Pub Date : 2025-12-01DOI: 10.1016/j.oftal.2025.06.019
A. Peraza , S. Gómez-Perera , R. Arnay , J. Sigut Saavedra , T. Díaz-Alemán
Objective
The main objective of this study is to develop a tool capable of synthesizing images of the ganglion cell layer (GCL) that simulate glaucoma progression using generative antagonistic networks (GANs).
Material and methods
The dataset includes 406 GCL images of 76 eyes with glaucoma and progression, recorded by a spectral domain optical coherence tomograph (OCT). The Pix2Pix model, a conditional antagonistic generative network, was used to transform the current GCL images into images representing glaucoma progression. A total of 70% of the samples were used for training and 30% for model testing. The structural similarity coefficient was used to analyze the similarity between the real and generated images, and finally, an expert's opinion was used to assess the originality of the generated images.
Results
The synthesized images successfully replicate glaucoma lesion patterns, with good generalizability and reproducibility. The results show a mean structural similarity between 0.76 and 0.78 in the different tests. The test with the expert obtained an accuracy of 57% in distinguishing between real and generated images.
Conclusions
The system developed can generate synthetic images of the GCL with a high similarity to the real ones, demonstrating the effectiveness of the model in synthesizing images that represent the evolution of glaucoma.
{"title":"Redes generativas antagónicas para generar imágenes de la progresión de la capa de células ganglionares de pacientes con glaucoma","authors":"A. Peraza , S. Gómez-Perera , R. Arnay , J. Sigut Saavedra , T. Díaz-Alemán","doi":"10.1016/j.oftal.2025.06.019","DOIUrl":"10.1016/j.oftal.2025.06.019","url":null,"abstract":"<div><h3>Objective</h3><div>The main objective of this study is to develop a tool capable of synthesizing images of the ganglion cell layer (GCL) that simulate glaucoma progression using generative antagonistic networks (GANs).</div></div><div><h3>Material and methods</h3><div>The dataset includes 406 GCL images of 76 eyes with glaucoma and progression, recorded by a spectral domain optical coherence tomograph (OCT). The Pix2Pix model, a conditional antagonistic generative network, was used to transform the current GCL images into images representing glaucoma progression. A total of 70% of the samples were used for training and 30% for model testing. The structural similarity coefficient was used to analyze the similarity between the real and generated images, and finally, an expert's opinion was used to assess the originality of the generated images.</div></div><div><h3>Results</h3><div>The synthesized images successfully replicate glaucoma lesion patterns, with good generalizability and reproducibility. The results show a mean structural similarity between 0.76 and 0.78 in the different tests. The test with the expert obtained an accuracy of 57% in distinguishing between real and generated images.</div></div><div><h3>Conclusions</h3><div>The system developed can generate synthetic images of the GCL with a high similarity to the real ones, demonstrating the effectiveness of the model in synthesizing images that represent the evolution of glaucoma<em>.</em></div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 12","pages":"Pages 759-766"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.oftal.2025.07.011
M. Gobira , M. Gobira , V. Freire , C. Tinoco , G.S. Avelino , P. Carricondo , A. Dias , M.A. Negreiros
Introduction and objectives
The aim of this study was to assess the precision of a web-based tool in measuring color vision in ophthalmic patients, comparing it to the traditional in-clinic evaluation using the Ishihara test, the most used test in clinical context.
Materials and methods
We conducted a prospective validation comparing the Eyecare Colour Vision Test® to the standard Ishihara test, with patients undergoing both tests sequentially. Patients wore their standard spectacles as needed for both tests. Inclusion criteria involved individuals above 18 years with visual acuity equal to or better than + 1 logMAR (20/200) in each eye. Visual acuity measurements were converted from Snellen to LogMAR, and statistical analyses included Bland-Altman and descriptive statistics.
