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Pulmonary Adiaspiromycosis in humans: an updated review of a rare mycosis 人类肺硬螺旋体真菌病：一种罕见真菌病的最新综述。
IF 9.2 3区 医学 Q1 RESPIRATORY SYSTEM
Archivos De Bronconeumologia
Pub Date : 2026-01-01 DOI: 10.1016/j.arbres.2025.08.011
Ángel Cilleruelo-Ramos , María Isabel Ramos-Cancelo , Álvaro Pérez-Rodríguez
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引用次数: 0
Airway Stenting for Endothoracic Goiter 气管支架置入术治疗胸内甲状腺肿。
IF 9.2 3区 医学 Q1 RESPIRATORY SYSTEM
Archivos De Bronconeumologia
Pub Date : 2026-01-01 DOI: 10.1016/j.arbres.2025.07.010
Toni Marín, Pedro J. Rodríguez, Rachid Tazi
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引用次数: 0
Impaired Ventilatory Efficiency Identifies High-Risk Mild-to-Moderate Chronic Obstructive Pulmonary Disease 通气效率受损可识别高危轻至中度慢性阻塞性肺疾病。
IF 9.2 3区 医学 Q1 RESPIRATORY SYSTEM
Archivos De Bronconeumologia
Pub Date : 2026-01-01 DOI: 10.1016/j.arbres.2025.04.005
Zhishan Deng , Fan Wu , Qi Wan , Cuiqiong Dai , Lifei Lu , Zihui Wang , Kunning Zhou , Xiaohui Wu , Gaoying Tang , Huajing Yang , Jieqi Peng , Suyin Huang , Guannan Cai , Fangyan Wu , Junfeng Lin , Xiaoyu Wang , Changli Yang , Yongqing Huang , Rongchang Chen , Nanshan Zhong , Pixin Ran

Objectives

Identifying high-risk patients is fundamental to slowing disease progression in mild-to-moderate COPD. Over one-fifth of these patients have impaired ventilatory efficiency, strongly associated with advanced disease severity, while its unclear prognostic value for high-risk case identification persists.

Methods

This was a prospective cohort study conducted from July 2019 to September 2024 (encompassing the COVID-19 pandemic period) in China. Non-COPD subjects and mild-to-moderate COPD patients who completed questionnaires, lung function tests and cardiopulmonary exercise tests at baseline were annually followed up over 3 years. Subjects with predefined high-risk criteria, including CAT score ≥ 10, mMRC score ≥ 2, postbronchodilator FEV1 < 60% predicted, and frequent exacerbations, were further excluded. Impaired ventilatory efficiency was defined as a nadir minute ventilation/CO2 output ≥ the upper limit of normal. Outcomes included annual lung function decline, exacerbation risks, and symptom scores.

Results

A total of 780 subjects were included, with 684 (88%) completing follow-up. Patients with impaired ventilatory efficiency displayed a greater annual decline in postbronchodilator FEV1 (54 [95% CI: 32–76] mL/year) than patients with normal ventilatory efficiency (31 [15–47] mL/year, adjusted P = 0.008) and non-COPD subjects (31 [22–40] mL/year, adjusted P = 0.001). However, no significant difference existed between patients with normal ventilatory efficiency and non-COPD subjects (adjusted P = 0.756). Similar results were observed for exacerbation risks and symptom scores.

