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ReTour au Travail du patient coronarien : étude multicentrique française RTT 冠心病患者重返工作岗位:法国多中心 RTT 研究
IF 0.3 Q4 Medicine Pub Date : 2024-09-20 DOI: 10.1016/j.ancard.2024.101796
Bruno Pavy , Marie-Christine Iliou , Sophie Péclet , Bernard Pierre , Catherine Monpère , Jean-Pierre Houppe , Sonia Corone , Alain Dibie , Jean-Michel Nguyen

Introduction

Coronary heart disease remains one of the leading causes of morbidity and mortality, and is responsible for significant social costs. Resumption of work is an essential objective when this pathology concerns working patients. French data remain patchy and relatively old. The French Society of Cardiology's Exercise, Rehabilitation, Sport and Prevention Group has proposed a multicentre study to update these data.

Methods

Following an acute coronary syndrome (ACS), the cardiology team asked the patient, who was currently working, to complete a questionnaire on his or her pathology, occupation and plans to return to work. An interview after 6 months enabled the clinical and professional situation of the patient to be analyzed, in order to study the factors predictive of a return to work.

Results

364 patients were included in 6 interventional and 17 cardiac rehabilitation centres between 2018 and 2019. The resumption rate was 81% (n = 295), 93% of them in the same position, with a mean delay of 106 ± 56 days. The cardiologic independent factors for non-return were left ventricular ejection fraction, the presence of an anticoagulant, angina or heart failure, and occupational factors, shift work, exposure to cold, and imposed work rates. Factors that lengthened the time taken to return to work included delayed access to rehabilitation, the carrying of heavy loads, difficult postures and imposed work rates, as well as the patient's lack of a project, the absence of a cardiologist's opinion and the request for a modified workstation.

Conclusion

The rate of return to work remains fairly stable despite the evolution of disease management, and the time to return to work relatively high. One way of improving the situation is to enhance access to cardiac rehabilitation programs, for example by offering alternatives such as tele-rehabilitation for a proportion of patients. This will free up more time for more severe patients, to better prepare them physically and psychologically for a return to work, which will also have a beneficial economic effect.

导言冠心病仍然是发病和死亡的主要原因之一,并造成巨大的社会成本。当这种病症影响到工作的病人时,恢复工作是一个基本目标。法国的数据仍然零散且相对陈旧。法国心脏病学会的运动、康复、体育和预防小组提议进行一项多中心研究,以更新这些数据。方法在急性冠状动脉综合征(ACS)发生后,心脏病小组要求正在工作的患者填写一份有关其病理、职业和重返工作岗位计划的问卷。6 个月后进行的访谈有助于分析患者的临床和职业状况,从而研究预测重返工作岗位的因素。结果 2018 年至 2019 年间,6 家介入治疗中心和 17 家心脏康复中心共纳入了 364 名患者。复工率为81%(n = 295),其中93%的患者在同一岗位工作,平均延迟时间为106±56天。未复出的心脏病学独立因素包括左心室射血分数、服用抗凝剂、心绞痛或心力衰竭,以及职业因素、轮班工作、暴露于寒冷环境和强加的工作率。延长重返工作岗位时间的因素包括:康复治疗延迟、搬运重物、高难度姿势和强加的工作强度,以及患者没有项目、没有心脏科医生的意见和要求改变工作站。改善这一状况的方法之一是提高心脏康复计划的可及性,例如为部分患者提供远程康复等替代方案。这将为更严重的病人腾出更多时间,使他们在身体和心理上为重返工作岗位做好更充分的准备,这也将产生有益的经济效应。
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引用次数: 0
Lésions coronaires calcifiées et résistantes en ambulatoire, mythe ou réalité ? 门诊抗性冠状动脉钙化病变:神话还是现实?
IF 0.3 Q4 Medicine Pub Date : 2024-09-20 DOI: 10.1016/j.ancard.2024.101806
Arthur Pagezy, Stéphanie Marlière

Progress in coronary angioplasty has enabled outpatients treatment with rates of immediate complications below 1%. This shows a clear improvement in patient's comfort and it represents an important medical and economic gain.

