Zeitschrift fur die gesamte Hygiene und ihre Grenzgebiete最新文献

The biological control procedure for carbon disulphide (CS2), the determination of free and bound CS2 in urine--a procedure already applied to hygienic surveillance--were modified by using gas chromatography and sulphide selective detection (FPD). The results obtained by the changed biological monitoring test in workplace and environmental surveillance are present and discussed. For CS2 concentrations at workplaces in the range of 8-54 mg/m3 a correlation coefficient of r = 0.56 (n = 11, p less than 0.07) was calculated for the mathematical connection of CS2 shift exposure and CS2 content in urine. For environmental exposures in the range of the CS2 immision short term threshold value (MIKK) of 0.03 mg/m3 the procedure may discriminate significantly exposure load from naturally occurring CS2 background.

The estimation of benzpyrene in workplace-air by thin-layer chromatography with fluorimetric detection is described. Using a excitation-wavelength of lambda = 366 nm allows the application of this method by low expenditure. The steps of mode are confirmed.

25 mercury-exposed workers as well as 27 age-matched controls were investigated in an electroneurographic study. The population of mercury-exposed workers was found to have --an increased latency of distal motor action potential at both median and peroneal nerves --an increased latency of distal sensory action potential at median nerve --a decrease of amplitudes of evoked muscle potentials at both median and peroneal nerves --a reduced motor nerve conduction velocity at both examined nerves --a reduced antidromic sensory nerve conduction velocity at median nerve. To detect early changes in nerval function we recommend regularly electroneurographic examinations of mercury-exposed people.

The present paper reports on toxicokinetics of bromoxynil after oral administration of two different dosages in male and female rats. The concentrations measured in serum proceed with a terminal half life of 20 h. Differences in sex are expressed in MRT- and AUC-values. The simulated concentration course after multiple dosing corresponds essentially to experimental course (male rats). Toxicokinetics studies of liver and kidney show a saturation kinetics in kidney after oral administration of a high dose (100 mg/kg KM) in case female rats.

Combinations of antimicrobial agents are often used in medical practice. The combination therapy aims a broader spectrum of chemotherapy and/or synergistic effects. The effect of combination of chemotherapeutics on bacteria may be described as synergistic, indifferent or antagonistic. Therefore, it is essential to test the effectivity of antimicrobial combinations in vitro. The checker-board-technique is the most frequently used test to assess antibacterial combinations. For this standard test macroscopically read an incubation time of 18-24 hours is necessary. To reduce this incubation time to 4 hours a rapid nephelometric method was developed. The results of this method showed a good correlation with the standard test.

On the basis of examinations of 229 children with rapid diagnostic method--latex agglutination of cerebrospinal fluid, serum and urine--this method is to compare with classic culture and it is evaluated as advantageous in the clinical practice. The etiologic agents was found out in 199 cases with the help of latex agglutination.