Pub Date : 2025-11-01DOI: 10.1016/j.abd.2025.501208
Kevin Yun Kim , Lung Wen Chao , Cyro Festa Neto
Teledermatology services in Brazil have a rich history, with several ongoing projects boosting academic research and providing efficiency gains by reducing waste, humanizing healthcare, and ensuring greater quality and speed in patient assistance. Reviewing the fundamentals and history of Teledermatology, along with the continuing evolution of Telemedicine services in Brazil and its practical aspects and future prospects, might bring better comprehension of how to further develop and improve these services.
{"title":"The history of Teledermatology and its evolution, practical aspects, and prospects in Brazil","authors":"Kevin Yun Kim , Lung Wen Chao , Cyro Festa Neto","doi":"10.1016/j.abd.2025.501208","DOIUrl":"10.1016/j.abd.2025.501208","url":null,"abstract":"<div><div>Teledermatology services in Brazil have a rich history, with several ongoing projects boosting academic research and providing efficiency gains by reducing waste, humanizing healthcare, and ensuring greater quality and speed in patient assistance. Reviewing the fundamentals and history of Teledermatology, along with the continuing evolution of Telemedicine services in Brazil and its practical aspects and future prospects, might bring better comprehension of how to further develop and improve these services.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 6","pages":"Article 501208"},"PeriodicalIF":3.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145386030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.abd.2025.501224
Christian Robles-Silva , Valentina Ross , Javier González , Alex Castro , Constanza Del Puerto
{"title":"Linear syringocystadenoma papilliferum: an unusual presentation in the inguinal region","authors":"Christian Robles-Silva , Valentina Ross , Javier González , Alex Castro , Constanza Del Puerto","doi":"10.1016/j.abd.2025.501224","DOIUrl":"10.1016/j.abd.2025.501224","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 6","pages":"Article 501224"},"PeriodicalIF":3.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145407913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01DOI: 10.1016/j.abd.2025.501239
María Olivares-Guerrero, Ana Jiménez-Sánchez, Mario Aparicio-Domínguez, Pablo Chicharro
{"title":"Effectiveness and safety of tralokinumab in a patient with severe atopic dermatitis and hepatitis B virus","authors":"María Olivares-Guerrero, Ana Jiménez-Sánchez, Mario Aparicio-Domínguez, Pablo Chicharro","doi":"10.1016/j.abd.2025.501239","DOIUrl":"10.1016/j.abd.2025.501239","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 6","pages":"Article 501239"},"PeriodicalIF":3.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145413648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-18DOI: 10.1016/j.abd.2025.501210
Ana Carolina Putini Vieira , Maria Antônia Costa Cruz Akabane , Gianna Carolinne Graff Caletti , Kélen Klein Heffel , Amanda Tauana Oliveira e Silva
Background
Prurigo nodularis (PN) is a chronic, debilitating inflammatory skin disorder characterized by persistent itching, firm pruritic nodular lesions, and evidence of frequent scratching, like excoriation, and lichenification. Nemolizumab, a monoclonal antibody targeting IL-31, has shown significant improvements in skin lesions, itching, and sleep disturbances by reducing type 2 immune responses in PN.
Objectives
Evaluate the efficacy and safety of nemolizumab in treating PN by systematically analyzing randomized controlled trials (RCTs). Methods: The authors conducted a systematic review and meta-analysis by searching Pubmed, Embase, Cochrane Central and Scopus for RCTs comparing nemolizumab to placebo for PN. Statistical analysis usedR Studio 4.3.2.
Results
Three trials, involving 630 patients, were included. Nemolizumab significantly reduced pruritus at week-4 (MD = −32.04; 95% CI: −38.47, −25.62) and at week-16 (MD = −347.34; 95% CI: −1039.71, 345.04). Investigator’s Global Assessment (IGA) success favored Nemolizumab at week-16 (RR = 3.50; 95% CI: 2.18, 5.63). No significant differences were observed in adverse events (RR = 1.10; 95% CI: 0.97, 1.25) or serious adverse events (RR = 0.77; 95% CI: 0.43, 1.39). Nemolizumab also significantly reduced neurodermatitis.
Study limitations
Limitations include variability in treatment duration, small sample sizes, and the lack of direct comparisons with other biologics.
