Pub Date : 2025-01-01DOI: 10.1016/j.abd.2024.03.014
Paula Rosa Coutinho Goulart Borges Mariottoni , Leonardo Spagnol Abraham , Leopoldo Duailibe Nogueira Santos , Daniel Fernandes Melo , Rodrigo Pirmez , Paulo Müller Ramos , Hélio Amante Miot
{"title":"Translation, cultural adaptation and validation of the Brazilian version of the Frontal Fibrosing Alopecia Quality of Life Index (FFA-QLI-BRA)","authors":"Paula Rosa Coutinho Goulart Borges Mariottoni , Leonardo Spagnol Abraham , Leopoldo Duailibe Nogueira Santos , Daniel Fernandes Melo , Rodrigo Pirmez , Paulo Müller Ramos , Hélio Amante Miot","doi":"10.1016/j.abd.2024.03.014","DOIUrl":"10.1016/j.abd.2024.03.014","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 165-168"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.abd.2023.12.010
Paulo Ricardo Criado , Mayra Ianhez , Hélio Amante Miot , Roberta Fachini Jardim Criado , Carolina Talhari , Paulo Müller Ramos
Drug-induced hypersensitivity syndrome, also known as DRESS syndrome, is a serious and potentially fatal reaction that occurs in response to prolonged use (generally between 14 and 60 days) of certain drugs, and which has no predilection for gender or age group. It is believed that DRESS syndrome has a genetic basis and results from the interaction between metabolites of certain pharmacological groups, reactivation of latent viruses (especially from the Herpesviridae family), and a cellular immune response. The classic manifestation of DRESS syndrome includes a generalized rash accompanied by fever, eosinophilia, lymphadenopathy, and systemic involvement such as hepatitis, nephritis, or pneumonitis. With the continuous increase in the availability of drugs and the aging of the population, there is a favorable scenario for the development of adverse drug reactions. Physicians should be prepared for the early diagnosis of DRESS syndrome, the identification and immediate suspension of the drug involved, and also manage systemic involvement, which may require prolonged immunosuppressive therapy. This article provides an update on the clinical, physiopathological and therapeutic aspects of DRESS syndrome.
{"title":"DRESS syndrome: an interaction between drugs, latent viruses, and the immune system","authors":"Paulo Ricardo Criado , Mayra Ianhez , Hélio Amante Miot , Roberta Fachini Jardim Criado , Carolina Talhari , Paulo Müller Ramos","doi":"10.1016/j.abd.2023.12.010","DOIUrl":"10.1016/j.abd.2023.12.010","url":null,"abstract":"<div><div>Drug-induced hypersensitivity syndrome, also known as DRESS syndrome, is a serious and potentially fatal reaction that occurs in response to prolonged use (generally between 14 and 60 days) of certain drugs, and which has no predilection for gender or age group. It is believed that DRESS syndrome has a genetic basis and results from the interaction between metabolites of certain pharmacological groups, reactivation of latent viruses (especially from the <em>Herpesviridae</em> family), and a cellular immune response. The classic manifestation of DRESS syndrome includes a generalized rash accompanied by fever, eosinophilia, lymphadenopathy, and systemic involvement such as hepatitis, nephritis, or pneumonitis. With the continuous increase in the availability of drugs and the aging of the population, there is a favorable scenario for the development of adverse drug reactions. Physicians should be prepared for the early diagnosis of DRESS syndrome, the identification and immediate suspension of the drug involved, and also manage systemic involvement, which may require prolonged immunosuppressive therapy. This article provides an update on the clinical, physiopathological and therapeutic aspects of DRESS syndrome.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 104-120"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.abd.2024.02.008
Tuany R. Schmidt , Belkiss C. Mármora , Fernanda T. Brochado , Lucas Gonçalves , Paloma S. Campos , Marcelo L. Lamers , Aurigena A. de Araújo , Caroline A.C.X. de Medeiros , Susana B. Ribeiro , Marco A.T. Martins , Emily F.S. Pilar , Manoela D. Martins , Vivian P. Wagner
Background
The clinical advantages of light-emitting diode (LED) therapy in skin healing and its underlying mechanism remain subjects of ongoing debate.
