RATIONALENewborns who live at high altitudes are chronically exposed to low oxygen levels, which may impair lung development and induce vascular remodeling, often resulting in pulmonary hypertension, right ventricular hypertrophy, and right heart failure. Nitric oxide (NO) has a critical role in mediating pulmonary vasodilation and supporting healthy lung development. The potential therapeutic role of long-term inhaled NO in hypoxia-induced pulmonary hypertension and right ventricular disease has not been determined.OBJECTIVETo investigate the therapeutic effects of long-term inhaled NO in a mouse model of pulmonary hypertension in the context of impaired lung development.METHODSBeginning on post-natal day 3-4, mice were exposed to either 21% or 11% FiO2, with or without continuous inhaled NO at 10 ppm. We assessed exhaled NO levels and plasma nitrite and nitrate concentrations on mice at age 2-3 months. Pulmonary hypertension, right ventricular hypertrophy and cardiac function were evaluated using echocardiography and invasive hemodynamic measurements. Vascular and alveolar structure was analyzed by histology.RESULTSChronic hypoxia impaired lung development and caused pulmonary hypertension. Levels of exhaled NO and plasma nitrite and nitrate concentrations were reduced by chronic hypoxia. Long-term inhaled NO therapy restored NO biomarkers and improved pulmonary hypertension, right ventricular hypertrophy, and right ventricular function. However, hypoxia-induced alveolar and vascular rarefaction were unaffected by inhaled NO.CONCLUSIONThese findings support further investigation of prolonged inhaled NO as a potential therapeutic strategy for conditions associated with chronic hypoxia, such as those experienced at high altitude.
{"title":"Effects of continuous low-dose nitric oxide in a murine model of pulmonary hypertension with impaired lung development.","authors":"Luca Zazzeron,Elisa Mereto,Paul Lichtenegger,Elizabeth Moore,Helena Tattersfield,Eizo Marutani,Binglan Yu,Lorenzo Berra,Donald B Bloch,Fumito Ichinose","doi":"10.1097/aln.0000000000005939","DOIUrl":"https://doi.org/10.1097/aln.0000000000005939","url":null,"abstract":"RATIONALENewborns who live at high altitudes are chronically exposed to low oxygen levels, which may impair lung development and induce vascular remodeling, often resulting in pulmonary hypertension, right ventricular hypertrophy, and right heart failure. Nitric oxide (NO) has a critical role in mediating pulmonary vasodilation and supporting healthy lung development. The potential therapeutic role of long-term inhaled NO in hypoxia-induced pulmonary hypertension and right ventricular disease has not been determined.OBJECTIVETo investigate the therapeutic effects of long-term inhaled NO in a mouse model of pulmonary hypertension in the context of impaired lung development.METHODSBeginning on post-natal day 3-4, mice were exposed to either 21% or 11% FiO2, with or without continuous inhaled NO at 10 ppm. We assessed exhaled NO levels and plasma nitrite and nitrate concentrations on mice at age 2-3 months. Pulmonary hypertension, right ventricular hypertrophy and cardiac function were evaluated using echocardiography and invasive hemodynamic measurements. Vascular and alveolar structure was analyzed by histology.RESULTSChronic hypoxia impaired lung development and caused pulmonary hypertension. Levels of exhaled NO and plasma nitrite and nitrate concentrations were reduced by chronic hypoxia. Long-term inhaled NO therapy restored NO biomarkers and improved pulmonary hypertension, right ventricular hypertrophy, and right ventricular function. However, hypoxia-induced alveolar and vascular rarefaction were unaffected by inhaled NO.CONCLUSIONThese findings support further investigation of prolonged inhaled NO as a potential therapeutic strategy for conditions associated with chronic hypoxia, such as those experienced at high altitude.","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"31 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145986570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-14DOI: 10.1097/ALN.0000000000005851
Simon Becker, Christian T Kurz, Romina Schnitzler, Johannes Geppert, Lisa-Marie Wichelhaus, Robin Denz, Jonas Poepping, Martin Rembecki, Dinah Maria Berres, Justus T Strauch, Declan G Bates, Gabor Erdoes, Nina Timmesfeld, Peter K Zahn
Background: Patients undergoing on-pump cardiac surgery are at high risk for perioperative lung injury and a hyperinflammatory state associated with postoperative complications. The authors investigated the hypothesis that flow-controlled ventilation (FCV) reduces the inflammatory stimulus compared to conventional pressure-controlled ventilation (PCV) in this patient cohort. FCV has the unique feature of controlling airway flows during inspiration and expiration and the potential to reduce mechanical power of invasive ventilation.
