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Novel SVM-based classification approaches for evaluating pancreatic carcinoma 基于支持向量机的胰腺癌分类新方法
IF 1.2 4区 计算机科学 Q4 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2023-08-14 DOI: 10.1007/s10472-023-09888-5
Ammon Washburn, Neng Fan, Hao Helen Zhang

In this paper, we develop two SVM-based classifiers named stable nested one-class support vector machines (SN-1SVMs) and decoupled margin-moment based SVMs (DMMB-SVMs), to predict the specific type of pancreatic carcinoma using quantitative histopathological signatures of images. For each patient, the diagnosis can produce hundreds of images, which can be used to classify the pancreatic tissues into three classes: chronic pancreatitis, intraductal papillary mucinous neoplasms, and pancreatic carcinoma. The proposed two approaches tackle the classification problems from two different perspectives: the SN-1SVM treats each image as a classification point in a nested fashion to predict malignancy of the tissues, while the DMMB-SVM treats each patient as a classification point by assembling information across images. One attractive feature of the DMMB-SVM is that, in addition to utilizing the mean information, it also takes into account the covariance of features extracted from images for each patient. We conduct numerical experiments to evaluate and compare performance of the two methods. It is observed that the SN-1SVM can take advantage of the data structure more effectively, while the DMMB-SVM demonstrates better computational efficiency and classification accuracy. To further improve interpretability of the final classifier, we also consider the (ell _1)-norm in the DMMB-SVM to handle feature selection.

在本文中,我们开发了两个基于支持向量机的分类器,即稳定嵌套的一类支持向量机(sn - 1svm)和解耦的基于边缘矩的支持向量机(dmmb - svm),利用图像的定量组织病理学特征来预测特定类型的胰腺癌。对于每个患者,诊断可产生数百张图像,这些图像可用于将胰腺组织分为三类:慢性胰腺炎,导管内乳头状粘液瘤和胰腺癌。提出的两种方法从两个不同的角度解决分类问题:SN-1SVM以嵌套的方式将每张图像作为一个分类点来预测组织的恶性程度,而DMMB-SVM通过聚集图像间的信息将每个患者作为一个分类点。DMMB-SVM的一个吸引人的特点是,除了利用均值信息外,它还考虑了从每个患者的图像中提取的特征的协方差。我们通过数值实验来评价和比较两种方法的性能。结果表明,SN-1SVM可以更有效地利用数据结构,而DMMB-SVM具有更好的计算效率和分类精度。为了进一步提高最终分类器的可解释性,我们还考虑了DMMB-SVM中的(ell _1) -范数来处理特征选择。
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引用次数: 0
To raise or not to raise: the autonomous learning rate question 提高还是不提高:自主学习率问题
IF 1.2 4区 计算机科学 Q4 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2023-08-08 DOI: 10.1007/s10472-023-09887-6
Xiaomeng Dong, Tao Tan, Michael Potter, Yun-Chan Tsai, Gaurav Kumar, V. Ratna Saripalli, Theodore Trafalis

There is a parameter ubiquitous throughout the deep learning world: learning rate. There is likewise a ubiquitous question: what should that learning rate be? The true answer to this question is often tedious and time consuming to obtain, and a great deal of arcane knowledge has accumulated in recent years over how to pick and modify learning rates to achieve optimal training performance. Moreover, the long hours spent carefully crafting the perfect learning rate can come to nothing the moment your network architecture, optimizer, dataset, or initial conditions change ever so slightly. But it need not be this way. We propose a new answer to the great learning rate question: the Autonomous Learning Rate Controller. Find it at https://github.com/fastestimator/ARC/tree/v2.0.

