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Primary mucosal melanoma masquerading as nasal polyp: A diagnostic challenge 伪装成鼻息肉的原发性粘膜黑色素瘤:一个诊断挑战
Pub Date : 2023-07-01 DOI: 10.4103/amhs.amhs_25_23
Nasal mucosal melanoma (MM) is a rare and aggressive tumor, first described by Lucke in 1869. It accounts for 0.5%–2% of all melanomas. Its incidence is more in fair skinned individuals, and most commonly seen in the mean age of 60 years with slight male predominance. MMs are associated with poor prognosis and overall less survival rates as symptoms develop slowly; therefore, many patients are lately diagnosed. An Indian female in her early 50s came to the ear, nose, and throat outpatient department with complaints of bleeding from her nose for 20 days and mass in the right nasal cavity. On examination, a dirty black mass arising from the septum and deviated nasal septum to the right side were noted on rhinoscopy. Contrast-enhanced computed tomography showed features of nasal polyp. Fine-needle aspiration cytology was performed and found to be inconclusive. A punch biopsy was done and sent for histopathological examination (HPE), tiny biopsy showed features suggestive of melanosis with focal atypia. After 3 months, the patient reported with recurrence of nasal mass that was progressive in size. An excision biopsy was performed by endoscopic surgery under local anesthesia and sent for HPE. To confirm the diagnosis, immunohistochemistry was performed by application of S100, HMB45, and vimentin (after bleach treatment) showed diffuse strong intensity nuclear and cytoplasmic positivity in all pigmented cells. Thereafter, diagnosis of “Nasal mucosal melanoma” was awarded.
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引用次数: 0
Clinical and cutaneous profile of patients with systemic sclerosis in a tertiary centre in South India 南印度一家三级中心系统性硬化症患者的临床和皮肤特征
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_275_22
Priya Kuryan, C. Peter, S. Pulimood, L. George, John Mathew
Background and Aims: Systemic sclerosis is an autoimmune disease, of which cutaneous sclerosis is a cardinal feature. Other skin manifestations include Raynaud's phenomenon, digital ulcers, gangrene, flexion contractures, and telangiectasias. It has been noted that the clinical and antibody profile varies within ethnic groups. The objective of the study was to study the clinical profile of patients with systemic sclerosis in a tertiary center in South India and to compare to other ethnic groups. Materials and Methods: Thirty-five patients were recruited in the study period between February 2014 and September 2015. A record of the disease details, systemic manifestations, morphology, and distribution of the cutaneous manifestations and investigations were done by the principal investigator. The severity of cutaneous sclerosis was assessed by modified Rodnan Skin Score (mRSS). Results: Our study had a female preponderance with diffuse type of disease in 91% of patients. The common cutaneous presenting complaints were sclerosis (n = 35, 100%), Raynaud's phenomenon (n = 25, 71.4%), and pigmentary disturbances (n = 33, 94.3%). Respiratory system was the most common system involved, with interstitial lung disease seen in 78.1% (n = 25). A significant association (P = 0.026) was noticed between the increase in mRSS and interstitial lung disease. Conclusion: Pigmentary disturbances were higher in our population, whereas Raynaud's phenomenon, digital ulcers, and telangiectasia were less common than in Western population. A significant association (P = 0.026) was found between mRSS and interstitial lung disease.
