Anais brasileiros de dermatologia最新文献

英文中文

Skin cancer after heart transplantation: a systematic review 心脏移植后的皮肤癌：系统回顾。

IF 2.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-01-01 DOI: 10.1016/j.abd.2024.05.004

Nathalia Hoffmann Guarda Aguzzoli , Ana Laura Bueno , Yağmur Halezeroğlu , Renan Rangel Bonamigo

Background

Cancer is an important cause of morbidity and mortality after solid organ transplants. Skin cancer is the most prevalent non-lymphoid malignancy occurring during heart transplantation follow-up. Due to the complexity of immunosuppressive therapy and the high prevalence and incidence of skin cancer in this population, dermatologists play an important role in the short and long-term follow-up of heart transplant recipients.

Objectives

The goal of this study is to present data from a systematic literature review focusing on the occurrence of skin cancer in patients who have undergone heart transplantation.

Methods

The authors conducted a systematic review of the literature in the EMBASE and PubMed databases from August to September 2021 to investigate the incidence of skin cancer in heart transplant patients. The authors selected retrospective and prospective cohort studies presenting data on the frequency of skin cancer in patients following heart transplantation. Exclusion criteria included articles that did not stratify the organ transplant type and studies that did not evaluate the frequency of skin cancer in the specific population.

Results

Based on the search strategy, the authors found 2589 studies, out of which 37 were eligible for inclusion in this study. Provided data are from 20 different countries, over the period 1974 to 2015. Incidence of non-melanoma skin cancer (NMSC) ranges from 0.97% to 52.8%. The incidence of squamous cell carcinoma (SCC) ranges from 1.19% to 89% and the incidence of basal cell carcinoma (BCC) ranges from 2% to 63%. Malignant Melanoma (MM) incidence ranges from 0.94% to 4.6%

Study limitations

The analysis involved an exclusive focus on heart transplant patients, and the statistical analysis of the sample may have been hampered. The significant heterogeneity among the studies emerged as a challenge during the analysis of the results. Furthermore, the study is limited by variations in follow-up periods among the included studies.

Conclusion

Although gathering methodologically heterogeneous data, this systematic review was able to show the epidemiological importance of skin cancer in heart transplant patients. This study reinforces the important role dermatologists play in the short and long-term follow-up of heart transplant patients.

背景：癌症是实体器官移植后发病和死亡的重要原因。皮肤癌是心脏移植后续治疗中最常见的非淋巴恶性肿瘤。由于免疫抑制治疗的复杂性以及皮肤癌在这一人群中的高流行率和发病率，皮肤科医生在心脏移植受者的短期和长期随访中发挥着重要作用：本研究的目的是通过系统性文献综述提供数据，重点关注心脏移植患者皮肤癌的发生情况：作者于 2021 年 8 月至 9 月对 EMBASE 和 PubMed 数据库中的文献进行了系统性回顾，以调查心脏移植患者皮肤癌的发病率。作者选择了一些回顾性和前瞻性队列研究，这些研究提供了心脏移植患者皮肤癌发病率的数据。排除标准包括未对器官移植类型进行分层的文章，以及未评估特定人群皮肤癌发病率的研究：根据搜索策略，作者找到了 2589 项研究，其中 37 项符合纳入本研究的条件。提供的数据来自 20 个不同国家，时间跨度为 1974 年至 2015 年。非黑色素瘤皮肤癌（NMSC）的发病率从 0.97% 到 52.8% 不等。鳞状细胞癌（SCC）的发病率从1.19%到89%不等，基底细胞癌（BCC）的发病率从2%到63%不等。恶性黑色素瘤 (MM) 的发病率从 0.94% 到 4.6% 不等：分析仅针对心脏移植患者，样本的统计分析可能受到影响。在对结果进行分析时，各研究之间存在明显的异质性，这也是一个挑战。此外，这项研究还受到所纳入研究的随访期不同的限制：尽管收集到的数据在方法上存在差异，但这篇系统综述能够显示皮肤癌在心脏移植患者中的流行病学重要性。这项研究加强了皮肤科医生在心脏移植患者短期和长期随访中的重要作用。

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引用次数: 0

Facial cutaneous Rosai-Dorfman disease treated with pulsed dye laser: a case report and literature review 用脉冲染料激光治疗面部皮肤罗赛-多夫曼病：病例报告和文献综述。

IF 2.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-01-01 DOI: 10.1016/j.abd.2024.05.002

Qin-Xiao Wang, Si-Yu Luo, Kai-Yi Zhou, Sheng Fang

引用次数: 0

Clinical and epidemiological characterization of demodicosis cases in the pediatric population at the Hospital Clinic of the University of Chile (2013‒2020) 智利大学医院门诊部儿科人群中脱皮病病例的临床和流行病学特征（2013-2020 年）。

IF 2.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-01-01 DOI: 10.1016/j.abd.2023.10.008

Claudia Schroder , Matías Gárate , Diego Orlandi , Ligia Aranibar , Francisco Silva

引用次数: 0

Plantar acral melanoma: epidemiological, clinical, dermoscopic and histopathological features. A Brazilian cohort 足底肢端黑色素瘤：流行病学、临床、皮肤镜和组织病理学特征。一群巴西人。

IF 2.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-01-01 DOI: 10.1016/j.abd.2024.03.006

Lucas Campos Garcia , João Renato Vianna Gontijo , Flávia Vasques Bittencourt

Background

Acral melanomas (AM) are rare and approximately two-thirds of them occur on the soles of the feet beeing more prevalent in black and Asian individuals. Data on this subtype of melanoma are scarce in the Brazilian population.

