Pub Date : 2024-03-13eCollection Date: 2024-01-01DOI: 10.1080/19768354.2024.2327340
Hyun-Jin Kim, Don Carlo Batara, Young-Jun Jeon, Seongsoo Lee, Samuel Beck, Sung-Hak Kim
Myeloid ecotropic virus insertion site 1 (MEIS1) is a HOX co-factor necessary for organ development and normal hematopoiesis. Recently, MEIS1 has been linked to the development and progression of various cancers. However, its role in gliomagenesis particularly on glioma stem cells (GSCs) remains unclear. Here, we demonstrate that MEIS1 is highly upregulated in GSCs compared to normal, and glioma cells and to its differentiated counterparts. Inhibition of MEIS1 expression by shRNA significantly reduced GSC growth in both in vitro and in vivo experiments. On the other hand, integrated transcriptomics analyses of glioma datasets revealed that MEIS1 expression is correlated to cell cycle-related genes. Clinical data analysis revealed that MEIS1 expression is elevated in high-grade gliomas, and patients with high MEIS1 levels have poorer overall survival outcomes. The findings suggest that MEIS1 is a prognostic biomarker for glioma patients and a possible target for developing novel therapeutic strategies against GBM.
{"title":"The impact of <i>MEIS1</i> TALE homeodomain transcription factor knockdown on glioma stem cell growth.","authors":"Hyun-Jin Kim, Don Carlo Batara, Young-Jun Jeon, Seongsoo Lee, Samuel Beck, Sung-Hak Kim","doi":"10.1080/19768354.2024.2327340","DOIUrl":"10.1080/19768354.2024.2327340","url":null,"abstract":"<p><p>Myeloid ecotropic virus insertion site 1 (<i>MEIS1</i>) is a HOX co-factor necessary for organ development and normal hematopoiesis. Recently, <i>MEIS1</i> has been linked to the development and progression of various cancers. However, its role in gliomagenesis particularly on glioma stem cells (GSCs) remains unclear. Here, we demonstrate that <i>MEIS1</i> is highly upregulated in GSCs compared to normal, and glioma cells and to its differentiated counterparts. Inhibition of <i>MEIS1</i> expression by shRNA significantly reduced GSC growth in both <i>in vitro</i> and <i>in vivo</i> experiments. On the other hand, integrated transcriptomics analyses of glioma datasets revealed that <i>MEIS1</i> expression is correlated to cell cycle-related genes. Clinical data analysis revealed that <i>MEIS1</i> expression is elevated in high-grade gliomas, and patients with high <i>MEIS1</i> levels have poorer overall survival outcomes. The findings suggest that <i>MEIS1</i> is a prognostic biomarker for glioma patients and a possible target for developing novel therapeutic strategies against GBM.</p>","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10939110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140130558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-03eCollection Date: 2024-01-01DOI: 10.1080/19768354.2024.2322054
Won Jun Jung, Soo-Ji Park, Seongkwang Cha, Kyoungmi Kim
The CRISPR-Cas system stands out as a promising genome editing tool due to its cost-effectiveness and time efficiency compared to other methods. This system has tremendous potential for treating various diseases, including genetic disorders and cancer, and promotes therapeutic research for a wide range of genetic diseases. Additionally, the CRISPR-Cas system simplifies the generation of animal models, offering a more accessible alternative to traditional methods. The CRISPR-Cas9 system can be used to cleave target DNA strands that need to be corrected, causing double-strand breaks (DSBs). DNA with DSBs can then be recovered by the DNA repair pathway that the CRISPR-Cas9 system uses to edit target gene sequences. High cleavage efficiency of the CRISPR-Cas9 system is thus imperative for effective gene editing. Herein, we explore several factors affecting the cleavage efficiency of the CRISPR-Cas9 system. These factors include the GC content of the protospacer-adjacent motif (PAM) proximal and distal regions, single-guide RNA (sgRNA) properties, and chromatin state. These considerations contribute to the efficiency of genome editing.