背景与目的:系统性硬化症是一种自身免疫性疾病,其中皮肤硬化症是其主要特征。其他皮肤表现包括雷诺现象、指溃疡、坏疽、屈曲性挛缩和毛细血管扩张。已经注意到,不同种族的临床和抗体特征各不相同。本研究的目的是研究南印度一家三级中心系统性硬化症患者的临床特征,并与其他种族进行比较。材料和方法:在2014年2月至2015年9月的研究期间,招募了35名患者。主要研究者对疾病细节、全身表现、形态和皮肤表现的分布进行了记录和调查。皮肤硬化症的严重程度通过改良的Rodnan皮肤评分(mRSS)进行评估。结果:我们的研究在91%的患者中以弥漫型疾病的女性为主。常见的皮肤表现为硬化(n=35100%)、雷诺现象(n=2517.14%)和色素紊乱(n=33194.3%)。呼吸系统是最常见的受累系统,间质性肺病占78.1%(n=25)。mRSS的增加与间质性肺病之间存在显著相关性(P=0.026)。结论:色素紊乱在我们的人群中较高,而雷诺现象、指溃疡和毛细血管扩张在西方人群中较不常见。mRSS与间质性肺病之间存在显著相关性(P=0.026)。
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引用次数: 0
Seroprevalence of bacterial isolates and their antimicrobial susceptibility pattern from exudate sample in Birla Institute of Medical Research Hospital, Gwalior, India 印度瓜利尔Birla医学研究所医院渗出液中分离细菌的血清阳性率及其药敏模式
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_154_22
Kamini Rajput, S. Johri, A. Goyal
Background and Aim: Infection characterized by the production of pus is classified as pyogenic or pus-producing infections. These infections are challenging to treat because bacteria are becoming increasingly resistant to antibiotics. It is critical to understand the microorganisms that cause infections and their antibiotic susceptibility patterns for optimal management of the patient. The purpose of this study was to examine the frequency and distribution of bacteria isolated from pus/wound, as well as their susceptibility patterns. Materials and Methods: A retrospective hospital-based study was conducted on 175 patients who provided pus and/or wound discharge samples in different wards (outpatient department or inpatient department). The samples were inoculated on MacConkey agar and blood agar plates and incubated at 37°C for 24 h. The Gram stain and biochemical tests were used to identify all isolates after incubation. Antibiotic sensitivity was performed using Kirby–Bauer disc diffusion test. Results: This study covered 175 patients, with a bacterial isolation rate of 102 (58.28%). Males outnumbered females in the samples (M: F-1.8:1), with a median age of 45 years. Majority were in the age group of 40–60 years which was 41 (40.20%). Monomicrobial infections were seen in 92 (90.19%) samples whereas polymicrobial infections in 10 (9.80%) samples and total 112 bacterial strains were isolated. Conclusion: Escherichia coli was the most prevalent isolate in our investigation, followed by Pseudomonas aeruginosa. For Gram-positive cocci, doxycycline, linezolid, and chloramphenicol are the most effective antibiotics, whereas for Gram-negative bacilli, amikacin, gentamicin, and chloramphenicol are the most effective antibiotics. The susceptibility statistics presented in this article may be useful in formulating empiric treatment regimens for pyogenic infections.
背景与目的:以产脓为特征的感染分为化脓性感染或产脓性感染。这些感染的治疗具有挑战性,因为细菌对抗生素的耐药性越来越强。了解引起感染的微生物及其抗生素敏感性模式对患者的最佳管理至关重要。本研究的目的是研究从脓液/伤口中分离的细菌的频率和分布,以及它们的易感模式。材料与方法:对175例在不同病房(门诊部或住院部)提供脓液和/或伤口分泌物样本的患者进行回顾性研究。将样品接种于MacConkey琼脂和血琼脂平板上,37℃孵育24 h。孵育后采用革兰氏染色法和生化试验对所有分离株进行鉴定。采用Kirby-Bauer圆盘扩散试验测定抗生素敏感性。结果:本研究共纳入175例患者,细菌分离率102例(58.28%)。样本中男性多于女性(M: f: 1.8:1),中位年龄为45岁。以40 ~ 60岁年龄组居多,41例(40.20%)。检出单菌感染92例(90.19%),多菌感染10例(9.80%),共检出112株细菌。结论:大肠杆菌是本次调查中最常见的分离菌,其次是铜绿假单胞菌。对于革兰氏阳性球菌,强力霉素、利奈唑胺和氯霉素是最有效的抗生素,而对于革兰氏阴性杆菌,阿米卡星、庆大霉素和氯霉素是最有效的抗生素。本文中提出的敏感性统计可能有助于制定化脓性感染的经验性治疗方案。