Considering the demographic evolution of the population, there is an increasing number of calcified coronary lesions which represent, according to the series, up to a quarter of angioplasties.

However, their care is more delicate with a greater risk of complications and procedural failure. In fact, with the difficulties of crossing and with the vascular intrusions related to pre-dilation or sub-dilation stent deployment, the complication risk increases by almost 10% in these cases of angioplasties. Similarly, the death rate at 30 days goes from 4.7% in angioplasty in general up to 24.4% in calcified lesions.

Several devices for atherectomy and plaque preparation have been developed in order to better overcome the lesions and better prepare the stent installation at the cost of a risk of complications between 2 and 10%. The three most frequent complications are dissection (1.8 to 7%), slow/no-flow (0.1 to 3%) and coronary perforation (0.2 to 4%).

Nevertheless, despite this procedural increased risk, ambulatory angioplasty of calcified complex lesions can become a reality subject to 4-6 hours monitoring in a specialized unit with dedicated protocols.

冠状动脉血管成形术的进步使门诊病人的治疗即时并发症发生率低于1%。考虑到人口结构的演变,冠状动脉钙化病变的数量越来越多,根据系列研究,钙化病变占血管成形术的四分之一,然而,这些病变的治疗更加棘手,并发症和手术失败的风险更高。事实上,由于穿越困难,以及预扩张或亚扩张支架植入造成的血管入侵,这类血管成形术的并发症风险增加了近 10%。同样,在钙化病变的血管成形术中,30 天内的死亡率从一般血管成形术的 4.7% 上升到 24.4%。为了更好地克服病变,更好地为支架安装做好准备,已经开发出了几种用于动脉粥样切除和斑块准备的设备,但并发症风险在 2% 到 10% 之间。最常见的三种并发症是夹层(1.8%-7%)、血流缓慢/无血流(0.1%-3%)和冠状动脉穿孔(0.2%-4%)。然而,尽管手术风险增加,但钙化复杂病变的非卧床血管成形术已成为现实,只需在专科病房进行4-6小时的监测,并制定专门的方案。
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引用次数: 0
Effets du programme d'aide au retour à domicile (PRADO-IC) sur le parcours de soins à un an d'une population de patients insuffisants cardiaques PRADO-IC 计划对心力衰竭患者一年护理路径的影响
IF 0.3 Q4 Medicine Pub Date : 2024-09-03 DOI: 10.1016/j.ancard.2024.101787
Philippe Abassade , Laetitia Fleury , Audrey Fels , Gilles Chatellier , Emmanuelle Sacco , Hélène Beaussier , Michel Komajda , Romain Cador

Introduction

Congestive heart failure (HF) is associated with prolonged and recurrent hospitalizations; the prognosis remains poor a better follow up might be beneficial. PRADO-IC program is provided in order to improve the transition of care.

Aim of the study

To evaluate PRADO-IC program in term of healthcare consumption and prognosis in a cohort of patients hospitalized for decompensated HF, using the insight of the national data base SNDS (Système National de Données de Santé).

Methods

From September 2016 to September 2018, all patients hospitalized for heart failure at Saint-Joseph Hospital were included in an observational study. The inclusion in the PRADO-IC program was at physician's discretion. Two groups were compared according to the inclusion in PRADO-IC (P group) or not (control group (C)). The primary endpoints were the comparison of one-year mortality and heart failure readmission rate between the two groups. The secondary end points were time to the first contact with a general practitioner (GP), a cardiologist, CHF drugs prescription, and others follow up data.

Results

Six hundred and fifteen patients were included, 254 in the P group and 361 in the C group. Patients in the P cohort presented more frequently severity criteria (age, weight, BNP level, arrhythmia, anemia, renal failure). Mortality at one year (n = 47; 18.5% P group vs. n = 65; 16.2% C group, p = 0.87) did not differ in both groups. There was no significant difference in one-year re-hospitalization rate for HF (n = 93, 36.6% in P group vs. n = 133, 26.8% in C group, p = 0.95). Time to the first contact with the GP was shorter in P group (8.00 vs. 18.50 days, p < 0.0001). Time to first hospitalization (69.0 vs. 37.0 days, p = 0.028) and the length of hospitalization (6.0 vs. 4.0 days, p = 0.045) were longer in P group. There was no difference for HF drugs prescription rate between the two groups.