Objectives

To describe and correlate the epidemiological, clinical, dermoscopic, and histopathological features of AM a.

Methods

Single-center, retrospective and cross-sectional study, evaluating data from a 15-year period.

Results

A total of 48 cases were included. Mean age was 62.54 years, with a predominance of women (62.5%). The percentage of amelanotic melanomas was higher among lighter skin patients (20% × 7.7%). Polychromia was the most prevalent finding (94.4%). The parallel ridge pattern (PRP) had a prevalence of 78% and a serrated pattern was associated with lower Breslow thickness (p = 0.041). Ulceration present on histopathological (p = 0.013) or dermoscopic (p = 0.047) evaluation was associated with greater Breslow thickness.

Study limitations

Retrospective study with loss of data.

Conclusion

Amelanotic tumors were more prevalent in ligther phototypes (20% × 7.7%). Polychromia was the most prevalent finding (94.4%) and ulceration observed on clinical or histopathological evaluation was associated with higher Breslow thickness (p = 0.013 and 0.047).

背景：肢端黑色素瘤（AM）是罕见的，大约三分之二发生在脚底，在黑人和亚洲人中更为普遍。在巴西人群中，关于这种黑色素瘤亚型的数据很少。目的：描述和关联AM的流行病学、临床、皮肤镜和组织病理学特征。方法：单中心、回顾性和横断面研究，评估15年的数据。结果：共纳入48例。平均年龄62.54岁，以女性居多（62.5%）。肤色较浅的患者无色素黑素瘤的比例较高（20% × 7.7%）。多色症是最普遍的发现（94.4%）。平行脊型（PRP）患病率为78%，锯齿型与较低的Breslow厚度相关（p = 0.041）。组织病理学（p = 0.013）或皮肤镜（p = 0.047）评估的溃疡与较大的Breslow厚度相关。研究局限性：有资料缺失的回顾性研究。结论：无色素瘤在浅色光型中发病率较高（20% × 7.7%）。多色症是最常见的发现（94.4%），临床或组织病理学评估中观察到的溃疡与较高的Breslow厚度相关（p = 0.013和0.047）。

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引用次数: 0

Cutaneous amoebiasis: a dermatological rarity 皮肤阿米巴病：一种罕见的皮肤病。

IF 2.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-01-01 DOI: 10.1016/j.abd.2024.04.008

John Verrinder Veasey , Helena Pladevall Moreira , Mariana de Figueiredo Silva Hafner , Rute Facchini Lellis

引用次数: 0

Monozygotic twins affected by SAPHO syndrome 患有 SAPHO 综合征的单卵双胞胎。

IF 2.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-01-01 DOI: 10.1016/j.abd.2024.03.008

Ilaria Scandagli , Elia Rosi , Gianmarco Silvi , Matteo Ruggieri , Tommaso Amadori , Francesca Prignano

引用次数: 0

The exposome impact on hair health: etiology, pathogenesis and clinical features ‒ Part I 暴露组对头发健康的影响：病因、发病机制和临床特征--第一部分。

IF 2.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-01-01 DOI: 10.1016/j.abd.2024.07.003

Stephano Cedirian , Ludmila Prudkin , Bianca Maria Piraccini , Julia Santamaria , Jaime Piquero-Casals , David Saceda-Corralo

Human hair, particularly on the scalp, serves as a significant aspect of social identity and well-being. The exposome, encompassing both intrinsic and extrinsic factors, plays a fundamental role in hair weathering. Intrinsic factors include genetic predispositions and physiological changes within the body, while extrinsic factors comprise environmental exposures such as UV radiation, pollution, humidity, temperature variations, lifestyle choices, and chemical treatments. These elements collectively contribute to the cumulative damage experienced by hair over time. Understanding the comprehensive impact of the exposome on hair health and hair aging necessitates an exploration of various environmental conditions, lifestyle factors, and technical artifacts. Despite advancements in research, the intricate mechanisms underlying the exposome influence on hair remain incompletely understood. Through a comprehensive review of current literature and emerging research findings, this study aims to enhance the understanding of exposome impact on hair health.