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引用次数: 0
Analytical evidence of social epidemiology in sociobiological context – A narrative review 社会生物学背景下的社会流行病学分析证据-叙述性回顾
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_66_23
G. Krishnaprakash, I. Mohammed, Rekha Shenoy
Social epidemiology is a relatively newer field of epidemiology that evaluates the socioeconomic distribution and determinants of health and disease and how those factors affect the health of individuals and populations. The explanation of the causal relationships between socioeconomic circumstances, health status, and consequences is a key challenge in social epidemiology. The current study was conducted to analyze the key substantive areas of focus in epidemiology in the sociobiological context. Data were collected electronically using databases such as PubMed, ScienceDirect, Scopus, Google Scholar, and three authorized textbooks to conduct relevant searches. Since the beginning of the history of public health, the relationship between socioeconomic class and health has been a significant study area. The impact which social factors have on both individual and population health is the central and initial question that needs to be addressed in social epidemiology. The recent attention given to this issue using modern epidemiological techniques is a relatively new phenomenon. Social epidemiology's primary goal is to produce fundamental knowledge. Social epidemiology must be necessarily multimethod, interdisciplinary, and broad due to its subject of research.
社会流行病学是一个相对较新的流行病学领域,它评估健康和疾病的社会经济分布和决定因素,以及这些因素如何影响个人和人群的健康。解释社会经济环境、健康状况和后果之间的因果关系是社会流行病学的一个关键挑战。本研究旨在分析社会生物学背景下流行病学的关键实质性重点领域。使用PubMed、ScienceDirect、Scopus、b谷歌Scholar等数据库和三本授权教科书进行相关检索,以电子方式收集数据。自公共卫生史开始以来,社会经济阶层与健康之间的关系一直是一个重要的研究领域。社会因素对个人和人口健康的影响是社会流行病学需要解决的中心和首要问题。最近利用现代流行病学技术对这一问题的关注是一个相对较新的现象。社会流行病学的主要目标是产生基础知识。由于社会流行病学的研究主题,它必然是多方法的、跨学科的和广泛的。
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引用次数: 0
Bilateral primary papillary serous carcinoma of the fallopian tube – A rare case scenario 双侧原发性输卵管浆液性乳头状癌——罕见病例
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_13_23
Satish Arakeri
Bilateral primary fallopian tube carcinoma is a very rare case scenario. Approximately, its incidence is 0.02% of all the gynecological malignancy. A 40-year-old female patient visited the hospital with complaints of lower abdominal pain for 3 months. Ultrasound of the pelvis shows complex bilateral adnexal lesions with ORADS score 4 – intermediate risk. The serum CA-125 is elevated. The provisional diagnosis of bilateral pyosalpinx was made. The uterus with bilateral ovaries and fallopian tubes was removed. On histopathology, thus, the final diagnosis of primary bilateral papillary serous carcinoma of the fallopian tube was made. Bilateral primary fallopian tube carcinoma is a very rare case scenario. Intraoperative frozen study is to be done to diagnose this entity. The high degree of suspicion is required to diagnose a case of bilateral fallopian tube carcinoma as it is a very rare case scenario and usually confused for pyosalpinx.
