Archivos De Bronconeumologia最新文献

{"title":"Right Cardiac Bronchus: An Uncommon Incidental Finding","authors":"Álvaro Fuentes-Martín , María Rosa López Pedreira , Ángel Cilleruelo Ramos","doi":"10.1016/j.arbres.2025.06.012","DOIUrl":"10.1016/j.arbres.2025.06.012","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 12","pages":"Pages 803-804"},"PeriodicalIF":9.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Checkpoint Biomarkers Galectin-9 and TIM-3 Predict Melanoma and Lung Cancer Mortality in Obstructive Sleep Apnoea","authors":"Elena Díaz-García ,&nbsp;Enrique Alfaro ,&nbsp;Paula Pérez-Moreno ,&nbsp;Cristina López-Fernández ,&nbsp;Aldara García-Sánchez ,&nbsp;Miguel Ángel Martínez-García ,&nbsp;Eva Mañas ,&nbsp;Irene Cano-Pumarega ,&nbsp;Raquel Casitas ,&nbsp;Francisco Campos-Rodríguez ,&nbsp;Manuel Sánchez-de-la-Torre ,&nbsp;Eduardo Nagore ,&nbsp;Antonio Martorell-Calatayud ,&nbsp;Luis Hernández Blasco ,&nbsp;Esther Pastor ,&nbsp;Jorge Abad-Capa ,&nbsp;Josep María Montserrat ,&nbsp;Valentín Cabriada-Nuño ,&nbsp;Jaime Corral-Peñafiel ,&nbsp;Eva Arias ,&nbsp;Carolina Cubillos-Zapata","doi":"10.1016/j.arbres.2025.03.018","DOIUrl":"10.1016/j.arbres.2025.03.018","url":null,"abstract":"<div><h3>Objectives</h3><div>Obstructive sleep apnoea (OSA) has been associated with increased cancer risk and mortality, yet specific biomarkers for patient stratification remain lacking. This study explores the role of immune checkpoint biomarkers, soluble Galectin-9 (sGalectin-9) and TIM-3 (sTIM-3), in identifying OSA patients at higher risk of cancer-related mortality.</div></div><div><h3>Methods</h3><div>We conducted a multicohort, prospective observational study including 684 patients, with and without cancer, who underwent sleep studies. Plasma levels of sGalectin-9 and sTIM-3 were assessed using bead-based multiplexed assays. In vitro and ex vivo models were employed to investigate the pathogenic mechanisms underlying biomarker upregulation and their immunological impact.</div></div><div><h3>Results</h3><div>In severe OSA patients with melanoma or lung cancer, sGalectin-9 and sTIM-3 were associated with tumour aggressiveness and with an increased mortality risk. In the three study cohorts, biomarker levels were higher in severe OSA patients than in the other groups. In non-cancer OSA patients’ monocyte intracellular Galectin-9 and T-lymphocyte membrane-bound TIM-3 were upregulated. Experimental data revealed that intermittent hypoxia drove the expression of these biomarkers, which were positively associated with inflammatory mediators and inversely related to T-cell proliferation and infiltration. These findings underscore a mechanistic link between hypoxemia and immune suppression.</div></div><div><h3>Interpretation</h3><div>sGalectin-9 and sTIM-3 are promising prognostic biomarkers for medium- to long-term survival in OSA patients with melanoma or lung cancer. Their upregulation highlights a potential pathophysiological pathway connecting OSA-induced hypoxemia to cancer aggressiveness through immune modulation. Further validation could inform risk stratification and personalised therapeutic strategies.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 12","pages":"Pages 735-748"},"PeriodicalIF":9.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 46-Year-Old Female With a Left Bronchial Neoplasm Swaying With Respiration","authors":"Qinglin Zhong ,&nbsp;Binglin Lai","doi":"10.1016/j.arbres.2025.06.013","DOIUrl":"10.1016/j.arbres.2025.06.013","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 12","pages":"Pages 805-806"},"PeriodicalIF":9.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COPD and Frailty: Results of a Study Using the Delphi Method","authors":"Roberto Bernabéu-Mora ,&nbsp;Pilar Cubo Romano ,&nbsp;Iñaki Martín Lesende ,&nbsp;Elsa Naval Sendra ,&nbsp;Juan José Soler-Cataluña ,&nbsp;Francisco José Tarazona-Santabalbina","doi":"10.1016/j.arbres.2025.06.008","DOIUrl":"10.1016/j.arbres.2025.06.008","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 12","pages":"Pages 783-786"},"PeriodicalIF":9.