Results
The study, encompassing 330 patients, compared Eyecare Color Vision Test® to conventional Ishihara test, The score for correct responses by the Eyecare Color Vision Test ® was 4073 as compared to 4081 by Ishihara standard test- a concordance rate of 87,88%. Sensitivity of 96.43% (CI 95%, 81.65% to 99.91%), and specificity of 99.34% (CI 95%, 97.63% to 99.92%) for the diagnosis of color vision deficiency.
Conclusion
The Eyecare Color Vision Test® demonstrates accuracy and reliability, with the potential to facilitate remote CVD diagnosis.
本研究的目的是评估一种基于网络的工具在测量眼科患者色视觉方面的准确性，并将其与传统的临床评估方法石原测试进行比较，石原测试是临床上最常用的测试。材料和方法我们进行了前瞻性验证，比较眼保健色觉测试®和标准石原测试，患者依次接受两项测试。患者在两项测试中都需要佩戴标准眼镜。纳入标准为18岁以上、每只眼视力等于或优于+ 1 logMAR（20/200）的个体。视敏度测量由Snellen转换为LogMAR，统计分析包括Bland-Altman和描述性统计。结果该研究包括330名患者，将Eyecare Color Vision Test®与传统的Ishihara测试进行比较，Eyecare Color Vision Test®的正确反应得分为4073，而石原标准测试的正确反应得分为4081，一致性率为87,88%。诊断色觉缺陷的灵敏度为96.43% (CI 95%, 81.65% ~ 99.91%)，特异性为99.34% （CI 95%, 97.63% ~ 99.92%）。结论眼保健色觉测试具有准确性和可靠性，具有促进心血管疾病远程诊断的潜力。
{"title":"Evaluación de la precisión de una prueba digital de visión del color","authors":"M. Gobira , M. Gobira , V. Freire , C. Tinoco , G.S. Avelino , P. Carricondo , A. Dias , M.A. Negreiros","doi":"10.1016/j.oftal.2025.07.011","DOIUrl":"10.1016/j.oftal.2025.07.011","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>The aim of this study was to assess the precision of a web-based tool in measuring color vision in ophthalmic patients, comparing it to the traditional in-clinic evaluation using the Ishihara test, the most used test in clinical context.</div></div><div><h3>Materials and methods</h3><div>We conducted a prospective validation comparing the Eyecare Colour Vision Test® to the standard Ishihara test, with patients undergoing both tests sequentially. Patients wore their standard spectacles as needed for both tests. Inclusion criteria involved individuals above 18 years with visual acuity equal to or better than<!--> <!-->+<!--> <!-->1 logMAR (20/200) in each eye. Visual acuity measurements were converted from Snellen to LogMAR, and statistical analyses included Bland-Altman and descriptive statistics.</div></div><div><h3>Results</h3><div>The study, encompassing 330 patients, compared Eyecare Color Vision Test® to conventional Ishihara test, The score for correct responses by the Eyecare Color Vision Test ® was 4073 as compared to 4081 by Ishihara standard test- a concordance rate of 87,88%. Sensitivity of 96.43% (CI 95%, 81.65% to 99.91%), and specificity of 99.34% (CI 95%, 97.63% to 99.92%) for the diagnosis of color vision deficiency.</div></div><div><h3>Conclusion</h3><div>The Eyecare Color Vision Test® demonstrates accuracy and reliability, with the potential to facilitate remote CVD diagnosis.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 12","pages":"Pages 781-787"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.oftal.2025.07.006
I.A. Domínguez-Varela , L.F. Pérez-Villarreal , J. Dalma-Weiszhausz
{"title":"Recuperación de la retinopatía de Purtscher tras un traumatismo craneoencefálico","authors":"I.A. Domínguez-Varela , L.F. Pérez-Villarreal , J. Dalma-Weiszhausz","doi":"10.1016/j.oftal.2025.07.006","DOIUrl":"10.1016/j.oftal.2025.07.006","url":null,"abstract":"","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 12","pages":"Pages 814-815"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-15DOI: 10.1016/j.oftal.2025.09.001
E. García-Esquinas , M.J. Sánchez , J.J. González-López , F. Rodríguez-Artalejo , B. Pérez-Gómez , en representación de todos los investigadores del proyecto AMBISiON-IMPaCT
{"title":"AMBISiON-IMPaCT: un proyecto de enriquecimiento de la cohorte IMPaCT con medidas de salud ocular para la medicina de precisión","authors":"E. García-Esquinas , M.J. Sánchez , J.J. González-López , F. Rodríguez-Artalejo , B. Pérez-Gómez , en representación de todos los investigadores del proyecto AMBISiON-IMPaCT","doi":"10.1016/j.oftal.2025.09.001","DOIUrl":"10.1016/j.oftal.2025.09.001","url":null,"abstract":"","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 11","pages":"Pages 655-657"},"PeriodicalIF":0.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-11DOI: 10.1016/j.oftal.2025.06.021