双侧原发性输卵管癌是一种非常罕见的情况。其发病率约占所有妇科恶性肿瘤的0.02%。一名40岁的女性患者因下腹疼痛就诊3个月。骨盆超声显示复杂的双侧附件病变,ORADS评分为4-中等风险。血清CA-125升高。临时诊断为双侧输卵管积脓。切除了带有双侧卵巢和输卵管的子宫。因此,在组织病理学上,最终诊断为原发性双侧输卵管浆液性乳头状癌。双侧原发性输卵管癌是一种非常罕见的情况。术中冷冻研究是为了诊断这个实体。诊断双侧输卵管癌需要高度怀疑,因为这是一种非常罕见的病例,通常与输卵管积脓相混淆。
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引用次数: 0
An assessment of understanding and perspectives of BDS undergraduate students related to child abuse and neglect in an Indian setup: A questionnaire-based study 对印度BDS本科生对虐待和忽视儿童的理解和观点的评估:一项基于问卷的研究
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_17_23
Shivani Mathur, A. Sultan, Priyanka Aggarwal, T. Nangia, A. Juneja
Background and Aim: A questionnaire-based study was conducted to assess the knowledge, understanding, and perception of dental undergraduate students toward child abuse and neglect in an Indian setup. Materials and Methods: The data were collected through a 38-item questionnaire to investigate the self-reported knowledge, understanding, and perception in relation to child abuse among 3rd, final-year, and interns among private and government dental colleges in India. There were 1277 responses to the questionnaire. Results: The responses were obtained from all regions of India, including both government and private dental institutes. 10% each of all government and private institutes in India participated in this survey. It was observed that the level of knowledge and awareness of BDS students increased from BDS 3rd year through the final year and internship. The amount of awareness regarding child abuse is better among the interns. Although 50.9% of the respondents were aware of nongovernmental organizations working actively for victims of child abuse and neglect in India. Conclusion: There is a restricted level of knowledge and awareness regarding child abuse and neglect among BDS students, wherein BDS interns were comparatively familiar with the facts. Although the majority of dental students were aware of organizations working for child abuse victims but were still confined to approaching legally and ethically.
背景与目的:本研究以问卷调查为基础,评估印度牙科专业本科生对儿童虐待和忽视的认知、理解和感知。材料与方法:采用38项问卷调查印度私立和公立牙科学院三年级学生、大四学生和实习生对儿童虐待的知识、理解和感知情况。调查问卷共有1277份回复。结果:回复来自印度所有地区,包括政府和私人牙科机构。印度所有政府和私人机构中各有10%参与了这项调查。我们观察到,从北斗系统的第三年到最后一年和实习,北斗系统学生的知识和意识水平有所提高。实习生对虐待儿童的认识程度更高。尽管50.9%的受访者知道非政府组织在印度积极为虐待和忽视儿童的受害者工作。结论:BDS学生对虐待和忽视儿童的知识和意识水平有限,其中BDS实习生对事实较为熟悉。虽然大多数牙科学生都知道为虐待儿童受害者工作的组织,但仍然局限于法律和道德上的接触。
{"title":"An assessment of understanding and perspectives of BDS undergraduate students related to child abuse and neglect in an Indian setup: A questionnaire-based study","authors":"Shivani Mathur, A. Sultan, Priyanka Aggarwal, T. Nangia, A. Juneja","doi":"10.4103/amhs.amhs_17_23","DOIUrl":"https://doi.org/10.4103/amhs.amhs_17_23","url":null,"abstract":"Background and Aim: A questionnaire-based study was conducted to assess the knowledge, understanding, and perception of dental undergraduate students toward child abuse and neglect in an Indian setup. Materials and Methods: The data were collected through a 38-item questionnaire to investigate the self-reported knowledge, understanding, and perception in relation to child abuse among 3rd, final-year, and interns among private and government dental colleges in India. There were 1277 responses to the questionnaire. Results: The responses were obtained from all regions of India, including both government and private dental institutes. 10% each of all government and private institutes in India participated in this survey. It was observed that the level of knowledge and awareness of BDS students increased from BDS 3rd year through the final year and internship. The amount of awareness regarding child abuse is better among the interns. Although 50.9% of the respondents were aware of nongovernmental organizations working actively for victims of child abuse and neglect in India. Conclusion: There is a restricted level of knowledge and awareness regarding child abuse and neglect among BDS students, wherein BDS interns were comparatively familiar with the facts. Although the majority of dental students were aware of organizations working for child abuse victims but were still confined to approaching legally and ethically.","PeriodicalId":8296,"journal":{"name":"Archives of Medicine and Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42283342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathological gamut of fallopian tube lesions: A 5-year retrospective descriptive study in a tertiary care teaching hospital in South India 输卵管病变的组织病理学范围:印度南部一家三级护理教学医院的5年回顾性描述性研究