Conclusion
Our meta-analysis shows that Nemolizumab significantly improves pruritus, IGA success rates, and PAS > 75% in treating patients with moderate to severe PN. Its safety profile is favorable, with no significant differences in adverse events compared to placebo. These findings support Nemolizumab as a viable treatment for moderate to severe PN.
{"title":"Efficacy and safety of nemolizumab in prurigo nodularis: a systematic review and meta-analysis of randomized controlled trials","authors":"Ana Carolina Putini Vieira , Maria Antônia Costa Cruz Akabane , Gianna Carolinne Graff Caletti , Kélen Klein Heffel , Amanda Tauana Oliveira e Silva","doi":"10.1016/j.abd.2025.501210","DOIUrl":"10.1016/j.abd.2025.501210","url":null,"abstract":"<div><h3>Background</h3><div>Prurigo nodularis (PN) is a chronic, debilitating inflammatory skin disorder characterized by persistent itching, firm pruritic nodular lesions, and evidence of frequent scratching, like excoriation, and lichenification. Nemolizumab, a monoclonal antibody targeting IL-31, has shown significant improvements in skin lesions, itching, and sleep disturbances by reducing type 2 immune responses in PN.</div></div><div><h3>Objectives</h3><div>Evaluate the efficacy and safety of nemolizumab in treating PN by systematically analyzing randomized controlled trials (RCTs). Methods: The authors conducted a systematic review and meta-analysis by searching Pubmed, Embase, Cochrane Central and Scopus for RCTs comparing nemolizumab to placebo for PN. Statistical analysis used<em>R</em> Studio 4.3.2.</div></div><div><h3>Results</h3><div>Three trials, involving 630 patients, were included. Nemolizumab significantly reduced pruritus at week-4 (MD = −32.04; 95% CI: −38.47, −25.62) and at week-16 (MD = −347.34; 95% CI: −1039.71, 345.04). Investigator’s Global Assessment (IGA) success favored Nemolizumab at week-16 (RR = 3.50; 95% CI: 2.18, 5.63). No significant differences were observed in adverse events (RR = 1.10; 95% CI: 0.97, 1.25) or serious adverse events (RR = 0.77; 95% CI: 0.43, 1.39). Nemolizumab also significantly reduced neurodermatitis.</div></div><div><h3>Study limitations</h3><div>Limitations include variability in treatment duration, small sample sizes, and the lack of direct comparisons with other biologics.</div></div><div><h3>Conclusion</h3><div>Our meta-analysis shows that Nemolizumab significantly improves pruritus, IGA success rates, and PAS > 75% in treating patients with moderate to severe PN. Its safety profile is favorable, with no significant differences in adverse events compared to placebo. These findings support Nemolizumab as a viable treatment for moderate to severe PN.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 6","pages":"Article 501210"},"PeriodicalIF":3.6,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145326888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Publications on vertical ex vivo dermoscopy of skin lesions are sporadic and present only as case reports.
Objectives
This study defines, describes, and determines the importance of structures visible by vertical ex vivo dermoscopy in the diagnosis of pigmented, benign skin lesions and their distinction between themselves, and in relation to other skin lesions.
Methods
The prospective, descriptive study was conducted in two University centers. Digital images of completely excised skin lesions, fixed in formalin before further processing, were evaluated dermoscopically. For the analysis of horizontal ex vivo dermoscopy, pattern analysis was used, while for the vertical section, a description of the visible structures was made.
Results
The research sample consisted of 80 benign pigmented skin lesions obtained from 73 patients. Histopathological diagnosis of the evaluated lesions included 59 nevi, 17 seborrheic keratoses, 3 angiomas and 1 clear cell acanthoma. Seborrheic keratosis had the most variable presentation on vertical ex vivo dermoscopy. By analyzing the vertical section of the evaluated skin lesions, the importance of vertical ex vivo dermoscopy in the diagnosis and/or differentiation of blue nevus, seborrheic keratosis and angioma from other skin lesions was noted.
Study limitations
Small number of analyzed lesions, and inclusion of Caucasian patients only.
Conclusions
Vertical ex vivo dermoscopy can contribute to the distinction between different pigmented benign skin lesions, as well as to their differentiation from other skin lesions. Furthermore, vertical section enables more accurate assessment of additional, descriptive lesional characteristics.