在深度学习的世界里有一个无处不在的参数:学习率。同样,还有一个普遍存在的问题:学习率应该是多少?这个问题的真正答案往往是冗长而耗时的,近年来,关于如何选择和修改学习率以获得最佳训练性能的大量神秘知识已经积累起来。此外,当您的网络架构、优化器、数据集或初始条件发生微小变化时,花在精心设计完美学习率上的长时间可能会付之一炬。但它不一定是这样的。我们提出了一种新的解决大学习率问题的方法:自主学习率控制器。请访问https://github.com/fastestimator/ARC/tree/v2.0。
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引用次数: 0
Two parameter-tuned multi-objective evolutionary-based algorithms for zoning management in marine spatial planning 海洋空间规划分区管理的两参数调整多目标进化算法
IF 1.2 4区 计算机科学 Q4 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2023-08-02 DOI: 10.1007/s10472-023-09853-2
Mohadese Basirati, Romain Billot, Patrick Meyer

Strategic spatial planning is becoming more popular around the world as a decision-making way to build a unified vision for directing the medium- to long-term development of land/marine areas. Recently, the study of marine areas in terms of spatial planning such as Marine Spatial Planning (MSP) has received much attention. One of the challenging issues in MSP is to make a balance between determining the ideal zone for a new activity while also considering the locations of existing activities. This spatial zoning problem for multi-uses with multiple objectives could be formulated as optimization models. This paper presents and compares the results of two multi-objective evolutionary-based algorithms (MOEAs), Synchronous Hypervolume-based non-dominated sorting genetic algorithm-II (SH-NSGA-II) which is an extension of NSGA-II and a memetic algorithm (MA) in which SH-NSGA-II is enhanced with a local search. These proposed algorithms are used to solve the multi-objective spatial zoning optimization problem, which seeks to maximize the zone interest value assigned to the new activity while simultaneously maximizing its spatial compactness. We introduce several innovations in these proposed algorithms to address the problem constraints and to improve the robustness of the traditional NSGA-II and MA approaches. Unlike traditional ones, a different stop condition, multiple crossover, mutation, and repairing operators, and also a local search operator are developed. A comparative study is presented between the results obtained using both algorithms. To guarantee robust results for both algorithms, their parameters are calibrated and tuned using the Multi-Response Surface Methodology (MRSM) method. The effective and non-effective components, as well as the validity of the regression models, are determined using analysis of variance (ANOVA). Although SH-NSGA-II has revealed a good efficiency, its performance is still improved using a local search scheme within SH-NSGA-II, which is specially tailored to the problem characteristics. The two methods are designed for raster data.

战略空间规划作为指导陆地/海洋地区中长期发展的统一愿景的决策方式,在世界范围内越来越受欢迎。近年来,以海洋空间规划(marine spatial planning, MSP)为代表的海洋区域空间规划研究备受关注。在MSP中,一个具有挑战性的问题是在确定新活动的理想区域和考虑现有活动的位置之间取得平衡。这种多用途、多目标的空间分区问题可以表述为优化模型。本文介绍并比较了两种多目标进化算法(moea)的结果,即NSGA-II的扩展——基于同步超卷的非支配排序遗传算法(SH-NSGA-II)和基于模因算法(MA)的局部搜索增强的SH-NSGA-II。这些算法用于解决多目标空间分区优化问题,该问题寻求最大化分配给新活动的区域兴趣值,同时最大化其空间紧凑性。我们在这些提出的算法中引入了一些创新,以解决问题约束并提高传统NSGA-II和MA方法的鲁棒性。与传统算法不同的是,该算法提出了不同的停车条件、多个交叉、突变和修复算子以及局部搜索算子。对两种算法得到的结果进行了比较研究。为了保证这两种算法的鲁棒性,使用多响应面方法(MRSM)对其参数进行了校准和调整。使用方差分析(ANOVA)确定有效和无效成分以及回归模型的有效性。尽管SH-NSGA-II显示出了良好的效率,但在SH-NSGA-II中使用针对问题特征专门定制的局部搜索方案,其性能仍然得到了提高。这两种方法都是针对栅格数据设计的。
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引用次数: 0
A study on the predictive strength of fractal dimension of white and grey matter on MRI images in Alzheimer’s disease 阿尔茨海默病MRI图像中白质和灰质分形维数预测强度的研究
IF 1.2 4区 计算机科学 Q4 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2023-08-01 DOI: 10.1007/s10472-023-09885-8
Niccolò Di Marco, Azzurra di Palma, Andrea Frosini, for the Alzheimer’s Disease Neuroimaging Initiative*