与其他方法相比,CRISPR-Cas 系统具有成本效益和时间效率高的特点,是一种前景广阔的基因组编辑工具。该系统在治疗包括遗传性疾病和癌症在内的各种疾病方面具有巨大潜力,并促进了对各种遗传性疾病的治疗研究。此外,CRISPR-Cas 系统还简化了动物模型的制作过程,为传统方法提供了更方便的替代方案。CRISPR-Cas9 系统可用于裂解需要校正的目标 DNA 链,造成双链断裂(DSB)。然后,带有 DSB 的 DNA 可以通过 CRISPR-Cas9 系统用于编辑目标基因序列的 DNA 修复途径恢复。因此,CRISPR-Cas9 系统的高切割效率是有效基因编辑的必要条件。在这里,我们探讨了影响CRISPR-Cas9系统裂解效率的几个因素。这些因素包括原位相邻基序(PAM)近端和远端区域的 GC 含量、单导向 RNA(sgRNA)特性和染色质状态。这些因素都有助于提高基因组编辑的效率。
{"title":"Factors affecting the cleavage efficiency of the CRISPR-Cas9 system.","authors":"Won Jun Jung, Soo-Ji Park, Seongkwang Cha, Kyoungmi Kim","doi":"10.1080/19768354.2024.2322054","DOIUrl":"10.1080/19768354.2024.2322054","url":null,"abstract":"<p><p>The CRISPR-Cas system stands out as a promising genome editing tool due to its cost-effectiveness and time efficiency compared to other methods. This system has tremendous potential for treating various diseases, including genetic disorders and cancer, and promotes therapeutic research for a wide range of genetic diseases. Additionally, the CRISPR-Cas system simplifies the generation of animal models, offering a more accessible alternative to traditional methods. The CRISPR-Cas9 system can be used to cleave target DNA strands that need to be corrected, causing double-strand breaks (DSBs). DNA with DSBs can then be recovered by the DNA repair pathway that the CRISPR-Cas9 system uses to edit target gene sequences. High cleavage efficiency of the CRISPR-Cas9 system is thus imperative for effective gene editing. Herein, we explore several factors affecting the cleavage efficiency of the CRISPR-Cas9 system. These factors include the GC content of the protospacer-adjacent motif (PAM) proximal and distal regions, single-guide RNA (sgRNA) properties, and chromatin state. These considerations contribute to the efficiency of genome editing.</p>","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10911232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01DOI: 10.1080/19768354.2024.2322055
Jiarui Zhang, Yaowen Liang, Weiyue Zeng, Xiaoyan Gao, Dingchen Wang, Cong Mai, Zhuoheng Lin, Haishan Zhao, Xin Li
Aortic aneurysm/dissection (AAD) poses a life-threatening cardiovascular emergency with complex mechanisms and a notably high mortality rate. Zebrafish (Danio rerio) serve as valuable models for AA...
{"title":"Inducing aortic aneurysm/dissection in zebrafish: evaluating the efficacy of β-Aminopropionic Nitrile as a model","authors":"Jiarui Zhang, Yaowen Liang, Weiyue Zeng, Xiaoyan Gao, Dingchen Wang, Cong Mai, Zhuoheng Lin, Haishan Zhao, Xin Li","doi":"10.1080/19768354.2024.2322055","DOIUrl":"https://doi.org/10.1080/19768354.2024.2322055","url":null,"abstract":"Aortic aneurysm/dissection (AAD) poses a life-threatening cardiovascular emergency with complex mechanisms and a notably high mortality rate. Zebrafish (Danio rerio) serve as valuable models for AA...","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140016633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-22DOI: 10.1080/19768354.2024.2321354
Yun Hwan Lim, Yoon Jin Park, Jieun Lee, Jung Hwa Kim
C-terminal binding protein 1 (CtBP1) is a critical transcriptional corepressor of many tumor suppressor genes and plays diverse roles in the progression of cancers. The transcriptional repression f...
C-terminal binding protein 1(CtBP1)是许多肿瘤抑制基因的关键转录核心抑制因子,在癌症进展中发挥着多种作用。CtBP1的转录抑制作用可抑制...