{"title":"Vertical ex vivo dermoscopy in diagnosing and differentiating skin lesions","authors":"Mirjana Popadić , Dimitrije Brasanac , Danijela Milošev , Ana Ravić Nikolić , Slobodanka Mitrović","doi":"10.1016/j.abd.2025.501209","DOIUrl":"10.1016/j.abd.2025.501209","url":null,"abstract":"<div><h3>Background</h3><div>Publications on vertical <em>ex vivo</em> dermoscopy of skin lesions are sporadic and present only as case reports.</div></div><div><h3>Objectives</h3><div>This study defines, describes, and determines the importance of structures visible by vertical <em>ex vivo</em> dermoscopy in the diagnosis of pigmented, benign skin lesions and their distinction between themselves, and in relation to other skin lesions.</div></div><div><h3>Methods</h3><div>The prospective, descriptive study was conducted in two University centers. Digital images of completely excised skin lesions, fixed in formalin before further processing, were evaluated dermoscopically. For the analysis of horizontal <em>ex vivo</em> dermoscopy, pattern analysis was used, while for the vertical section, a description of the visible structures was made.</div></div><div><h3>Results</h3><div>The research sample consisted of 80 benign pigmented skin lesions obtained from 73 patients. Histopathological diagnosis of the evaluated lesions included 59 nevi, 17 seborrheic keratoses, 3 angiomas and 1 clear cell acanthoma. Seborrheic keratosis had the most variable presentation on vertical <em>ex vivo</em> dermoscopy. By analyzing the vertical section of the evaluated skin lesions, the importance of vertical <em>ex vivo</em> dermoscopy in the diagnosis and/or differentiation of blue nevus, seborrheic keratosis and angioma from other skin lesions was noted.</div></div><div><h3>Study limitations</h3><div>Small number of analyzed lesions, and inclusion of Caucasian patients only.</div></div><div><h3>Conclusions</h3><div>Vertical <em>ex vivo</em> dermoscopy can contribute to the distinction between different pigmented benign skin lesions, as well as to their differentiation from other skin lesions. Furthermore, vertical section enables more accurate assessment of additional, descriptive lesional characteristics.</div></div>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 6","pages":"Article 501209"},"PeriodicalIF":3.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-08-09DOI: 10.1016/j.abd.2025.501184
Luis Alberto Ribeiro Fróes, Carla Pagliari, Maria Angela Bianconcini Trindade, Mirian Nacagami Sotto
Background: Leprosy is a chronic infectious disease marked by complex immune interactions, yet the roles of specific B-lymphocyte subsets in its pathology are poorly understood.
Objectives: To investigate the presence and distribution of B-cell subsets, including B1 cells, Marginal Zone (MZ) B-cells, Regulatory B-cells (Bregs), and Effector-1 B-cells (Be1), across different clinical forms of leprosy and reactional states.
Methods: Immunohistochemical and morphometric analyses were performed on skin lesions from patients with various clinical presentations of leprosy.
Results: CD20+ B-cells were abundant in tuberculoid lesions, whereas MZB-1 expression varied significantly among leprosy subtypes. Type 1 Reaction (T1R) lesions exhibited significantly higher counts of B1 and MZ B-cells compared to Type 2 Reaction (T2R), lepromatous leprosy (LL), and indeterminate leprosy (I). Expression patterns of PAX5/MZB-1 and PAX5/CD5 suggested a dominant presence of these cells in the Th1 pole. Be1 cells, strongly linked to Th1 immune response, were also more abundant in Th1 clinical presentations (tuberculoid and T1R leprosy). Although Bregs were generally scarce, they were most frequently observed in T1R.
Study limitations: This study was limited by the relatively small number of cases analyzed per clinical subtype and reactional state.
Conclusions: This is the first study to document the presence and distribution of these specific B-cell subsets in leprosy lesions. The findings suggest distinct roles for B-lymphocyte subtypes, particularly at the tuberculoid pole and during Type 1 reactions.
