Anais brasileiros de dermatologia最新文献

{"title":"Omalizumab for cholinergic pruritus in a renal transplant and hemodialysis patient","authors":"Qing Shu , Xiang Zhong , Lixia Zhang , Qian Wang","doi":"10.1016/j.abd.2025.501167","DOIUrl":"10.1016/j.abd.2025.501167","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501167"},"PeriodicalIF":3.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence on inflammatory dermatoses: where we are and where are we going?","authors":"Dimitri Luz F. Silva ,&nbsp;Rafael Rubinho ,&nbsp;Ariany Denofre ,&nbsp;Sandra Avila ,&nbsp;Renata Ferreira Magalhães","doi":"10.1016/j.abd.2025.501164","DOIUrl":"10.1016/j.abd.2025.501164","url":null,"abstract":"<div><h3>Background</h3><div>Artificial intelligence (AI) is increasingly gaining ground in dermatology, with studies reporting accuracy equal to or greater than dermatologists for the diagnosis of skin lesions from clinical and dermoscopic images.<span><span>¹</span></span> AI has been developed and improved constantly for dermatology, however, the focus has been much more on neoplastic diseases, due to their high prevalence and high morbidity.</div></div><div><h3>Objectives</h3><div>Describe the possible applications of AI in inflammatory dermatoses.</div></div><div><h3>Methods</h3><div>Articles published between 2013 and 2023 in Medline and Lilacs were retrieved after applying the inclusion and exclusion criteria 19 articles were selected. From each selected article, the necessary information was extracted and with this data, the present review was written.</div></div><div><h3>Results</h3><div>The first studies on AI in dermatology focused on the diagnosis of neoplasms, especially melanoma, due to the ease of standardization of images, obtaining accuracy equivalent to that of a dermatologist in clinical and dermoscopic lesions. Actually, there are many studies on artificial intelligence in inflammatory dermatosis, such as psoriasis, helping to calculate the PASI, hidradenitis suppurativa, and atopic dematitis.</div></div><div><h3>Study limitations</h3><div>The limitation of the study is that it is a literature review and because it is an innovative topic with a limited number of studies published in the literature.</div></div><div><h3>Conclusions</h3><div>Considerable of what is published in the literature is in computer science journals, but it is possible to perceive that there is an important interest in the area and that artificial intelligence will advance to assist dermatologists.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501164"},"PeriodicalIF":2.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bullous pemphigoid: epidemiological, clinical, and therapeutic analysis of 189 patients in a tertiary center in Brazil","authors":"Cecília Mirelle Almeida Honorato,&nbsp;Claudia Giuli Santi,&nbsp;Celina Wakisaka Maruta,&nbsp;Valeria Aoki,&nbsp;Denise Miyamoto","doi":"10.1016/j.abd.2025.501163","DOIUrl":"10.1016/j.abd.2025.501163","url":null,"abstract":"<div><h3>Background</h3><div>Bullous pemphigoid (BP) is the most prevalent autoimmune bullous dermatosis with increasing incidence globally. There is a lack of literature on BP in the multiethnic Brazilian population.</div></div><div><h3>Objectives</h3><div>To assess the epidemiological, clinical, and therapeutic characteristics of BP patients in a tertiary center in Brazil.</div></div><div><h3>Methods</h3><div>Retrospective longitudinal review of clinical records of 189 BP patients from January 1986 to September 2023.</div></div><div><h3>Results</h3><div>BP primarily affected elderly individuals, predominantly females, with an average onset of symptoms at 65.7-years. Non-bullous presentations had a longer time to diagnose compared to the bullous form. Mucosal involvement was observed in 24.9% of patients. Subepidermal blistering was the predominant histopathological feature. Most cases presented fluorescence of IgG and C3 at the basement membrane zone (BMZ) on direct immunofluorescence. Indirect immunofluorescence mainly revealed fluorescence of IgG along the BMZ, and with salt-split skin technique demonstrated predominantly IgG fluorescence on the epidermal side of the cleavage. Eosinophilia, elevated IgE levels, and D-dimer were common. Systemic corticosteroids remained the mainstay of treatment. BP was associated with significant complications, including thromboembolism, hospitalization, and infections, along with numerous comorbidities and a notable percentage (10.6%) of patients using potentially BP-inducing medications.