{"title":"Transcriptional corepressor activity of CtBP1 is regulated by ISG15 modification","authors":"Yun Hwan Lim, Yoon Jin Park, Jieun Lee, Jung Hwa Kim","doi":"10.1080/19768354.2024.2321354","DOIUrl":"https://doi.org/10.1080/19768354.2024.2321354","url":null,"abstract":"C-terminal binding protein 1 (CtBP1) is a critical transcriptional corepressor of many tumor suppressor genes and plays diverse roles in the progression of cancers. The transcriptional repression f...","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139921693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-09eCollection Date: 2024-01-01DOI: 10.1080/19768354.2024.2315950
Seung-Woo Kim, Chan Woo Kim, Hong Seok Kim
Breast cancer is a frequently occurring malignant tumor that is one of the leading causes of cancer-related deaths in women worldwide. Monoclonal antibodies that block programed cell death 1 (PD-1)/programed cell death ligand 1 (PD-L1) - a typical immune checkpoint - are currently the recommended standard therapies for many advanced and metastatic tumors such as triple-negative breast cancer. However, some patients develop drug resistance, leading to unfavorable treatment outcomes. Therefore, other approaches are required for anticancer treatments, such as downregulation of PD-L1 expression and promotion of degradation of PD-L1. Scoparone (SCO) is a bioactive compound isolated from Artemisia capillaris that exhibits antitumor activity. However, the effect of SCO on PD-L1 expression in cancer has not been confirmed yet. This study aimed to evaluate the role of SCO in PD-L1 expression in breast cancer cells in vitro. Our results show that SCO downregulated PD-L1 expression in a dose-dependent manner, via AKT inhibition. Interestingly, SCO treatment did not alter PTEN expression, but increased the expression of mitogen-activated protein kinase phosphatase-3 (MKP-3). In addition, the SCO-induced decrease in PD-L1 expression was reversed by siRNA-mediated MKP-3 knockdown. Collectively, these findings suggest that SCO inhibited the expression of PD-L1 in breast cancer cells by upregulating MKP-3 expression. Therefore, SCO may serve as an innovative combinatorial agent for cancer immunotherapy.
{"title":"Scoparone attenuates PD-L1 expression in human breast cancer cells by MKP-3 upregulation.","authors":"Seung-Woo Kim, Chan Woo Kim, Hong Seok Kim","doi":"10.1080/19768354.2024.2315950","DOIUrl":"10.1080/19768354.2024.2315950","url":null,"abstract":"<p><p>Breast cancer is a frequently occurring malignant tumor that is one of the leading causes of cancer-related deaths in women worldwide. Monoclonal antibodies that block programed cell death 1 (PD-1)/programed cell death ligand 1 (PD-L1) - a typical immune checkpoint - are currently the recommended standard therapies for many advanced and metastatic tumors such as triple-negative breast cancer. However, some patients develop drug resistance, leading to unfavorable treatment outcomes. Therefore, other approaches are required for anticancer treatments, such as downregulation of PD-L1 expression and promotion of degradation of PD-L1. Scoparone (SCO) is a bioactive compound isolated from <i>Artemisia capillaris</i> that exhibits antitumor activity. However, the effect of SCO on PD-L1 expression in cancer has not been confirmed yet. This study aimed to evaluate the role of SCO in PD-L1 expression in breast cancer cells in vitro. Our results show that SCO downregulated PD-L1 expression in a dose-dependent manner, via AKT inhibition. Interestingly, SCO treatment did not alter PTEN expression, but increased the expression of mitogen-activated protein kinase phosphatase-3 (MKP-3). In addition, the SCO-induced decrease in PD-L1 expression was reversed by siRNA-mediated MKP-3 knockdown. Collectively, these findings suggest that SCO inhibited the expression of PD-L1 in breast cancer cells by upregulating MKP-3 expression. Therefore, SCO may serve as an innovative combinatorial agent for cancer immunotherapy.</p>","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10860470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29eCollection Date: 2024-01-01DOI: 10.1080/19768354.2024.2307559
Jiwon Chae, Mina Choi, Juyoung Choi, Seung-Jun Yoo
Cerebrospinal fluid (CSF) plays a crucial role in the brain's lymphatics as it traverses the central nervous system (CNS). Its primary function is to facilitate the outward transport of waste. Among the various CSF outflow pathways, the route through the cribriform plate along the olfactory nerves stands out as the most predominant. This review describes the outflow pathway of CSF into the nasal lymphatics. Additionally, we examine existing studies to describe mutual influences observed between the brain and extracranial regions due to this outflow pathway. Notably, pathological conditions in the CNS often influence CSF outflow, leading to observable changes in extracranial regions. The established connection between the brain and the nose is significant, and our review underscores its potential relevance in monitoring CNS ailments, including neurodegenerative diseases. Considering that aging - the most significant risk factor for the onset of neurodegeneration - is also a principal factor in CSF turnover alterations, we suggest a novel approach to studying neurodegenerative diseases in therapeutic terms.
