Anais brasileiros de dermatologia最新文献

英文中文

Vertical ex vivo dermoscopy in diagnosing and differentiating skin lesions 垂直离体皮肤镜在诊断和鉴别皮肤病变中的应用。

IF 3.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-10-16 DOI: 10.1016/j.abd.2025.501209

Mirjana Popadić , Dimitrije Brasanac , Danijela Milošev , Ana Ravić Nikolić , Slobodanka Mitrović

Background

Publications on vertical ex vivo dermoscopy of skin lesions are sporadic and present only as case reports.

Objectives

This study defines, describes, and determines the importance of structures visible by vertical ex vivo dermoscopy in the diagnosis of pigmented, benign skin lesions and their distinction between themselves, and in relation to other skin lesions.

Methods

The prospective, descriptive study was conducted in two University centers. Digital images of completely excised skin lesions, fixed in formalin before further processing, were evaluated dermoscopically. For the analysis of horizontal ex vivo dermoscopy, pattern analysis was used, while for the vertical section, a description of the visible structures was made.

Results

The research sample consisted of 80 benign pigmented skin lesions obtained from 73 patients. Histopathological diagnosis of the evaluated lesions included 59 nevi, 17 seborrheic keratoses, 3 angiomas and 1 clear cell acanthoma. Seborrheic keratosis had the most variable presentation on vertical ex vivo dermoscopy. By analyzing the vertical section of the evaluated skin lesions, the importance of vertical ex vivo dermoscopy in the diagnosis and/or differentiation of blue nevus, seborrheic keratosis and angioma from other skin lesions was noted.

Study limitations

Small number of analyzed lesions, and inclusion of Caucasian patients only.

Conclusions

Vertical ex vivo dermoscopy can contribute to the distinction between different pigmented benign skin lesions, as well as to their differentiation from other skin lesions. Furthermore, vertical section enables more accurate assessment of additional, descriptive lesional characteristics.

背景：关于皮肤病变的垂直离体皮肤镜检查的出版物是零星的，仅作为病例报告。目的：本研究定义、描述并确定垂直离体皮肤镜下可见结构在诊断色素沉着、良性皮肤病变、区分它们之间的区别以及与其他皮肤病变的关系中的重要性。方法：前瞻性、描述性研究在两个大学中心进行。完全切除的皮肤病变的数字图像，在进一步处理之前固定在福尔马林中，在皮肤镜下进行评估。对于水平离体皮肤镜的分析，采用模式分析，而对于垂直切片，则对可见结构进行描述。结果：研究样本包括73例患者的80个良性色素皮损。组织病理学诊断为59例痣，17例脂溢性角化病，3例血管瘤和1例透明细胞棘层瘤。脂溢性角化病在垂直离体皮肤镜下表现最为多变。通过分析评估的皮肤病变的垂直切片，注意到垂直离体皮肤镜在诊断和/或区分蓝色痣、脂溢性角化病和血管瘤与其他皮肤病变中的重要性。研究局限性：分析的病变数量少，且仅包括白种人患者。结论：垂直离体皮肤镜检查有助于区分不同色素的良性皮肤病变，并有助于与其他皮肤病变的鉴别。此外，垂直剖面可以更准确地评估额外的描述性病变特征。

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引用次数: 0

B-cell subsets in leprosy lesions: unraveling the complex interplay. 麻风病病变中的b细胞亚群：揭示复杂的相互作用。

IF 3.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.abd.2025.501184

Luis Alberto Ribeiro Fróes, Carla Pagliari, Maria Angela Bianconcini Trindade, Mirian Nacagami Sotto

Background: Leprosy is a chronic infectious disease marked by complex immune interactions, yet the roles of specific B-lymphocyte subsets in its pathology are poorly understood.

Objectives: To investigate the presence and distribution of B-cell subsets, including B1 cells, Marginal Zone (MZ) B-cells, Regulatory B-cells (Bregs), and Effector-1 B-cells (Be1), across different clinical forms of leprosy and reactional states.

