCA patients support the idea that the syndrome is of immunologic origin. It seems that the thymoma is only a manifestation of impaired immunologic state, and its role in producing the aplasia is a subject of controversy. Besides, we can not say that all cases of PRCA have the same pathogenesis and further investigations are necessary to provide some informations about the pathogenesis of this syndrome.

Acceptable Daily Intakes (ADI) of phosphorus set by the FAO/WHO Committee are fixed at 70 and 30 mg P/kg body weight, for conditional (C) (where Ca intake is high) and unconditional (UC) intake, respectively. In light of the increasing application of phosphates in food industries, the question arises whether these permissible limits are not exceeded by certain population group (s). The groups studied in this paper included: children, nursing mothers, farmers and town's men, and students. Average per capita and excessive consumptions were also estimated. Spectrometric techniques were used for analysis of both phosphorus and calcium. Unless for few items, Dutch Food Composition Tables were found accurate enough to use for calculations. Intake of P was found to exceed the UC ADI in most groups, and even the C ADI in infants (1 year). Food intakes of all groups resulted in P/Ca ratios higher than the recommended dietary allowances of U.S.A. Milk and dairy products proved important items for lowering this ratio in the Dutch diet. It is concluded that more investigation for the toxicological evaluation of phosphates is required, and a more clear ADI need be set. Food laws must take into account addition of phosphates during food processing. Estimation of P intake should be carried out particularly in countries of low calcium intake or high consumption of phosphate-treated or phosphate-rich foods (e.g. wholemeal bread and nut consumption in Iran).