{"title":"The nasal lymphatic route of CSF outflow: implications for neurodegenerative disease diagnosis and monitoring.","authors":"Jiwon Chae, Mina Choi, Juyoung Choi, Seung-Jun Yoo","doi":"10.1080/19768354.2024.2307559","DOIUrl":"10.1080/19768354.2024.2307559","url":null,"abstract":"<p><p>Cerebrospinal fluid (CSF) plays a crucial role in the brain's lymphatics as it traverses the central nervous system (CNS). Its primary function is to facilitate the outward transport of waste. Among the various CSF outflow pathways, the route through the cribriform plate along the olfactory nerves stands out as the most predominant. This review describes the outflow pathway of CSF into the nasal lymphatics. Additionally, we examine existing studies to describe mutual influences observed between the brain and extracranial regions due to this outflow pathway. Notably, pathological conditions in the CNS often influence CSF outflow, leading to observable changes in extracranial regions. The established connection between the brain and the nose is significant, and our review underscores its potential relevance in monitoring CNS ailments, including neurodegenerative diseases. Considering that aging - the most significant risk factor for the onset of neurodegeneration - is also a principal factor in CSF turnover alterations, we suggest a novel approach to studying neurodegenerative diseases in therapeutic terms.</p>","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139641501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-29eCollection Date: 2024-01-01DOI: 10.1080/19768354.2024.2302529
Eun-Jeong Kim, Donggu Jeon, Yeon-Jeong Park, Hyunmin Woo, Seong-Il Eyun
Harmful substances like the cyanotoxin microcystin-leucine-arginine (MC-LR) are commonly found in eutrophic freshwater environments, posing risks to aquatic organisms. The water flea, Daphnia, is a well-established model organism for environmental toxicology research. Nevertheless, there is currently insufficient research on the genes that respond to MC-LR in Daphnia galeata. This study aimed to gain insights into the notable genes that react significantly to MC-LR. In this study, we generated an extensive RNA-Seq sequences isolated from the D. galeata HK strain, Han River in Korea. This strain was nourished with a diet of the green microalga Chlorella vulgaris and treated with pure MC-LR at a concentration of 36 ug/L. The transcriptome profile in response to the MC-LR treatment was obtained and 336 differentially expressed genes were subjected to Gene Ontology (GO) and euKaryotic Orthologous Groups of proteins analyses. GO enrichment analysis showed that chemical stimulus, amino sugar metabolic and catabolic process, oxidative stress, and detoxification were highly enriched, in reverse, proteolysis and fucosylation were underpresented. Detoxification process related genes such as peroxidase-like, chorion, and thyroid peroxidase-like were enriched for eliminating or neutralizing MC_LR from an organism's body. Furthermore, functional protein classification revealed an upregulation of lipid and inorganic ion transport processes, while amino acid and carbohydrate transport processes were found to be downregulated. These findings offer insights into how organisms respond to ecotoxic stimuli, providing valuable information for understanding adaptation or defense pathways.
富营养化淡水环境中普遍存在微囊藻毒素-亮氨酸-精氨酸(MC-LR)等有害物质,对水生生物造成危害。水蚤水蚤是环境毒理学研究的成熟模式生物。然而,目前有关水蚤对 MC-LR 反应基因的研究尚不充分。本研究旨在深入了解对 MC-LR 有显著反应的基因。在这项研究中,我们从韩国汉江的 D. galeata HK 品系中分离出大量 RNA-Seq 序列。该菌株以绿色微藻小球藻为食,并接受浓度为 36 微克/升的纯 MC-LR 处理。对 336 个差异表达基因进行了基因本体(GO)和 euKaryotic Orthologous Groups 蛋白质分析。GO富集分析表明,化学刺激、氨基酸糖代谢和分解代谢过程、氧化应激和解毒的富集程度较高,反之,蛋白水解和岩藻糖基化的富集程度较低。与解毒过程相关的基因,如过氧化物酶样、绒毛膜过氧化物酶样和甲状腺过氧化物酶样等,在消除或中和生物体内的 MC_LR 过程中得到了富集。此外,功能蛋白分类显示脂质和无机离子转运过程上调,而氨基酸和碳水化合物转运过程下调。这些发现深入揭示了生物如何应对生态毒性刺激,为了解适应或防御途径提供了宝贵的信息。
