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”VELscope as an adjuvant chairside diagnostic tool” – A clinical case series “VELscope作为辅助椅侧诊断工具”-临床病例系列
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_81_23
SimranSunil Singh, Manjula Hebbale, Amit Mhapuskar, Subharina Mahapatra, Avneet Kaur
The aim of this study was to evaluate the use of visually-enhanced lesion scope (VELscope) as an adjuvant diagnostic tool along with clinical examination. VELscope device which works on the principle of tissue fluorescence and helps in diagnosis or identification of suspected dysplastic lesions. The use of VELscope in dentistry is contributory as it aids in the detection of dysplastic changes in oral potentially malignant disorders and appropriate surgical margins for resection, VELscope-guided biopsy procedures, indicative of bacterial, fungal, and viral infections, and also inflammatory lesions. The cases discussed in the report are clinical cases where VELscope has been used as an accessory tool to enhance the clinical efficacy of diagnosis. There are different domains of cases where the use of VELscope has been assessed, also cases where VELscope can be beneficial to identify most preferred site of biopsy, aiding in the identification of fungal, bacterial presence, and evaluation of premalignant lesions and different oral carcinomas. Both the advantages, limitations, and significance of the device in each clinical condition have been discussed. VELscope is a handheld, noninvasive adjuvant device which can be used along with conventional clinical conditions for enhanced diagnostic accuracy. It can also be used as a screening tool for the early detection of oral carcinoma and dysplastic lesions in mass screening and tertiary centers. Further studies are required to establish the efficacy of VELscope in the clinical practice of oral medicine and radiology. Increasing incidence of oral carcinoma is a worrying scenario. Early detection of these conditions can be assessed by various diagnostic methods which broadly includes conventional staining dyes such as Lugol’s iodine, methylene blue, toluidine blue, or light-based detection such as chemiluminescence, VELscope, Vizilite, or optical-based system such as colposcopy and optical coherence tomography. VELscope can be one of the tool for assessing dysplastic lesions at an early stage. Due to its portability, cost-effectiveness, and noninvasive advantages, it can be a promising tool for screening mass population for oral carcinomas.
本研究的目的是评估视觉增强病变范围(VELscope)作为辅助诊断工具与临床检查的使用。VELscope装置,它的工作原理是组织荧光,并有助于诊断或鉴定可疑的发育不良病变。在牙科中使用VELscope是有贡献的,因为它有助于检测口腔潜在恶性疾病的发育不良变化和适当的手术切除边缘,VELscope引导的活检程序,指示细菌,真菌和病毒感染,以及炎症性病变。本报告所讨论的病例均为使用VELscope作为辅助工具以提高临床诊断效果的临床病例。VELscope的使用在不同的领域得到了评估,VELscope也有助于确定活检的最佳部位,帮助确定真菌、细菌的存在,并评估癌前病变和不同的口腔癌。讨论了该装置在每种临床条件下的优点、局限性和意义。VELscope是一种手持式无创辅助设备,可与常规临床条件一起使用,以提高诊断准确性。它也可以作为一种筛查工具,用于早期发现口腔癌和发育不良病变的大规模筛查和三级中心。VELscope在口腔医学和放射学临床实践中的疗效有待进一步研究。口腔癌发病率的上升令人担忧。这些疾病的早期检测可以通过各种诊断方法进行评估,这些方法广泛包括传统的染色染料,如Lugol 's碘,亚甲基蓝,甲苯胺蓝,或基于光的检测,如化学发光,VELscope, Vizilite,或基于光学的系统,如阴道镜和光学相干断层扫描。VELscope可作为早期评估发育不良病变的工具之一。由于其便携性、成本效益和非侵入性的优点,它可以成为一种很有前途的口腔癌筛查工具。
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引用次数: 0
Ovarian endometriosis with borderline serous tumor: A rare occurrence 卵巢子宫内膜异位症合并交界性浆液性肿瘤:罕见
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_48_23
ZeebaShamim Jairajpuri, Safia Rana, Arushi Gupta, Shaan Khetrapal, Sujata Jetley, Aruna Nigam
Endometriosis is a prevalent benign condition arising from the female reproductive system and affects about 7%–10% of females. The association of endometriosis with serous borderline ovarian tumors has been a matter of interest in gynecology. Sampson first described the association between endometriosis and carcinoma. The endometriosis-associated ovarian malignancies are clear cell adenocarcinoma and endometrioid adenocarcinoma, whereas serous and mucinous are rare malignancies associated with endometriosis. Here, we present the case report of a 45-year-old female in which endometriosis was associated with borderline serous tumor, since there is a lack of enough confident criteria for diagnosing endometriosis-associated ovarian tumors.
