Problemy medycyny wieku rozwojowego最新文献

The influence of prenatal repetitive 2450 MHz microwave irradiation of Swiss mice on postnatal survival and development was investigated. The animals were divided after mating into experimental and control groups and irradiated at power densities of 10 or 40 mW/cm2 at various periods of gestation. The pregnant females were allowed to deliver at term and feed their offsprings. Size of the litters and body mass of springs were checked on the 4th, 12th day of life. In progeny delivered by females irradiated at 40 mW/cm2 during the second half of pregnancy lowered increments of body mass before the 12th day of life was noted. We observed as well the lower size of litters delivered by females irradiated in the same conditions during the first half of pregnancy.

A case of asymptomatic perforation of uterine wall as a complication of polish IUD " Spiran " application was demonstrated. Underlying rareness of this complication hypothesis of its mechanism in this case are discussed.

A congenital alcoholic syndrome (CAS) belongs to rarely diagnosed embryopathies . It consists of polysymptomatic misdevelopings in numerous organs of the fetus caused by alcoholic abuse through the mother during the pregnancy. The diagnosis of the CAS is established on the basis of following topics: the anamnesis confirming the chronic alcoholism of baby's mother, the excluding of congenital genetic defects and intrauterine infections as well as qualitative and quantitative feeding deficits. In the differential diagnosis should be taken congenital cranial and facial dysmorphies which are most often seen in many syndromes such as: Pierre-Robin, Treacher-Collins, Weyer , Franceschetti - Zwahlen . In the presented paper there is described one case of the CAS observed during 15 months clinically and radiologically.

The author observed 58 obese and 28 control children aged from 7,7 to 15,1. Every child had drawn two pictures, the first presenting ideal body figure and the second--his (her) own portrait. There were differences between obese and control groups. It was found that 63% of obese children had a wrong estimation of her (his) own portrait. The study showed that they underestimated their figures, because they are not able to make critical selfestimation (very young children) or they do not realize their obesity. They prefer to show themselves without unpopular obesity. The investigation may be helpful in recognition of the children's attitude to their obesity, which assures the success in therapy.

Follicular development represents one of the essential functions of the ovary. It was done a lot of various classifications including kinetics or morphometry of growing follicles. All these experiments were carried on adult animals and so very little was known about developing follicles in youngs. In the view of this, we decided to investigate the postnatal development of rat ovary. Ovaries from rats between 14-84 days were examined; our own modification was used for classification of follicles, the number of each type of follicles and their diameter was counted, the number of granulosa cells in small growing follicles was noted and diameter of luteal cell and its elements in luteal body in which ovulation took place, were described.

Teratology has grown from a little known discipline to a discipline embracing a vast accumulation of literature on experimental studies in many animal forms. Emphasis has shifted from preoccupation with descriptions of anatomical defects to concern about subtle and interacting causative factors. The aim of this work is to assemble a source of facts, concepts, methods and references within the broad scope of teratology. Our review summarizes reports of teratogenic effects in mammals. The major intent of this work, however, has been to introduce into a field of teratology. Special attention has been paid to the relation of animal studies to the problem in man and to the interactions between teratogens and environmental variables. We present a number of illustrative examples of various kinds of interactions that may occur and their possible significance. Striking degrees of potentiative interactions have been demonstrated in laboratory animals when two or more compounds were used simultaneously at doses at or below the threshold level for teratogenicity of the same compound when applied singly. We propose the name coteratogenesis for the agents which are not teratogenic but which aggravate teratogenicity of the other factors known as teratogens.

The effect of repeated expositions to 2450 cm2 microwaves at power densities of 10 or 40 mW/cm2 on fecundity of female Swiss mice was investigated. After microwave irradiations during whole pregnancy mice were allowed to have offsprings. On the day of birth litters were inspected, the number of pups noted. 30 days later female mice were mated with males for the second time and after delivery the litters were controlled, offsprings were counted. The size of first and second litters were compared. The size of second litters of irradiated animals were compared with controls. We concluded, that microwave repetitive exposure of female mice in presented conditions does not result in impaired fecundity measured as a litter size.

Examination of rat liver (Wistar strain) led us to distinguish 3 periods of its morphological development. The differences concerned the development hepatocyte cytoplasm and trabecular liver structure. The particularly essential period was observed between 21-42 days after birth; when cytoplasm capacity had the highest rate.

In a longitudinally followed series of Warsaw children from good socioeconomic conditions 12 anthropometrical traits increments were calculated during the period from 4 to 11 years of life at 1 year intervals. Number of children in age groups ranges from 73 to 104. On the basis of these results were calculated the 10th, 25th, 50th, 75th and 90th percentiles of annual growth velocity. Height and weight velocity is expressed in the form of centile charts. The results are compared with those obtained in series of Polish children born in 1953 and also of British and Swedish children.

The authors present their own clinical material of 74 cases of rhabdomyosarcoma in children, treated in the years 1962-1980. The analysis consists of generally used methods of diagnosis and treatment. Diagnosis was made on the base of clinical, radiological and pathological examination. Treatment was established after stagging qualification and after actually used methods. The treatment based on surgery, radiotherapy, and simple drug chemotherapy was giving bad prognosis and good results was obtained in single cases only. Significant improvement in the results was obtained after multidrug chemotherapy introduced into combined treatment (40%).