Many recent studies have shown that Fractal Dimension (FD), a ratio for figuring out the complexity of a system given its measurements, can be used as an useful index to provide information about certain brain disease. Our research focuses on the Alzheimer’s disease changes in white and grey brain matters detected through the FD indexes of their contours. Data used in this study were obtained from the Alzheimer’s Disease (AD) Neuroimaging Initiative database (Normal Condition, N = 57, and Alzheimer’s Disease, N = 60). After standard preprocessing pipeline, the white and grey matter 3D FD indexes are computed for the two groups. A statistical analysis shows that only grey matter 3D FD indexes are able to differentiate healthy and AD subjects. Although white matter 3D FD indexes do not, it is remarkable that their presence enhance the separation capability of previous ones. In order to valuate the classification capability of these indexes on healthy and AD subjects, we define several Neural Networks models. The performances of these models vary according to the statistical analysis and reach their best performances when each 3D FD input index is changed into a sequence of 2D FD indexes of (a subset of) the horizontal slices of the white and grey matter volumes.

最近的许多研究表明,分形维度(FD)是一种根据测量结果计算系统复杂性的比率,它可以作为一种有用的指标,提供有关某些脑部疾病的信息。我们的研究重点是通过白质和灰质轮廓的分形维度指数来检测阿尔茨海默病在白质和灰质中的变化。本研究中使用的数据来自阿尔茨海默病(AD)神经影像倡议数据库(正常状态,N = 57;阿尔茨海默病,N = 60)。经过标准预处理流程后,计算出两组患者的白质和灰质三维 FD 指数。统计分析表明,只有灰质三维 FD 指数能够区分健康受试者和老年痴呆症受试者。虽然白质三维 FD 指数无法区分,但值得注意的是,它们的存在增强了之前指数的分离能力。为了评估这些指标对健康人和注意力缺失症患者的分类能力,我们定义了几个神经网络模型。根据统计分析,这些模型的性能各不相同,而当每个三维 FD 输入指数被转换为白质和灰质体积水平切片(子集)的二维 FD 指数序列时,这些模型的性能达到最佳。
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引用次数: 0
Using answer set programming to deal with boolean networks and attractor computation: application to gene regulatory networks of cells 用答案集编程处理布尔网络和吸引子计算:在细胞基因调控网络中的应用
IF 1.2 4区 计算机科学 Q4 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2023-07-31 DOI: 10.1007/s10472-023-09886-7
Tarek Khaled, Belaid Benhamou, Van-Giang Trinh

Deciphering gene regulatory networks’ functioning is an essential step for better understanding of life, as these networks play a fundamental role in the control of cellular processes. Boolean networks have been widely used to represent gene regulatory networks. They allow to describe the dynamics of complex gene regulatory networks straightforwardly and efficiently. The attractors are essential in the analysis of the dynamics of a Boolean network. They explain that a particular cell can acquire specific phenotypes that may be transmitted over several generations. In this work, we consider a new representation of Boolean networks’ dynamics based on a new semantics used in Answer Set Programming (ASP). We use logic programs and ASP to express and deal with gene regulatory networks seen as Boolean networks, and develop a method to detect all the attractors of such networks. We first show how to represent and deal with general Boolean networks for the synchronous and asynchronous updates modes, where the computation of attractors requires a simulation of these networks’ dynamics. Then, we propose an approach for the particular case of circular networks where no simulation is needed. This last specific case plays an essential role in biological systems. We show several theoretical properties; in particular, simple attractors of the gene networks are represented by the stable models of the corresponding logic programs and cyclic attractors by its extra-stable models. These extra-stable models correspond to the extra-extensions of the new semantics that are not captured by the semantics of stable models. We then evaluate the proposed approach for general Boolean networks on real biological networks and the one dedicated to the case of circular networks on Boolean networks generated randomly. The obtained results for both approaches are encouraging.