子宫内膜异位症是由女性生殖系统引起的一种常见的良性疾病,约影响7%-10%的女性。子宫内膜异位症与浆液性交界性卵巢肿瘤的关系一直是妇科研究的热点。Sampson首先描述了子宫内膜异位症和癌症之间的联系。子宫内膜异位症相关的卵巢恶性肿瘤是透明细胞腺癌和子宫内膜样腺癌,而浆液性和粘液性恶性肿瘤是罕见的与子宫内膜异位症相关的恶性肿瘤。由于缺乏诊断子宫内膜异位症相关卵巢肿瘤的足够自信的标准,我们在此报告一例45岁女性子宫内膜异位症合并交界性浆液性肿瘤的病例。
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引用次数: 0
Role of epigenetics variation with focus on DNA methylation in triple-negative breast cancer patients 表观遗传学变异在三阴性乳腺癌患者中的作用,重点是DNA甲基化
Pub Date : 2023-01-01 DOI: 10.4103/2321-4848.379062
G Deepika, GDeepthi Reddy, V Brahmaiah, BY Kavitha, Jayalatha Nethagani, ElizabethCaroline Palaparthi, RajasekharReddy Lebaka
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引用次数: 1
Perception toward wearing white coat among clinical students of a dental college in South India: A cross-sectional study 南印度一所牙科学院临床学生对穿白大褂的看法:一项横断面研究
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_72_23
KuldeepSingh Shekhawat, S Sakthidevi, Juhi Gupta, Deepika Jain
Background and Aim: Wearing white coat is a recognizable symbol among dental students. It is associated with dignity and respect. However, students are often spotted wearing white coat/apron in public places, a trait that needs to be explored/rectified. Therefore, the aim was to determine student’s perception regarding the usage of white coat/aprons. Materials and Methods: A 10-item closed-ended questionnaire was distributed among clinical students of a dental institute. The questionnaire elicited their understanding of wearing white coat in hospital/college premises, reasons for wearing it after college hours/outside premises, maintenance of white apron, and their willingness to substitute with scrubs. The data were analyzed for frequency distribution. Results: About 65% wore white coat as personal protective equipment within college premises. About 40% commuted to college wearing white coat. More than 91% wore white coat outside college premises during and immediately after college hours. More than 71% kept their belongings in apron pockets. Reasons such as “To lazy to remove white coat” and “For a different feeling” were common responses for wearing white coat outside premises. Eleven percent cited “ease of clothing” as another reason. Majority of study participants preferred white coat over scrubs during college hours. Conclusion: The study provides insight of students understanding of white coat. There is a clear lack of awareness regarding when, where, and how to use a white coat. Institutions have an important role in promoting and disseminating the importance of using white coat. In addition, there is a need for standard white coat handling and maintenance policy to be drafted and implemented.
