Pub Date : 2024-02-18DOI: 10.21608/aps.2023.254995.1153
Sara Abdel Aziz, Diaa Eldin Sherif, Nagwa Sabri, May Shawki
Single nucleotide polymorphisms (SNPs) in the ATP-binding cassette C2 (ABCC2) gene increased intracellular oxaliplatin accumulation in the dorsal root ganglia may result in an increased risk of oxaliplatin-induced peripheral neuropathy (OXAIPN). The present study aims to study the association between the SNPs rs1885301 G>A, rs4148396 C>T, and rs3740066 C>T in the ABCC2 gene and the incidence of OXAIPN in gastrointestinal cancer patients. The study was a prospective cohort study carried out at the Clinical Oncology Department, Ain Shams University Hospitals. Eligible patients received FOLFOX6 and FOLFIRINOX for 8-12 cycles. The SNPs assessment was performed using Real-time PCR using the Rotor gene Q (QIAGEN ® ) system. The patients were followed up with each cycle to assess the incidence and severity of OXAIPN and other common toxicities including diarrhea, vomiting, and neutropenia. One hundred and twenty patients were included in the study. The minor allele frequency for the SNPs rs1885301 G>A, rs4148396 C>T, and rs3740066 C>T were 0.4-0.2, and 0.3 respectively. The current study showed no association between the three SNPs and the incidence and grade of OXAIPN with less than 50% of the participants reporting grade III and IV peripheral neuropathy. A significant association was found between rs4148396 C>T and the occurrence of neutropenia where TT haplotype showed a significantly higher incidence of neutropenia compared to CC + CT. In conclusion, no association was found between the SNPs and the occurrence of PN, diarrhea, and vomiting. There was only a significant difference in the incidence grades of neutropenia among haplotypes of rs4148396 C>T.
{"title":"The Association between ATP-Binding Cassette C2 (ABCC2) Transporter Genetic Polymorphism and Peripheral Neuropathy in Gastrointestinal Cancer Patients Receiving Oxaliplatin.","authors":"Sara Abdel Aziz, Diaa Eldin Sherif, Nagwa Sabri, May Shawki","doi":"10.21608/aps.2023.254995.1153","DOIUrl":"https://doi.org/10.21608/aps.2023.254995.1153","url":null,"abstract":"Single nucleotide polymorphisms (SNPs) in the ATP-binding cassette C2 (ABCC2) gene increased intracellular oxaliplatin accumulation in the dorsal root ganglia may result in an increased risk of oxaliplatin-induced peripheral neuropathy (OXAIPN). The present study aims to study the association between the SNPs rs1885301 G>A, rs4148396 C>T, and rs3740066 C>T in the ABCC2 gene and the incidence of OXAIPN in gastrointestinal cancer patients. The study was a prospective cohort study carried out at the Clinical Oncology Department, Ain Shams University Hospitals. Eligible patients received FOLFOX6 and FOLFIRINOX for 8-12 cycles. The SNPs assessment was performed using Real-time PCR using the Rotor gene Q (QIAGEN ® ) system. The patients were followed up with each cycle to assess the incidence and severity of OXAIPN and other common toxicities including diarrhea, vomiting, and neutropenia. One hundred and twenty patients were included in the study. The minor allele frequency for the SNPs rs1885301 G>A, rs4148396 C>T, and rs3740066 C>T were 0.4-0.2, and 0.3 respectively. The current study showed no association between the three SNPs and the incidence and grade of OXAIPN with less than 50% of the participants reporting grade III and IV peripheral neuropathy. A significant association was found between rs4148396 C>T and the occurrence of neutropenia where TT haplotype showed a significantly higher incidence of neutropenia compared to CC + CT. In conclusion, no association was found between the SNPs and the occurrence of PN, diarrhea, and vomiting. There was only a significant difference in the incidence grades of neutropenia among haplotypes of rs4148396 C>T.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-18DOI: 10.21608/aps.2024.249632.1143
Engy Nady, M. El-Derany, Haidy Michel, E. El-demerdash
