Pub Date : 2026-02-01DOI: 10.1016/j.arbres.2025.07.025
Antoine Léotard , Maxime Patout , Vincent Delord , Marie-Christine Blandin , Hélène Prigent , Pierre Tankéré
{"title":"Impact of CPAP in Patients With Central, Neuromuscular and Chest Wall Causes of Chronic Respiratory Failure and Comorbid OSA: A Retrospective Study","authors":"Antoine Léotard , Maxime Patout , Vincent Delord , Marie-Christine Blandin , Hélène Prigent , Pierre Tankéré","doi":"10.1016/j.arbres.2025.07.025","DOIUrl":"10.1016/j.arbres.2025.07.025","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 2","pages":"Pages 126-129"},"PeriodicalIF":9.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1016/j.arbres.2025.07.019
Elvan Senturk Topaloglu , Omer Topaloglu
{"title":"Spontaneous Tracheal Fistulization of a Progressive Bronchogenic Cyst: A Four-Year Conservative Follow-Up Case Report","authors":"Elvan Senturk Topaloglu , Omer Topaloglu","doi":"10.1016/j.arbres.2025.07.019","DOIUrl":"10.1016/j.arbres.2025.07.019","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 2","pages":"Pages 139-140"},"PeriodicalIF":9.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1016/j.arbres.2025.06.015
Mirjam P. Roffel , Corry-Anke Brandsma , Alen Faiz , Marnix R. Jonker , Wim Timens , Guy F. Joos , Guy G. Brusselle , Tania Maes , Ken R. Bracke , Maarten van den Berge , Irene H. Heijink
Introduction
The mechanisms driving abnormal pro-inflammatory responses to cigarette smoke in COPD remain unclear. MicroRNA (miR)-320d was previously shown to have anti-inflammatory effects, being upregulated by inhaled corticosteroids. Therefore, our objective was to study whether miR-320d suppresses smoke-induced airway epithelial pro-inflammatory responses and if this is compromised in COPD.
Methods
We investigated the anti-inflammatory mechanisms of miR-320d in cigarette smoke extract (CSE)-exposed primary bronchial epithelial cells (PBECs), comparing COPD and control cells using a miR-320d mimic. Additionally, we assessed whether miR-320d expression is altered with COPD and its severity, investigating lung tissue from two independent cohorts of non-COPD controls (non/current/ex-smokers) and COPD patients (current/ex-smokers) with mild/moderate and severe disease.
Results
MiR-320d overexpression attenuated baseline and CSE-induced pro-inflammatory CXCL8, IL-1α and GM-CSF secretion in non-COPD-derived PBECs. This effect was not observed for CXCL8 and IL-1α in COPD-derived PBECs. RNA-sequencing showed that miR-320d significantly regulates the expression of 137 genes in CSE-exposed epithelium, the upregulated genes being enriched in “interleukin-33-mediated signaling” and the downregulated genes in “response to cytokine” (including IRAK1) pathways. Higher miR-320d levels were associated with lower IRAK1 expression in control but not COPD-derived PBECs. Finally, miR-320d levels were lower in lung tissue of COPD patients vs non-smoking controls and in severe vs mild/moderate COPD patients.
Conclusions
miR-320d's suppressive effect on bronchial epithelial pro-inflammatory responses cells may be compromised in COPD. Additionally, miR-320d expression in lung tissue was lower with COPD severity. Thus, lower miR-320d anti-inflammatory action may contribute to persisting inflammation in COPD.
