Pub Date : 2023-09-21DOI: 10.21608/aps.2023.199372.1112
Doaa ElBohy, Hayam Ateyya, Sara Elkot
{"title":"A cross-sectional study in Egypt on the dentist-pharmacist communication for optimum skeletal muscle relaxant use","authors":"Doaa ElBohy, Hayam Ateyya, Sara Elkot","doi":"10.21608/aps.2023.199372.1112","DOIUrl":"https://doi.org/10.21608/aps.2023.199372.1112","url":null,"abstract":"","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136237962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-21DOI: 10.21608/aps.2023.227507.1131
Ahmed Elissawy, Abdel-Nasser Singab, reem ElShiekh
{"title":"Unearthing the Potential Fungal Bioactive Secondary Metabolites from the Red Sea: A Comprehensive Review","authors":"Ahmed Elissawy, Abdel-Nasser Singab, reem ElShiekh","doi":"10.21608/aps.2023.227507.1131","DOIUrl":"https://doi.org/10.21608/aps.2023.227507.1131","url":null,"abstract":"","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136237963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular Detection of Upper Respiratory Tract Viral Infection with RSV, HPIV & Adenovirus among SARS-CoV2 Negative patients with respiratory illness admitted in tertiary care hospital in Eastern India","authors":"Nivedita Mukherjee, Swati Nayek, Sanjoy Mondal, Tanusri Biswas, Arghya Nath","doi":"10.21608/aps.2023.214314.1124","DOIUrl":"https://doi.org/10.21608/aps.2023.214314.1124","url":null,"abstract":"","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136237961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/aps.2023.207482.1119
A. Salem, Nada M. Mostafa, Eman Al‐Sayed, A. Singab
Erythrina is a genus comprising several plant species that are distributed in tropical and subtropical regions. This genus is a source of many phytoconstituents, with alkaloids and flavonoids as the main bioactive components. Erythrina alkaloids are characterized by a unique nucleus. One hundred ninety-eight alkaloids were isolated from Erythrina plants till early 2023. Recently, an increase in the number of isolated dimeric alkaloids has been witnessed. Erythrina plants have been used in the management of different conditions such as oxidative stress and diseases like cancer, inflammation, viral diseases, malaria, and diabetes, with the alkaloids showing a good potential against certain neurological disorders like anxiety, epilepsy, and Alzheimer’s disease. All data on Erythrina alkaloids were collected from Google Scholar, ScienceDirect, SCOPUS, and SciFinder. For compounds isolated from multiple Erythrina species, the plant source was traced only from 2008 till 2023. The reported anxiolytic, anti-convulsant, and anti-Alzheimer’s activities of Erythrina plant metabolites were traced from 2002 till 2023.
{"title":"Erythrina Alkaloids: An Updated Review with Neurological Perspective.","authors":"A. Salem, Nada M. Mostafa, Eman Al‐Sayed, A. Singab","doi":"10.21608/aps.2023.207482.1119","DOIUrl":"https://doi.org/10.21608/aps.2023.207482.1119","url":null,"abstract":"Erythrina is a genus comprising several plant species that are distributed in tropical and subtropical regions. This genus is a source of many phytoconstituents, with alkaloids and flavonoids as the main bioactive components. Erythrina alkaloids are characterized by a unique nucleus. One hundred ninety-eight alkaloids were isolated from Erythrina plants till early 2023. Recently, an increase in the number of isolated dimeric alkaloids has been witnessed. Erythrina plants have been used in the management of different conditions such as oxidative stress and diseases like cancer, inflammation, viral diseases, malaria, and diabetes, with the alkaloids showing a good potential against certain neurological disorders like anxiety, epilepsy, and Alzheimer’s disease. All data on Erythrina alkaloids were collected from Google Scholar, ScienceDirect, SCOPUS, and SciFinder. For compounds isolated from multiple Erythrina species, the plant source was traced only from 2008 till 2023. The reported anxiolytic, anti-convulsant, and anti-Alzheimer’s activities of Erythrina plant metabolites were traced from 2002 till 2023.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":"505 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76392903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/aps.2023.202342.1114
C. Fahim, N. Ibrahim, N. Swilam, R. Milad
Genus Becium of the Lamiaceae family encounters numerous medicinally and economically valued aromatic plants. The hydrodistilled essential oil of Becium grandiflorum (Lam.) Pic. Serm. aerial part was analyzed using GC/MS. A total of 32 compounds amounting to 99.68% of the essential oil were identified. Oxygenated diterpenes constituted the largest share (43.45%) in the studied oil followed by sesquiterpenes hydrocarbons (34.24%). Pimara-7,15-dien-3-ol (20.58%), 3- α -hydroxymanool (14.07%), caryophyllene (8.17%), sandaracopimaradiene (7.98%), Selina-3,7 (11)-diene (5.61%), and germacrene D (4.95%) are the chief identified compounds in B. grandiflorum essential oil. The essential oil was assessed for its antiviral potential against herpes simplex virus 1 (HSV-1) at a non-cytotoxic concentration using a cytopathic effect (CPE) inhibition assay on the Vero cell line. B. grandiflorum essential oil exhibited a pronounced in vitro cytotoxicity against Vero cells with 50 % cytotoxic concentration (CC 50 ) of 7.75 ± 0.84 µg/mL and weak anti-HSV-1 potency with percent inhibition of 21.36 ± 2.13 at a maximum non-toxic concentration of 1 µg/mL.