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_97_23
Ramya Katta, Madana Padma, VelpuriSai Abhishek, Bharath Teendra
Background and Aim: Even though the fallopian tubes are commonly encountered surgical specimens in histopathology, there exists a paucity of data that describe the incidence and types of pathologies that can be encountered in the fallopian tubes. The present study was taken up as a small attempt to bridge this gap and describe the various fallopian tube lesions which can be encountered in routine practice. Materials and Methods: The fallopian tubes that were received, either separately or as a part of other gynecological specimens, during the 5-year study were included. Specimens were routinely fixed, processed and sectioned. The Sectioning and Extensively Examining the Fimbriated End of the fallopian tube protocol for grossing was used in cases associated with malignancies. Results: A total of 5256 fallopian tubes were received from 3258 patients during the study. The age ranged between 12 and 70 years. The most common clinical indication for salpingectomy in the present study was uterus related (51.9%). Of the total 5256 fallopian tubes examined, 29.8% tubes showed some pathology. The most common clinically diagnosed tubal pathology, in the present study, was tubal ectopic gestation. The most common clinically undiagnosed finding was hydrosalpinx. Conclusion: It is essential to extensively gross and microscopically examine all fallopian tube specimens to identify precursor lesions and help in patient workup and treatment.
背景与目的:尽管输卵管是组织病理学中常见的手术标本,但目前缺乏描述输卵管中可能遇到的病变的发生率和类型的数据。目前的研究是作为一个小的尝试,以弥合这一差距,并描述各种输卵管病变,可以在日常实践中遇到。材料与方法:纳入5年研究期间单独或作为其他妇科标本一部分接受的输卵管。标本常规固定、处理和切片。在与恶性肿瘤相关的病例中,使用了输卵管内纤束末端的切片和广泛检查方案。结果:3258例患者共获得5256根输卵管。年龄在12岁到70岁之间。本研究中输卵管切除术最常见的临床指征为子宫相关(51.9%)。在5256根输卵管中,29.8%的输卵管出现病变。最常见的临床诊断的输卵管病理,在本研究中,是输卵管异位妊娠。最常见的临床未确诊的表现是输卵管积水。结论:对所有输卵管标本进行广泛的肉眼和显微镜检查,以发现先兆病变,有助于患者的检查和治疗。
{"title":"Histopathological gamut of fallopian tube lesions: A 5-year retrospective descriptive study in a tertiary care teaching hospital in South India","authors":"Ramya Katta, Madana Padma, VelpuriSai Abhishek, Bharath Teendra","doi":"10.4103/amhs.amhs_97_23","DOIUrl":"https://doi.org/10.4103/amhs.amhs_97_23","url":null,"abstract":"Background and Aim: Even though the fallopian tubes are commonly encountered surgical specimens in histopathology, there exists a paucity of data that describe the incidence and types of pathologies that can be encountered in the fallopian tubes. The present study was taken up as a small attempt to bridge this gap and describe the various fallopian tube lesions which can be encountered in routine practice. Materials and Methods: The fallopian tubes that were received, either separately or as a part of other gynecological specimens, during the 5-year study were included. Specimens were routinely fixed, processed and sectioned. The Sectioning and Extensively Examining the Fimbriated End of the fallopian tube protocol for grossing was used in cases associated with malignancies. Results: A total of 5256 fallopian tubes were received from 3258 patients during the study. The age ranged between 12 and 70 years. The most common clinical indication for salpingectomy in the present study was uterus related (51.9%). Of the total 5256 fallopian tubes examined, 29.8% tubes showed some pathology. The most common clinically