{"title":"Dietary exposure of the water flea <i>Daphnia galeata</i> to microcystin-LR.","authors":"Eun-Jeong Kim, Donggu Jeon, Yeon-Jeong Park, Hyunmin Woo, Seong-Il Eyun","doi":"10.1080/19768354.2024.2302529","DOIUrl":"10.1080/19768354.2024.2302529","url":null,"abstract":"<p><p>Harmful substances like the cyanotoxin microcystin-leucine-arginine (MC-LR) are commonly found in eutrophic freshwater environments, posing risks to aquatic organisms. The water flea, <i>Daphnia</i>, is a well-established model organism for environmental toxicology research. Nevertheless, there is currently insufficient research on the genes that respond to MC-LR in <i>Daphnia galeata</i>. This study aimed to gain insights into the notable genes that react significantly to MC-LR. In this study, we generated an extensive RNA-Seq sequences isolated from the <i>D</i>. <i>galeata</i> HK strain, Han River in Korea. This strain was nourished with a diet of the green microalga <i>Chlorella vulgaris</i> and treated with pure MC-LR at a concentration of 36 ug/L. The transcriptome profile in response to the MC-LR treatment was obtained and 336 differentially expressed genes were subjected to Gene Ontology (GO) and euKaryotic Orthologous Groups of proteins analyses. GO enrichment analysis showed that chemical stimulus, amino sugar metabolic and catabolic process, oxidative stress, and detoxification were highly enriched, in reverse, proteolysis and fucosylation were underpresented. Detoxification process related genes such as peroxidase-like, chorion, and thyroid peroxidase-like were enriched for eliminating or neutralizing MC_LR from an organism's body. Furthermore, functional protein classification revealed an upregulation of lipid and inorganic ion transport processes, while amino acid and carbohydrate transport processes were found to be downregulated. These findings offer insights into how organisms respond to ecotoxic stimuli, providing valuable information for understanding adaptation or defense pathways.</p>","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10829830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139650129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Visual impairment associated with uveitis is among the potential complications in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Bioinformatics analy...
{"title":"Eugenol ameliorates uveitis in mice with experimental autoimmune encephalomyelitis through the suppression of key inflammatory genes","authors":"Sungmoo Hong, Kyungsook Jung, Meejung Ahn, Jeongtae Kim, Changjong Moon, Taekyun Shin","doi":"10.1080/19768354.2024.2304557","DOIUrl":"https://doi.org/10.1080/19768354.2024.2304557","url":null,"abstract":"Visual impairment associated with uveitis is among the potential complications in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Bioinformatics analy...","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139497257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-04DOI: 10.1080/19768354.2023.2301009
Soonjae Hwang, Sangbin Park, Jaewan Kim, Ah-Reum Oh, Ho-Jae Lee, Ji-Young Cha
Glucose transporter 5 (GLUT5), the main fructose transporter in mammals, is primarily responsible for absorbing dietary fructose in the small intestine. The expression of this intestinal gene signi...
{"title":"Role of Carbohydrate response element-binding protein in mediating dexamethasone-induced glucose transporter 5 expression in Caco-2BBE cells and during the developmental phase in mice","authors":"Soonjae Hwang, Sangbin Park, Jaewan Kim, Ah-Reum Oh, Ho-Jae Lee, Ji-Young Cha","doi":"10.1080/19768354.2023.2301009","DOIUrl":"https://doi.org/10.1080/19768354.2023.2301009","url":null,"abstract":"Glucose transporter 5 (GLUT5), the main fructose transporter in mammals, is primarily responsible for absorbing dietary fructose in the small intestine. The expression of this intestinal gene signi...","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139105053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-03DOI: 10.1080/19768354.2023.2300437
Dawn Lee, Heeyoung Lee, Ha-neul Jo, Eunsik Yun, Byung Su Kwon, Jongmin Kim, Aram Lee
Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling associated with extracellular matrix (ECM) deposition, vascular cell hyperproliferation, and neointima formation in the...
{"title":"Endothelial periostin regulates vascular remodeling by promoting endothelial dysfunction in pulmonary arterial hypertension","authors":"Dawn Lee, Heeyoung Lee, Ha-neul Jo, Eunsik Yun, Byung Su Kwon, Jongmin Kim, Aram Lee","doi":"10.1080/19768354.2023.2300437","DOIUrl":"https://doi.org/10.1080/19768354.2023.2300437","url":null,"abstract":"Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling associated with extracellular matrix (ECM) deposition, vascular cell hyperproliferation, and neointima formation in the...","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139082283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}