破译基因调控网络的功能是更好地理解生命的重要一步,因为这些网络在控制细胞过程中发挥着根本作用。布尔网络已被广泛用于表示基因调控网络。它们可以直接有效地描述复杂基因调控网络的动力学。在布尔网络的动力学分析中,吸引子是必不可少的。他们解释说,一个特定的细胞可以获得特定的表型,这些表型可能会在几代人中传播。在这项工作中,我们考虑了一种基于答案集编程(ASP)中使用的新语义的布尔网络动力学的新表示。我们使用逻辑程序和ASP来表达和处理被视为布尔网络的基因调控网络,并开发了一种检测这种网络的所有吸引子的方法。我们首先展示了如何表示和处理同步和异步更新模式的通用布尔网络,其中吸引子的计算需要模拟这些网络的动力学。然后,我们针对不需要模拟的圆形网络的特殊情况提出了一种方法。最后一个具体案例在生物系统中起着至关重要的作用。我们展示了几个理论性质;特别地,基因网络的简单吸引子由相应逻辑程序的稳定模型表示,循环吸引子由其超稳定模型表示。这些额外的稳定模型对应于新语义的额外扩展,这些扩展没有被稳定模型的语义捕获。然后,我们评估了所提出的用于真实生物网络上的一般布尔网络的方法,以及用于随机生成的布尔网络上的圆形网络的方法。这两种方法都取得了令人鼓舞的结果。
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引用次数: 0
Altruism in coalition formation games 结盟博弈中的利他主义
IF 1.2 4区 计算机科学 Q4 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2023-07-31 DOI: 10.1007/s10472-023-09881-y
Anna Maria Kerkmann, Simon Cramer, Jörg Rothe

Nguyen et al. (2016) introduced altruistic hedonic games in which agents’ utilities depend not only on their own preferences but also on those of their friends in the same coalition. We propose to extend their model to coalition formation games in general, considering also the friends in other coalitions. Comparing our model to altruistic hedonic games, we argue that excluding some friends from the altruistic behavior of an agent is a major disadvantage that comes with the restriction to hedonic games. After introducing our model and showing some desirable properties, we additionally study some common stability notions and provide a computational analysis of the associated verification and existence problems.

Nguyen 等人(2016 年)引入了利他主义享乐博弈,在这种博弈中,代理人的效用不仅取决于他们自己的偏好,还取决于他们在同一联盟中的朋友的偏好。我们建议将他们的模型扩展到一般的联盟形成博弈,同时考虑其他联盟中的朋友。将我们的模型与利他主义享乐博弈相比较,我们认为,将一些朋友排除在代理人的利他行为之外是限制享乐博弈的一个主要缺点。在介绍了我们的模型并展示了一些理想特性之后,我们还研究了一些常见的稳定性概念,并对相关的验证和存在问题进行了计算分析。
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引用次数: 0
An improved multi-task least squares twin support vector machine 一种改进的多任务最小二乘双支持向量机
IF 1.2 4区 计算机科学 Q4 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2023-07-27 DOI: 10.1007/s10472-023-09877-8
Hossein Moosaei, Fatemeh Bazikar, Panos M. Pardalos