diagnosed tubal pathology, in the present study, was tubal ectopic gestation. The most common clinically undiagnosed finding was hydrosalpinx. Conclusion: It is essential to extensively gross and microscopically examine all fallopian tube specimens to identify precursor lesions and help in patient workup and treatment.","PeriodicalId":8296,"journal":{"name":"Archives of Medicine and Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135007242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of academic support program on the academic performance of low-achiever students of first-phase MBBS 学业支持计划对第一阶段MBBS低年级学生学业成绩的影响
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_111_23
NazeemIshrat Siddiqui, Sukhwant Bose
Background and Aim: The rigorous medical curriculum and stressful environment of medical college for the newer entrants make their transition from school to medical college difficult. Their academic performances get affected adversely due to difficulties in conceptual thinking, language, communication, fear of failing, parental and peer pressure, misguided friendships, and difficult interaction with seniors and faculty members. Keeping this in mind the present study is aimed to identify and address students’ difficulties in the medical college, provide remedial support, and record students’ perceptions about the academic support program. Materials and Methods: The newly entered first phase MBBS students were grouped as high achiever (HA) (>50% marks) and low achiever (LA) (<50% marks) based on their marks in internal examinations. They were further divided into small groups and allocated a mentor. Mentor is a senior faculty member who acts as counselor and facilitator to support students for their academic and nonacademic problems. Mean, standard deviation, and percentage were calculated for the marks scored in the internal examinations. Unpaired t-test was applied and learning gain (g) was calculated. Results: The average scores of LA and HA groups in the first internal examination were 23.87% and 53.15% which rose to 48.90% and 68.34%, respectively, in university examinations; learning gains in these groups were 33% and 32%, respectively, indicating a positive impact of the program. Majority of the students were strongly agreed that their academic performances improved, and they developed self-confidence to perform better in the subsequent parts of the curriculum. Conclusions: Academic performance improves when students are provided with a conducive environment along with academic and emotional support and feedback about their learning.
背景与目的:医学院严格的医学课程和紧张的环境使新生很难从中学过渡到医学院。由于概念思维、语言、沟通困难、害怕失败、父母和同辈压力、误入歧途的友谊以及与学长和教职员工难以互动,他们的学习成绩受到不利影响。在此基础上,本研究旨在识别和解决学生在医学院的困难,提供补救支持,并记录学生对学术支持计划的看法。材料与方法:将新入学一期MBBS学生根据其内部考试成绩分为优等生(HA)(>50%分)和低等生(LA)(<50%分)。他们被进一步分成小组,并分配了一名导师。导师是一名资深教师,他作为顾问和促进者,为学生的学术和非学术问题提供支持。计算内部考试得分的平均值、标准差和百分比。采用非配对t检验,计算学习增益(g)。结果:LA组和HA组首次内部考试平均得分分别为23.87%和53.15%,大学考试平均得分分别为48.90%和68.34%;这两组学生的学习收益分别为33%和32%,表明该项目产生了积极影响。大多数学生都强烈认为他们的学习成绩提高了,他们在接下来的课程中表现得更好。结论:当学生被提供一个有利的环境,以及学术和情感上的支持和学习反馈时,他们的学习成绩会提高。
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引用次数: 0
Hemimegalencephaly with adult-onset seizures and normal intellectual function: A rare case report 半巨脑畸形伴成人癫痫发作,智力功能正常:罕见病例报告
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_47_23
Amit Kumar, Rajesh Chetiwal, Shweta Tanwar
Hemimegalencephaly (HME) is one of the rarest congenital malformations of the brain characterized by abnormal enlargement of a cerebral hemisphere. It can present as an isolated sporadic form or associated with other neurodevelopmental syndromes. The classical clinical manifestation develops in infancy or early childhood and includes intellectual impairment, developmental delay, intractable epilepsy, and motor abnormalities. We report here an atypical case of HME with normal intellectual functions and adult-onset nonrefractory epilepsy demonstrating the wide variation in clinical expressivity of the disease.