{"title":"B-cell subsets in leprosy lesions: unraveling the complex interplay.","authors":"Luis Alberto Ribeiro Fróes, Carla Pagliari, Maria Angela Bianconcini Trindade, Mirian Nacagami Sotto","doi":"10.1016/j.abd.2025.501184","DOIUrl":"10.1016/j.abd.2025.501184","url":null,"abstract":"<p><strong>Background: </strong>Leprosy is a chronic infectious disease marked by complex immune interactions, yet the roles of specific B-lymphocyte subsets in its pathology are poorly understood.</p><p><strong>Objectives: </strong>To investigate the presence and distribution of B-cell subsets, including B1 cells, Marginal Zone (MZ) B-cells, Regulatory B-cells (Bregs), and Effector-1 B-cells (Be1), across different clinical forms of leprosy and reactional states.</p><p><strong>Methods: </strong>Immunohistochemical and morphometric analyses were performed on skin lesions from patients with various clinical presentations of leprosy.</p><p><strong>Results: </strong>CD20+ B-cells were abundant in tuberculoid lesions, whereas MZB-1 expression varied significantly among leprosy subtypes. Type 1 Reaction (T1R) lesions exhibited significantly higher counts of B1 and MZ B-cells compared to Type 2 Reaction (T2R), lepromatous leprosy (LL), and indeterminate leprosy (I). Expression patterns of PAX5/MZB-1 and PAX5/CD5 suggested a dominant presence of these cells in the Th1 pole. Be1 cells, strongly linked to Th1 immune response, were also more abundant in Th1 clinical presentations (tuberculoid and T1R leprosy). Although Bregs were generally scarce, they were most frequently observed in T1R.</p><p><strong>Study limitations: </strong>This study was limited by the relatively small number of cases analyzed per clinical subtype and reactional state.</p><p><strong>Conclusions: </strong>This is the first study to document the presence and distribution of these specific B-cell subsets in leprosy lesions. The findings suggest distinct roles for B-lymphocyte subtypes, particularly at the tuberculoid pole and during Type 1 reactions.</p>","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"501184"},"PeriodicalIF":3.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-08-09DOI: 10.1016/j.abd.2025.501189
Hugo J Leme, José Ramos, António Magarreiro-Silva, Ana Isabel Gouveia, João Alves
{"title":"Penile erosions: an atypical initial manifestation of pemphigus vulgaris.","authors":"Hugo J Leme, José Ramos, António Magarreiro-Silva, Ana Isabel Gouveia, João Alves","doi":"10.1016/j.abd.2025.501189","DOIUrl":"10.1016/j.abd.2025.501189","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"501189"},"PeriodicalIF":3.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-08-09DOI: 10.1016/j.abd.2025.501166
Marilda Aparecida Milanez Morgado de Abreu, Carolina Aparecida de Almeida Ferreira, Gisele Alborghetti Nai
{"title":"Composite hemangioendothelioma: report of a rare neoplasm.","authors":"Marilda Aparecida Milanez Morgado de Abreu, Carolina Aparecida de Almeida Ferreira, Gisele Alborghetti Nai","doi":"10.1016/j.abd.2025.501166","DOIUrl":"10.1016/j.abd.2025.501166","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"501166"},"PeriodicalIF":3.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-08-09DOI: 10.1016/j.abd.2025.501190
Catalina Buchroithner, Nelson Lobos, Gabriel Neely, Arturo Madrid, Valentina Darlic, Alex Castro
{"title":"Appearance of basal cell carcinoma on untreated capillary malformation.","authors":"Catalina Buchroithner, Nelson Lobos, Gabriel Neely, Arturo Madrid, Valentina Darlic, Alex Castro","doi":"10.1016/j.abd.2025.501190","DOIUrl":"10.1016/j.abd.2025.501190","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"501190"},"PeriodicalIF":3.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2025-08-09DOI: 10.1016/j.abd.2025.501177
Marilda Aparecida Milanez Morgado de Abreu, Naíra M de A Guaresemin, Murilo de Oliveira Lima Carapeba
{"title":"Posterior reversible encephalopathy syndrome in a patient treated with ustekinumab.","authors":"Marilda Aparecida Milanez Morgado de Abreu, Naíra M de A Guaresemin, Murilo de Oliveira Lima Carapeba","doi":"10.1016/j.abd.2025.501177","DOIUrl":"10.1016/j.abd.2025.501177","url":null,"abstract":"","PeriodicalId":7787,"journal":{"name":"Anais brasileiros de dermatologia","volume":"100 5","pages":"501177"},"PeriodicalIF":3.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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