M. Rabinovich , K. Vandekerckhove , A. Gericke
We document the clinical ocular presentation of methylmalonic acidemia (MMA) with a mutase defect, specifically the MUT N219Y variant, in a 27-year-old female who presented with sudden bilateral visual acuity deterioration. The ophthalmologic workup included visual acuity testing, biomicroscopic and fundus examinations, macular spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence, multicolor imaging, retinal nerve fiber layer analysis, kinetic and static visual field testing, and head magnetic resonance imaging. The patient demonstrated bilateral visual acuity loss, more severe in the left eye. SD-OCT of the macula and optic nerve appeared normal, yet static visual field testing showed elevated central threshold values bilaterally, and kinetic testing revealed bilateral constriction. MRI of the head revealed bilateral focal signal abnormalities of the optic nerves, with left-sided predominance. This case represents the first detailed ophthalmologic description in a patient with MMA carrying the MUT N219Y variant.
{"title":"Hallazgos oftalmológicos en un paciente con acidemia metilmalónica y la mutación N219Y en la metilmalonil-CoA mutasa","authors":"M. Rabinovich , K. Vandekerckhove , A. Gericke","doi":"10.1016/j.oftal.2025.06.021","DOIUrl":"10.1016/j.oftal.2025.06.021","url":null,"abstract":"<div><div>We document the clinical ocular presentation of methylmalonic acidemia (MMA) with a mutase defect, specifically the MUT N219Y variant, in a 27-year-old female who presented with sudden bilateral visual acuity deterioration. The ophthalmologic workup included visual acuity testing, biomicroscopic and fundus examinations, macular spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence, multicolor imaging, retinal nerve fiber layer analysis, kinetic and static visual field testing, and head magnetic resonance imaging. The patient demonstrated bilateral visual acuity loss, more severe in the left eye. SD-OCT of the macula and optic nerve appeared normal, yet static visual field testing showed elevated central threshold values bilaterally, and kinetic testing revealed bilateral constriction. MRI of the head revealed bilateral focal signal abnormalities of the optic nerves, with left-sided predominance. This case represents the first detailed ophthalmologic description in a patient with MMA carrying the MUT N219Y variant.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 11","pages":"Pages 737-741"},"PeriodicalIF":0.0,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-06DOI: 10.1016/j.oftal.2025.07.012
C. Martínez-Pérez , C. Álvarez-Peregrina , M.Á. Sánchez-Tena , Á. Arance-Gil , C. Villa-Collar
This study explores the interconnections between various publications and authors, identifies distinct research domains concerning light's role in myopia control, and pinpoints the most referenced study within citation networks. A systematic literature search was conducted in the Web of Science database using the keywords «(Myopia OR ‘Refractive error’) AND (Control OR Treatment OR Therapy OR Management) AND (Light OR Ultraviolet OR Solar OR Outdoors)» covering the period from 1990 to December 2024. Citation Network Explorer, VOSviewer, and CiteSpace were used to analyze the publications. A total of 1,468 publications and 5,473 citation networks were identified, with the highest publication volume in 2023 (153 papers). The most cited article, by He et al. in JAMA 2015, focused on the effect of outdoor time on myopia development among children, receiving 588 citations. The analysis clustered the findings into 5 key research areas: dopamine's role, outdoor exposure time, red light therapy, scleral cross-linking efficacy, and intrastromal cross-linking benefits. Overall, the citation network provides a comprehensive assessment of significant studies on sunlight and monochromatic light in myopia prevention and management, emphasizing the importance of preventing axial eye growth.