半巨脑畸形(HME)是一种罕见的先天性脑畸形,其特征是大脑半球异常增大。它可以表现为孤立的散发形式或与其他神经发育综合征相关。典型的临床表现出现在婴儿期或幼儿期,包括智力障碍、发育迟缓、顽固性癫痫和运动异常。我们在这里报告一个不典型的HME与正常的智力功能和成人发病的非难治性癫痫的情况下,显示了广泛的变化在临床表现的疾病。
{"title":"Hemimegalencephaly with adult-onset seizures and normal intellectual function: A rare case report","authors":"Amit Kumar, Rajesh Chetiwal, Shweta Tanwar","doi":"10.4103/amhs.amhs_47_23","DOIUrl":"https://doi.org/10.4103/amhs.amhs_47_23","url":null,"abstract":"Hemimegalencephaly (HME) is one of the rarest congenital malformations of the brain characterized by abnormal enlargement of a cerebral hemisphere. It can present as an isolated sporadic form or associated with other neurodevelopmental syndromes. The classical clinical manifestation develops in infancy or early childhood and includes intellectual impairment, developmental delay, intractable epilepsy, and motor abnormalities. We report here an atypical case of HME with normal intellectual functions and adult-onset nonrefractory epilepsy demonstrating the wide variation in clinical expressivity of the disease.","PeriodicalId":8296,"journal":{"name":"Archives of Medicine and Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135007698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overview of the cause, complications, immunity, therapy, medication, and certain behavioral changes of premature babies 早产儿的病因、并发症、免疫力、治疗、药物和某些行为变化概述
Pub Date : 2023-01-01 DOI: 10.4103/amhs.amhs_3_23
Rajani Vallepu, M. Kadapa, Chaithanya Katheragandla, C. Nagaraju
Babies born before 37 weeks of pregnancy are considered preterm. Babies born prematurely are also referred to as “preemies” or “preterms.” India has the world's highest rate of premature births. About 1.5 million babies are born prematurely every year. As they grow up, preemies will encounter a variety of challenges. Many children who die before the age of 15 do so due to complications related to their premature birth. Although researchers have yet to pinpoint what exactly causes premature birth, doctors have shown that maternal health plays a role. Preterm birth can be caused by a variety of circumstances, including those of the mother as well as those of the pregnancy and the fetus. There are special care nurseries and neonatal intensive care units worldwide that provide medical attention to premature infants. The infant is placed in an incubator, and all vital signs are monitored, as well as feeding tubes, blood transfusions, and other forms of resuscitation. Major problems, behavioral changes, and therapies for premature infants were covered in this article. Problems with breathing, heart, brain, digestive tract, eyes, ears, teeth, and blood are among the most common serious consequences. The behavior of premature infants is distinct from that of full-term children. They are unable to effectively interact with others due to a lack of emotional intelligence, social awareness, and communication abilities. Medication given to premature infants has the potential to promote growth and appropriate lung, heart, and circulation development. The administration of these drugs is conditional on the state of the infant.
在怀孕37周之前出生的婴儿被认为是早产。早产婴儿也被称为“早产儿”或“早产儿”。印度是世界上早产率最高的国家。每年约有150万婴儿早产。随着他们的成长,早产儿会遇到各种各样的挑战。许多在15岁之前死亡的儿童是由于与早产有关的并发症。尽管研究人员还没有确定早产的确切原因,但医生们已经表明,产妇健康在其中发挥了作用。早产可以由多种情况引起,包括母亲以及怀孕和胎儿的情况。世界各地都有特殊护理托儿所和新生儿重症监护病房,为早产儿提供医疗护理。婴儿被放置在保温箱中,监测所有生命体征,以及喂食管、输血和其他形式的复苏。本文涵盖了早产儿的主要问题、行为改变和治疗方法。呼吸、心脏、大脑、消化道、眼睛、耳朵、牙齿和血液的问题是最常见的严重后果。早产儿的行为与足月儿童不同。由于缺乏情商、社会意识和沟通能力,他们无法有效地与他人互动。给予早产儿的药物有可能促进生长和适当的肺、心脏和循环发育。这些药物的使用要视婴儿的情况而定。
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引用次数: 0
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