{"title":"GC/MS Profiling of Becium grandiflorum Essential Oil and Evaluation of Its Antiviral Activity","authors":"C. Fahim, N. Ibrahim, N. Swilam, R. Milad","doi":"10.21608/aps.2023.202342.1114","DOIUrl":"https://doi.org/10.21608/aps.2023.202342.1114","url":null,"abstract":"Genus Becium of the Lamiaceae family encounters numerous medicinally and economically valued aromatic plants. The hydrodistilled essential oil of Becium grandiflorum (Lam.) Pic. Serm. aerial part was analyzed using GC/MS. A total of 32 compounds amounting to 99.68% of the essential oil were identified. Oxygenated diterpenes constituted the largest share (43.45%) in the studied oil followed by sesquiterpenes hydrocarbons (34.24%). Pimara-7,15-dien-3-ol (20.58%), 3- α -hydroxymanool (14.07%), caryophyllene (8.17%), sandaracopimaradiene (7.98%), Selina-3,7 (11)-diene (5.61%), and germacrene D (4.95%) are the chief identified compounds in B. grandiflorum essential oil. The essential oil was assessed for its antiviral potential against herpes simplex virus 1 (HSV-1) at a non-cytotoxic concentration using a cytopathic effect (CPE) inhibition assay on the Vero cell line. B. grandiflorum essential oil exhibited a pronounced in vitro cytotoxicity against Vero cells with 50 % cytotoxic concentration (CC 50 ) of 7.75 ± 0.84 µg/mL and weak anti-HSV-1 potency with percent inhibition of 21.36 ± 2.13 at a maximum non-toxic concentration of 1 µg/mL.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":"100 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85795474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/aps.2023.209218.1120
O. Eldahshan, Gina Zakaria, Nada A. Mostafa, Rania F Abou El-Ezz
Numerous species of the genus Cinnamomum have been utilized in traditional medicine for their diverse range of health benefits. One of the key properties of cinnamon that has gained significant attention in recent years is its antioxidant activity. Numerous well-known cinnamon species have been assessed for their antioxidant properties and have exhibited surprisingly positive results, which have prompted further investigation into the potential antioxidant effects of the species under study that have yet to be studied. Cinnamon is classified as a nutraceutical which is a desirable characteristic in the studied plant. In the current study, the essential oil of the leaf of Cinnamomum glanduliferum (Wall.) Nees (Lauraceae) was isolated using the Clevenger apparatus and was subjected to GC/MS analysis, enabling the chemical profiling of its constituents. Results revealed that cineole, sabinene, and α -terpineol were identified as the prominent compounds in the oil. Our study aimed at examining the antioxidant activity of Cinnamomum glanduliferum through the utilization of three widely recognized antioxidant assays: DPPH assay by comparing IC 50 values of oil with trolox as a standard, FRAP assay by comparing ferrous equivalents of oil with that of ascorbic acid, and ORAC assay by comparing IC 50 values of oil with quercetin. The results suggest that it may be a promising candidate for further investigation as a potential therapeutic or preventative agent against oxidative stress-related diseases and disorders.
{"title":"Evaluation of Antioxidant Activity of Cinnamomum glanduliferum Leaf Oil Using Several In-vitro Assays","authors":"O. Eldahshan, Gina Zakaria, Nada A. Mostafa, Rania F Abou El-Ezz","doi":"10.21608/aps.2023.209218.1120","DOIUrl":"https://doi.org/10.21608/aps.2023.209218.1120","url":null,"abstract":"Numerous species of the genus Cinnamomum have been utilized in traditional medicine for their diverse range of health benefits. One of the key properties of cinnamon that has gained significant attention in recent years is its antioxidant activity. Numerous well-known cinnamon species have been assessed for their antioxidant properties and have exhibited surprisingly positive results, which have prompted further investigation into the potential antioxidant effects of the species under study that have yet to be studied. Cinnamon is classified as a nutraceutical which is a desirable characteristic in the studied plant. In the current study, the essential oil of the leaf of Cinnamomum glanduliferum (Wall.) Nees (Lauraceae) was isolated using the Clevenger apparatus and was subjected to GC/MS analysis, enabling the chemical profiling of its constituents. Results revealed that cineole, sabinene, and α -terpineol were identified as the prominent compounds in the oil. Our study aimed at examining the antioxidant activity of Cinnamomum glanduliferum through the utilization of three widely recognized antioxidant assays: DPPH assay by comparing IC 50 values of oil with trolox as a standard, FRAP assay by comparing ferrous equivalents of oil with that of ascorbic acid, and ORAC assay by comparing IC 50 values of oil with quercetin. The results suggest that it may be a promising candidate for further investigation as a potential therapeutic or preventative agent against oxidative stress-related diseases and disorders.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83985859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/aps.2023.212124.1125
Riham EL- Hakeem, S. Saleh, M. Aboulwafa, N. Hassouna
Acinetobacter baumannii is an alarming pathogen that threatens human health around the world and most of the antibiotics have become unable to cope with it. It has been classified by the World Health Organization (WHO) as a member of the most dangerous ESKAPE organisms “ Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae, A. baumannii, Pseudomonas aeruginosa, and Enterobacter cloacae ” which show high resistance rates toward antibacterial agents. A. baumannii causes life-threatening infections with limited treatment options that include pneumonia, bacteremia, meningitis, urinary tract infection, and wound infection, and numerous reports have documented A. baumannii infection after SARS-CoV-2 infections in multiple publications through the COVID-19 catastrophe. Many virulence factors such as efflux pumps, outer membrane proteins (OMPs), phospholipase, lipopolysaccharide, capsule, protein secretion systems, nutrient-acquisition systems, biofilm production, and quorum sensing account for the pathological and lethal effects of A. baumannii . The present review concentrates on highlighting the major mechanisms of antibiotic resistance declared in A. baumannii , the virulence factors of A. baumannii, and the novel therapeutic strategies. These strategies include novel antibiotics, drug repurposing, antimicrobial peptides (AMPs), nanoparticles, bacteriophage therapy, monoclonal antibodies of humans (Hu-mAbs), and gene amendment in an attempt to help the scientific research society.