</div></div><div><h3>Study limitations</h3><div>The study's limitations include its retrospective design, reliance on potentially incomplete clinical records, and findings of a single tertiary center.</div></div><div><h3>Conclusions</h3><div>This study provides crucial insights into the multifaceted nature of BP in the Brazilian population, emphasizing the need for comprehensive management strategies to address its diverse complications and associated conditions.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501163"},"PeriodicalIF":2.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arsenic exposure and risk of skin cancer (melanoma and non-melanoma): A systematic review and meta-analysis","authors":"Lijiao He,&nbsp;Meiying Wei,&nbsp;Qikui Yang,&nbsp;Yun Huang,&nbsp;Zuyuan Wei","doi":"10.1016/j.abd.2025.501161","DOIUrl":"10.1016/j.abd.2025.501161","url":null,"abstract":"<div><h3>Background</h3><div>Arsenic, recognized as a potentially lethal substance and a carcinogen, has been associated with an increased risk of skin cancer; however, the findings have been inconsistent. The aim of this study was to assess the impact of arsenic exposure on skin cancer risk (including melanoma and non-melanoma) through a meta-analysis of the available data.</div></div><div><h3>Objectives</h3><div>To assess the risk of skin cancer from arsenic exposure.</div></div><div><h3>Methods</h3><div>Searches were performed in databases such as PubMed, Web of Science, Embase, and CNKI (as of June 10, 2024). The pooled odds ratio (OR) and its 95% Confidence Interval (95% CI) were calculated using a random effects model. Subgroup analyses were performed considering sample size, study centers, U.S. regions, arsenic exposure routes, and measurement methods.</div></div><div><h3>Results</h3><div>A total of 12 papers were included, comprising 48,003 participants. The findings indicated an association between arsenic exposure and the risk of skin cancer ([OR = 1.51], 95% CI 1.26–1.80). Specifically, the OR was 1.52 (95% CI 1.06–2.17) for melanoma, 1.64 (95% CI 1.16–2.32) for squamous cell carcinoma, and 1.36 (95% CI 1.04–1.77) for basal cell carcinoma. Subgroup analyses also revealed an association between arsenic exposure and skin cancer in the United States (OR = 1.52, 95% CI 1.25–1.87). Both ingestion and inhalation pathways of arsenic exposure showed a trend toward an increased risk of skin cancer.</div></div><div><h3>Study limitations</h3><div>An important limitation of this study is a degree of heterogeneity, and another is due to the limited number of research papers available.</div></div><div><h3>Conclusion</h3><div>This meta-analysis indicates that arsenic exposure may be associated with an elevated risk of skin cancer. Additional prospective research is necessary to verify the association between arsenic exposure and the incidence of skin cancer, encompassing both cutaneous malignant melanoma and non-melanoma skin cancer.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501161"},"PeriodicalIF":2.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized clinical trial of silver hydrofiber dressing versus collagenase ointment for venous ulcer: analysis of biofilm-producing bacteria and bacterial clonality","authors":"Taís Lopes Saranholi ,&nbsp;Natalie Carlos Ferreira Mello Sampaio ,&nbsp;Hélio Amante Miot ,&nbsp;Stéfani Thais Alves Dantas ,&nbsp;Vera Lucia Mores Rall ,&nbsp;Luciana Patricia Fernandes Abbade","doi":"10.1016/j.abd.2025.501162","DOIUrl":"10.1016/j.abd.2025.501162","url":null,"abstract":"<div><h3>Background</h3><div>Superficial infection in venous ulcers (VU) hinders healing.</div></div><div><h3>Objective</h3><div>To evaluate the action of hydrofiber dressing with silver (HAg) compared to collagenase ointment (Col) in VU.