Conclusions

Impaired ventilatory efficiency can identify high-risk mild-to-moderate COPD patients with poor prognosis independently of established risk factors. Further studies are needed to explore effective interventions for patients with impaired ventilatory efficiency.
目的：识别高危患者是减缓轻至中度COPD疾病进展的基础。超过五分之一的患者通气效率受损，与疾病严重程度密切相关，但其对高风险病例识别的预后价值仍不明确。方法：这是一项2019年7月至2024年9月（包括COVID-19大流行期）在中国进行的前瞻性队列研究。非COPD受试者和轻至中度COPD患者在基线时完成问卷调查、肺功能测试和心肺运动测试，每年随访3年以上。受试者具有预定义的高危标准，包括CAT评分≥10分，mMRC评分≥2分，支气管扩张剂后FEV12输出≥正常上限。结果包括年度肺功能下降、恶化风险和症状评分。结果：共纳入780例受试者，684例（88%）完成随访。通气效率受损患者支气管扩张剂后FEV1的年下降幅度（54 [95% CI: 32-76]mL/年）大于通气效率正常患者（31 [15-47]mL/年，调整P=0.008）和非copd患者（31 [22-40]mL/年，调整P=0.001）。而正常通气效率患者与非copd患者间无显著性差异（P=0.756）。在加重风险和症状评分方面也观察到类似的结果。结论：通气效率受损可独立于已确定的危险因素识别预后不良的轻中度COPD高危患者。需要进一步的研究来探索对通气效率受损患者的有效干预措施。
{"title":"Impaired Ventilatory Efficiency Identifies High-Risk Mild-to-Moderate Chronic Obstructive Pulmonary Disease","authors":"Zhishan Deng ,&nbsp;Fan Wu ,&nbsp;Qi Wan ,&nbsp;Cuiqiong Dai ,&nbsp;Lifei Lu ,&nbsp;Zihui Wang ,&nbsp;Kunning Zhou ,&nbsp;Xiaohui Wu ,&nbsp;Gaoying Tang ,&nbsp;Huajing Yang ,&nbsp;Jieqi Peng ,&nbsp;Suyin Huang ,&nbsp;Guannan Cai ,&nbsp;Fangyan Wu ,&nbsp;Junfeng Lin ,&nbsp;Xiaoyu Wang ,&nbsp;Changli Yang ,&nbsp;Yongqing Huang ,&nbsp;Rongchang Chen ,&nbsp;Nanshan Zhong ,&nbsp;Pixin Ran","doi":"10.1016/j.arbres.2025.04.005","DOIUrl":"10.1016/j.arbres.2025.04.005","url":null,"abstract":"<div><h3>Objectives</h3><div>Identifying high-risk patients is fundamental to slowing disease progression<span> in mild-to-moderate COPD. Over one-fifth of these patients have impaired ventilatory efficiency, strongly associated with advanced disease severity, while its unclear prognostic value for high-risk case identification persists.</span></div></div><div><h3>Methods</h3><div><span>This was a prospective cohort study<span><span> conducted from July 2019 to September 2024 (encompassing the COVID-19 pandemic period) in China. Non-COPD subjects and mild-to-moderate COPD<span> patients who completed questionnaires, lung function tests and </span></span>cardiopulmonary exercise tests at baseline were annually followed up over 3 years. Subjects with predefined high-risk criteria, including CAT score</span></span> <!-->≥<!--> <span>10, mMRC score</span> <!-->≥<!--> <!-->2, postbronchodilator FEV<sub>1</sub> <!-->&lt;<!--> <!-->60% predicted, and frequent exacerbations, were further excluded. Impaired ventilatory efficiency was defined as a nadir minute ventilation/CO<sub>2</sub> output<!--> <!-->≥<!--> <!-->the upper limit of normal. Outcomes included annual lung function decline, exacerbation risks, and symptom scores.</div></div><div><h3>Results</h3><div>A total of 780 subjects were included, with 684 (88%) completing follow-up. Patients with impaired ventilatory efficiency displayed a greater annual decline in postbronchodilator FEV<sub>1</sub> (54 [95% CI: 32–76]<!--> <!-->mL/year) than patients with normal ventilatory efficiency (31 [15–47] mL/year, adjusted <em>P</em> <!-->=<!--> <!-->0.008) and non-COPD subjects (31 [22–40]<!--> <!-->mL/year, adjusted <em>P</em> <!-->=<!--> <!-->0.001). However, no significant difference existed between patients with normal ventilatory efficiency and non-COPD subjects (adjusted <em>P</em> <!-->=<!--> <!-->0.756). Similar results were observed for exacerbation risks and symptom scores.</div></div><div><h3>Conclusions</h3><div>Impaired ventilatory efficiency can identify high-risk mild-to-moderate COPD patients with poor prognosis independently of established risk factors. Further studies are needed to explore effective interventions for patients with impaired ventilatory efficiency.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 1","pages":"Pages 10-19"},"PeriodicalIF":9.2,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk validation of a new quantitative score for clinical control of chronic obstructive pulmonary disease: The RADAR score 一种新的慢性阻塞性肺疾病临床控制定量评分的风险验证：RADAR评分。
IF 9.2 3区 医学 Q1 RESPIRATORY SYSTEM
Archivos De Bronconeumologia
Pub Date : 2026-01-01 DOI: 10.1016/j.arbres.2025.06.003
Juan José Soler-Cataluña , María Villagrasa , Pablo Catalán , Bernardino Alcázar-Navarrete , Myriam Calle Rubio , Marc Miravitlles

Objective

Clinical control has been proposed as a composite endpoint in chronic obstructive pulmonary disease (COPD), assessable through the COPD Clinical Control Questionnaire (CCOq). A new score, derived from the CCOq, and termed as RADAR (Rescue medication, Acute exacerbations, Dyspnea, physical Activity, and Risk) has been developed. This study aimed to validate the RADAR score by analyzing its predictive value for future risk and health status.

Methods

A 12-month prospective observational study was conducted in stable COPD patients. Clinical control was assessed at 3 months using both the CCOq and the RADAR score (range 0–8). Dyspnea was evaluated both adjusted and unadjusted for FEV1%. The primary outcome was time to the first composite event (emergency visit, COPD hospitalization, or all-cause mortality); the secondary outcome was the COPD Assessment Test (CAT) score at 12 months.