本研究探讨了各种出版物和作者之间的相互联系，确定了关于光在近视控制中的作用的不同研究领域，并在引文网络中确定了被引用最多的研究。使用关键词“（近视或屈光不正”）和（控制或治疗或治疗或管理）和（光或紫外线或太阳能或户外）”在Web of Science数据库中进行了系统的文献检索，检索时间为1990年至2024年12月。使用Citation Network Explorer、VOSviewer和CiteSpace对出版物进行分析。共发现1468篇论文和5473个引文网络，其中2023年的论文发表量最高（153篇）。被引用最多的文章是He等人在2015年JAMA上发表的一篇关于户外时间对儿童近视发展的影响的文章，被引用588次。该分析将这些发现集中在5个关键研究领域：多巴胺的作用、户外暴露时间、红光疗法、巩膜交联疗效和眼内交联益处。总的来说，引文网络全面评估了日光和单色光在近视预防和管理中的重要研究，强调了防止轴眼生长的重要性。
{"title":"El papel de la luz en el manejo de la miopía: un análisis de redes de citación","authors":"C. Martínez-Pérez , C. Álvarez-Peregrina , M.Á. Sánchez-Tena , Á. Arance-Gil , C. Villa-Collar","doi":"10.1016/j.oftal.2025.07.012","DOIUrl":"10.1016/j.oftal.2025.07.012","url":null,"abstract":"<div><div>This study explores the interconnections between various publications and authors, identifies distinct research domains concerning light's role in myopia control, and pinpoints the most referenced study within citation networks. A systematic literature search was conducted in the Web of Science database using the keywords «(Myopia OR ‘Refractive error’) AND (Control OR Treatment OR Therapy OR Management) AND (Light OR Ultraviolet OR Solar OR Outdoors)» covering the period from 1990 to December 2024. Citation Network Explorer, VOSviewer, and CiteSpace were used to analyze the publications. A total of 1,468 publications and 5,473 citation networks were identified, with the highest publication volume in 2023 (153 papers). The most cited article, by He et al. in <em>JAMA</em> 2015, focused on the effect of outdoor time on myopia development among children, receiving 588 citations. The analysis clustered the findings into 5<!--> <!-->key research areas: dopamine's role, outdoor exposure time, red light therapy, scleral cross-linking efficacy, and intrastromal cross-linking benefits. Overall, the citation network provides a comprehensive assessment of significant studies on sunlight and monochromatic light in myopia prevention and management, emphasizing the importance of preventing axial eye growth.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 11","pages":"Pages 696-709"},"PeriodicalIF":0.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bacteria isolated in postoperative endophthalmitis (PE) were reduced to cefuroxime-resistant bacteria in cataract surgery with intracameral cefuroxime as prophylaxis; age > 84 years was at risk for PEs caused by Gram-negative-bacteria and Staphylococci; no risks were identified for Enterococci, the most abundant isolations. The prevalence of Enterococci in the preoperative conjunctiva was associated with age > 74 years, diabetes, obesity, and dacryocystorhinostomy-history (DCR-history). The aim of the study is to differentiate the risk of age from that of other patient characteristics, establishing 2 different age groups.
Materials and methods
We conducted a retrospective cross-sectional study in a tertiary referral center. In 7,085 patients < 75 years old and 7,798 ≥ 75 years, the incidence rate ratio (IRR) of Enterococci, Enterobacteriaceae, Non-fermentative-Gram-negative-bacilli (NFGNB) and Coagulase-negative-Staphylococci (CNS) was calculated for the following factors: diabetes, obesity, DCR-history, sex-male, smoking-habit, and climate, using multivariate Poisson regression, IBM SPSS Statistic for Windows, version 25.0. Armonk, NY: IBM Corp.