Depression is well-known to be a widespread, disabling mental disorder. Despite the many theories that have been put forth to explain the underlying pathophysiology of depression, the exact pathophysiology remains uncertain. In this review, we aim to summarize pathophysiological pathways and experimental animal models for depression, focusing mainly on inflammatory pathways. Stress is a well-known predisposing factor for depression. So, we aim to demonstrate the link between stress and inflammation in depression pathophysiology, highlighting the role of microglia activation, the release of proinflammatory cytokines, and the production of neurotoxic metabolites. We also aim to show the link between inflammation and the disturbance of serotonin, which is also known as 5-hydroxytryptamine (5-HT), and norepinephrine (NE) levels in the brain. Activated microglia produce reactive oxygen species (ROS), which further enhances the inflammatory response. Additionally, we aim to illustrate the hypothalamic-pituitary-adrenal (HPA) axis hyperactivity that occurs as a result of stressful conditions and the consequent resistance of glucocorticoid receptors (GRs), leading to the failure of glucocorticoids to suppress inflammation. We also aim to demonstrate experimental animal models of depression that are based on psychological stress, such as the maternal separation model and the social defeat stress (SDS) model, as well as reviewing the lipopolysaccharide (LPS) inflammation-based model. We also aim to briefly review the widely used chronic unpredictable mild stress (CUMS) model.
{"title":"Pathophysiology of depression: inflammation and its relation with oxidative stress and the hypothalamic-pituitary-adrenal axis","authors":"Engy Nady, M. El-Derany, Haidy Michel, E. El-demerdash","doi":"10.21608/aps.2024.249632.1143","DOIUrl":"https://doi.org/10.21608/aps.2024.249632.1143","url":null,"abstract":"Depression is well-known to be a widespread, disabling mental disorder. Despite the many theories that have been put forth to explain the underlying pathophysiology of depression, the exact pathophysiology remains uncertain. In this review, we aim to summarize pathophysiological pathways and experimental animal models for depression, focusing mainly on inflammatory pathways. Stress is a well-known predisposing factor for depression. So, we aim to demonstrate the link between stress and inflammation in depression pathophysiology, highlighting the role of microglia activation, the release of proinflammatory cytokines, and the production of neurotoxic metabolites. We also aim to show the link between inflammation and the disturbance of serotonin, which is also known as 5-hydroxytryptamine (5-HT), and norepinephrine (NE) levels in the brain. Activated microglia produce reactive oxygen species (ROS), which further enhances the inflammatory response. Additionally, we aim to illustrate the hypothalamic-pituitary-adrenal (HPA) axis hyperactivity that occurs as a result of stressful conditions and the consequent resistance of glucocorticoid receptors (GRs), leading to the failure of glucocorticoids to suppress inflammation. We also aim to demonstrate experimental animal models of depression that are based on psychological stress, such as the maternal separation model and the social defeat stress (SDS) model, as well as reviewing the lipopolysaccharide (LPS) inflammation-based model. We also aim to briefly review the widely used chronic unpredictable mild stress (CUMS) model.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140452989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Penetration enhancer containing vesicles for dermal and transdermal drug delivery. A review.","authors":"Fatma Sarhan, Riham Elgogary, Manal Yassin, Mahmoud Soliman","doi":"10.21608/aps.2023.246357.1141","DOIUrl":"https://doi.org/10.21608/aps.2023.246357.1141","url":null,"abstract":"","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-10DOI: 10.21608/aps.2023.226758.1130
Amany Kamal, Anas Soltan, Reham A. El-Shemy, Hala El-Mesallamy
{"title":"Serum NLRP3 and S1P as Potential Diagnostic and Prognostic Biomarkers in Female Metastatic and Non-Metastatic Breast Cancer Patients","authors":"Amany Kamal, Anas Soltan, Reham A. El-Shemy, Hala El-Mesallamy","doi":"10.21608/aps.2023.226758.1130","DOIUrl":"https://doi.org/10.21608/aps.2023.226758.1130","url":null,"abstract":"","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-10DOI: 10.21608/aps.2023.250333.1146
Raghda Elsisi, Dina Helal, George Mekhail, Dalia Abou Hussein, Amany Osama
