Pub Date : 2026-03-10DOI: 10.1097/aln.0000000000005938
Paul Potnuru,Holger K Eltzschig,Gyorgy Frendl
{"title":"Mind the Gap: Discordant Creatinine and Cystatin C Estimates of Renal Function and Postoperative Outcomes.","authors":"Paul Potnuru,Holger K Eltzschig,Gyorgy Frendl","doi":"10.1097/aln.0000000000005938","DOIUrl":"https://doi.org/10.1097/aln.0000000000005938","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"52 1","pages":"756-758"},"PeriodicalIF":8.8,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1097/aln.0000000000005908
Michael R Pinsky
{"title":"Defining the Determinants of Tissue Perfusion at the Bedside in Septic Shock Patients.","authors":"Michael R Pinsky","doi":"10.1097/aln.0000000000005908","DOIUrl":"https://doi.org/10.1097/aln.0000000000005908","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"52 1","pages":"759-760"},"PeriodicalIF":8.8,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of Drug Treatments at High Temperatures: Comment.","authors":"Shingo Kawashima,Hiroyuki Kinoshita,Tetsuro Kimura,Atsushi Kobayashi","doi":"10.1097/aln.0000000000005915","DOIUrl":"https://doi.org/10.1097/aln.0000000000005915","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"104 1","pages":"1027-1028"},"PeriodicalIF":8.8,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1097/aln.0000000000005951
Ruth Landau,Yandong Jiang
{"title":"Pain during Cesarean Delivery with Neuraxial Anesthesia: Have We Made Any Progress?","authors":"Ruth Landau,Yandong Jiang","doi":"10.1097/aln.0000000000005951","DOIUrl":"https://doi.org/10.1097/aln.0000000000005951","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"53 1","pages":"749-751"},"PeriodicalIF":8.8,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147383603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1097/aln.0000000000005849
Sheila Riazi,Stacey Watt,Jennifer Plester,Leslie G Biesecker
Malignant hyperthermia, a pharmacogenetic disorder of skeletal muscle, is a potentially fatal reaction triggered by exposure to volatile anesthetics or succinylcholine. Genetic testing of the three known involved genes (RYR1, CACNA1S, and STAC3) has become the first line of testing for malignant hyperthermia susceptibility. However, genetic testing has sensitivity of only up to 70%. Contracture testing may be used to rule out the disorder for some individuals. This study outlines a stepwise approach, using clinical history and assessment as well as interpretation of genetic variants to balance risks and benefits for individuals at risk of this disorder. This work has received an Affirmation of Value designation from the American Society of Anesthesiologists (Schaumburg, Illinois) and endorsement from the Canadian Anesthesiologists' Society (Toronto, Canada).
{"title":"A Proposed North American Approach for Genetic Testing of Individuals at Risk for Malignant Hyperthermia.","authors":"Sheila Riazi,Stacey Watt,Jennifer Plester,Leslie G Biesecker","doi":"10.1097/aln.0000000000005849","DOIUrl":"https://doi.org/10.1097/aln.0000000000005849","url":null,"abstract":"Malignant hyperthermia, a pharmacogenetic disorder of skeletal muscle, is a potentially fatal reaction triggered by exposure to volatile anesthetics or succinylcholine. Genetic testing of the three known involved genes (RYR1, CACNA1S, and STAC3) has become the first line of testing for malignant hyperthermia susceptibility. However, genetic testing has sensitivity of only up to 70%. Contracture testing may be used to rule out the disorder for some individuals. This study outlines a stepwise approach, using clinical history and assessment as well as interpretation of genetic variants to balance risks and benefits for individuals at risk of this disorder. This work has received an Affirmation of Value designation from the American Society of Anesthesiologists (Schaumburg, Illinois) and endorsement from the Canadian Anesthesiologists' Society (Toronto, Canada).","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"48 1","pages":"776-783"},"PeriodicalIF":8.8,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147383604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1097/aln.0000000000005923
Michael P Eaton,Sergiy M Nadtochiy
{"title":"Dabigatran in Sheep Cardiopulmonary Bypass: Reply.","authors":"Michael P Eaton,Sergiy M Nadtochiy","doi":"10.1097/aln.0000000000005923","DOIUrl":"https://doi.org/10.1097/aln.0000000000005923","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"222 1","pages":"1029-1030"},"PeriodicalIF":8.8,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1097/aln.0000000000005828
Carin A Hagberg,Takashi Asai,Thomas Heidegger,Sheila N Myatra,Jaideep J Pandit,Yandong Jiang
Sugammadex reverses the effects of steroidal neuromuscular blocking agents rapidly and completely. Unlike neostigmine, its antagonism is long lasting, has no ceiling effect, and minimizes the risk of residual neuromuscular block. These unique pharmacologic properties may influence not only the emergence from anesthesia but also induction and tracheal intubation strategies across perioperative settings, including critical care, emergency medicine, and prehospital resuscitation, especially in the context of difficult airway management. However, the full impact of sugammadex on airway management has been underappreciated. As a reversal agent for difficult airways, it remains underutilized, largely due to limited awareness of its unique properties. This narrative review synthesizes the current literature, highlights practical considerations in daily airway management, and examines the potential paradigm shift introduced by sugammadex while also outlining future directions for research.
{"title":"Era of Sugammadex: A Paradigm Shift in Airway Management.","authors":"Carin A Hagberg,Takashi Asai,Thomas Heidegger,Sheila N Myatra,Jaideep J Pandit,Yandong Jiang","doi":"10.1097/aln.0000000000005828","DOIUrl":"https://doi.org/10.1097/aln.0000000000005828","url":null,"abstract":"Sugammadex reverses the effects of steroidal neuromuscular blocking agents rapidly and completely. Unlike neostigmine, its antagonism is long lasting, has no ceiling effect, and minimizes the risk of residual neuromuscular block. These unique pharmacologic properties may influence not only the emergence from anesthesia but also induction and tracheal intubation strategies across perioperative settings, including critical care, emergency medicine, and prehospital resuscitation, especially in the context of difficult airway management. However, the full impact of sugammadex on airway management has been underappreciated. As a reversal agent for difficult airways, it remains underutilized, largely due to limited awareness of its unique properties. This narrative review synthesizes the current literature, highlights practical considerations in daily airway management, and examines the potential paradigm shift introduced by sugammadex while also outlining future directions for research.","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"51 1","pages":"978-997"},"PeriodicalIF":8.8,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1097/aln.0000000000005949
Julien Cobert,Grace Lim
{"title":"Maternal Cardiac Arrest: Big Data, Rare Events, and Moving from Incidence to Insight.","authors":"Julien Cobert,Grace Lim","doi":"10.1097/aln.0000000000005949","DOIUrl":"https://doi.org/10.1097/aln.0000000000005949","url":null,"abstract":"","PeriodicalId":7970,"journal":{"name":"Anesthesiology","volume":"253 1","pages":"752-755"},"PeriodicalIF":8.8,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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