背景与目的:穿白大褂是牙科学生公认的标志。它与尊严和尊重联系在一起。然而,学生在公共场所经常被发现穿着白色外套/围裙,这一特点需要探索/纠正。因此,目的是确定学生对使用白色外套/围裙的看法。材料与方法:对某牙科学院临床学生进行问卷调查。通过问卷调查,了解他们对在医院/学院穿白大褂的理解、在课外/校外穿白大褂的原因、白围裙的维护情况,以及他们是否愿意用消毒服代替白大褂。对数据进行频率分布分析。结果:约65%的大学生在校期间穿着白大褂作为个人防护装备。大约40%的人穿白大褂上下班去大学。超过91%的学生在校期间和课后在校外穿着白大褂。超过71%的人把自己的东西放在围裙口袋里。在户外穿白大褂的常见原因是“懒得脱掉白大褂”和“为了一种不同的感觉”。11%的人认为“穿着方便”是另一个原因。大多数研究参与者在大学期间更喜欢白大褂而不是工作服。结论:本研究提供了学生对白大褂的理解。对于何时、何地以及如何使用白大褂,人们显然缺乏意识。机构在促进和传播穿白大褂的重要性方面发挥着重要作用。此外,还需要起草和实施标准的白大褂处理和维护政策。
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引用次数: 0
Anti-Mycobacterial arthritis activity of Heliotropium zeylanicum by freund's adjuvant-induced rodents model 用弗氏佐剂诱导啮齿类动物模型研究泽兰Heliotropicum的抗分枝杆菌关节炎活性
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_292_22
V. Krishnakumar, R. Pandiyan, R. Velu
Background and Aim: Rheumatoid arthritis (RA) is a prevalent and debilitating disease that affects the joints. The study was intended to evaluate the anti-arthritic activity of aerial parts of Heliotropium zeylanicum (EEHZ). EEHZ constituting phytoconstituents to treat adjuvant induced arthritic rats to minimize the side effects. Materials and Methods: The anti-arthritic activity study was carried out by using adjuvant induced model of Wistar albino strain rats. EEHZ was injected at different doses such as 100 and 300 mg/kg/i.p., and the study was compared with standard drug dexamethazone (5 g/kg). The results obtained from the above methods were subjected to statistical analysis. Results: The study was conducted various hematological parameters and histopathological sections were carried out. The plant has various phytoconstituents such as reducing sugars, saponins, starch, steroids and terpenoids. Significantly one among those phytoconstituent lessens to oedema and arthritis of the rodents. The EEHZ showed the maximum inhibitory activity at (300 mg/kg/i.p.) by dose dependent manner. These inhibitions were statistically significant (P < 0.01-0.001). Conclusion: From these results indicate that EEHZ is a bioactive agent and having significant results in anti-inflammatory and anti-arthritic action by inhibition of the exudation, and leukocytes recruitment into the inflamed tissues and bone regeneration calcium deposition.
背景与目的:类风湿关节炎(RA)是一种影响关节的普遍和衰弱性疾病。本研究旨在评价泽兰草(Heliotropium zeylanicum, EEHZ)气生部分的抗关节炎活性。含植物成分的EEHZ治疗佐剂性关节炎大鼠,减少副作用。材料与方法:采用佐剂诱导的Wistar白化病大鼠模型,研究其抗关节炎活性。以100、300 mg/kg/i.p不同剂量注射EEHZ。,并与标准药物地塞米松(5 g/kg)进行比较。对以上方法得到的结果进行统计分析。结果:本研究进行了各项血液学参数及组织病理切片。这种植物含有多种植物成分,如还原糖、皂苷、淀粉、类固醇和萜类。其中一种植物成分显著减轻了啮齿动物的水肿和关节炎。EEHZ在(300 mg/kg/i.p)时抑制活性最大,且呈剂量依赖性。这些抑制作用具有统计学意义(P < 0.01-0.001)。结论:EEHZ是一种生物活性物质,具有明显的抗炎、抗关节炎作用,可抑制炎症组织的渗出、白细胞的聚集和骨再生钙沉积。
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引用次数: 0
Measuring what matters: Decoding the long-term impact of assessment methods in medical education 衡量重要的:解读评估方法在医学教育中的长期影响
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_157_23
SaurabhRamBihariLal Shrivastava, GandesRetno Rahayu
In the field of delivery of medical education, assessment plays a pivotal role in measuring attainment of the student learning outcome. However, we must acknowledge that more often than not, assessment methods have been employed to predominantly measure short-term outcomes. Nevertheless, with the passage of time, medical educators have realized that we must also aim to assess the long-term impact of educational strategies, including assessment methods, in facilitating long-term learning and skill development among medical students. Evaluating the long-term impact of assessment methods has gradually gained importance owing to multiple reasons, such as we can measure the impact of assessment methods in contributing toward the acquisition and retention of knowledge and skills over an extended period of time. In conclusion, the process of evaluating the long-term impact of assessment methods is extremely crucial to gain an understanding of their effectiveness in promoting lasting learning and skill development. In fact, the evaluation findings are expected to provide valuable information in the domains of knowledge retention, skill application, critical thinking, and continuous learning and thereby provide adequate evidence for policymakers to bring about timely and appropriate modifications in the curriculum to ensure the attainment of learning outcomes.