Methods: In this single-center randomized controlled trial, 140 adult patients undergoing cardiac surgery with cardiopulmonary bypass were allocated 1:1 to FCV or PCV from August 10, 2020, to November 16, 2022. Participants received perioperatively either individualized FCV with a compliance-guided positive end-expiratory pressure (PEEP) and a compliance-guided driving pressure (ΔP) or PCV with a compliance-guided PEEP and ΔP for tidal volumes of 6 to 8 ml/kg predicted body weight. Postoperative plasmatic interleukin 8 (IL-8) levels 6 h after cardiopulmonary bypass were defined as the primary endpoint. Explorative secondary outcomes included incidences of postoperative pulmonary and extrapulmonary complications and hospital length of stay.
Results: Median postoperative IL-8 levels did not differ significantly between FCV and PCV (FCV, 3.08 vs . PCV, 3.60; β, 0.08 pg/ml; 95% CI, -0.17 to 0.33; P = 0.573). ΔP values and tidal volumes were higher in the FCV group but FCV yielded lower respiratory rates and minute volumes required for normocapnia. As a result, the FCV approach reduced the perioperatively applied mechanical power by 55%. After FCV, incidences of single postoperative pulmonary complications ( e.g. , confirmed pneumonia, moderate and severe hypoxemia) and any postoperative extrapulmonary complication were lower and the hospital stay shorter.
Conclusions: FCV did not reduce plasmatic IL-8 levels at the predefined timepoint 6 h after cardiopulmonary bypass. However, the reduction of mechanical power during individualized FCV application and the findings of the explorative secondary study outcomes justify future trials.
背景：接受无泵心脏手术的患者围手术期肺损伤和与术后并发症相关的高炎症状态的风险很高。在该患者队列中，我们研究了流量控制通气（FCV）与常规压力控制通气（PCV）相比减少炎症刺激的假设。FCV具有控制吸气和呼气时气道流量的独特功能，并具有降低有创通气机械功率的潜力。方法：在这项单中心随机对照试验中，从2020年8月10日至2022年11月16日，140例接受心脏手术合并体外循环的成年患者按1:1分配到FCV或PCV组。患者围手术期接受个体化呼气末正压（PEEP）和依从性驱动压力（ΔP）的FCV治疗，或接受依从性呼气末正压（PEEP）和ΔP的PCV治疗，潮气量为6-8 ml/kg预测体重。体外循环术后6小时血浆白细胞介素8 （IL-8）水平被定义为主要终点。探索性次要结局包括术后肺部和肺外并发症的发生率以及住院时间。结果：术后中位IL-8水平在FCV和PCV之间无显著差异（FCV 3.08 vs. PCV 3.60， β系数0.08 pg/ml, 95% CI -0.17 ~ 0.33; P = 0.573）。ΔP值和潮气量在FCV组较高，但FCV产生较低的呼吸速率和正常运动能力所需的分钟气量。结果，FCV入路将围手术期施加的机械功率降低了55%。FCV术后单一肺部并发症（如确诊肺炎、中重度低氧血症）及术后任何肺外并发症发生率较低，住院时间较短。结论：体外循环术后6小时内，FCV并没有降低血浆IL-8水平。然而，在个体化FCV应用过程中机械功率的降低和探索性二次研究结果的发现证明了未来的试验是合理的。
{"title":"Individualized Flow-controlled versus Pressure-controlled Ventilation in Cardiac Surgery: A Randomized Controlled Trial.","authors":"Simon Becker, Christian T Kurz, Romina Schnitzler, Johannes Geppert, Lisa-Marie Wichelhaus, Robin Denz, Jonas Poepping, Martin Rembecki, Dinah Maria Berres, Justus T Strauch, Declan G Bates, Gabor Erdoes, Nina Timmesfeld, Peter K Zahn","doi":"10.1097/ALN.0000000000005851","DOIUrl":"10.1097/ALN.0000000000005851","url":null,"abstract":"<p><strong>Background: </strong>Patients undergoing on-pump cardiac surgery are at high risk for perioperative lung injury and a hyperinflammatory state associated with postoperative complications. The authors investigated the hypothesis that flow-controlled ventilation (FCV) reduces the inflammatory stimulus compared to conventional pressure-controlled ventilation (PCV) in this patient cohort. FCV has the unique feature of controlling airway flows during inspiration and expiration and the potential to reduce mechanical power of invasive ventilation.</p><p><strong>Methods: </strong>In this single-center randomized controlled trial, 140 adult patients undergoing cardiac surgery with cardiopulmonary bypass were allocated 1:1 to FCV or PCV from August 10, 2020, to November 16, 2022. Participants received perioperatively either individualized FCV with a compliance-guided positive end-expiratory pressure (PEEP) and a compliance-guided driving pressure (ΔP) or PCV with a compliance-guided PEEP and ΔP for tidal volumes of 6 to 8 ml/kg predicted body weight. Postoperative plasmatic interleukin 8 (IL-8) levels 6 h after cardiopulmonary bypass were defined as the primary endpoint. Explorative secondary outcomes included incidences of postoperative pulmonary and extrapulmonary complications and hospital length of stay.