{"title":"Advancements in Skin Aging Treatment: Exploring Antioxidants and Nanoparticles for Enhanced Skin Permeation","authors":"Raghda Elsisi, Dina Helal, George Mekhail, Dalia Abou Hussein, Amany Osama","doi":"10.21608/aps.2023.250333.1146","DOIUrl":"https://doi.org/10.21608/aps.2023.250333.1146","url":null,"abstract":"","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138982824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-09DOI: 10.21608/aps.2023.229635.1132
Sarah Milad, Sarra Saleh, Mohammad Aboulwafa, Nadia Hassouna
Across the planet, lignin is widely distributed as one of the most pervasive polymers in existence. It naturally exists as an inherent component of the plant’s structure. In the paper industry, kraft lignin (KL) disposal in large amounts as a waste by-product may potentially result in toxicity to aquatic ecosystems. We can get more value from this plentiful polymer and convert it to value-added products instead of its disposal. Several methods have been described to degrade lignin. These procedures are frequently severe and harmful to the environment. Out of them, biological methods are eco-friendly, ensure consistent production, and cause lower toxicity to the environment. Due to their extensive environmental adaptability and easy genetic engineering, numerous ligninolytic bacteria have been found and studied for lignin use. This includes biodegradation and valorization of lignin into commercial compounds such as fuels, phenolic compounds, ferulic acid, polyhydroxyalkanoates (PHAs), and vanillin. Besides, ligninolytic enzymes produced from several microorganisms have tremendous applications in other industrial fields including textile dye effluent decolorization and bioremediation. This review elucidates the current approaches to lignin degradation. We give an overview of the recent research on the discovery and application of bacterial ligninolytic enzymes and their various optimization strategies. This article also includes the new applications for the utilization of lignin as an economical and alternative-resource material either in the medical field or through biological conversion to value-added products and highlights future perspectives for the improvement of the lignin biodegradation process.
{"title":"Lignin from a disposable by-product to a repository of value-added compounds","authors":"Sarah Milad, Sarra Saleh, Mohammad Aboulwafa, Nadia Hassouna","doi":"10.21608/aps.2023.229635.1132","DOIUrl":"https://doi.org/10.21608/aps.2023.229635.1132","url":null,"abstract":"Across the planet, lignin is widely distributed as one of the most pervasive polymers in existence. It naturally exists as an inherent component of the plant’s structure. In the paper industry, kraft lignin (KL) disposal in large amounts as a waste by-product may potentially result in toxicity to aquatic ecosystems. We can get more value from this plentiful polymer and convert it to value-added products instead of its disposal. Several methods have been described to degrade lignin. These procedures are frequently severe and harmful to the environment. Out of them, biological methods are eco-friendly, ensure consistent production, and cause lower toxicity to the environment. Due to their extensive environmental adaptability and easy genetic engineering, numerous ligninolytic bacteria have been found and studied for lignin use. This includes biodegradation and valorization of lignin into commercial compounds such as fuels, phenolic compounds, ferulic acid, polyhydroxyalkanoates (PHAs), and vanillin. Besides, ligninolytic enzymes produced from several microorganisms have tremendous applications in other industrial fields including textile dye effluent decolorization and bioremediation. This review elucidates the current approaches to lignin degradation. We give an overview of the recent research on the discovery and application of bacterial ligninolytic enzymes and their various optimization strategies. This article also includes the new applications for the utilization of lignin as an economical and alternative-resource material either in the medical field or through biological conversion to value-added products and highlights future perspectives for the improvement of the lignin biodegradation process.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135147853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-09DOI: 10.21608/aps.2023.231700.1133
Salma Elshafey, Dalia El-Khouly, Esther Menze, Mariane Tadros