Conclusion

Our study shows that the PRADO-IC program concerned more severe patients. Despite this, the one-year mortality and the HF readmission rates are similar between the two groups. The follow up is improved in P group.

导言充血性心力衰竭(HF)与长期和反复住院有关;预后仍然不佳,更好的随访可能会有所帮助。PRADO-IC 计划旨在改善护理过渡。研究目的利用国家数据库 SNDS(Système National de Données de Santé)的洞察力,评估 PRADO-IC 计划在失代偿性心力衰竭住院患者队列中的医疗消耗和预后情况。方法从 2016 年 9 月至 2018 年 9 月,圣约瑟医院的所有心力衰竭住院患者均被纳入一项观察性研究。是否纳入 PRADO-IC 计划由医生决定。根据纳入 PRADO-IC 计划(P 组)或未纳入 PRADO-IC 计划(对照组 (C))分为两组进行比较。主要终点是比较两组的一年死亡率和心衰再入院率。次要终点是首次接触全科医生(GP)和心脏病专家的时间、心衰药物处方以及其他随访数据。结果共纳入了 615 名患者,其中 P 组 254 人,C 组 361 人。P组患者更常出现严重程度标准(年龄、体重、BNP水平、心律失常、贫血、肾衰竭)。一年后的死亡率(P 组 47 人,18.5%;C 组 65 人,16.2%,P = 0.87)在两组中没有差异。一年内因心房颤动而再次住院的比例没有明显差异(P 组 93 例,36.6%;C 组 133 例,26.8%,P = 0.95)。P 组患者首次接触全科医生的时间更短(8.00 天 vs. 18.50 天,p < 0.0001)。P 组患者首次住院时间(69.0 对 37.0 天,p = 0.028)和住院时间(6.0 对 4.0 天,p = 0.045)更长。结论我们的研究表明,PRADO-IC 项目涉及的重症患者更多。尽管如此,两组患者的一年死亡率和高血压再入院率相似。P组的随访情况有所改善。
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引用次数: 0
Sommaire 目录
IF 0.3 Q4 Medicine Pub Date : 2024-09-01 DOI: 10.1016/S0003-3928(24)00094-5
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引用次数: 0
L'expérience : donner comme nous avons reçu est un devoir 经验:我们的责任是付出与收获并重
IF 0.3 Q4 Medicine Pub Date : 2024-09-01 DOI: 10.1016/j.ancard.2024.101811
Dr Hakim Benamer
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引用次数: 0
Editorial board / Ours rédaction 编辑部 / Ours rédaction
IF 0.3 Q4 Medicine Pub Date : 2024-09-01 DOI: 10.1016/S0003-3928(24)00092-1
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引用次数: 0
Réducteur de sinus coronaire : aspects techniques, prévention et gestion des complications [冠状窦减压器:技术方面、潜在并发症的预防和处理]。
IF 0.3 Q4 Medicine Pub Date : 2024-08-15 DOI: 10.1016/j.ancard.2024.101785
Matthieu Périer , Hachem-Ali Haidar , David Sulman , Florent Huang , Hakim Benamer

Coronary sinus reducer implantation is a percutaneous technique creating a narrowing in the coronary sinus through the implantation of an hourglass-shaped endoprosthesis. It is proposed to reduce symptoms in patients suffering from refractory angina pectoris. This innovative treatment is experiencing a major craze among interventional cardiologists. It is associated with very high procedural success rates. Complications are rare and include coronary sinus dissection or perforation and migration of the device.

This review exposes the device implantation technique, the potential anatomical difficulties, the tips and tricks to overcome challenging situations. It also focuses on the prevention and management of potential complications.