</p><p><strong>Results: </strong>Median postoperative IL-8 levels did not differ significantly between FCV and PCV (FCV, 3.08 vs . PCV, 3.60; β, 0.08 pg/ml; 95% CI, -0.17 to 0.33; P = 0.573). ΔP values and tidal volumes were higher in the FCV group but FCV yielded lower respiratory rates and minute volumes required for normocapnia. As a result, the FCV approach reduced the perioperatively applied mechanical power by 55%. After FCV, incidences of single postoperative pulmonary complications ( e.g. , confirmed pneumonia, moderate and severe hypoxemia) and any postoperative extrapulmonary complication were lower and the hospital stay shorter.</p><p><strong>Conclusions: </strong>FCV did not reduce plasmatic IL-8 levels at the predefined timepoint 6 h after cardiopulmonary bypass. However, the reduction of mechanical power during individualized FCV application and the findings of the explorative secondary study outcomes justify future trials.</p>","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145538800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1097/aln.0000000000005857
Roberta Garberi,David W Kaczka
{"title":"Volumetric Capnography and the Interpretation of Regional Ventilation-to-Perfusion Matching.","authors":"Roberta Garberi,David W Kaczka","doi":"10.1097/aln.0000000000005857","DOIUrl":"https://doi.org/10.1097/aln.0000000000005857","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"38 1","pages":"263-265"},"PeriodicalIF":8.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1097/aln.0000000000005837
Daniel I McIsaac,Karim S Ladha
{"title":"Causality in Perioperative Acute Pain Research.","authors":"Daniel I McIsaac,Karim S Ladha","doi":"10.1097/aln.0000000000005837","DOIUrl":"https://doi.org/10.1097/aln.0000000000005837","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"57 1","pages":"257-259"},"PeriodicalIF":8.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUNDPost-operative bleeding is frequent in cardiac surgery, but its incidence, risk factors and consequences remain largely unknown after heart transplantation. The main objective of this study was to describe the incidence of severe bleeding complications after adult heart transplantation.METHODSWe conducted an observational study including all adult patients who received a heart transplant between 2015 and 2022, in two French referral centers. The primary endpoint was the incidence of severe bleeding complications defined by a UDPB score ≥ 3 (Universal Definition of Perioperative Bleeding). Multivariable logistic regression was used to identify variables associated with the incidence of severe post-operative bleeding. The impact of severe post-operative bleeding on one-year mortality was evaluated using a multivariable Cox regression model.RESULTSAmong the 446 patients included, 112 (25%) developed severe bleeding. In multivariable analysis, long-term mechanical cardiac support (adjOR 2.21 [1.01-4.88]), preoperative hemoglobin (adjOR 0.85 [0.76-0.95]) and the duration of CPB (per 10min increase, adjOR=1.08 [1.03-1.15]) were associated with severe bleeding. Severe postoperative bleeding was associated with an increased mortality at one-year (35% vs 13%, p<0.001), with an adjusted HR of 1.91 (95% CI, 1.18-3.09, p=0.008).CONCLUSIONSThis study reports a high incidence of severe hemorrhagic complications following heart transplantation, particularly in patients with mechanical circulatory support. Bleeding complications were associated with a significant increase in morbidity and mortality. Larger-scale studies are needed to identify and evaluated potential prevention strategies.