人类的头发，尤其是头皮上的头发，是社会身份和福祉的一个重要方面。包括内在和外在因素在内的 "暴露体 "在头发风化过程中起着根本性的作用。内在因素包括遗传倾向和体内生理变化，而外在因素则包括环境暴露，如紫外线辐射、污染、湿度、温度变化、生活方式选择和化学治疗。这些因素共同造成了头发长期遭受的累积性损伤。要了解暴露体对头发健康和头发老化的综合影响，就必须对各种环境条件、生活方式因素和技术手段进行探索。尽管研究取得了进展，但人们对暴露体影响头发的复杂机制仍不甚了解。本研究旨在通过对当前文献和新兴研究成果的全面回顾，加深人们对暴露组对头发健康影响的理解。

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引用次数: 0

Allergic contact dermatitis to lettuce 莴苣过敏性接触性皮炎。

IF 2.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-01-01 DOI: 10.1016/j.abd.2024.04.006

Mariany Lima Rezende , Ana Luiza Castro Fernandes Villarinho , Maria das Graças Mota Melo , Clarissa Vita Campos

引用次数: 0

Comparison of long term efficacy and cost-effectiveness of omalizumab in 150 mg and 300 mg doses in patients with chronic spontaneous urticaria 慢性自发性荨麻疹患者使用 150 毫克和 300 毫克剂量的奥马珠单抗的长期疗效和成本效益比较。

IF 2.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-01-01 DOI: 10.1016/j.abd.2024.02.006

Fikriye Kalkan, Sait Yeşillik, Fevzi Demirel, Ezgi Sönmez, Yasemin Balaban, Mustafa İlker İnan, Özgür Kartal

Background

Chronic spontaneous urticaria (CSU) is a clinical condition that affects patients quality of life. Omalizumab is preferred in antihistamines resistant CSU cases. Urticaria activity score-7 (UAS-7) is a scale that shows the severity of the disease.

Objectives

The authors aimed to compare the long-term (60 months) efficacy and side effects of 150 mg and 300 mg doses of omalizumab in patients with CSU.

Methods

108 patients followed up at the clinic with the diagnosis of CSU were included. Omalizumab was started in patients who were resistant to conventional CSU treatment. Two groups were formed to receive 150 mg and 300 mg doses of omalizumab. Urticaria activity score (UAS-7), antihistamine usage, time to achieve disease-free stage, relapse after treatment, and side effects of omalizumab treatment were compared in the two groups.

Results

There were no statistically significant differences between the groups regarding basal characteristics and laboratory findings. Average follow-up time was sixty months. UAS-7 scores were similar in the follow-up. There were no adverse events in both groups.

Study limitations

Retroactive design and single-center nature to reach a more significant number of patients. Lack of patients receiving the lowest dose 75 mg and the highest dose 600 mg of omalizumab. Absence of total body mass indexes of all patients. Besides, the use of distinct drugs may contribute to non confident results and is another limitation of this study.

Conclusion

Since there is no significant difference between 150–300 mg omalizumab doses regarding long-term treatment efficacy and side effects in CSU patients, starting treatment with a 150 mg dose may be suitable. In patients who do not respond to 150 mg, the omalizumab dose can be increased to 300 mg. It will prevent unpredictable dose and time-dependent complications and will be a cost-effective approach even in strong economies.

背景：慢性自发性荨麻疹（CSU慢性自发性荨麻疹（CSU）是一种影响患者生活质量的临床症状。抗组胺药耐药的 CSU 病例首选奥马珠单抗。荨麻疹活动评分-7（UAS-7）是一种显示疾病严重程度的量表：作者旨在比较 150 毫克和 300 毫克剂量的奥马珠单抗对 CSU 患者的长期（60 个月）疗效和副作用。对常规CSU治疗耐药的患者开始使用奥马珠单抗。两组患者分别接受150毫克和300毫克剂量的奥马珠单抗治疗。比较了两组患者的荨麻疹活动评分（UAS-7）、抗组胺药用量、达到无病期的时间、治疗后复发情况以及奥马珠单抗治疗的副作用：结果：两组患者的基本特征和实验室检查结果无明显统计学差异。平均随访时间为 60 个月。随访期间的 UAS-7 评分相似。两组患者均未出现不良反应：研究的局限性：追溯性设计和单中心性质，无法覆盖更多患者。缺乏接受最低剂量75毫克和最高剂量600毫克奥马珠单抗的患者。缺少所有患者的总体重指数。此外，使用不同的药物可能会导致结果不确定，这也是本研究的另一个局限性：由于150-300毫克剂量的奥马珠单抗在CSU患者的长期疗效和副作用方面没有明显差异，因此从150毫克剂量开始治疗可能是合适的。如果患者对 150 毫克的剂量没有反应，可将奥马珠单抗的剂量增加到 300 毫克。这将避免出现不可预测的剂量和时间依赖性并发症，即使在经济实力雄厚的国家也是一种具有成本效益的方法。

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引用次数: 0

The Brazilian Society of Dermatology on the centennial of the Anais Brasileiros de Dermatologia 巴西皮肤病学会纪念《巴西皮肤病学年鉴》（Anais Brasileiros de Dermatologia）一百周年。

IF 2.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-01-01 DOI: 10.1016/j.abd.2024.09.001

Heitor de Sá Gonçalves , Carlos Baptista Barcaui , Francisca Regina Oliveira Carneiro , Márcio Soares Serra , Rosana Lazzarini , Fabiane Andrade Mulinari Brenner

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