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Knowledge, Attitude, and Practice of Diabetic Patients Following Up In King Khalid University Hospital about Insulin Use; a Cross-Sectional Study 哈立德国王大学医院糖尿病患者胰岛素使用的知识、态度与实践横断面研究
Pub Date : 2023-01-01 DOI: 10.26502/aimr.0153
Faisal Alshuwair, Abdulaziz Alalwan, Ibrahim Alshayea, Nasser AbuDujain, Eman Alhammad, Ibtisam Alkhlassi, Yousef Alluhaymid
Objectives: There are not many studies evaluating the knowledge, attitudes, and practices of insulin self-administration in Saudi Arabia; therefore, we conducted this study aiming to determine the level of knowledge diabetic patients have on insulin use. amd also to establish the most common mistakes, most patients do.
目的:评估沙特阿拉伯胰岛素自我给药的知识、态度和实践的研究并不多;因此,我们进行这项研究的目的是确定糖尿病患者对胰岛素使用的知识水平。也建立Amd最常见的错误,大多数患者都这样做。
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引用次数: 0
Association of mortality and aspirin use for COVID-19 residents at VA Community Living Center Nursing Homes 弗吉尼亚州社区生活中心养老院COVID-19居民死亡率与阿司匹林使用的关系
Pub Date : 2022-08-04 DOI: 10.1101/2022.08.03.22278392
Y. Abul, F. Devone, Thomas A Bayer, C. Halladay, K. McConeghy, Nadia Mujahid, Mriganka Singh, C. Leeder, S. Gravenstein, James L. Rudolph
Background/Objectives: Coronavirus disease 2019 (COVID-19) is associated with a hypercoagulable state and increased thrombotic risk in infected individuals. Several complex and varied coagulation abnormalities were proposed for this association1 .Acetylsalicylic acid(ASA, aspirin) is known to have inflammatory, antithrombotic properties and its use was reported as having potency to reduce RNA synthesis and replication of some types of coronaviruses including human coronavirus-299E (CoV-229E) and Middle East Respiratory Syndrome (MERS)-CoV 2,3. We hypothesized that chronic low dose aspirin use may decrease COVID-19 mortality relative to ASA non-users. Methods: This is a retrospective, observational cohort analysis of residents residing at Veterans Affairs Community Living Centers from December 13, 2020, to September 18, 2021, with a positive SARS-CoV-2 PCR test. Low dose aspirin users had low dose (81mg) therapy (10 of 14 days) prior to the positive COVID date and were compared to aspirin non-users (no ASA in prior 14 days). The primary outcome was mortality at 30 and 56 days post positive test and hospitalization within 14 days of positive test result. Results: We identified 1.823 residents who had SARS-CoV-2 infection and 1,687 residents were eligible as a final analytic sample after excluding high dose and intermittent/partial dose aspirin users. Overall mean age was 72.28+/-11.66 years and 3.3% (n=67) female in the final analytic sample. Among the 511 (30.3%) residents taking chronic low dose aspirin, 30-day mortality after an initial SARS-CoV-2 test establishing infection was 6.46% (n=33) compared to 10.29% (n=121) of non-users (SMD >0.1). 56-day mortality after initial SARS-CoV-2 test establishing infection was 9.0% (n=46) compared to 13.18% (n=155) not taking low dose aspirin (SMD >0.1). Cox proportional hazards model showed that aspirin use was independently associated with a reduced risk of 30 days of mortality (adjusted HR, 0.60, 95% CI, 0.40-0.90) and 56 days of mortality (adjusted HR, 0.67, 95% CI, 0.47-0.95) Conclusion: In this retrospective observational study of VA Community Living Center residents infected with SARS-CoV-2, low dose aspirin use for primary or secondary prevention of cardiovascular events is associated with lower COVID-19 mortality and fewer breakthrough cases. Although additional randomized controlled trials are required to understand these associations and the potential implications more fully for improving care, aspirin remains a medication with known side effects and clinical practice should not change based on these findings.