Results
Diabetes, obesity, male-sex and smoking-habit were more prevalent in patients < 75 years old. The IRRs of Enterococci, Enterobacteriaceae and NFGNB were higher in this age group: [Enterococci IRRs: diabetes, 1.54 vs 1.42; obesity, 2.95 vs 1.50; DCR-history, 3.78 vs 1.08]; [Enterobacteriaceae IRRs: diabetes, 1.47 vs 1.13; obesity, 2.27 vs 1.99; male-sex, 1.76 vs 1.65]; [NFGNB IRRs: diabetes, 1.79 vs 1.16; autumn-weather, 2.05 vs 1.56]. Diabetes-obesity simultaneously: Enterobacteriaceae IRR, 3.30 vs 2.28; Enterococci IRR, 3.28 vs 1.62.
Conclusions
Diabetes, obesity and DCR-history increase the IRR of Enterococci, Enterobacteriaceae and NFGNB in patients < 75 years more than they actually do in patients ≥ 75.
背景与目的应用头孢呋辛预防白内障术后眼内炎（PE）的细菌减少为头孢呋辛耐药菌；84岁的患者存在革兰氏阴性菌和葡萄球菌所致PEs的风险；未发现最丰富的分离株肠球菌的风险。术前结膜中肠球菌的流行与年龄（74岁）、糖尿病、肥胖和泪囊造口史（DCR-history）相关。该研究的目的是区分年龄与其他患者特征的风险，建立了两个不同的年龄组。材料和方法我们在一家三级转诊中心进行了回顾性横断面研究。在7085例75岁和7798例≥75岁的患者中，采用IBM SPSS统计软件（Windows） 25.0版本的多元泊松回归，计算肠球菌、肠杆菌科、非发酵革兰氏阴性杆菌（NFGNB）和凝固酶阴性葡萄球菌（CNS）的发病率比（IRR），考虑以下因素：糖尿病、肥胖、dcr病史、性别-男性、吸烟习惯和气候。结果糖尿病、肥胖、男性性行为和吸烟习惯在75岁以上的患者中更为普遍。该年龄组肠球菌、肠杆菌科和NFGNB的IRRs较高：[肠球菌：糖尿病，1.54 vs 1.42；肥胖，2.95比1.50；dcr -病史（3.78 vs 1.08）；[肠杆菌科IRRs：糖尿病，1.47 vs 1.13；肥胖，2.27 vs 1.99；男性（1.76 vs 1.65）；[NFGNB irs：糖尿病，1.79 vs 1.16；秋天的天气，2.05 vs 1.56]。糖尿病-肥胖同时发生：肠杆菌科IRR， 3.30 vs 2.28；肠球菌IRR为3.28 vs 1.62。结论糖尿病、肥胖和有dcr病史的患者中肠球菌、肠杆菌科和NFGNB的IRR比实际≥75岁的患者高75岁。
{"title":"Riesgo de colonización conjuntival por bacterias cefuroxima-resistentes en la cirugía de cataratas de pacientes menores de 75 años y en los de esa edad o mayor","authors":"J.L. Urcelay-Segura , J.M. Bellón-Cano , T. Cuesta-Rodríguez , M.E. Fernández-Rubio","doi":"10.1016/j.oftal.2025.06.004","DOIUrl":"10.1016/j.oftal.2025.06.004","url":null,"abstract":"<div><h3>Background and objective</h3><div>Bacteria isolated in postoperative endophthalmitis (PE) were reduced to cefuroxime-resistant bacteria in cataract surgery with intracameral cefuroxime as prophylaxis; age ><!--> <!-->84 years was at risk for PEs caused by Gram-negative-bacteria and Staphylococci; no risks were identified for Enterococci, the most abundant isolations. The prevalence of Enterococci in the preoperative conjunctiva was associated with age<!--> <!-->><!--> <!-->74 years, diabetes, obesity, and dacryocystorhinostomy-history (DCR-history). The aim of the study is to differentiate the risk of age from that of other patient characteristics, establishing 2 different age groups.</div></div><div><h3>Materials and methods</h3><div>We conducted a retrospective cross-sectional study in a tertiary referral center. In 7,085 patients <<!--> <!-->75 years old and 7,798 ≥<!--> <!-->75 years, the incidence rate ratio (IRR) of Enterococci, Enterobacteriaceae, Non-fermentative-Gram-negative-bacilli (NFGNB) and Coagulase-negative-Staphylococci (CNS) was calculated for the following factors: diabetes, obesity, DCR-history, sex-male, smoking-habit, and climate, using multivariate Poisson regression, IBM SPSS Statistic for Windows, version 25.0. Armonk, NY: IBM Corp.</div></div><div><h3>Results</h3><div>Diabetes, obesity, male-sex and smoking-habit were more prevalent in patients <<!--> <!