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Failure, Late Failure, and Sustained Response to Biologics in Severe Asthma: A Long-term, Real-world, Multicentre study","authors":"D. Dacal Rivas ,&nbsp;E. Martinez-Moragón ,&nbsp;V. Plaza ,&nbsp;C. Cisneros Serrano ,&nbsp;C. Benchimol ,&nbsp;H. Izaguirre Flores ,&nbsp;S. Sánchez-Cuéllar ,&nbsp;M.D. Martínez-Pitarch ,&nbsp;C. Fernández Aracil ,&nbsp;A. Trisán Alonso ,&nbsp;J.C. Serrano Rebollo ,&nbsp;Z. Vásquez Gambasica ,&nbsp;R.M. Díaz Campos ,&nbsp;P. Trujillo Mulato ,&nbsp;I. Escribano Gimeno ,&nbsp;D. Laorden ,&nbsp;E. Arismendi ,&nbsp;N. Marina Malanda ,&nbsp;A. De Diego Damia ,&nbsp;M. Ferrer Galvan ,&nbsp;L.A. Pérez de Llano","doi":"10.1016/j.arbres.2025.04.003","DOIUrl":"10.1016/j.arbres.2025.04.003","url":null,"abstract":"<div><h3>Objectives</h3><div>Only one-third of patients with severe asthma (SA) achieve a complete response to biologics. This study aims to characterize two types of failure: early (EF), occurring ≤12 months after biologic initiation, and late (LF), occurring at any time during follow-up after response has been achieved at 12 months.</div></div><div><h3>Methods</h3><div>This is a multicentre retrospective study of adults treated with the same biologic for ≥24 months. Response was defined as no severe exacerbations in the preceding 12 months, asthma control test ≥20, and no need for maintenance oral corticosteroids. Failure (EF or LF) was defined as non-achievement of any of these objectives.</div></div><div><h3>Results</h3><div>Two hundred and seventy-two patients were analysed with a mean follow-up of 46.1<!--> <!-->±<!--> <!-->19.4 months. At 12 months, 97/272 were classified as PF, but 40% of them recovered response on subsequent visits (by changing inhaled therapy in 74%). Among the 175 responders at 12 months, 124 (70.8%) maintained response throughout the study period, while 51 (29.1%) experienced SF; those patients had lower FEV1 values after 12 months of biological therapy. SF reverted in 36% of cases, with inhaled therapy changes in 41.6%. FEV1 decreased by ≥100<!--> <!-->mL in 12 of 16 cases who did not recover response after SF.</div></div><div><h3>Conclusion</h3><div>Most patients who achieve response at 12 months maintain it over time, but 29% of them suffer LF. Optimization of inhaled therapy can aid response recovery from EF or LF. Maximizing pulmonary function helps to prevent loss of response.</div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 12","pages":"Pages 749-756"},"PeriodicalIF":9.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic Pneumatoceles Mimicking Pulmonary Tuberculosis","authors":"Chee Kiang Phua ,&nbsp;Ming Ren Toh ,&nbsp;Chee Kiang Tay","doi":"10.1016/j.arbres.2025.06.006","DOIUrl":"10.1016/j.arbres.2025.06.006","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 12","pages":"Pages 801-802"},"PeriodicalIF":9.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bordetella bronchiseptica Pneumonia in an Immunocompetent Young Man","authors":"Atif Saleem Siddiqui","doi":"10.1016/j.arbres.2025.07.015","DOIUrl":"10.1016/j.arbres.2025.07.015","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 12","pages":"Pages 799-800"},"PeriodicalIF":9.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood Pulmonary Virus Infection and Future Bronchiectasis","authors":"Paul T. King","doi":"10.1016/j.arbres.2025.05.019","DOIUrl":"10.1016/j.arbres.2025.05.019","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 12","pages":"Pages 730-731"},"PeriodicalIF":9.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Future of Sleep Apnea Research: From Foundational Discoveries to Personalized Medicine","authors":"Monica Levy Andersen ,&nbsp;Sergio Brasil Tufik ,&nbsp;Sergio Tufik","doi":"10.1016/j.arbres.2025.06.011","DOIUrl":"10.1016/j.arbres.2025.06.011","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 12","pages":"Pages 732-734"},"PeriodicalIF":9.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability of Asthma Biomarkers Over a Two-year Period Using Three Distinct Classifications in the MEGA Cohort","authors":"Diana Betancor ,&nbsp;Manuel Jorge Rial ,&nbsp;José María Olaguibel ,&nbsp;Victoria Del Pozo ,&nbsp;María José Alvarez Puebla ,&nbsp;Ebymar Arismendi ,&nbsp;Blanca Barroso ,&nbsp;Irina Bobolea ,&nbsp;Blanca Cárdaba ,&nbsp;Jose Antonio Cañas ,&nbsp;Javier Domínguez-Ortega ,&nbsp;Astrid Crespo-Leshman ,&nbsp;María Jesús Cruz ,&nbsp;Alberto Garcia de la Fuente ,&nbsp;Francisco-Javier González-Barcala ,&nbsp;Jose Antonio Luna-Porta ,&nbsp;Carlos Martínez-Rivera ,&nbsp;Joaquim Mullol ,&nbsp;Xavier Muñoz ,&nbsp;Vicente Plaza ,&nbsp;Joaquin Sastre","doi":"10.1016/j.arbres.2025.06.016","DOIUrl":"10.1016/j.arbres.2025.06.016","url":null,"abstract":"","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":"61 12","pages":"Pages 794-796"},"PeriodicalIF":9.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}