Results

Of 265 patients enrolled (16.2% women; mean age: 68 ± 9 years; FEV1%: 58 ± 17), 239 completed the 3-month assessment. Among patients with RADAR scores of 0–1, 96.5% met CCOq control criteria, whereas none with scores ≥4 were classified as controlled. Patients were categorized as good (0–1), partial (2–3), or poor control (≥4). Time to composite event differed significantly across groups (p < 0.001), with RADAR remaining an independent predictor after adjustment. Predictive accuracy (C-statistic) was 0.697 (adjusted) and 0.713 (unadjusted).

Conclusion

The RADAR score effectively predicts clinical risk and health status, offering a practical tool for monitoring COPD and guiding clinical decisions.
目的：临床控制已被提出作为慢性阻塞性肺疾病（COPD）的一个复合终点，可通过COPD临床控制问卷（CCOq）进行评估。从CCOq衍生出一种新的评分方法，称为RADAR（急救用药、急性加重、呼吸困难、体力活动和风险）。本研究旨在通过分析RADAR评分对未来风险和健康状况的预测价值来验证其有效性。方法：对稳定期COPD患者进行为期12个月的前瞻性观察研究。临床对照在3个月时使用CCOq和RADAR评分（范围0-8）进行评估。在FEV1%调整和未调整时评估呼吸困难。主要终点是发生第一次复合事件（急诊就诊、COPD住院或全因死亡率）的时间；次要终点是12个月时COPD评估测试（CAT）评分。结果：265例入组患者中(16.2%为女性；平均年龄：68±9岁；FEV1%: 58±17)，239例完成3个月评估。RADAR评分为0 ~ 1分的患者中，96.5%的患者符合CCOq控制标准，而评分≥4分的患者均未被归为对照。患者分为良好（0-1）、部分（2-3）和控制不良（≥4）。结论：RADAR评分可有效预测临床风险和健康状况，为COPD监测和指导临床决策提供实用工具。
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引用次数: 0
Pulmonary Arterial Hypertension Mortality in Latin America and the Caribbean: Trends and Future Projections (1980-2030). 拉丁美洲和加勒比地区肺动脉高压死亡率：趋势和未来预测（1980-2030）。
IF 9.2 3区 医学 Q1 RESPIRATORY SYSTEM
Archivos De Bronconeumologia
Pub Date : 2025-12-23 DOI: 10.1016/j.arbres.2025.12.002
Marcos Vinicius Fernandes Garcia, Evans R Fernández Pérez
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引用次数: 0
Severe Asthma Unresponsive to Therapy as the Initial Presentation of Pulmonary Venous Drainage Obstruction. 对治疗无反应的严重哮喘作为肺静脉引流阻塞的初始表现。
IF 9.2 3区 医学 Q1 RESPIRATORY SYSTEM
Archivos De Bronconeumologia
Pub Date : 2025-12-23 DOI: 10.1016/j.arbres.2025.11.014
Clara Seghers-Carreras, Miguel Jiménez-Gómez, Rocío Magdalena Díaz-Campos
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引用次数: 0
Exhaled Volatile Organic Compounds as Potential Biomarkers of Exacerbation Risk in Asthma. 呼出的挥发性有机化合物作为哮喘恶化风险的潜在生物标志物。
IF 9.2 3区 医学 Q1 RESPIRATORY SYSTEM
Archivos De Bronconeumologia
Pub Date : 2025-12-22 DOI: 10.1016/j.arbres.2025.12.003
Rocío Díaz-Campos, Miguel Jiménez-Gómez, Carolina Cisneros-Serrano, Andrea Trisán-Alonso, Antolín López-Viña, Rocío García-García, Irina Bobolea, José Javier Jareño-Esteban, Mª Ángeles Muñoz Lucas, Carlos Melero-Moreno
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引用次数: 0
Sustained Tumor Response After Pembrolizumab Discontinuation Due to Severe Bullous Pemphigoid. 严重大疱性类天疱疮导致的派姆单抗停药后持续的肿瘤反应。
IF 9.2 3区 医学 Q1 RESPIRATORY SYSTEM
Archivos De Bronconeumologia
Pub Date : 2025-12-22 DOI: 10.1016/j.arbres.2025.12.001
Sofia Magno Pinto, Gustavo Silva, Filipa Ferro
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引用次数: 0
Lessons From the ANTES B+ Study. 来自ANTES B+研究的经验教训。
IF 9.2 3区 医学 Q1 RESPIRATORY SYSTEM
Archivos De Bronconeumologia
Pub Date : 2025-12-22 DOI: 10.1016/j.arbres.2025.12.004
Alvar Agusti, Juan José Soler-Cataluña
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引用次数: 0
Pulmonary Hypoplasia and Congenital Dextrocardia Presenting With Hypercapnia in Advanced Age. 老年伴高碳酸血症的肺发育不全和先天性右心。
IF 9.2 3区 医学 Q1 RESPIRATORY SYSTEM
Archivos De Bronconeumologia
Pub Date : 2025-12-20 DOI: 10.1016/j.arbres.2025.11.013
Mónica Matute-Villacís, Macarena Lovera, Adriana Martín Pascual
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引用次数: 0
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