{"title":"Severe post-operative bleeding after heart transplantation.","authors":"Alexandre Mansour,Adrien Bougle,Marion Turpin,Adel Zaouini,Nicolas Patou Parvedy,Céline Chabanne,Geoffroy Hariri,Guillaume Coutance,Erwan Flecher,Pascal Leprince,Nicolas Nesseler","doi":"10.1097/aln.0000000000005930","DOIUrl":"https://doi.org/10.1097/aln.0000000000005930","url":null,"abstract":"BACKGROUNDPost-operative bleeding is frequent in cardiac surgery, but its incidence, risk factors and consequences remain largely unknown after heart transplantation. The main objective of this study was to describe the incidence of severe bleeding complications after adult heart transplantation.METHODSWe conducted an observational study including all adult patients who received a heart transplant between 2015 and 2022, in two French referral centers. The primary endpoint was the incidence of severe bleeding complications defined by a UDPB score ≥ 3 (Universal Definition of Perioperative Bleeding). Multivariable logistic regression was used to identify variables associated with the incidence of severe post-operative bleeding. The impact of severe post-operative bleeding on one-year mortality was evaluated using a multivariable Cox regression model.RESULTSAmong the 446 patients included, 112 (25%) developed severe bleeding. In multivariable analysis, long-term mechanical cardiac support (adjOR 2.21 [1.01-4.88]), preoperative hemoglobin (adjOR 0.85 [0.76-0.95]) and the duration of CPB (per 10min increase, adjOR=1.08 [1.03-1.15]) were associated with severe bleeding. Severe postoperative bleeding was associated with an increased mortality at one-year (35% vs 13%, p<0.001), with an adjusted HR of 1.91 (95% CI, 1.18-3.09, p=0.008).CONCLUSIONSThis study reports a high incidence of severe hemorrhagic complications following heart transplantation, particularly in patients with mechanical circulatory support. Bleeding complications were associated with a significant increase in morbidity and mortality. Larger-scale studies are needed to identify and evaluated potential prevention strategies.","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"46 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1097/aln.0000000000005850
Lynn R Kohan,Eugene R Viscusi
{"title":"Rising Treatment for Substance Use Disorder Presents New Challenges for Anesthesiologists as Perioperative Medicine Specialists.","authors":"Lynn R Kohan,Eugene R Viscusi","doi":"10.1097/aln.0000000000005850","DOIUrl":"https://doi.org/10.1097/aln.0000000000005850","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"42 1","pages":"266-269"},"PeriodicalIF":8.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1097/aln.0000000000005860
Mariusz Ligocki,Nikolaos J Skubas
{"title":"Turning Down the Surge: Preemptive Magnesium during Pheochromocytoma and Paraganglioma Resection.","authors":"Mariusz Ligocki,Nikolaos J Skubas","doi":"10.1097/aln.0000000000005860","DOIUrl":"https://doi.org/10.1097/aln.0000000000005860","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"22 1","pages":"260-262"},"PeriodicalIF":8.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUNDThe majority of dorsal root ganglion neurons are excitatory glutamatergic neurons. Recent studies suggest that a subset of dorsal root ganglion neurons are able to synthesize γ-aminobutyric acid (GABA) and are immunoreactive to vesicular GABA transporter (Vgat) that packages GABA into the synaptic vesicles critical for inhibitory neurotransmission. The current study aimed to investigate the spinal circuits innervated by these Vgat+ primary sensory neurons and interrogate the role of Vgat+ primary sensory neurons in nociceptive modification.METHODSThe authors used viral tracings, immunohistochemistry, patch clamp electrophysiologic recordings, optogenetics, chemogenetics, and behavioral assays in male Vgat-Cre mice to dissect the