Neuroinflammation plays a crucial role in cognitive decline and neurodegenerative diseases, such as Alzheimer's. Within the central nervous system, microglia express Toll-like receptor 4 (TLR-4) abundantly, which prompts the secretion of proinflammatory cytokines like TNF-α, PGE2, IL-1β, and NO that are considered essential components of neuroinflammation. The emergence of neurological complications in patients with COVID-19 has spurred investigations into the potential involvement of TLR-4. Particularly intriguing is its contribution to the cytokine storms triggered by SARS-CoV-2 and SARS-CoV-1 infections. This comprehensive review investigates TLR-4-induced neuroinflammation, focusing on its potential connection to cognitive decline and neurological symptoms triggered by COVID-19. By unraveling the intricate mechanisms by which TLR-4 mediates neuroinflammation, this review aims to shed light on its possible role in the context of COVID-19. Understanding the implications of TLR-4 activation could pave the way for targeted interventions to alleviate the cognitive and neurological impacts of COVID-19. As the world seeks to comprehend the far-reaching effects of the pandemic, grasping the nuances of TLR-4-associated neuroinflammation stands as a crucial step in addressing the challenges posed by cognitive decline and neurological manifestations in patients with COVID-19.
{"title":"Insights on the role of TLR-4 in neuroinflammation: a hint on COVID-19 relationship","authors":"Salma Elshafey, Dalia El-Khouly, Esther Menze, Mariane Tadros","doi":"10.21608/aps.2023.231700.1133","DOIUrl":"https://doi.org/10.21608/aps.2023.231700.1133","url":null,"abstract":"Neuroinflammation plays a crucial role in cognitive decline and neurodegenerative diseases, such as Alzheimer's. Within the central nervous system, microglia express Toll-like receptor 4 (TLR-4) abundantly, which prompts the secretion of proinflammatory cytokines like TNF-α, PGE2, IL-1β, and NO that are considered essential components of neuroinflammation. The emergence of neurological complications in patients with COVID-19 has spurred investigations into the potential involvement of TLR-4. Particularly intriguing is its contribution to the cytokine storms triggered by SARS-CoV-2 and SARS-CoV-1 infections. This comprehensive review investigates TLR-4-induced neuroinflammation, focusing on its potential connection to cognitive decline and neurological symptoms triggered by COVID-19. By unraveling the intricate mechanisms by which TLR-4 mediates neuroinflammation, this review aims to shed light on its possible role in the context of COVID-19. Understanding the implications of TLR-4 activation could pave the way for targeted interventions to alleviate the cognitive and neurological impacts of COVID-19. As the world seeks to comprehend the far-reaching effects of the pandemic, grasping the nuances of TLR-4-associated neuroinflammation stands as a crucial step in addressing the challenges posed by cognitive decline and neurological manifestations in patients with COVID-19.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135147860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-09DOI: 10.21608/aps.2023.224318.1127
maiy Jaballah, Norhan Abdelrahman, Ahmed Al-Karmalawy, Khaled Abouzid
Pyridazine-based compounds have been identified as potent PARP1 inhibitors. The PARP is an enzyme family essential for many cellular activities such as the Repair of DNA, apoptosis, and genomic stability, also known as poly (ADP-ribose) synthetases and poly (ADP-ribose) transferases. PARP1 (Poly (ADP-ribose) polymerase 1) is an enzyme that plays a critical role in DNA repair and maintenance of genomic stability. The inhibition of PARP1 has emerged as a promising strategy for the treatment of various cancers, especially those with defects in DNA repair pathways. An array of Diazine-based-containing compounds was recognized as redoubtable PARP1 inhibitors, including Olaparib, and Talazoparib. These compounds have manifested successful results in clinical studies, exhibiting their benefit in various cancer therapies, including ovarian, breast, and pancreatic cancers. In the following review, we will highlight some of the most recent Pyridazine-based compounds and their role in the development of tacit PAPR1 inhibitors.
