Pub Date : 2025-02-01DOI: 10.1016/j.arbres.2024.07.026
Roberto Bernabeu-Mora , Elisa Valera-Novella , Elodia Teresa Bernabeu-Serrano , Juan José Soler-Cataluña , Myriam Calle-Rubio , Francesc Medina-Mirapeix
Objective
To determine if adding performance on the five-repetition sit-to-stand test (5-STS) to chronic obstructive pulmonary disease (COPD) high-risk criteria, proposed by the Spanish COPD guidelines (GesEPOC), affects mortality prognosis.
Methods
Observational study of COPD outpatients involved prospective follow-up for 5 years. Patients were classified based on 5-STS performance and risk criteria proposed by GesEPOC version 2021. Outcome measures were 5-year mortality timing and rate. Kaplan–Meier curves and univariate and multivariate Cox proportional-hazard analyses, analysis of variance, and univariate and multivariate linear and logistic regression models were used.
Results
One hundred and thirty-seven patients were included. Mean age was 66 ± 8.3 years, and 87.6% were men. Of them, 115 (83.9%) were classified as high risk, 43 (34.4%) of whom had poor performance on the 5-STS. Overall mortality at 5 years was 27% and was significantly higher in the high-risk (29.6%) compared with the low-risk (13.6%) group. Among high-risk patients, mortality at 5 years was significantly worse with poor 5-STS performance (60.5%) compared with non-poor performance (11.1%). Poor performance on the 5-STS was independently associated with increased 5-year mortality risk (HR 4.70; 95% CI: 1.96–11.27) in a model adjusted for history of heart disease and dyspnea.
Conclusion
Among high-risk COPD patients, those with poor performance on the 5-STS have a significantly higher mortality at 5 years than those with non-poor 5-STS performance.
{"title":"Five-Repetition Sit-to-Stand Test as Predictor of Mortality in High Risk COPD Patients","authors":"Roberto Bernabeu-Mora , Elisa Valera-Novella , Elodia Teresa Bernabeu-Serrano , Juan José Soler-Cataluña , Myriam Calle-Rubio , Francesc Medina-Mirapeix","doi":"10.1016/j.arbres.2024.07.026","DOIUrl":"10.1016/j.arbres.2024.07.026","url":null,"abstract":"<div><h3>Objective</h3><div>To determine if adding performance on the five-repetition sit-to-stand test (5-STS) to chronic obstructive pulmonary disease (COPD) high-risk criteria, proposed by the Spanish COPD guidelines (GesEPOC), affects mortality prognosis.</div></div><div><h3>Methods</h3><div>Observational study of COPD outpatients involved prospective follow-up for 5 years. Patients were classified based on 5-STS performance and risk criteria proposed by GesEPOC version 2021. Outcome measures were 5-year mortality timing and rate. Kaplan–Meier curves and univariate and multivariate Cox proportional-hazard analyses, analysis of variance, and univariate and multivariate linear and logistic regression models were used.</div></div><div><h3>Results</h3><div>One hundred and thirty-seven patients were included. Mean age was 66<!--> <!-->±<!--> <!-->8.3 years, and 87.6% were men. Of them, 115 (83.9%) were classified as high risk, 43 (34.4%) of whom had poor performance on the 5-STS. Overall mortality at 5 years was 27% and was significantly higher in the high-risk (29.6%) compared with the low-risk (13.6%) group. Among high-risk patients, mortality at 5 years was significantly worse with poor 5-STS performance (60.5%) compared with non-poor performance (11.1%). Poor performance on the 5-STS was independently associated with increased 5-year mortality risk (HR 4.70; 95% CI: 1.96–11.27) in a model adjusted for history of heart disease and dyspnea.</div></div><div><h3>Conclusion</h3><div>Among high-risk COPD patients, those with poor performance on the 5-STS have a significantly higher mortality at 5 years than those with non-poor 5-STS performance.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 2","pages":"Pages 90-95"},"PeriodicalIF":8.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.arbres.2024.10.001
Alejandro Cruz-Utrilla , Fernando Vargas-Ursúa , Alberto Fernández-Villar , Pilar Escribano-Subías
{"title":"Development of a Nomogram for Genetic Risk of PAH","authors":"Alejandro Cruz-Utrilla , Fernando Vargas-Ursúa , Alberto Fernández-Villar , Pilar Escribano-Subías","doi":"10.1016/j.arbres.2024.10.001","DOIUrl":"10.1016/j.arbres.2024.10.001","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 2","pages":"Pages 107-109"},"PeriodicalIF":8.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.1016/j.arbres.2025.01.012
Martina Koziar Vasakova, Martina Sterclova
{"title":"Serum Specific Immunoglobulins G. Do They Belong to the Standard Diagnostic Workup in Interstitial Lung Diseases?","authors":"Martina Koziar Vasakova, Martina Sterclova","doi":"10.1016/j.arbres.2025.01.012","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.01.012","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-31DOI: 10.1016/j.arbres.2025.01.011
Gregory Reychler, Zoé Verdereau, Anne-Sophie Aubriot, Sophie Gohy, Silvia Berardis, Lidvine Boland, Vincent Haufroid, Jean-Christophe Dubus
{"title":"Risk of Exposure for the Caregivers During Aminoglycoside Nebulization: An Observational Study.","authors":"Gregory Reychler, Zoé Verdereau, Anne-Sophie Aubriot, Sophie Gohy, Silvia Berardis, Lidvine Boland, Vincent Haufroid, Jean-Christophe Dubus","doi":"10.1016/j.arbres.2025.01.011","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.01.011","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-31DOI: 10.1016/j.arbres.2025.01.014
Yoshiyasu Takefuji
{"title":"Reevaluating Feature Selection in Machine Learning Models for Identifying Disease-Modifying Agents in Obstructive Sleep Apnea.","authors":"Yoshiyasu Takefuji","doi":"10.1016/j.arbres.2025.01.014","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.01.014","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-31DOI: 10.1016/j.arbres.2025.01.009