冠状动脉窦缩窄器植入术是一种经皮技术,通过植入沙漏形的内假体,使冠状动脉窦变窄。其目的是减轻难治性心绞痛患者的症状。这种创新疗法在介入心脏病专家中掀起了一股热潮。它的手术成功率非常高。并发症非常罕见,包括冠状动脉窦夹层或穿孔以及装置移位。这篇综述介绍了装置植入技术、潜在的解剖学困难、克服挑战性情况的技巧和窍门。它还重点介绍了潜在并发症的预防和处理。
{"title":"Réducteur de sinus coronaire : aspects techniques, prévention et gestion des complications","authors":"Matthieu Périer ,&nbsp;Hachem-Ali Haidar ,&nbsp;David Sulman ,&nbsp;Florent Huang ,&nbsp;Hakim Benamer","doi":"10.1016/j.ancard.2024.101785","DOIUrl":"10.1016/j.ancard.2024.101785","url":null,"abstract":"<div><p>Coronary sinus reducer implantation is a percutaneous technique creating a narrowing in the coronary sinus through the implantation of an hourglass-shaped endoprosthesis. It is proposed to reduce symptoms in patients suffering from refractory angina pectoris. This innovative treatment is experiencing a major craze among interventional cardiologists. It is associated with very high procedural success rates. Complications are rare and include coronary sinus dissection or perforation and migration of the device.</p><p>This review exposes the device implantation technique, the potential anatomical difficulties, the tips and tricks to overcome challenging situations. It also focuses on the prevention and management of potential complications.</p></div>","PeriodicalId":7899,"journal":{"name":"Annales de cardiologie et d'angeiologie","volume":"73 4","pages":"Article 101785"},"PeriodicalIF":0.3,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fermeture percutanée d'une fistule coronaro-pulmonaire : à propos d'un cas [经皮闭合冠状动脉-肺瘘管:病例报告]。
IF 0.3 Q4 Medicine Pub Date : 2024-08-09 DOI: 10.1016/j.ancard.2024.101788
Zakariae Laraichi , Amani Farah , Armand Aymard , Hakim Benamer

Background

A coronary artery fistula is an abnormal connection between one or more coronary arteries and a cardiac chamber or great vessel, often discovered incidentally through cardiac imaging. Although coronary artery fistulas are typically asymptomatic during the first two decades of life, particularly when small, they can become clinically significant over time.

Case presentation

We present the case of a 71-year-old female patient with a history of exertional dyspnea. Diagnostic coronary angiography revealed a significant coronary artery fistula originating from the proximal right coronary artery and draining into the pulmonary artery trunk. Given the patient's symptoms and the anatomical features of the fistula, she was successfully treated with transcutaneous closure using a liquid embolic agent (Onyx).

Conclusion

Although surgical intervention has historically been the primary treatment for CAF, minimally invasive techniques such as transcutaneous closure are proving to be effective alternatives.

背景:冠状动脉瘘是一条或多条冠状动脉与心腔或大血管之间的异常连接,通常通过心脏成像偶然发现。虽然冠状动脉瘘在患者出生后的头二十年内通常没有症状,尤其是在瘘口较小时,但随着时间的推移,瘘口可能会出现明显的临床症状:本病例是一名 71 岁女性患者的病例,她曾有过劳累性呼吸困难病史。诊断性冠状动脉造影显示,有一个明显的冠状动脉瘘,源于右冠状动脉近端,引流至肺动脉干。考虑到患者的症状和瘘管的解剖特征,我们使用液体栓塞剂(Onyx)对她进行了经皮闭合治疗,并取得了成功:结论:虽然手术治疗历来是 CAF 的主要治疗方法,但经皮闭合术等微创技术已被证明是有效的替代方法。
{"title":"Fermeture percutanée d'une fistule coronaro-pulmonaire : à propos d'un cas","authors":"Zakariae Laraichi ,&nbsp;Amani Farah ,&nbsp;Armand Aymard ,&nbsp;Hakim Benamer","doi":"10.1016/j.ancard.2024.101788","DOIUrl":"10.1016/j.ancard.2024.101788","url":null,"abstract":"<div><h3>Background</h3><p>A coronary artery fistula is an abnormal connection between one or more coronary arteries and a cardiac chamber or great vessel, often discovered incidentally through cardiac imaging. Although coronary artery fistulas are typically asymptomatic during the first two decades of life, particularly when small, they can become clinically significant over time.</p></div><div><h3>Case presentation</h3><p>We present the case of a 71-year-old female patient with a history of exertional dyspnea. Diagnostic coronary angiography revealed a significant coronary artery fistula originating from the proximal right coronary artery and draining into the pulmonary artery trunk. Given the patient's symptoms and the anatomical features of the fistula, she was successfully treated with transcutaneous closure using a liquid embolic agent (Onyx).</p></div><div><h3>Conclusion</h3><p>Although surgical intervention has historically been the primary treatment for CAF, minimally invasive techniques such as transcutaneous closure are proving to be effective alternatives.</p></div>","PeriodicalId":7899,"journal":{"name":"Annales de cardiologie et d'angeiologie","volume":"73 4","pages":"Article 101788"},"PeriodicalIF":0.3,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141911383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
La fibrillation atriale à l'Hôpital Principal de Dakar au Sénégal : résultats et limites de la prise en charge [塞内加尔达喀尔主要医院的心房颤动:治疗效果和局限性]。
IF 0.3 Q4 Medicine Pub Date : 2024-08-09 DOI: 10.1016/j.ancard.2024.101758
Mboup Waly Niang, Dia Khadidiatou, Ka Mame Madjiguène, Ndao Serigne Cheikh Tidiane, Yassine Rabab, Diop Marième, Mboup Mouhamed Cherif