Objective
This study aims to explore the impact of LED therapy on normal skin keratinocytes (HaCaT) and in the repair of full-thickness dorsal wounds in Wistar rats.
Methods
HaCaT cell viability (SRB assay) and migration (scratch assay) were assessed under LED therapy, comparing stress conditions (2.5% FBS) with sham irradiation and optimal conditions (10% FBS). In vivo, 50 rats with induced wounds were divided into Sham and LED (daily treatment) groups. Euthanasia occurred at 3, 5, 10, 14, and 21 days for clinical, morphological, oxidative stress (MDA, SOD, and GSH), and cytokine analyses (IL-1β, IL-10, TNF-α).
Results
LED therapy significantly enhanced keratinocytes viability compared to sham irradiation, with minimal impact on cell migration. Clinical benefits were prominent on day 10, influencing inflammation progression and resolution on days 3 and 10. Re-epithelization remained unaffected. Reduced MDA and increased GSH levels were observed throughout, while SOD levels varied temporally. Notably, on day 10, LED significantly decreased IL-1β, IL-10, and TNF-α.
Study limitations
Although translational, clinical trial confirmation of observed benefits is warranted.
Conclusions
LED therapy expedites cutaneous healing in the experimental model, primarily modulating inflammation and enhancing antioxidant activity.
{"title":"Red light-emitting diode on skin healing: an in vitro and in vivo experimental study","authors":"Tuany R. Schmidt , Belkiss C. Mármora , Fernanda T. Brochado , Lucas Gonçalves , Paloma S. Campos , Marcelo L. Lamers , Aurigena A. de Araújo , Caroline A.C.X. de Medeiros , Susana B. Ribeiro , Marco A.T. Martins , Emily F.S. Pilar , Manoela D. Martins , Vivian P. Wagner","doi":"10.1016/j.abd.2024.02.008","DOIUrl":"10.1016/j.abd.2024.02.008","url":null,"abstract":"<div><h3>Background</h3><div>The clinical advantages of light-emitting diode (LED) therapy in skin healing and its underlying mechanism remain subjects of ongoing debate.</div></div><div><h3>Objective</h3><div>This study aims to explore the impact of LED therapy on normal skin keratinocytes (HaCaT) and in the repair of full-thickness dorsal wounds in Wistar rats.</div></div><div><h3>Methods</h3><div>HaCaT cell viability (SRB assay) and migration (scratch assay) were assessed under LED therapy, comparing stress conditions (2.5% FBS) with sham irradiation and optimal conditions (10% FBS). In vivo, 50 rats with induced wounds were divided into Sham and LED (daily treatment) groups. Euthanasia occurred at 3, 5, 10, 14, and 21 days for clinical, morphological, oxidative stress (MDA, SOD, and GSH), and cytokine analyses (IL-1β, IL-10, TNF-α).</div></div><div><h3>Results</h3><div>LED therapy significantly enhanced keratinocytes viability compared to sham irradiation, with minimal impact on cell migration. Clinical benefits were prominent on day 10, influencing inflammation progression and resolution on days 3 and 10. Re-epithelization remained unaffected. Reduced MDA and increased GSH levels were observed throughout, while SOD levels varied temporally. Notably, on day 10, LED significantly decreased IL-1β, IL-10, and TNF-α.</div></div><div><h3>Study limitations</h3><div>Although translational, clinical trial confirmation of observed benefits is warranted.</div></div><div><h3>Conclusions</h3><div>LED therapy expedites cutaneous healing in the experimental model, primarily modulating inflammation and enhancing antioxidant activity.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 54-62"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.abd.2024.01.009
Ci-Juan Zhong , Fang-Gu Li , Wen Li , Yi-Ming Fan
{"title":"Amyloidosis cutis dyschromica caused by compound heterozygous GPNMB mutations in a Chinese pedigree","authors":"Ci-Juan Zhong , Fang-Gu Li , Wen Li , Yi-Ming Fan","doi":"10.1016/j.abd.2024.01.009","DOIUrl":"10.1016/j.abd.2024.01.009","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 174-178"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.abd.2024.04.005
Zeynep Keskinkaya , Özge Kaya , Selda Işık Mermutlu , Hilay Garipcan Karaemir , Sevilay Oğuz Kılıç
Background
Childhood and adolescence are the most active periods for nevi development, which provide insights into nevogenesis.