Methods: Immunohistochemical and morphometric analyses were performed on skin lesions from patients with various clinical presentations of leprosy.

Results: CD20+ B-cells were abundant in tuberculoid lesions, whereas MZB-1 expression varied significantly among leprosy subtypes. Type 1 Reaction (T1R) lesions exhibited significantly higher counts of B1 and MZ B-cells compared to Type 2 Reaction (T2R), lepromatous leprosy (LL), and indeterminate leprosy (I). Expression patterns of PAX5/MZB-1 and PAX5/CD5 suggested a dominant presence of these cells in the Th1 pole. Be1 cells, strongly linked to Th1 immune response, were also more abundant in Th1 clinical presentations (tuberculoid and T1R leprosy). Although Bregs were generally scarce, they were most frequently observed in T1R.

Study limitations: This study was limited by the relatively small number of cases analyzed per clinical subtype and reactional state.

Conclusions: This is the first study to document the presence and distribution of these specific B-cell subsets in leprosy lesions. The findings suggest distinct roles for B-lymphocyte subtypes, particularly at the tuberculoid pole and during Type 1 reactions.

背景：麻风病是一种以复杂的免疫相互作用为特征的慢性传染病，然而特异性b淋巴细胞亚群在其病理中的作用尚不清楚。目的：研究b细胞亚群的存在和分布，包括B1细胞、边缘区（MZ） b细胞、调节性b细胞（Bregs）和效应-1 b细胞（Be1），在不同临床形式的麻风病和反应状态中。方法：对不同临床表现的麻风患者的皮肤病变进行免疫组织化学和形态计量学分析。结果：CD20+ b细胞在结核样病变中表达丰富，而MZB-1在麻风亚型中表达差异显著。与2型反应（T2R）、麻风病（LL）和不确定麻风病(I)相比，1型反应（T1R）病变中B1和MZ b细胞的计数明显更高。PAX5/MZB-1和PAX5/CD5的表达模式表明这些细胞主要存在于Th1极点。Be1细胞与Th1免疫反应密切相关，在Th1临床表现（结核样和T1R麻风病）中也更为丰富。虽然布雷格斯通常很少见，但它们最常见于T1R。研究局限性：本研究受限于每个临床亚型和反应状态分析的病例数量相对较少。结论：这是第一个记录麻风病变中这些特异性b细胞亚群的存在和分布的研究。研究结果表明，b淋巴细胞亚型具有不同的作用，特别是在结核样极和1型反应中。

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引用次数: 0

Penile erosions: an atypical initial manifestation of pemphigus vulgaris. 阴茎糜烂：寻常型天疱疮的非典型初始表现。

IF 3.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.abd.2025.501189

Hugo J Leme, José Ramos, António Magarreiro-Silva, Ana Isabel Gouveia, João Alves

引用次数: 0

Composite hemangioendothelioma: report of a rare neoplasm. 复合血管内皮瘤：一罕见肿瘤报告。

IF 3.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.abd.2025.501166

Marilda Aparecida Milanez Morgado de Abreu, Carolina Aparecida de Almeida Ferreira, Gisele Alborghetti Nai

引用次数: 0

Appearance of basal cell carcinoma on untreated capillary malformation. 未经治疗的毛细血管畸形的基底细胞癌的表现。

IF 3.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.abd.2025.501190

Catalina Buchroithner, Nelson Lobos, Gabriel Neely, Arturo Madrid, Valentina Darlic, Alex Castro

引用次数: 0

Posterior reversible encephalopathy syndrome in a patient treated with ustekinumab. Ustekinumab治疗患者的后部可逆性脑病综合征

IF 3.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.abd.2025.501177

Marilda Aparecida Milanez Morgado de Abreu, Naíra M de A Guaresemin, Murilo de Oliveira Lima Carapeba

引用次数: 0

Sporotrichosis in Amazon: series of 46 cases with emphasis on zoonotic transmission. 亚马逊地区孢子虫病：46例，重点是人畜共患传播。