Objectives

The aim of the study was to determine the prevalence of AF in the cardiology department of the Hospital Principal of Dakar, then to evaluate the clinical, paraclinical, etiological and evolutionary profiles of AF and finally to identify the limits of its management in our context.

Patients and methods

This was a retrospective, descriptive, analytical, mono-centric study carried out at Hospital Principal of Dakar from January 2019 to August 2021. Were included, all patients admitted for atrial fibrillation, or patients who presented an atrial fibrillation during hospitalization, confirmed by electrocardiogram or long-term electrocardiographic recording during the study period.

Results

The prevalence of atrial fibrillation during the period of our study compared to the hospital population was 7.71%, with a sex ratio of 1.03. The mean age was 67.88 ± 14.09 years. We noted that 83.64% of patients had at least one cardiovascular risk factor, with 56.36% suffering from hypertension, 50.91% of sedentary person and 23.64% of diabetics. Clinically, 92.72% of the patients were symptomatic, with dyspnea predominating (70.91%). Cardiac arrhythmia was present in 85.45% of patients, and congestive heart failure in 47.27%. Long-term electrocardiographic recording was performed in 10 patients, showing 50% of paroxysmal atrial fibrillation. Sixty-three patients (57.27%) had permanent AF, twenty-three patients (20.91%) had persistent AF, fourteen patients (12.73%) had long-term persistent AF and ten patients (9.09%) had paroxysmal AF. Transthoracic echocardiography showed 57.27% of left atrial dilatation and 72.3% of reduced left ventricular ejection fraction. Etiologies for cardiac causes were dominated by dilated cardiomyopathy (21.82%), followed by ischemic heart disease (17.27%). In terms of treatment, the most commonly used molecule was bisoprolol (38.18%), followed by digoxin (21.81%). Anticoagulants were used in 85.46% of cases. Acenocoumarol alone was used in 69.09% of patients. Drug-induced cardioversion was attempted in 2 patients without success, and 4 patients benefited from external electric shock with 3 successes. Most patients had a favorable outcome, but 34.54% suffered hemodynamic complications (18.18%) and thromboembolic ones as well (16.36%). In-hospital mortality in our series was 20%. It was significantly related to heart failure, with a left ventricular ejection fraction < 35% (p < 0.001).

Conclusion

Atrial fibrillation is serious because of its hemodynamic, thromboembolic and rhythmic complications. The high mortality is explained by the underlying condition, but also by the delay in management with late diagnosis and, above all, the unavailability of ablation procedures in our context.