背景/目的:冠状病毒病2019 (COVID-19)与感染者的高凝状态和血栓形成风险增加有关。一些复杂而多样的凝血异常被认为与此相关1 .乙酰水杨酸(ASA,阿司匹林)已知具有炎症和抗血栓特性,据报道,它的使用具有减少某些类型冠状病毒的RNA合成和复制的能力,包括人类冠状病毒- 299e (CoV-229E)和中东呼吸综合征(MERS)-CoV 2,3。我们假设,相对于非ASA使用者,慢性低剂量阿司匹林使用可能会降低COVID-19死亡率。方法:对2020年12月13日至2021年9月18日在退伍军人事务社区生活中心居住的SARS-CoV-2 PCR检测阳性的居民进行回顾性、观察性队列分析。低剂量阿司匹林使用者在COVID阳性日期之前接受了低剂量(81mg)治疗(14天中的10天),并与非阿司匹林使用者(前14天没有ASA)进行了比较。主要转归是阳性检测后30天和56天的死亡率以及阳性检测结果后14天内的住院率。结果:我们确定了1.823名感染SARS-CoV-2的居民,在排除高剂量和间歇性/部分剂量阿司匹林使用者后,有1687名居民符合最终分析样本的条件。最终分析样本的总体平均年龄为72.28±11.66岁,女性占3.3% (n=67)。在511名(30.3%)服用慢性低剂量阿司匹林的居民中,首次进行SARS-CoV-2检测确定感染后的30天死亡率为6.46% (n=33),而非服药者(SMD >0.1)的死亡率为10.29% (n=121)。初始SARS-CoV-2检测确定感染后56天死亡率为9.0% (n=46),而未服用低剂量阿司匹林(SMD >0.1)的患者为13.18% (n=155)。Cox比例风险模型显示,阿司匹林的使用与降低30天死亡率(校正HR, 0.60, 95% CI, 0.40-0.90)和56天死亡率(校正HR, 0.67, 95% CI, 0.47-0.95)的风险独立相关。在这项对VA社区生活中心感染SARS-CoV-2的居民的回顾性观察研究中,低剂量阿司匹林用于心血管事件的一级或二级预防与较低的COVID-19死亡率和较少的突破性病例相关。尽管需要额外的随机对照试验来了解这些关联以及更充分地改善护理的潜在影响,但阿司匹林仍然是一种已知副作用的药物,临床实践不应根据这些发现而改变。
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引用次数: 0
Telemedicine and Use of Remote Monitoring in Cardiovascular Disease: A Systematic Review 远程医疗和心血管疾病远程监测的应用:系统综述
Pub Date : 2022-01-01 DOI: 10.26502/aimr.0085
Umna Safdar Khan, Babivigasan Gunasegaran, Ann Mary Behanan, Suganya Giri Ravindran, Obianuju Efobi, N. Sultana, Iffat Iqbal, Srija Chowdary Vanka, Deepkumar Patel, Abiodun O. Aboaba, Olubukola Oloniyo, Esosa Daniel Omoregie, Stephen Dada, Mayowa Stephen Apata, Osahon David Omoregie
Dow International Medical College (DIMC), Dow University of Health Sciences (DUHS), Pakistan Caribbean Medical University, Willemstad Curacao Kanyakumari Government Medical College, India Danylo Halytsky Lviv National Medical University, Ukraine Shaheed Suhrawardy Medical College, Bangladesh Dow University of Health Sciences (DUHS), Pakistan Dr. Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, India Smt. B. K. Shah Medical Institute & Research Centre (SBKS), India Avalon University School of Medicine, Willemstad Curacao Windsor University School of Medicine, St. Kitts University of Benin, School of Medicine, Nigeria
陶氏国际医学院(DIMC)、陶氏健康科学大学(DUHS)、巴基斯坦加勒比医科大学、威廉斯塔德库拉索坎亚库马里政府医学院、印度达尼洛哈利茨基利沃夫国立医科大学、乌克兰沙希德苏赫瓦迪医学院、孟加拉国陶氏健康科学大学(DUHS)、巴基斯坦Pinnamaneni Siddhartha医学科学研究所和研究基金会、印度Smt。印度阿瓦隆大学医学院、威廉斯塔德库拉索温莎大学医学院、贝宁圣基茨大学医学院、尼日利亚B. K. Shah医学研究所和研究中心(SBKS)
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引用次数: 1
Iron Deficiency Anemia Predisposing to Acute Ischemic Stroke – Is there a Need for more Aggressive Approach? 缺铁性贫血易致急性缺血性中风——是否需要更积极的治疗方法?