anatomical connectivity and function of Vgat+ primary sensory neurons.RESULTSThe data showed that the central terminals of Vgat+ primary sensory neurons made inhibitory connections with spinal cord somatostatin-positive excitatory interneurons and meanwhile formed glutamatergic connections with local GABAergic interneurons driving feedforward inhibition. The functional dichotomy of Vgat+ primary sensory neurons constituted an inhibitory spinal circuit that prevented aversive and pain-like responses of mice to innocuous or noxious mechanical stimuli. After peripheral nerve injury, the reduction of inhibitory drive from Vgat+ primary sensory neurons to spinal somatostatin-positive interneurons correlated with mechanical nociceptive sensitization. Optogenetic or chemogenetic stimulation of Vgat+ primary sensory neurons effectively alleviated the nerve injury-induced hypersensitivity to mechanical stimulation.CONCLUSIONSThe data suggested that the Vgat+ primary sensory neurons innervating a discrete spinal microcircuit were ideally suited to suppress the mechanical pain transmission.
{"title":"Effects of γ-Aminobutyric Acid and Glutamate Signalings from Primary Sensory Neurons to Gate the Spinal Transmission of Mechanical Pain in Mice.","authors":"Shu-Jin Wu,Hu-Hu Bai,Yan-Ni Liu,Qi Zhang,Yu-Bo Gao,Juan Li,Xu Yang,Jia-Ning Dang,Xiao-Xue Liu,Xue Bai,Xian Yang,Zhan-Wei Suo,Xiao-Dong Hu","doi":"10.1097/aln.0000000000005854","DOIUrl":"https://doi.org/10.1097/aln.0000000000005854","url":null,"abstract":"BACKGROUNDThe majority of dorsal root ganglion neurons are excitatory glutamatergic neurons. Recent studies suggest that a subset of dorsal root ganglion neurons are able to synthesize γ-aminobutyric acid (GABA) and are immunoreactive to vesicular GABA transporter (Vgat) that packages GABA into the synaptic vesicles critical for inhibitory neurotransmission. The current study aimed to investigate the spinal circuits innervated by these Vgat+ primary sensory neurons and interrogate the role of Vgat+ primary sensory neurons in nociceptive modification.METHODSThe authors used viral tracings, immunohistochemistry, patch clamp electrophysiologic recordings, optogenetics, chemogenetics, and behavioral assays in male Vgat-Cre mice to dissect the anatomical connectivity and function of Vgat+ primary sensory neurons.RESULTSThe data showed that the central terminals of Vgat+ primary sensory neurons made inhibitory connections with spinal cord somatostatin-positive excitatory interneurons and meanwhile formed glutamatergic connections with local GABAergic interneurons driving feedforward inhibition. The functional dichotomy of Vgat+ primary sensory neurons constituted an inhibitory spinal circuit that prevented aversive and pain-like responses of mice to innocuous or noxious mechanical stimuli. After peripheral nerve injury, the reduction of inhibitory drive from Vgat+ primary sensory neurons to spinal somatostatin-positive interneurons correlated with mechanical nociceptive sensitization. Optogenetic or chemogenetic stimulation of Vgat+ primary sensory neurons effectively alleviated the nerve injury-induced hypersensitivity to mechanical stimulation.CONCLUSIONSThe data suggested that the Vgat+ primary sensory neurons innervating a discrete spinal microcircuit were ideally suited to suppress the mechanical pain transmission.","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"14 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-09DOI: 10.1097/ALN.0000000000005858
Kathryn E McGoldrick
{"title":"The Stitch-Up: How Medical Misogyny Harms Us All.","authors":"Kathryn E McGoldrick","doi":"10.1097/ALN.0000000000005858","DOIUrl":"https://doi.org/10.1097/ALN.0000000000005858","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145931919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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