Pub Date : 2025-11-14DOI: 10.1016/j.arbres.2025.11.002
Winnifer Briceño, Juan Manuel Velasco, Ana Castillo, Ignacio Jara, Laura Lago, Edwin Yong, Gema Díaz, Gregory Piazza, Behnood Bikdeli, David Jiménez
Background: In patients with acute symptomatic pulmonary embolism (PE), embolic burden has an uncertain prognostic significance.
Methods: We performed a meta-analysis of studies including patients with PE to assess the prevalence and prognostic relevance of central PE (i.e., saddle or main pulmonary emboli) for short-term death and other adverse outcome events. A random-effects model was used to pool study results, and I2 testing was used to test for heterogeneity.
Results: Data from 28 studies (205,877 patients) were included in the analysis. Of the 26 studies with 205,410 participants that enrolled consecutive patients with PE, 7748 (3.8%) had central PE. Though there was no statistically significant difference between central and noncentral PE for odds of short-term all-cause mortality (odds ratio [OR] 1.19; 95% confidence interval [CI], 0.91-1.55), central PE had a significant association with short-term PE-related deterioration or death (OR, 2.47; 95% CI, 1.44-4.25). Results from 9 studies with 4325 PE patients that had available data showed that central PE had a significant association with the odds of short-term PE-related mortality (OR, 1.77; 95% CI, 1.22-2.55). Results were consistent for prospective (OR, 1.67; 95% CI, 1.21-2.32), and studies that only enrolled stable patients (OR, 1.42; 95% CI, 1.06-1.92).
Conclusions: Central PE was an uncommon finding in unselected patients diagnosed with PE. While central thrombus did not have an association with increased risk of all-cause mortality, it was significantly associated with an increased risk of PE-related deterioration and death short after diagnosis.
{"title":"Prevalence and Prognostic Relevance of Central Pulmonary Embolism: Systematic Review and Meta-Analysis.","authors":"Winnifer Briceño, Juan Manuel Velasco, Ana Castillo, Ignacio Jara, Laura Lago, Edwin Yong, Gema Díaz, Gregory Piazza, Behnood Bikdeli, David Jiménez","doi":"10.1016/j.arbres.2025.11.002","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.11.002","url":null,"abstract":"<p><strong>Background: </strong>In patients with acute symptomatic pulmonary embolism (PE), embolic burden has an uncertain prognostic significance.</p><p><strong>Methods: </strong>We performed a meta-analysis of studies including patients with PE to assess the prevalence and prognostic relevance of central PE (i.e., saddle or main pulmonary emboli) for short-term death and other adverse outcome events. A random-effects model was used to pool study results, and I<sup>2</sup> testing was used to test for heterogeneity.</p><p><strong>Results: </strong>Data from 28 studies (205,877 patients) were included in the analysis. Of the 26 studies with 205,410 participants that enrolled consecutive patients with PE, 7748 (3.8%) had central PE. Though there was no statistically significant difference between central and noncentral PE for odds of short-term all-cause mortality (odds ratio [OR] 1.19; 95% confidence interval [CI], 0.91-1.55), central PE had a significant association with short-term PE-related deterioration or death (OR, 2.47; 95% CI, 1.44-4.25). Results from 9 studies with 4325 PE patients that had available data showed that central PE had a significant association with the odds of short-term PE-related mortality (OR, 1.77; 95% CI, 1.22-2.55). Results were consistent for prospective (OR, 1.67; 95% CI, 1.21-2.32), and studies that only enrolled stable patients (OR, 1.42; 95% CI, 1.06-1.92).</p><p><strong>Conclusions: </strong>Central PE was an uncommon finding in unselected patients diagnosed with PE. While central thrombus did not have an association with increased risk of all-cause mortality, it was significantly associated with an increased risk of PE-related deterioration and death short after diagnosis.</p>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145660050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1016/j.arbres.2025.11.004