{"title":"Acinetobacter baumannii Virulence Factors, Resistance Mechanisms, and New Insights on Infection Treatment","authors":"Riham EL- Hakeem, S. Saleh, M. Aboulwafa, N. Hassouna","doi":"10.21608/aps.2023.212124.1125","DOIUrl":"https://doi.org/10.21608/aps.2023.212124.1125","url":null,"abstract":"Acinetobacter baumannii is an alarming pathogen that threatens human health around the world and most of the antibiotics have become unable to cope with it. It has been classified by the World Health Organization (WHO) as a member of the most dangerous ESKAPE organisms “ Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae, A. baumannii, Pseudomonas aeruginosa, and Enterobacter cloacae ” which show high resistance rates toward antibacterial agents. A. baumannii causes life-threatening infections with limited treatment options that include pneumonia, bacteremia, meningitis, urinary tract infection, and wound infection, and numerous reports have documented A. baumannii infection after SARS-CoV-2 infections in multiple publications through the COVID-19 catastrophe. Many virulence factors such as efflux pumps, outer membrane proteins (OMPs), phospholipase, lipopolysaccharide, capsule, protein secretion systems, nutrient-acquisition systems, biofilm production, and quorum sensing account for the pathological and lethal effects of A. baumannii . The present review concentrates on highlighting the major mechanisms of antibiotic resistance declared in A. baumannii , the virulence factors of A. baumannii, and the novel therapeutic strategies. These strategies include novel antibiotics, drug repurposing, antimicrobial peptides (AMPs), nanoparticles, bacteriophage therapy, monoclonal antibodies of humans (Hu-mAbs), and gene amendment in an attempt to help the scientific research society.","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88894073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/aps.2023.212265.1122
S. Sherkawy, Lamia Elwakeel, M. Schaalan, A. Moharram, Mohamed Abouelwafa
{"title":"Impact of N-Acetylcysteine on Modulating Inflammation in Patients Hospitalized with Moderate COVID-19 Infections: A Prospective Randomized Trial","authors":"S. Sherkawy, Lamia Elwakeel, M. Schaalan, A. Moharram, Mohamed Abouelwafa","doi":"10.21608/aps.2023.212265.1122","DOIUrl":"https://doi.org/10.21608/aps.2023.212265.1122","url":null,"abstract":"","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":"140 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75623770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/aps.2023.170188.1102
Ragaa Magdy, A. Hemdan, M. Abdel Ghany, N. Fares
{"title":"Determination of Sacubitril and Valsartan Binary Mixture using Different Eco-friendly Spectrophotometric approaches with or without Regression Equations; greenness and whiteness assessments","authors":"Ragaa Magdy, A. Hemdan, M. Abdel Ghany, N. Fares","doi":"10.21608/aps.2023.170188.1102","DOIUrl":"https://doi.org/10.21608/aps.2023.170188.1102","url":null,"abstract":"","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":"98 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77205106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21608/aps.2023.189998.1107
O. Eldahshan, Mira Abdelhalim, Eman Elsayed, khaled Ahmed Saad
{"title":"GC/Ms analysis and antimicrobial activities of different extracts of Egyptian sprouting Broccoli leaves (Brassica oleracea L. var. italica) family Brassicaceae","authors":"O. Eldahshan, Mira Abdelhalim, Eman Elsayed, khaled Ahmed Saad","doi":"10.21608/aps.2023.189998.1107","DOIUrl":"https://doi.org/10.21608/aps.2023.189998.1107","url":null,"abstract":"","PeriodicalId":8314,"journal":{"name":"Archives of Pharmaceutical Sciences Ain Shams University","volume":"134 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80177746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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