-->75 years old. The IRRs of Enterococci, Enterobacteriaceae and NFGNB were higher in this age group: [Enterococci IRRs: diabetes, 1.54 vs 1.42; obesity, 2.95 vs 1.50; DCR-history, 3.78 vs 1.08]; [Enterobacteriaceae IRRs: diabetes, 1.47 vs 1.13; obesity, 2.27 vs 1.99; male-sex, 1.76 vs 1.65]; [NFGNB IRRs: diabetes, 1.79 vs 1.16; autumn-weather, 2.05 vs 1.56]. Diabetes-obesity simultaneously: Enterobacteriaceae IRR, 3.30 vs 2.28; Enterococci IRR, 3.28 vs 1.62.</div></div><div><h3>Conclusions</h3><div>Diabetes, obesity and DCR-history increase the IRR of Enterococci, Enterobacteriaceae and NFGNB in patients <<!--> <!-->75 years more than they actually do in patients ≥ 75.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 10","pages":"Pages 592-600"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.oftal.2025.05.002
R. Estévez-Domínguez , C. Rocha-de-Lossada , M. Rodríguez-Calvo-de-Mora , J. Etxebarria-Ecenarro , J. García-Montesinos-Gutiérrez
Keratitis-ichthyosis-deafness (KID) syndrome is a rare disease caused by mutations in the GJB2 gene. This gene encodes the protein connexin 26, which is essential for gap junctions in the epidermis, inner ear and corneal epithelium. Clinically, it is characterised by dermal hyperkeratotic lesions, sensorineural deafness and chronic keratitis that is difficult to manage. We describe two siblings diagnosed with KID syndrome who were followed up in our department for more than 15 years. Both developed numerous ocular complications associated with chronic keratitis and limbar insufficiency that required multiple keratoplasties, systemic immunosuppression and even keratoprosthesis. This case is noteworthy for the long-term follow-up of this condition and the difficult ocular management, highlighting the importance of a multidisciplinary approach and personalised therapeutic strategies.
{"title":"Manejo oftalmológico en el síndrome de KID: experiencia clínica a largo plazo","authors":"R. Estévez-Domínguez , C. Rocha-de-Lossada , M. Rodríguez-Calvo-de-Mora , J. Etxebarria-Ecenarro , J. García-Montesinos-Gutiérrez","doi":"10.1016/j.oftal.2025.05.002","DOIUrl":"10.1016/j.oftal.2025.05.002","url":null,"abstract":"<div><div>Keratitis-ichthyosis-deafness (KID) syndrome is a rare disease caused by mutations in the GJB2 gene. This gene encodes the protein connexin 26, which is essential for gap junctions in the epidermis, inner ear and corneal epithelium. Clinically, it is characterised by dermal hyperkeratotic lesions, sensorineural deafness and chronic keratitis that is difficult to manage. We describe two siblings diagnosed with KID syndrome who were followed up in our department for more than 15 years. Both developed numerous ocular complications associated with chronic keratitis and limbar insufficiency that required multiple keratoplasties, systemic immunosuppression and even keratoprosthesis. This case is noteworthy for the long-term follow-up of this condition and the difficult ocular management, highlighting the importance of a multidisciplinary approach and personalised therapeutic strategies.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 10","pages":"Pages 625-629"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.oftal.2025.05.003
J.L. Sánchez-Vicente, M. Portillo-Martínez, J.V. Guijarro-Ambel, E.M. Gámez-Jiménez, E. Cosano-Palma, F. López-Herrero
Perforation of the eyeball during retrobulbar anesthesia is rarely reported. A case of inadvertent ocular perforation during retrobulbar anesthesia in cataract surgery is presented. Retinal complications and follow up after six months are described.