Javier Sayas Catalán, Maxime Patout
{"title":"Breathing on the Bench: Are We Over-simulating or Underestimating NIV Realities? A PRO/CON Debate.","authors":"Javier Sayas Catalán, Maxime Patout","doi":"10.1016/j.arbres.2025.11.004","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.11.004","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145628234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1016/j.arbres.2025.11.003
Francisco Javier Álvarez-Gutiérrez, Francisco Casas-Maldonado, José Valverde-Molina
{"title":"News From the Severe Asthma Consensus 2025 Review.","authors":"Francisco Javier Álvarez-Gutiérrez, Francisco Casas-Maldonado, José Valverde-Molina","doi":"10.1016/j.arbres.2025.11.003","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.11.003","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145628276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1016/j.arbres.2025.10.017
Aida Monge, Ane Martínez-De Las Fuentes, Javier Burgos, Cristina Pou, Joel-Suresh Lakhani, Annie Navarro, Rosa Abril Castañon, Eduardo J García-Urrestarazu, Alicia Sayés, Ana Belén Alcaide, Marta Erro, Beatriz Raboso Moreno, Anna Sánchez-Cucó, Sally Santisteve, Iván D Benítez, Anna Moncusí-Moix, Esther Gracia-Lavedan, Carlos Manzano, Arturo Morales, Ferrán Barbé, Guillermo Suarez-Cuartín, David de la Rosa-Carrillo, Juan P de-Torres, Jessica González
{"title":"Combining Airway Clearance Techniques and Inhaled Antibiotics in Chronic Bronchial Infection: Real-World Evidence of Exacerbation Reduction (INBREATHING Study).","authors":"Aida Monge, Ane Martínez-De Las Fuentes, Javier Burgos, Cristina Pou, Joel-Suresh Lakhani, Annie Navarro, Rosa Abril Castañon, Eduardo J García-Urrestarazu, Alicia Sayés, Ana Belén Alcaide, Marta Erro, Beatriz Raboso Moreno, Anna Sánchez-Cucó, Sally Santisteve, Iván D Benítez, Anna Moncusí-Moix, Esther Gracia-Lavedan, Carlos Manzano, Arturo Morales, Ferrán Barbé, Guillermo Suarez-Cuartín, David de la Rosa-Carrillo, Juan P de-Torres, Jessica González","doi":"10.1016/j.arbres.2025.10.017","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.10.017","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145548000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1016/j.arbres.2025.10.018
Paola Ordóñez Gómez, María Dolores Miñana, Carlos García-Ballesteros, Jaime Signes-Costa, Juan José Soler-Cataluña
{"title":"Immune Gene Polymorphisms and Lung Cancer Risk in Chronic Obstructive Pulmonary Disease with Emphysema.","authors":"Paola Ordóñez Gómez, María Dolores Miñana, Carlos García-Ballesteros, Jaime Signes-Costa, Juan José Soler-Cataluña","doi":"10.1016/j.arbres.2025.10.018","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.10.018","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145628262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1016/j.arbres.2025.10.016
Adriano D S Targa, Manuel Sánchez-de-la-Torre, Ferran Barbé
{"title":"A Timely Call to Understand the Link Between Obstructive Sleep Apnoea and Circadian Disruption.","authors":"Adriano D S Targa, Manuel Sánchez-de-la-Torre, Ferran Barbé","doi":"10.1016/j.arbres.2025.10.016","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.10.016","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145522814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-04DOI: 10.1016/j.arbres.2025.10.020
Joshua Ray Tanzer, Leonid Lecca, Betsabe Roman Sinche, Victoria Sanchez Guzman, Justin J Wyda, Anthony L Byrne, Silvia S Chiang
{"title":"Evaluation of New and Repurposed Tools to Assess Post-Tuberculosis Lung Disease in Adolescents: A Cross-Sectional Analysis.","authors":"Joshua Ray Tanzer, Leonid Lecca, Betsabe Roman Sinche, Victoria Sanchez Guzman, Justin J Wyda, Anthony L Byrne, Silvia S Chiang","doi":"10.1016/j.arbres.2025.10.020","DOIUrl":"10.1016/j.arbres.2025.10.020","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145628285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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