Pub Date : 2022-01-01 DOI: 10.26502/aimr.0135
Rida Mansoor, Mohammad Waseem Lodhi, Hania Zafar, Shahbaz Haider, Rukhsana Abdul Sattar
anemia results in decreased iron causing microcytic hypochromic erythropoiesis with decreased serum iron and Abstract Background: An increase or
贫血导致铁减少,引起小细胞性低色素红细胞生成伴血清铁减少
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引用次数: 1
Perspectives of Hospitalists in an Academic Health System. 学术卫生系统中医院医师的观点。
Pub Date : 2022-01-01 DOI: 10.26502/aimr.0139
T R Clarke, Josh Laban, Ahmed Luqman

Objectives: The primary outcome of this study is to assess the perspectives of Hospitalists on their workload and their perceived effects on patient care. The secondary outcomes are to evaluate the satisfaction of the Hospitalists with their compensation, quality of life, scholarship activity and promotion in their department and the support received to achieve this.

Methodology: We developed a 49-question questionnaire. The questionnaire was based on (a) Oldenburg Burnout Inventory and (b) topics specific to census, compensation, academic support with desire for promotion, and the effects of workload on patient care and teaching. All questions were formatted with a 4-point Likert-type response scale. The questionnaires were distributed electronically using an online survey platform to all 32 of the Hospitalists at our institution.

Conclusion: Each institution needs to do a self-assessment based on clinician feedback: Hospitalists workload, burn-out and satisfaction to reduce the high turnover rates and brevity of this role. From this study in this academic institution, the perspectives of Hospitalists revealed a high level of burn out (exhaustion and disengagement) and high assigned patient censuses that negatively impact their ability to deliver optimal patient care. Most Hospitalists reported lack of mentorship and inadequate time allocated for scholarly activity. The majority reported not having their input on decisions made by the administration that directly affect them. Most were unsatisfied with their compensation and the lack of PTO (paid time off). The majority would like to be promoted in this academic institution but feel unsupported to achieve this goal.

目的:本研究的主要结果是评估医院医生对他们的工作量和他们对病人护理的感知影响的看法。次要结果是评估医院医生对其薪酬、生活质量、奖学金活动和在其部门的晋升以及为实现这一目标所获得的支持的满意度。方法:我们设计了一份包含49个问题的问卷。问卷基于(a)奥尔登堡职业倦怠量表和(b)特定于人口普查、薪酬、学术支持与晋升愿望以及工作量对患者护理和教学的影响的主题。所有问题均采用李克特式4分制回答量表。问卷通过在线调查平台以电子方式分发给我院所有32名住院医生。结论:各机构需要根据临床医生的反馈进行自我评估:医院医生的工作量、工作倦怠和满意度,以减少这一角色的高流失率和简短性。从该学术机构的这项研究中,医院医生的观点揭示了高水平的倦怠(疲惫和脱离)和高分配的患者人口,这对他们提供最佳患者护理的能力产生了负面影响。大多数住院医生报告缺乏指导和分配给学术活动的时间不足。大多数人报告说,他们对政府做出的直接影响他们的决定没有意见。大多数人对他们的薪酬和缺乏PTO(带薪休假)不满意。大多数人希望在这个学术机构得到提升,但却感到无法实现这一目标。
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引用次数: 0
Learning Objectives, What’s to Gain in Bedside Teaching? 学习目标,床边教学有何收获?
Pub Date : 2022-01-01 DOI: 10.26502/aimr.0118
Verkleij S P C, de Graaf I M
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引用次数: 0
Impact of the COVID-19 Pandemic on Florida Medical Students’ Wellbeing and Academic Experience During “Lockdown” COVID-19大流行对佛罗里达州医学生在“封锁”期间的健康和学术经历的影响
Pub Date : 2022-01-01 DOI: 10.26502/aimr.0136
Shadi A. Baajour, W. Wahood, Kate J F Carnevale
record-Abstract Introduction: The global pandemic of coronavirus disease 2019 (COVID-19) has continued to demonstrate considerable impacts on all aspects of life, as well as mental health across populations. Medical students may be considered a particularly vulnerable population during the COVID-19 pandemic due to the compounding mental stress of a demanding medical education. Methods: A cross-sectional online
摘要导论:2019冠状病毒病(COVID-19)的全球大流行继续对人们生活的各个方面以及心理健康产生重大影响。在COVID-19大流行期间,医学生可能被认为是一个特别脆弱的群体,因为严格的医学教育带来了复杂的精神压力。方法:横断面在线