在医学教育的实施过程中,评估是衡量学生学习成果的关键环节。然而,我们必须承认,评估方法往往主要用于衡量短期结果。然而,随着时间的推移,医学教育工作者已经认识到,我们还必须致力于评估教育战略的长期影响,包括评估方法,以促进医学生的长期学习和技能发展。由于多种原因,评估评估方法的长期影响逐渐变得重要,例如我们可以衡量评估方法在较长时间内对知识和技能的获取和保留做出贡献的影响。总之,评估评估方法的长期影响的过程对于了解其在促进持久学习和技能发展方面的有效性至关重要。事实上,评估结果有望在知识保留、技能应用、批判性思维和持续学习等领域提供有价值的信息,从而为政策制定者及时、适当地修改课程提供充分的证据,以确保学习成果的实现。
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引用次数: 0
Severe hypertension in a sub Saharan African teenager 撒哈拉以南非洲一名青少年患有严重高血压
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_37_23
K. Uwanuruochi, Ibeneme Adaeze, Kelechi Elendu
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引用次数: 0
Morphometry of human ear ossicles 人耳听骨形态学
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_16_23
BSenthil Kumar, Asra Anjum, R Vallinayagam, GPanneer Selvi, KEzhil Vendhan
Background and Aim: Congenital anomalies and malformations of ear ossicles will cause hearing problems. Most commonly they will be either the absence of long process of incus or capitulum of stapes. The basic knowledge on variations of the ear ossicles and its morphometric data will help the otologist for performing reconstructive surgery and it also provides necessary information for the prosthesis designers. This study aimed to study and analyze the morphometric and morphological features of ear ossicles with correlation on both sides from wet and dry specimens Materials and Methods: A total of 15 sets of human ear ossicles were collected from both cadavers and as well from dry skulls in the Department of Anatomy, VMKV Medical College and Hospital, Salem. A good-quality photograph was taken, and the image was transferred to the computer and magnified. The measuring tool was used, and all the morphometry parameters were recorded and analyzed. Results: The ear ossicles morphometry of the right and left were analyzed and compared. Morphological variations were noted, and morphometric variations (length and width) were also analyzed. Conclusion: The knowledge of variations of these ossicles and its morphometric data will help the otologist during reconstructive surgery and provide necessary information for the prosthesis designer.
背景与目的:先天性听骨畸形会引起听力问题。最常见的症状是镫骨或镫骨头状突起缺失。耳部听骨变化的基本知识及其形态测量数据将有助于耳科医生进行重建手术,也为假体设计者提供必要的信息。本研究旨在研究和分析湿、干标本耳听骨两侧相关性的形态学特征和形态学特征。材料和方法:在美国塞勒姆VMKV医学院及医院解剖学系共采集了15组人耳听骨,分别取自两具尸体和干颅骨。拍了一张高质量的照片,然后把图像传送到电脑上放大。使用测量工具,记录并分析所有形态学参数。结果:对左、右听骨形态学进行了分析比较。形态学变化被记录下来,形态计量学变化(长度和宽度)也被分析。结论:了解这些小听骨的变化及其形态测量数据将有助于耳科医生进行重建手术,并为假体设计者提供必要的信息。
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引用次数: 0
Modified mallampati score – Does it predict more than a difficult airway? A community-based study assessing the association between modified mallampati score and obstructive sleep apnea 改良mallampati评分-它预测的不仅仅是气道困难吗?一项基于社区的研究评估改良mallampati评分与阻塞性睡眠呼吸暂停之间的关系
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_152_23
JithinMathew Abraham, SangeethaMerrin Varghese, GincyAnn Lukachan, AshuSara Mathai
Background and Aims: The suspicion of obstructive sleep apnea (OSA) has serious implications for an anesthesiologist perioperatively. This study examines the association between the modified Mallampati scoring (MMS) and the STOP-BANG score in a community setting. Materials and Methods: This was a community-based cross-sectional survey among 702 adults in a rural area in South India. Airway assessment using MMS and assessment for OSA using STOP-BANG scoring were made by junior doctors trained in the anesthesia department. The association between the Mallampati score and the STOP-BANG score was tested by the Chi-square test using the SPSS version 21. Results: Among the community-dwelling adults, 19.2% had a score of 1, 27.9% had a score of 2, 31.3% had a score of 3, and 21.5% had a score of 4 on the Mallampati scoring system. Using the STOP-BANG score for risk stratification of OSA, 29.2% had an intermediate risk and 5.8% had a high risk for OSA. Higher Mallampati Grades (3 and 4) were a significant risk factor for OSA (61.8% vs. 38.2%, P = 0.001). Conclusion: A higher Mallampati class (3 or 4) is significantly associated with an intermediate-to high risk for OSA as assessed using STOP-BANG score criteria. Therefore, we suggest using the MMS not only as an airway screening tool but also as a predictor of OSA, in view of the rising obesity rates in India.