Grace Oscullo, Amina Bekki, Miguel Angel Martinez-Garcia
{"title":"Microbiome, Metabolome and Complexity in Bronchiectasis: The Future is Here.","authors":"Grace Oscullo, Amina Bekki, Miguel Angel Martinez-Garcia","doi":"10.1016/j.arbres.2025.01.009","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.01.009","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-31DOI: 10.1016/j.arbres.2025.01.016
César Picado, Nestor Soler
{"title":"Organizing Pneumonia Caused by Letrozole Therapy for Breast Cancer: A Case Report.","authors":"César Picado, Nestor Soler","doi":"10.1016/j.arbres.2025.01.016","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.01.016","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-31DOI: 10.1016/j.arbres.2025.01.010
Javier Sayas Catalán, Cristina Lalmolda, Ana Hernández-Voth, Marta Corral Blanco, Patrick Murphy, Laura Gonzalez-Ramos, Pablo Florez-Solarana, Berta Lloret-Puig, Manel Lujan
Introduction: Patients with severe Chronic Obstructive Pulmonary Disease (COPD) often experience breathlessness and exercise limitations due to expiratory flow limitation. Pulmonary rehabilitation programmes, including exercise with non-invasive ventilation (NIV) or high-flow nasal therapy (HFT), aims to improve quality of life and exercise tolerance. This study investigates the relationship between thoracoabdominal asynchrony (TAA) during supported (NIV and HFT) and unsupported (conventional oxygen therapy - COT) exercise and clinical and functional parameters in severe COPD patients awaiting lung transplantation.
Methods: This experimental, longitudinal, prospective, controlled study included 20 severe COPD patients on the lung transplant waiting list. Patients underwent three constant load exercise tests under COT, NIV, and HFT conditions. TAA was measured using respiratory inductance plethysmography, and neurorrespiratory drive (NRD) was assessed via parasternal electromyography.
Results: Patients exhibited distinct TAA patterns during exercise. Clockwise rotation (thorax ahead) was associated with worse baseline lung function, higher peak exercise dyspnoea and higher peak exercise NRD compared to counterclockwise rotation (abdomen ahead). No significant differences in TAA were observed between the three exercise conditions (COT, NIV, HFT). However, patients with clockwise TAA were more likely to have reduction in breathlessness with NIV compared to COT than those with counterclockwise rotation.
Conclusions: TAA patterns during exercise in severe COPD patients can indicate the severity of lung function impairment and predict severity of exercise induced dyspnoea. Analysis of TAA may predict response to respiratory support modalities and therefore monitoring TAA and NRD should be further studied to allow better tailoring of respiratory support during rehabilitation.
{"title":"Thoracoabdominal Asynchrony in Very Severe COPD: Clinical and Functional Correlates During Exercise.","authors":"Javier Sayas Catalán, Cristina Lalmolda, Ana Hernández-Voth, Marta Corral Blanco, Patrick Murphy, Laura Gonzalez-Ramos, Pablo Florez-Solarana, Berta Lloret-Puig, Manel Lujan","doi":"10.1016/j.arbres.2025.01.010","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.01.010","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with severe Chronic Obstructive Pulmonary Disease (COPD) often experience breathlessness and exercise limitations due to expiratory flow limitation. Pulmonary rehabilitation programmes, including exercise with non-invasive ventilation (NIV) or high-flow nasal therapy (HFT), aims to improve quality of life and exercise tolerance. This study investigates the relationship between thoracoabdominal asynchrony (TAA) during supported (NIV and HFT) and unsupported (conventional oxygen therapy - COT) exercise and clinical and functional parameters in severe COPD patients awaiting lung transplantation.</p><p><strong>Methods: </strong>This experimental, longitudinal, prospective, controlled study included 20 severe COPD patients on the lung transplant waiting list. Patients underwent three constant load exercise tests under COT, NIV, and HFT conditions. TAA was measured using respiratory inductance plethysmography, and neurorrespiratory drive (NRD) was assessed via parasternal electromyography.</p><p><strong>Results: </strong>Patients exhibited distinct TAA patterns during exercise. Clockwise rotation (thorax ahead) was associated with worse baseline lung function, higher peak exercise dyspnoea and higher peak exercise NRD compared to counterclockwise rotation (abdomen ahead). No significant differences in TAA were observed between the three exercise conditions (COT, NIV, HFT). However, patients with clockwise TAA were more likely to have reduction in breathlessness with NIV compared to COT than those with counterclockwise rotation.</p><p><strong>Conclusions: </strong>TAA patterns during exercise in severe COPD patients can indicate the severity of lung function impairment and predict severity of exercise induced dyspnoea. Analysis of TAA may predict response to respiratory support modalities and therefore monitoring TAA and NRD should be further studied to allow better tailoring of respiratory support during rehabilitation.</p>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-31DOI: 10.1016/j.arbres.2025.01.013
Grace Oscullo, Jose Daniel Gómez-Olivas, Miguel Ángel Martínez-García
{"title":"Isolation of Haemophilus influenzae in Patients With Steady-State Chronic Obstructive Pulmonary Disease: A Long-Term Longitudinal Study.","authors":"Grace Oscullo, Jose Daniel Gómez-Olivas, Miguel Ángel Martínez-García","doi":"10.1016/j.arbres.2025.01.013","DOIUrl":"https://doi.org/10.1016/j.arbres.2025.01.013","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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