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引用次数: 0
Mitochondrial Genome Screening Identified 26 Novel Variants in Children with Nonsyndromic Congenital Hearing Impairment 线粒体基因组筛选鉴定出26种非综合征性先天性听力障碍儿童的新变异
Pub Date : 2022-01-01 DOI: 10.26502/aimr.0095
Hema Bindu L, Shehnaz Sultana, P. Pardhanandana Reddy
Mitochondrial Genome Screening Identified 26 Novel Variants in Children with Nonsyndromic Congenital Hearing Impairment. Abstract Background: Mitochondrial DNA (mtDNA) mutations may be responsible for the pathogenesis of maternally inherited hearing loss in both nonsyndromic and syndromic condition. Several mitochondrial genes, including genes coding for rRNA, tRNA, and respiratory chain complex subunits and protein coding genes play significant role in nonsyndromic deafness. Materials and Methods: 175 children with congenital hearing impairment and 92 normal subjects were screened for 13 mitochondrial genes comprising of two small ribosomal genes (12S rRNA and 16S rRNA), 7 tRNA genes (tRNA Val, tRNA Leu (UUR), tRNA Ile, tRNA Gln, tRNA Met, tRNA Ser (UCN) and tRNA Asp) and 4 protein coding genes (NADH dehydrogenase 1, NADH dehydrogenase 2, Cytochrome Oxidase I and Cytochrome Oxidase II) genes using specific sets of overlapping oligonucleotide primers for amplification. Results: A total of 26 novel variations were observed in the present study. 8 of COI genes. Three variants, each belonging to ND1 (3456T/G), COI (6140C/A) and COII (8115G/A) genes were found to be heteroplasmic. Out of 26, 8 variants were observed to be transversions and 11 as transitions. Out of 19 novel variants of protein coding genes, 3 missense (A3652G, G7830A, 8115G/A) mutations and 16 silent mutations were observed. Conclusion: This study demonstrated that various mitochondrial genes including protein-coding genes might be responsible for nonsyndromic deafness, providing new insights on the molecular bases of this pathology.
线粒体基因组筛选鉴定出26种非综合征性先天性听力障碍儿童的新变异。背景:线粒体DNA (mtDNA)突变可能是导致非综合征和综合征两种情况下母系遗传性听力损失的发病机制。一些线粒体基因,包括编码rRNA、tRNA和呼吸链复合体亚基的基因和蛋白质编码基因在非综合征性耳聋中发挥重要作用。材料与方法:对175例先天性听力障碍患儿和92例正常人进行线粒体基因筛选,筛选出13个线粒体基因,包括2个小核糖体基因(12S rRNA和16S rRNA)、7个tRNA基因(tRNA Val、tRNA Leu (UUR)、tRNA Ile、tRNA Gln、tRNA Met、tRNA Ser (UCN)和tRNA Asp)和4个蛋白质编码基因(NADH脱氢酶1、NADH脱氢酶2、细胞色素氧化酶I和细胞色素氧化酶II)。结果:本研究共观察到26个新的变异。8个COI基因。发现ND1 (3456T/G)、COI (6140C/A)和COII (8115G/A)基因的3个异质变异。在26个变异中,8个被观察到是颠倒的,11个是过渡的。在19个蛋白编码基因新变异中,发现3个错义突变(A3652G、G7830A、8115G/A)和16个沉默突变。结论:本研究表明,包括蛋白质编码基因在内的多种线粒体基因可能与非综合征性耳聋有关,为该病理的分子基础提供了新的认识。
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引用次数: 0
Why the HPV Vaccine is Essential to Preventing a Rising Threat 为什么HPV疫苗对预防不断上升的威胁至关重要
Pub Date : 2022-01-01 DOI: 10.26502/aimr.0086
Krishna Vedala MD MPH, Gopika Gopakumar, Raghuveer Vedala MD
Over the past few decades, the prevalence of HPVassociated oral cancers has steadily risen. Such a trend can be attributed to changing sexual behaviors, specifically oral sexual activity among adolescents. The HPV vaccine has been a key component in the battle against cervical cancer. It is therefore imperative we similarly emphasize adherence to the HPV vaccine among adolescents for greater prevention of HPV-associated oral cancers.
在过去的几十年里,hpv相关口腔癌的患病率稳步上升。这种趋势可归因于性行为的改变,特别是青少年的口交活动。HPV疫苗一直是抗击宫颈癌的关键组成部分。因此,我们同样必须强调青少年对HPV疫苗的依从性,以更好地预防HPV相关的口腔癌。
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引用次数: 0
Digital Gangrene Accelerated by Diabetic Ketoacidosis in the Setting of Polycythemia Vera 真性红细胞增多症背景下糖尿病酮症酸中毒加速数字坏疽
Pub Date : 2022-01-01 DOI: 10.26502/aimr.0094
Goonja Patel, S. Singhal, P. Khandwala, Oladimeji Lanade, Robert Kleyman
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引用次数: 0
期刊
Archives of Internal Medicine Research
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