Therapia Hungarica (English edition)最新文献

Considering the eventual role of non-specific cell-mediated immune reactions in the pathogenesis of Parkinson's syndrome based on the destruction of dopaminergic cells of the substantia nigra the killer cell activity of patients suffering from this disease has been examined. According to the results the killer cell activity of Parkinson patients is significantly lower in the age group below 60 years as compared to the higher age groups. When comparing the age groups below 60 years, significantly lower activity was measured in the patients than in the controls. Killer cell activity is significantly higher in patients suffering from more severe conditions (Hoehn-Yahr's stage IV-V) when compared to the milder cases. These results suggest the possibility that killer cell-mediated ADCC reaction may play a role in the pathogenesis of the disease. The results of these examinations open new therapeutic perspectives. It may be hoped that, as a result of our increasing knowledge and technical progress in immunology, the damaged immune system could be selectively influenced and target specific immune therapy could be used in the near future by means of for instance inactivations of cytotoxic cells, elimination of antibodies or other immunological methods.

The effect of Paxirasol nasal spray has been examined in 25 patients by the open method. The goal of the study was to assess and evaluate the clinical effectivity of the product and to observe the eventual side-effects. Among the examined patients 14 were acute and 11 chronic disease cases. In 20 of the 25 patients treated with Paxirasol nasal spray the pathological alteration of the nasal mucosa was controlled, mild alteration persisted in 4 patients, and moderately severe condition in 1 patient. The product significantly improved the viscosity of nasal discharge in all of them. The cessation or moderation of difficult nose blowing improved the general condition of the patients and accelerated recovery. Occasionally manifesting olfactory disorders ceased as well. The treatment needed not be discontinued because of the development of side-effects. Considering the healing tendency difference could be observed between the acute and chronic cases, especially in rhinitis sicca patients who were treated with Paxirasol nasal spray. In 23 of the 25 patients notable improvement of both the subjective and objective symptoms was observed. Paxirasol nasal spray is of value in very frequently occurring diseases of the nasal mucosa accompanied by dehydration. In the majority of acute disease patients the use of the product as monotherapy may result in complete cessation of symptoms.

Klion suspension was given to 42 girl and woman patients suffering from vaginal trichomoniasis. Negativity for Trichomonas was recorded in 73.8% of the cases in response to the first 10-day cure, and in 90.5% of the patients following repeated cures. The therapy had no notable side-effects. The liquid form of the medicine proved to be advantageous especially in the treatment of young girls but the possibility to take the drug diluted in soft drinks also facilitated the treatment of the partner.

Parallel with the increasing incidence of cerebrovascular diseases, and the limitations of possible surgical methods, the importance of drug therapy has significantly increased. Due to our knowledge of haemorheology the effectiveness of therapies may be measured by means of useful circulatory markers. In course of our research activities of one and a half decades the changes in blood viscosity were measured during vinpocetine therapy, and were compared to the changes of haematocrit and mean corpuscular volume (MCV) values. The effect of vinpocetine and secale alkaloids or vinpocetine and pentoxifylline were compared by sequential analysis in other cases. The results of these examinations proved that vinpocetine is effective in both short and long-term therapy.

Tensiomin treatment was applied in 20 hypertensive patients with impaired renal function but not requiring dialysis therapy and in 18 patients undergoing regular dialysis. In patients still not requiring dialysis the slowing down of the progression of renal failure, in the dialysed patients insufficient earlier therapy were the indications of Tensiomin treatment. Tensiomin was found to be an effective hypotensive drug in both groups, the majority of the side-effects were mild and of temporary character. The progression of renal failure was slower in the non-dialysed patients compared to the control group but the differences were statistically insignificant.

The study deals with the return of fertility following the discontinuance of the use of different oral contraceptives. On the basis of the evaluation of data of 222 cases the following were concluded: after the discontinuance of the use of oral contraceptives for a shorter-longer period delay may be observed in the return of fertility. This was not longer that 7 months in the evaluated cases. Compared to monophasic tablets, following the use of multiphasic tablets (Anteovin, Tri-Regol) regeneration, that is first ovulation and the following pregnancy, occur within a shorter period. The role of the duration of treatment in this delay could not be cleared because of the relatively low number of cases. Since, according to international data the post-pill return of fertility of nulliparas is slower than that of paras, the author highly recommends the use of multiphasic products for temporary contraception of nulliparas.

The effectivity of recently introduced beta adrenergic agents in the USA prompted physicians to reevaluate the usefulness of theophylline having been used solely as a bronchodilator in the treatment of obstructive respiratory tract diseases. As part of a complex therapy applied in different diseases (acute asthmatic attacks, chronic asthma, acute exacerbation, and long-term treatment of obstructive bronchitis) theophylline is still a drug of value. The risk of toxicity can be reduced to a minimum. In the prevention of certain symptoms (e.g. nocturnal dyspnoea of asthmatics) (slow release) theophylline preparations proved to be the most advantageous. In aged patients technical difficulties limit the use of inhalation therapy, the oral applicability of theophylline is a further advantage of this product.

Means and the currently accepted principles of hormone therapy of breast cancer have been summarized on the basis of data from references. Fields of application and adverse effects of anti-oestrogens, aromatase inhibitors, gestagens, gonadotrophin-releasing, and androgenic hormones have been analysed. Drugs with various mechanisms of action and available in Hungary have been discussed.

Dormicum is a rapidly absorbed up-to date hypnotic of 3-4 hours' duration of action physiologically influencing the phases of normal sleep. In the course of the examination of 26 patients, 21 found the hypnotic action of 7.5-mg or 15-mg Dormicum doses to be highly effective. The drug proved to be an effective hypnotic also in the group of patients above 60 years of age (14). It is of special importance in the everyday practice of a general practitioner that the intake of Dormicum in the evening did not influence the physical and mental activity of the patients the next day.