{"title":"The Role of miR-320d in Regulation of Cigarette Smoke-Induced Pro-Inflammatory Responses in COPD","authors":"Mirjam P. Roffel , Corry-Anke Brandsma , Alen Faiz , Marnix R. Jonker , Wim Timens , Guy F. Joos , Guy G. Brusselle , Tania Maes , Ken R. Bracke , Maarten van den Berge , Irene H. Heijink","doi":"10.1016/j.arbres.2025.06.015","DOIUrl":"10.1016/j.arbres.2025.06.015","url":null,"abstract":"<div><h3>Introduction</h3><div>The mechanisms driving abnormal pro-inflammatory responses to cigarette smoke in COPD remain unclear. MicroRNA (miR)-320d was previously shown to have anti-inflammatory effects, being upregulated by inhaled corticosteroids. Therefore, our objective was to study whether miR-320d suppresses smoke-induced airway epithelial pro-inflammatory responses and if this is compromised in COPD.</div></div><div><h3>Methods</h3><div>We investigated the anti-inflammatory mechanisms of miR-320d in cigarette smoke extract (CSE)-exposed primary bronchial epithelial cells (PBECs), comparing COPD and control cells using a miR-320d mimic. Additionally, we assessed whether miR-320d expression is altered with COPD and its severity, investigating lung tissue from two independent cohorts of non-COPD controls (non/current/ex-smokers) and COPD patients (current/ex-smokers) with mild/moderate and severe disease.</div></div><div><h3>Results</h3><div>MiR-320d overexpression attenuated baseline and CSE-induced pro-inflammatory CXCL8, IL-1α and GM-CSF secretion in non-COPD-derived PBECs. This effect was not observed for CXCL8 and IL-1α in COPD-derived PBECs. RNA-sequencing showed that miR-320d significantly regulates the expression of 137 genes in CSE-exposed epithelium, the upregulated genes being enriched in “interleukin-33-mediated signaling” and the downregulated genes in “response to cytokine” (including <em>IRAK1</em>) pathways. Higher miR-320d levels were associated with lower <em>IRAK1</em> expression in control but not COPD-derived PBECs. Finally, miR-320d levels were lower in lung tissue of COPD patients <em>vs</em> non-smoking controls and in severe <em>vs</em> mild/moderate COPD patients.</div></div><div><h3>Conclusions</h3><div>miR-320d's suppressive effect on bronchial epithelial pro-inflammatory responses cells may be compromised in COPD. Additionally, miR-320d expression in lung tissue was lower with COPD severity. Thus, lower miR-320d anti-inflammatory action may contribute to persisting inflammation in COPD.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 2","pages":"Pages 86-93"},"PeriodicalIF":9.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1016/j.arbres.2025.07.004
Alejandro Romero-Linares , Antonio Cárdenas-Cruz , Jose M. Pérez-Villares , Jose A. Sánchez-Martínez , Patricia Fuentes-García , Bernardino Alcázar-Navarrete
{"title":"Inclusion of the Intermediate Respiratory Care Unit as a Detection Area for Controlled Donation After Circulatory Death: Results of a Pilot Project","authors":"Alejandro Romero-Linares , Antonio Cárdenas-Cruz , Jose M. Pérez-Villares , Jose A. Sánchez-Martínez , Patricia Fuentes-García , Bernardino Alcázar-Navarrete","doi":"10.1016/j.arbres.2025.07.004","DOIUrl":"10.1016/j.arbres.2025.07.004","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 2","pages":"Pages 118-120"},"PeriodicalIF":9.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1016/j.arbres.2025.08.007
Génesis Isabel Victoriano Soriano , Begoña Gregorio Crespo , José Soro García
{"title":"Unusual Case of Multiple and Delayed Recurrence of a Solitary Fibrous Tumor of the Pleura After Complete Resection","authors":"Génesis Isabel Victoriano Soriano , Begoña Gregorio Crespo , José Soro García","doi":"10.1016/j.arbres.2025.08.007","DOIUrl":"10.1016/j.arbres.2025.08.007","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 2","pages":"Pages 143-144"},"PeriodicalIF":9.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-01DOI: 10.1016/j.arbres.2025.08.001
Marta Arteaga , Laura López-Duque , Daniel Laorden , Inés Torrado , David Romero-Ribate , Elena Villamañán , Santiago Quirce , Rodolfo Álvarez-Sala , Javier Domínguez-Ortega
{"title":"Inhaled Corticosteroid Reduction Effects on Asthma Outcomes After Three Years of Benralizumab Treatment in Severe Asthma Patients","authors":"Marta Arteaga , Laura López-Duque , Daniel Laorden , Inés Torrado , David Romero-Ribate , Elena Villamañán , Santiago Quirce , Rodolfo Álvarez-Sala , Javier Domínguez-Ortega","doi":"10.1016/j.arbres.2025.08.001","DOIUrl":"10.1016/j.arbres.2025.08.001","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"62 2","pages":"Pages 130-132"},"PeriodicalIF":9.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-15DOI: 10.1016/j.arbres.2026.01.001