IF 3.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.abd.2025.501171

Luiza Rennó Rocha de Oliveira, Isabela de Nazaré Tavares Cardoso Souza, Murilo Dos Santos Souza, Carla Andrea Avelar Pires, Maria Amélia Lopes Dos Santos, Francisca Regina Oliveira Carneiro

引用次数: 0

Derm dotting technique to detect micro-invasive component in lentigo maligna and subsequent margin control with a modified staged excision technique. 真皮点阵技术检测恶性小晶体的微创成分和随后改良的分期切除技术的边缘控制。

IF 3.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-09-01 Epub Date: 2025-08-09 DOI: 10.1016/j.abd.2025.501191

Nelson Lobos-Guede, Pablo Vargas-Mora, Gabriela Coulon, Chantal Caussade, Valentina Darlic, Magdalena Delgado

引用次数: 0

Phenol in dermatology: updated evidence on efficacy and safety 苯酚在皮肤病学：功效和安全性的最新证据

IF 3.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-08-25 DOI: 10.1016/j.abd.2025.501200

Carolina Reato Marçon

Phenol, or carbolic acid, is an organic compound with caustic and antiseptic properties widely used in dermatology. Since its introduction as an antiseptic in the 19^th century, its use has expanded to various areas of medicine, including the treatment of dermatological conditions such as vitiligo, warts, guttate leukoderma, hidradenitis suppurativa, angiosarcoma, acne scars, alopecia areata, onychocryptosis, and actinic keratoses. In deep peels, phenol stands out for its effectiveness in skin rejuvenation, promoting intense and sustained neocollagenesis, with unparalleled results. Its ability to alter dermal structure makes it an essential therapeutic tool in various dermatological approaches. However, its use requires extreme caution due to its rapid cutaneous absorption and unique toxicokinetic profile. The substance can induce serious complications, such as cardiac arrhythmias, renal failure, neurotoxicity, and multiple organ failure, especially when applied to large areas or with inadequate techniques and formulations. Historical and contemporary studies report cases of fatal poisoning due to cutaneous exposure to phenol, highlighting the need for strict precautions in its use. To minimize these risks, it is essential that procedures be performed by highly trained physicians, with constant monitoring and controlled application, to ensure safety and maximize the therapeutic benefits of this substance, whose efficacy is widely recognized.

苯酚，或称石炭酸，是一种具有腐蚀性和防腐性能的有机化合物，广泛用于皮肤病学。自19世纪作为防腐剂引入以来，它的用途已经扩展到医学的各个领域，包括治疗皮肤病，如白癜风、疣、斑疹性白皮病、化脓性汗腺炎、血管肉瘤、痤疮疤痕、斑秃、甲爪隐症和光化性角化病。在深层去皮中，苯酚因其在皮肤再生方面的有效性而脱颖而出，促进强烈和持续的新胶原形成，具有无与伦比的效果。其改变皮肤结构的能力使其成为各种皮肤病治疗方法中必不可少的治疗工具。然而，由于其快速的皮肤吸收和独特的毒性动力学特征，它的使用需要非常谨慎。该物质可引起严重的并发症，如心律失常、肾功能衰竭、神经毒性和多器官衰竭，特别是在大面积应用或技术和配方不充分的情况下。历史和当代研究报告了由于皮肤接触苯酚而导致致命中毒的病例，强调了在使用苯酚时需要严格预防。为了尽量减少这些风险，必须由训练有素的医生进行操作，并持续监测和控制应用，以确保安全性并最大限度地发挥该物质的治疗效果，其疗效已得到广泛认可。

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引用次数: 0

Paradoxical lichenoid reaction during dupilumab treatment- a case report and literature review 杜匹单抗治疗期间矛盾的地衣样物质反应-一例报告和文献综述

IF 3.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia

Pub Date : 2025-08-22 DOI: 10.1016/j.abd.2025.501192

Fuchen Huang , Zequn Tong , Xueting Zeng , Jiawen Chen , Ying Zou , Chao Ji

引用次数: 0

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