In recent years, multi-task learning (MTL) has become a popular field in machine learning and has a key role in various domains. Sharing knowledge across tasks in MTL can improve the performance of learning algorithms and enhance their generalization capability. A new approach called the multi-task least squares twin support vector machine (MTLS-TSVM) was recently proposed as a least squares variant of the direct multi-task twin support vector machine (DMTSVM). Unlike DMTSVM, which solves two quadratic programming problems, MTLS-TSVM solves two linear systems of equations, resulting in a reduced computational time. In this paper, we propose an enhanced version of MTLS-TSVM called the improved multi-task least squares twin support vector machine (IMTLS-TSVM). IMTLS-TSVM offers a significant advantage over MTLS-TSVM by operating based on the empirical risk minimization principle, which allows for better generalization performance. The model achieves this by including regularization terms in its objective function, which helps control the model’s complexity and prevent overfitting. We demonstrate the effectiveness of IMTLS-TSVM by comparing it to several single-task and multi-task learning algorithms on various real-world data sets. Our results highlight the superior performance of IMTLS-TSVM in addressing multi-task learning problems.

近年来,多任务学习(MTL)已成为机器学习的一个热门领域,并在各个领域发挥着关键作用。在MTL中,跨任务共享知识可以提高学习算法的性能,增强其泛化能力。作为直接多任务双支持向量机(DMTSVM)的最小二乘变体,最近提出了一种新的多任务最小二乘双支持向量机(MTLS-TSVM)方法。与DMTSVM解决两个二次规划问题不同,MTLS-TSVM解决两个线性方程组,从而减少了计算时间。在本文中,我们提出了一个增强版本的MTLS-TSVM,称为改进的多任务最小二乘双支持向量机(IMTLS-TSVM)。与MTLS-TSVM相比,IMTLS-TSVM基于经验风险最小化原则进行操作,具有显著的优势,具有更好的泛化性能。该模型通过在其目标函数中包含正则化项来实现这一目标,这有助于控制模型的复杂性并防止过拟合。我们通过将IMTLS-TSVM与几种单任务和多任务学习算法在各种真实数据集上进行比较,证明了IMTLS-TSVM的有效性。我们的研究结果突出了IMTLS-TSVM在解决多任务学习问题方面的优越性能。
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引用次数: 0
MADTwin: a framework for multi-agent digital twin development: smart warehouse case study MADTwin:多智能体数字孪生开发框架:智能仓库案例研究
IF 1.2 4区 计算机科学 Q4 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2023-07-25 DOI: 10.1007/s10472-023-09872-z
Hussein Marah, Moharram Challenger

A Digital Twin (DT) is a frequently updated virtual representation of a physical or a digital instance that captures its properties of interest. Incorporating both cyber and physical parts to build a digital twin is challenging due to the high complexity of the requirements that should be addressed and satisfied during the design, implementation and operation. In this context, we introduce the MADTwin (Multi-Agent Digital Twin) framework driven by a Multi-agent Systems (MAS) paradigm and supported by flexible architecture and extendible upper ontology for modelling agent-based digital twins. A comprehensive case study of a smart warehouse supported by multi-robots has been presented to show the feasibility and applicability of this framework. The introduced framework powered by intelligent agents integrated with enabler technologies enabled us to cope with parts of the challenges imposed by modelling and integrating Cyber-Physical Systems (CPS) with digital twins for multi-robots of the smart warehouse. In this framework, different components of CPS (robots) are represented as autonomous physical agents with their digital twin agents in the digital twin environment. Agents act autonomously and cooperatively to achieve their local goals and the objectives of the whole system. Eventually, we discuss the framework’s strengths and identify areas of improvement and plans for future work.