A 58-year-old man presented with vision loss following cataract surgery on his right eye by phacoemulsification and intraocular lens implantation under retrobulbar anaesthesia performed one week earlier. Visual acuity was 0.05. Fundus examination revealed a vitreous haemorrhage in the lower area. A rounded haemorrhage was present next to the lower temporal arcade with a possible entry orifice. Optical coherence tomography, tomographic angiography and fluorescein angiography showed retinal ischaemia in the juxtapapillary macular area.
The patient was followed for 6 months. Visual acuity improved to 0.5. Optical coherence tomography and tomographic angiography showed a reduction of the edema in the retinal layers, with a persistent loss of the inner nuclear and outer plexiform layer
Accidental intravitreal injection of bupivacaine and lidocaine during retrobulbar anaesthesia can result in permanent visual impairment. Extreme attention should be paid to the injection technique to avoid this complication.
{"title":"Isquemia macular tras perforación inadvertida del globo ocular e inyección intravítrea de anestésicos durante una anestesia retrobulbar","authors":"J.L. Sánchez-Vicente, M. Portillo-Martínez, J.V. Guijarro-Ambel, E.M. Gámez-Jiménez, E. Cosano-Palma, F. López-Herrero","doi":"10.1016/j.oftal.2025.05.003","DOIUrl":"10.1016/j.oftal.2025.05.003","url":null,"abstract":"<div><div>Perforation of the eyeball during retrobulbar anesthesia is rarely reported. A case of inadvertent ocular perforation during retrobulbar anesthesia in cataract surgery is presented. Retinal complications and follow up after six months are described.</div><div>A 58-year-old man presented with vision loss following cataract surgery on his right eye by phacoemulsification and intraocular lens implantation under retrobulbar anaesthesia performed one week earlier. Visual acuity was 0.05. Fundus examination revealed a vitreous haemorrhage in the lower area. A rounded haemorrhage was present next to the lower temporal arcade with a possible entry orifice. Optical coherence tomography, tomographic angiography and fluorescein angiography showed retinal ischaemia in the juxtapapillary macular area.</div><div>The patient was followed for 6 months. Visual acuity improved to 0.5. Optical coherence tomography and tomographic angiography showed a reduction of the edema in the retinal layers, with a persistent loss of the inner nuclear and outer plexiform layer</div><div>Accidental intravitreal injection of bupivacaine and lidocaine during retrobulbar anaesthesia can result in permanent visual impairment. Extreme attention should be paid to the injection technique to avoid this complication.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 10","pages":"Pages 630-635"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.oftal.2025.06.013
F. Calleja Casado , A. Caro Ortega , E. Gracia Rovira , A. Duch Samper
{"title":"Inteligencia artificial y telemedicina en oculoplastia: avances recientes, aplicaciones clínicas y desafíos emergentes","authors":"F. Calleja Casado , A. Caro Ortega , E. Gracia Rovira , A. Duch Samper","doi":"10.1016/j.oftal.2025.06.013","DOIUrl":"10.1016/j.oftal.2025.06.013","url":null,"abstract":"","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 10","pages":"Pages 650-651"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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