研究目的本研究旨在确定达喀尔特等医院心内科房颤的发病率,然后评估房颤的临床、辅助临床、病因学和演变概况,最后确定在我们的情况下房颤治疗的局限性:这是一项回顾性、描述性、分析性、单一中心研究,于2019年1月至2021年8月在达喀尔特等医院进行。研究对象包括所有因心房颤动入院的患者,或在住院期间出现心房颤动并在研究期间经心电图或长期心电图记录证实的患者:与住院人群相比,研究期间心房颤动的发病率为 7.71%,性别比为 1.03。平均年龄为 67.88±14.09 岁。我们注意到,83.64%的患者至少有一个心血管风险因素,其中高血压患者占 56.36%,久坐不动者占 50.91%,糖尿病患者占 23.64%。临床上,92.72%的患者有症状,其中以呼吸困难为主(70.91%)。85.45%的患者有心律失常,47.27%的患者有充血性心力衰竭。对 10 名患者进行了长期心电图记录,结果显示 50%的患者存在阵发性心房颤动。63名患者(57.27%)为永久性房颤,23名患者(20.91%)为持续性房颤,14名患者(12.73%)为长期持续性房颤,10名患者(9.09%)为阵发性房颤。经胸超声心动图显示,57.27%的患者左房扩张,72.3%的患者左室射血分数降低。心脏病的病因主要是扩张型心肌病(21.82%),其次是缺血性心脏病(17.27%)。在治疗方面,最常用的分子是比索洛尔(38.18%),其次是地高辛(21.81%)。85.46%的病例使用了抗凝剂。69.09%的患者仅使用了醋硝香豆素。有 2 名患者尝试过药物诱导心脏复律,但没有成功,有 4 名患者受益于体外电击,其中 3 人成功。大多数患者的预后良好,但也有 34.54% 的患者出现血流动力学并发症(18.18%)和血栓栓塞并发症(16.36%)。在我们的系列研究中,院内死亡率为20%。这与左心室射血分数小于35%的心力衰竭有很大关系(P < 0.001):结论:心房颤动因其血液动力学、血栓栓塞和节律性并发症而十分严重。死亡率高的原因不仅在于潜在的疾病,还在于诊断过晚导致的治疗延误,更重要的是,在我们这里无法进行消融手术。
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引用次数: 0
Un infarctus, mais pas du myocarde! [梗塞,但不是心肌梗塞!]
IF 0.3 Q4 Medicine Pub Date : 2024-08-09 DOI: 10.1016/j.ancard.2024.101795
Pierre Robert, Benoit Lattuca

Pulmonary embolism (PE) is a common and serious cardiovascular disease. The management of PE patients with myocardial damage but without hemodynamic instability (intermediate/high risk) has long remained limited to anticoagulant therapy with no demonstrated positive effect of thrombolysis. In this specific population, percutaneous techniques have been developed and appear as interesting alternative in patients with clinical, biological and morphological severity criteria to reduce the evolutive risk to a more severe form and improve patients’ prognosis. We report here the case of a 49-year-old patient treated for a massive bilateral and proximal PE revealed by syncope with right ventricular impact in whom percutaneous pulmonary thrombectomy was proposed in the absence of clinical improvement after the initiation of anticoagulant therapy. The precise indications for percutaneous techniques need to be clarified in patients with intermediate/high risk PE and ongoing randomized studies should provide additional results to better identify their place in the therapeutic arsenal.

肺栓塞(PE)是一种常见的严重心血管疾病。长期以来,对有心肌损伤但无血流动力学不稳定(中/高风险)的肺栓塞患者的治疗仅限于抗凝疗法,而溶栓疗法并无明显的积极效果。针对这一特殊人群,经皮溶栓技术应运而生,对于符合临床、生物学和形态学严重程度标准的患者来说,经皮溶栓技术似乎是一种有趣的替代疗法,可降低病情恶化的风险,改善患者的预后。我们在此报告了一例 49 岁患者的病例,该患者因右心室受冲击出现晕厥而导致双侧近端大面积肺栓塞,在开始抗凝治疗后临床症状未见好转,因此建议对其进行经皮肺血栓切除术。经皮技术在中/高风险 PE 患者中的确切适应症有待明确,目前正在进行的随机研究应能提供更多结果,从而更好地确定其在治疗手段中的地位。
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引用次数: 0
期刊
Annales de cardiologie et d'angeiologie
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