We performed Monte Carlo simulations to explore the behaviors of the microscopically fourfold magnetocrystalline anisotropy and macroscopically Néel temperature (TN) of an antiferromagnetic IrMn layer as well as the exchange bias blocking temperature (TB) in CoFeB/IrMn bilayers under combined in-plane biaxial and out-of-plane uniaxial strains. We demonstrate that the fourfold symmetric anisotropy remains robust, with both its strength and easy-axis orientation being tunable. The exchange coupling constants between Mn–Mn pairs exhibit long-range characteristics. Through precise strain control, TN can be significantly enhanced from 510 to 1346 K, and TB can be increased from 420 to 1050 K. Additionally, these strains can diminish or even completely eliminate exchange bias and coercivity. This study elucidates the mechanisms underlying microscopic magnetism, TN, and TB via strain control, while also proposing a promising strategy for utilizing multi-dimensional strain engineering to advance the practical applications of room-temperature or high-temperature exchange-bias-based spintronic devices.