背景和目的:阻塞性睡眠呼吸暂停(OSA)的怀疑对麻醉医师围手术期具有重要意义。本研究探讨了改良Mallampati评分(MMS)与社区环境中STOP-BANG评分之间的关系。材料和方法:这是一项以社区为基础的横断面调查,调查对象为印度南部农村地区的702名成年人。使用MMS评估气道和使用STOP-BANG评分评估OSA由麻醉科培训的初级医生进行。Mallampati得分与STOP-BANG得分之间的相关性采用χ 2检验,使用SPSS 21版。结果:在社区居住的成年人中,有19.2%的人在Mallampati评分系统中得分为1,27.9%的人得分为2,31.3%的人得分为3,21.5%的人得分为4。使用STOP-BANG评分进行OSA风险分层,29.2%的人有中度风险,5.8%的人有高风险。较高的Mallampati分级(3级和4级)是OSA的重要危险因素(61.8%比38.2%,P = 0.001)。结论:使用STOP-BANG评分标准评估,较高的Mallampati分级(3或4)与OSA的中至高风险显著相关。因此,鉴于印度肥胖率的上升,我们建议使用MMS不仅作为气道筛查工具,而且作为OSA的预测指标。
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引用次数: 0
A case of bacteremia by Achromobacter xylosoxidans in an immunocompromised host and review of literature 免疫功能低下的宿主中木糖氧化无色杆菌引起菌血症1例并文献复习
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_222_22
E. Rajni, Shaveta Kataria, M. Sarna, V. Garg
Achromobacter xylosoxidans is an uncommon nosocomial pathogen known to cause serious infections in immunocompromised patients. Long stays in critical care units often predispose to infection with this bacterium. A female patient, who is a known case of diabetes mellitus type 2, hypertension, and chronic kidney disease, presented to the emergency department with complaints of shortness of breath, generalized swelling, decreased urine output for 7 days, and altered sensorium for 1 day. A. xylosoxidans was isolated from paired blood culture. She was managed according to the antibiotic susceptibility report and was improving when she left against medical advice due to personal issues. The objective of presenting this case report is to stress upon the importance of communication between the microbiologist and the clinician. Embracing automation in microbiology laboratories is essential to identify such novel bacterium in time to achieve clinical and microbiological cures.
木氧化无色杆菌是一种罕见的医院病原体,已知会导致免疫功能低下患者的严重感染。长期呆在重症监护室往往容易感染这种细菌。一名已知患有2型糖尿病、高血压和慢性肾脏疾病的女性患者在急诊科就诊,主诉呼吸急促、全身肿胀、尿量减少7天,感觉功能改变1天。从配对血液培养物中分离出木糖氧化酶。根据抗生素敏感性报告对她进行了治疗,当她因个人问题违背医嘱离开时,情况正在好转。本病例报告的目的是强调微生物学家和临床医生之间沟通的重要性。微生物实验室的自动化对于及时识别这种新型细菌以实现临床和微生物治疗至关重要。
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引用次数: 0
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