Daniel López-Padilla, Vitalii Poberezhets, Nicolas Roche, Catharina C Moor, Marie Bruyneel, Carla Ribeiro, Hilary Pinnock
This narrative review summarizes current evidence and clinical experience regarding telemonitoring across major respiratory diseases and care settings, including chronic obstructive pulmonary disease (COPD), asthma, interstitial lung diseases, obstructive sleep apnea, as well as non-invasive ventilation and pulmonary rehabilitation programmes. Advances in connectivity, artificial intelligence (AI), and wearable devices are facilitating the early detection of clinical deterioration, personalized interventions, and improved self-management, thereby optimizing the use of healthcare resources. Strong evidence supports the benefits of telemonitoring in COPD, particularly in reducing exacerbations and hospital admissions, whereas results are more heterogeneous in asthma and emerging conditions such as interstitial lung diseases. Telemonitoring systems leverage AI-driven analytical frameworks and interoperable digital platforms to process and interpret large volumes of patient data, enabling both automated responses and targeted human interventions. Key challenges include ensuring patient engagement, addressing digital literacy and inequities in access, safeguarding data privacy, and integrating digital solutions into standard care and reimbursement frameworks. The COVID-19 pandemic accelerated the adoption of telemonitoring, confirming its feasibility and acceptability, but also revealed persistent gaps in long-term cost-effectiveness and implementation strategies. Future directions should focus on integrating telemonitoring with AI-supported, coordinated clinical decision-making, enhancing system interoperability, and above all, prioritizing equitable access to digital care. Telemonitoring is poised to become a central component of respiratory patient management, although its large-scale implementation will require overcoming existing technical, ethical, and organizational barriers to fully realize its clinical potential.
{"title":"Telemonitoring in Respiratory Diseases: Current Evidence, Clinical Experience, and Future Challenges.","authors":"Daniel López-Padilla, Vitalii Poberezhets, Nicolas Roche, Catharina C Moor, Marie Bruyneel, Carla Ribeiro, Hilary Pinnock","doi":"10.1016/j.arbres.2026.01.001","DOIUrl":"https://doi.org/10.1016/j.arbres.2026.01.001","url":null,"abstract":"<p><p>This narrative review summarizes current evidence and clinical experience regarding telemonitoring across major respiratory diseases and care settings, including chronic obstructive pulmonary disease (COPD), asthma, interstitial lung diseases, obstructive sleep apnea, as well as non-invasive ventilation and pulmonary rehabilitation programmes. Advances in connectivity, artificial intelligence (AI), and wearable devices are facilitating the early detection of clinical deterioration, personalized interventions, and improved self-management, thereby optimizing the use of healthcare resources. Strong evidence supports the benefits of telemonitoring in COPD, particularly in reducing exacerbations and hospital admissions, whereas results are more heterogeneous in asthma and emerging conditions such as interstitial lung diseases. Telemonitoring systems leverage AI-driven analytical frameworks and interoperable digital platforms to process and interpret large volumes of patient data, enabling both automated responses and targeted human interventions. Key challenges include ensuring patient engagement, addressing digital literacy and inequities in access, safeguarding data privacy, and integrating digital solutions into standard care and reimbursement frameworks. The COVID-19 pandemic accelerated the adoption of telemonitoring, confirming its feasibility and acceptability, but also revealed persistent gaps in long-term cost-effectiveness and implementation strategies. Future directions should focus on integrating telemonitoring with AI-supported, coordinated clinical decision-making, enhancing system interoperability, and above all, prioritizing equitable access to digital care. Telemonitoring is poised to become a central component of respiratory patient management, although its large-scale implementation will require overcoming existing technical, ethical, and organizational barriers to fully realize its clinical potential.</p>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146096764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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