Objectives
To evaluate the clinical and dermoscopic characteristics of acquired melanocytic nevi in Turkish children (aged ≤ 10-years) and adolescents (aged > 10-years) regarding demographic, constitutional, and environmental factors.
Methods
A cross-sectional study on participants aged < 18-years examined for acquired melanocytic nevi between January and June 2023.
Results
One hundred participants (female: male ratio = 1:1; median age: 10) were assessed. The median nevi number was significantly higher in adolescents than in children (6 vs. 4; p < 0.05). The upper extremities (n = 68) and trunk (n = 67) were the most commonly involved anatomical regions. Females had a significantly higher nevi rate on the upper extremities than males (80% vs. 56%; p < 0.05). The trunk was involved slightly more frequently in males (76% vs. 58%; p = 0.06). The globular pattern rate was higher in children than in adolescents (70.6% vs. 42.9%; p < 0.05), whereas a striking increase was observed in the reticular pattern from childhood (2%) to adolescence (14.3%) (p < 0.05). The globular pattern was the major dermoscopic pattern in all anatomical locations except lower extremities where the homogeneous pattern prevailed. Sunscreen use had no impact on the nevi number or dermoscopic pattern.
Study limitations
Limited number of participants.
Conclusions
The age and anatomical site were the most relevant factors influencing the number and dermoscopic patterns of nevi. The gender-related distribution pattern of nevi, without any effect of sunscreen use on either nevus count or dermoscopic pattern, suggests a genetic predisposition.
{"title":"Clinical and dermoscopic patterns of acquired melanocytic nevi in children and adolescents: a cross-sectional study from Turkey","authors":"Zeynep Keskinkaya , Özge Kaya , Selda Işık Mermutlu , Hilay Garipcan Karaemir , Sevilay Oğuz Kılıç","doi":"10.1016/j.abd.2024.04.005","DOIUrl":"10.1016/j.abd.2024.04.005","url":null,"abstract":"<div><h3>Background</h3><div>Childhood and adolescence are the most active periods for nevi development, which provide insights into nevogenesis.</div></div><div><h3>Objectives</h3><div>To evaluate the clinical and dermoscopic characteristics of acquired melanocytic nevi in Turkish children (aged ≤ 10-years) and adolescents (aged > 10-years) regarding demographic, constitutional, and environmental factors.</div></div><div><h3>Methods</h3><div>A cross-sectional study on participants aged < 18-years examined for acquired melanocytic nevi between January and June 2023.</div></div><div><h3>Results</h3><div>One hundred participants (female: male ratio = 1:1; median age: 10) were assessed. The median nevi number was significantly higher in adolescents than in children (6 vs. 4; p < 0.05). The upper extremities (n = 68) and trunk (n = 67) were the most commonly involved anatomical regions. Females had a significantly higher nevi rate on the upper extremities than males (80% vs. 56%; p < 0.05). The trunk was involved slightly more frequently in males (76% vs. 58%; p = 0.06). The globular pattern rate was higher in children than in adolescents (70.6% vs. 42.9%; p < 0.05), whereas a striking increase was observed in the reticular pattern from childhood (2%) to adolescence (14.3%) (p < 0.05). The globular pattern was the major dermoscopic pattern in all anatomical locations except lower extremities where the homogeneous pattern prevailed. Sunscreen use had no impact on the nevi number or dermoscopic pattern.</div></div><div><h3>Study limitations</h3><div>Limited number of participants.</div></div><div><h3>Conclusions</h3><div>The age and anatomical site were the most relevant factors influencing the number and dermoscopic patterns of nevi. The gender-related distribution pattern of nevi, without any effect of sunscreen use on either nevus count or dermoscopic pattern, suggests a genetic predisposition.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 22-30"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of positivity in patch tests and reactivity to substances present in the main dressings in patients with chronic leg ulcers","authors":"Ísis Fiorello de Oliveira Mesquita , Larissa Pierri Carvalho Fonseca , Maria Rita Parise Fortes , Hélio Amante Miot , Luciana Patricia Fernandes Abbade","doi":"10.1016/j.abd.2024.05.003","DOIUrl":"10.1016/j.abd.2024.05.003","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 1","pages":"Pages 162-165"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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