</div></div><div><h3>Methods</h3><div>Randomized controlled clinical trial in which patients with VU with superficial infection were randomized to the intervention (HAg) or comparison (Col) group. After 30 days (T30), the primary outcomes evaluated were: rate of ulcers without signs of superficial infection, decrease in bacterial load, presence of biofilm-producing bacteria, and bacterial clonality.</div></div><div><h3>Results</h3><div>Thirty-four patients (56 ulcers) were included ‒ 18 patients (28 ulcers) in the HAg group and 16 (28 ulcers) in the Col group. There was a reduction in ulcers with superficial infection in both groups over time but with no differences (<em>p</em> = 0.422). There was no decrease in total bacterial load over time (<em>p</em> = 0.054) or between the groups (<em>p</em> = 0.113). There was a reduction in the rate of ulcers with biofilm-forming bacteria over time (<em>p</em> = 0.047) but no differences between groups (<em>p</em> = 0.558). Regarding the clonality of <em>Staphylococcus aureus</em>, 92.8% of ulcers in the HAg group and 85% in the Col group, the clones identified at T0 were the same at T30 (<em>p</em> = 0.553). There was no change in the identity of <em>Pseudomonas aeruginosa</em> in any ulcer in either group.</div></div><div><h3>Study limitations</h3><div>Short follow-up time.</div></div><div><h3>Conclusion</h3><div>Both interventions improved the clinical and some microbiologic characteristics, but there was no difference between both interventions. In addition, most ulcers showed indistinguishable genetic profiles of <em>S. aureus</em> and <em>P. aeruginosa</em> between T0 and T30, with no difference between the groups.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501162"},"PeriodicalIF":2.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical-demographic profile, aggravating factors, comorbidities, and quality of life in patients with Rosacea: a Brazilian multicenter study (GBPER: Brazilian Research and Studies Group on Rosacea)","authors":"Renan Rangel Bonamigo ,&nbsp;Paula Barea ,&nbsp;Juliano Peruzzo ,&nbsp;Juliana Boza ,&nbsp;Hélio Amante Miot ,&nbsp;Edileia Bagatin ,&nbsp;Luiz Maurício Costa Almeida ,&nbsp;Giovanni Indelicato Milano ,&nbsp;Carla Wanderley Gayoso de Lima ,&nbsp;Linácia Freitas Vidal ,&nbsp;Fabíola Rosa Picosse ,&nbsp;Bruna Manuella de Figueiredo Afonso ,&nbsp;Clivia Maria Moraes de Oliveira","doi":"10.1016/j.abd.2025.501160","DOIUrl":"10.1016/j.abd.2025.501160","url":null,"abstract":"<div><h3>Background</h3><div>Rosacea is the most prevalent chronic vascular-inflammatory dermatosis of the face. Its pathogenesis includes genetic and environmental factors, neurovascular alterations, and innate immunity. Many triggering and aggravating factors, as well as systemic comorbidities, have been associated with the disease, but there are few studies on its epidemiology in Brazil.</div></div><div><h3>Objectives</h3><div>To describe the profile of patients with rosacea treated at referral centers, as well as to investigate the presence of comorbidities, dietary aspects, worsening factors, and quality of life.</div></div><div><h3>Methods</h3><div>Cross-sectional and multicenter Brazilian study. Clinical and demographic data, disease severity, triggering and/or aggravating factors, diet, comorbidities, and impact on quality of life were evaluated.</div></div><div><h3>Results</h3><div>258 patients were included, predominantly women, between 35 and 65 years old and phototypes III, IV and II. The clinical picture ranged from mild to moderate in 89% of cases and quality of life was reasonable to slightly affected in 58% of cases. Aggravating factors for rosacea were reported by 96% of patients, with climate exposure, alcoholic beverages, and emotional changes being the most frequent. Among the foods mentioned as aggravating factors (28%), pepper, other condiments and hot beverages were the most frequently reported. Comorbidities were reported by 89% of the participants, with emphasis on endocrine (48%), psychiatric (35%), cardiovascular (31%) and gastrointestinal (28%) diseases.</div></div><div><h3>Study limitations</h3><div>Uncontrolled study, including patients undergoing dermatological treatment.