数字孪生(DT)是一个物理或数字实例的经常更新的虚拟表示,它捕捉了其相关属性。由于在设计、实施和运行过程中需要解决和满足的要求非常复杂,因此结合网络和物理部分来构建数字孪生系统具有挑战性。在这种情况下,我们引入了 MADTwin(多代理数字孪生)框架,该框架由多代理系统(MAS)范式驱动,并由灵活的架构和可扩展的上层本体提供支持,用于模拟基于代理的数字孪生。为了展示该框架的可行性和适用性,介绍了一个由多机器人支持的智能仓库的综合案例研究。引入的框架由集成了辅助技术的智能代理驱动,使我们能够应对智能仓库的多机器人数字孪生建模和集成网络物理系统(CPS)所带来的部分挑战。在这一框架中,CPS 的不同组成部分(机器人)被表示为数字孪生环境中的自主物理代理及其数字孪生代理。代理通过自主和合作来实现其本地目标和整个系统的目标。最后,我们讨论了该框架的优势,并确定了需要改进的领域和未来工作计划。
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引用次数: 0
Agents and Digital Twins for the engineering of Cyber-Physical Systems: opportunities, and challenges 网络物理系统工程中的代理和数字孪生:机遇与挑战
IF 1.2 4区 计算机科学 Q4 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2023-07-20 DOI: 10.1007/s10472-023-09884-9
Stefano Mariani, Marco Picone, Alessandro Ricci

Digital Twins (DTs) are emerging as a fundamental brick of engineering Cyber-Physical Systems (CPSs), but their notion is still mostly bound to specific business domains (e.g. manufacturing), goals (e.g. product design), or applications (e.g. the Internet of Things). As such, their value as general purpose engineering abstractions is yet to be fully revealed. In this paper, we relate DTs with agents and multiagent systems, as the latter are arguably the most rich abstractions available for the engineering of complex socio-technical and CPSs, and the former could both fill in some gaps in agent-oriented software engineering and benefit from an agent-oriented interpretation—in a cross-fertilisation journey.

数字孪生(DTs)正在成为工程网络物理系统(CPSs)的基本组成部分,但其概念仍主要局限于特定的业务领域(如制造业)、目标(如产品设计)或应用(如物联网)。因此,它们作为通用工程抽象的价值尚未充分显现。在本文中,我们将 DT 与代理和多代理系统联系起来,因为后者可以说是复杂社会技术和 CPS 工程中最丰富的抽象,而前者既能填补面向代理的软件工程中的某些空白,又能从面向代理的解释中获益--这是一个相互促进的过程。
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引用次数: 0
Bayesian optimization over the probability simplex 概率单纯形上的贝叶斯优化
IF 1.2 4区 计算机科学 Q4 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE Pub Date : 2023-07-18 DOI: 10.1007/s10472-023-09883-w
Antonio Candelieri, Andrea Ponti, Francesco Archetti

Gaussian Process based Bayesian Optimization is largely adopted for solving problems where the inputs are in Euclidean spaces. In this paper we associate the inputs to discrete probability distributions which are elements of the probability simplex. To search in the new design space, we need a distance between distributions. The optimal transport distance (aka Wasserstein distance) is chosen due to its mathematical structure and the computational strategies enabled by it. Both the GP and the acquisition function is generalized to an acquisition functional over the probability simplex. To optimize this functional two methods are proposed, one based on auto differentiation and the other based on proximal-point algorithm and the gradient flow. Finally, we report a preliminary set of computational results on a class of problems whose dimension ranges from 5 to 100. These results show that embedding the Bayesian optimization process in the probability simplex enables an effective algorithm whose performance over standard Bayesian optimization improves with the increase of problem dimensionality.

基于高斯过程的贝叶斯优化被广泛用于解决输入在欧几里德空间中的问题。在本文中,我们将输入与作为概率单纯形元素的离散概率分布联系起来。为了在新的设计空间中搜索,我们需要分布之间的距离。最佳传输距离(又名Wasserstein距离)是根据它的数学结构和计算策略来选择的。将GP和获取函数推广到概率单纯形上的获取泛函。为了优化该函数,提出了两种方法,一种是基于自微分的方法,另一种是基于近点算法和梯度流的方法。最后,我们报告了一类维数从5到100的问题的初步计算结果。这些结果表明,将贝叶斯优化过程嵌入到概率单纯形中是一种有效的算法,其性能随问题维数的增加而提高。
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引用次数: 0
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Annals of Mathematics and Artificial Intelligence
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