{"title":"Pyridazine Based Compounds with PARP-1 Inhibitory Activity","authors":"maiy Jaballah, Norhan Abdelrahman, Ahmed Al-Karmalawy, Khaled Abouzid","doi":"10.21608/aps.2023.224318.1127","DOIUrl":"https://doi.org/10.21608/aps.2023.224318.1127","url":null,"abstract":"Pyridazine-based compounds have been identified as potent PARP1 inhibitors. The PARP is an enzyme family essential for many cellular activities such as the Repair of DNA, apoptosis, and genomic stability, also known as poly (ADP-ribose) synthetases and poly (ADP-ribose) transferases. PARP1 (Poly (ADP-ribose) polymerase 1) is an enzyme that plays a critical role in DNA repair and maintenance of genomic stability. The inhibition of PARP1 has emerged as a promising strategy for the treatment of various cancers, especially those with defects in DNA repair pathways. An array of Diazine-based-containing compounds was recognized as redoubtable PARP1 inhibitors, including Olaparib, and Talazoparib. These compounds have manifested successful results in clinical studies, exhibiting their benefit in various cancer therapies, including ovarian, breast, and pancreatic cancers. In the following review, we will highlight some of the most recent Pyridazine-based compounds and their role in the development of tacit PAPR1 inhibitors.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135147855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-09DOI: 10.21608/aps.2023.226661.1128
Rosaline Ashraf, Mai Adel, Rabah Serya, Khaled Abouzid
Histone deacetylase inhibitors (HDACIs) represent a well-known class of compounds that exhibit potential therapeutic efficacy in a variety of diseases, particularly cancer and neurodegenerative disorders. This article discusses the development of compound 6 as a new HDAC inhibitor. It was designed based on the structure-activity relationship (SAR) of the previously reported HDAC inhibitors and the molecular modeling studies. Compound 6 was synthesized, and its structure was verified using different spectroscopic methods. It was biologically evaluated to assess its inhibitory activity against different HDAC isoforms, including HDAC1, 6, and 8. The results showed moderate inhibition against HDAC 1 and HDAC 8 over HDAC 6. It was also evaluated for its antineoplastic activity against the NCI 60 cancer cell line panel. The results revealed inhibitory activity against both the UO-31 renal cancer cell line and the BT-549 breast cancer cell line. Moreover, the Molecular modeling studies revealed a favorable binding affinity for the HDAC8 active site. These results suggest that compound 6 can be considered a promising candidate for the development of new selective class I HDACIs in the future.
{"title":"Identification of Novel 4-Oxo-4H-chromen-Hydroxamic Acid Derivative Targeting Selected HDAC Isoforms","authors":"Rosaline Ashraf, Mai Adel, Rabah Serya, Khaled Abouzid","doi":"10.21608/aps.2023.226661.1128","DOIUrl":"https://doi.org/10.21608/aps.2023.226661.1128","url":null,"abstract":"Histone deacetylase inhibitors (HDACIs) represent a well-known class of compounds that exhibit potential therapeutic efficacy in a variety of diseases, particularly cancer and neurodegenerative disorders. This article discusses the development of compound 6 as a new HDAC inhibitor. It was designed based on the structure-activity relationship (SAR) of the previously reported HDAC inhibitors and the molecular modeling studies. Compound 6 was synthesized, and its structure was verified using different spectroscopic methods. It was biologically evaluated to assess its inhibitory activity against different HDAC isoforms, including HDAC1, 6, and 8. The results showed moderate inhibition against HDAC 1 and HDAC 8 over HDAC 6. It was also evaluated for its antineoplastic activity against the NCI 60 cancer cell line panel. The results revealed inhibitory activity against both the UO-31 renal cancer cell line and the BT-549 breast cancer cell line. Moreover, the Molecular modeling studies revealed a favorable binding affinity for the HDAC8 active site. These results suggest that compound 6 can be considered a promising candidate for the development of new selective class I HDACIs in the future.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135147859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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