</div></div><div><h3>Conclusions</h3><div>This study establishes that the profile of Brazilian patients with rosacea corroborates that described in the literature, with the presence of the disease in higher phototypes being relevant. Pepper and other condiments and hot beverages were important aggravating factors, and the presence of various comorbidities was reported by most of the patients.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501160"},"PeriodicalIF":2.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship of Fric test responses with an urticaria activity score, urticaria control test and quality of life scales in patients with symptomatic dermographism","authors":"Ömer Faruk Kıraç ,&nbsp;Mustafa Tosun ,&nbsp;Rukiye Yasak Güner ,&nbsp;Melih Akyol","doi":"10.1016/j.abd.2025.501147","DOIUrl":"10.1016/j.abd.2025.501147","url":null,"abstract":"<div><h3>Background</h3><div>The FricTest is used as a valuable tool for diagnosing and conducting threshold testing for Symptomatic Dermographism (SD).</div></div><div><h3>Objective</h3><div>In this study, the authors aimed to make a comparison between the Urticaria Activity Score (UAS), Urticaria Control Test (UCT), Visual Analog Scale (VAS), Dermatology Life Quality Index (DLQI), and Chronic Urticaria-Specific Quality of Life (CU-QoL) used to evaluate disease activity and control in the follow-up of urticaria patients and the Fric Test responses used in the diagnosis of dermographism.</div></div><div><h3>Methods</h3><div>71 patients with SD were included in the study. Fric test 4.0 was performed in all patients at baseline and at month 1. The correlations of Fric test scores with UCT, UAS, VAS, DLQI, and CU-QoL at baseline as well as the changes in responses of treatment in the mean scores at month 1 were performed.</div></div><div><h3>Results</h3><div>In the correlation analyses, positive correlations were observed between UAS, DLQI, and CU-QoL scores and changes in Fric test 4.5 mm and 4 mm responses from baseline to the first month of treatment (<em>p</em> &lt; 0.05). No significant correlations were found between Fric test 3.5 mm and 3 mm responses and CU-QoL, UAS, DLQI, and VAS scores (<em>p</em> &gt; 0.05).</div></div><div><h3>Study limitations</h3><div>This study includes results from a small sample size, and larger-scale clinical trials are needed.</div></div><div><h3>Conclusion</h3><div>Changes in the Fric test 4.5 mm and 4 mm responses of treatment were found to be more sensitive in detecting UCT, UAS, CU-QoL, and DLQI changes than the responses of the Fric test 3.5 mm and 3 mm.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"Article 501147"},"PeriodicalIF":2.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144569894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphocytic thrombophilic arteritis, an infrequent cause of livedo reticularis – case report","authors":"Dominga Peirano ,&nbsp;Maria Luz Hubner-Garretón ,&nbsp;Martha Fernandez ,&nbsp;Andrés Figueroa","doi":"10.1016/j.abd.2025.501148","DOIUrl":"10.1016/j.abd.2025.501148","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 4","pages":"Article 501148"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical super-high magnification dermoscopy versus standard dermoscopy in basal cell carcinoma","authors":"Izadora Moreira do Amaral ,&nbsp;Elisa Scandiuzzi Maciel ,&nbsp;Daniela Surjan Milheti ,&nbsp;Camila Arai Seque ,&nbsp;Milvia Maria Simões e Silva Enokihara ,&nbsp;Sérgio Henrique Hirata","doi":"10.1016/j.abd.2025.501152","DOIUrl":"10.1016/j.abd.2025.501152","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 4","pages":"Article 501152"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological profile of anogenital lesions in 4,029 consultations at a Sexually Transmitted Infections Clinic in São Paulo, Brazil","authors":"Julia Aires Thomaz Maya ,&nbsp;Kaique Arriel ,&nbsp;Laura Stamato de Figueiredo ,&nbsp;John Verrinder Veasey","doi":"10.1016/j.abd.2025.501145","DOIUrl":"10.1016/j.abd.2025.501145","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 4","pages":"Article 501145"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}