Archivos De La Sociedad Espanola De Oftalmologia最新文献

英文中文

Eficacia y seguridad del implante de acetónido de fluocinolona en edema macular y uveítis posterior no infecciosa: seguimiento de 5 años 氟喹诺酮类丙酮类植入物治疗非传染性黄斑水肿和后卵母细胞炎的有效性和安全性：5年随访

Q3 Medicine

Archivos De La Sociedad Espanola De Oftalmologia

Pub Date : 2025-12-01 Epub Date: 2025-08-18 DOI: 10.1016/j.oftal.2025.07.003

N. Ruiz del Rio, F. Garcia Ibor, E. Gracia Rovira, J.M. Vilaplana Mora, L. Sanz Gallen, A.M. Duch Samper

Objective

To evaluate the safety and efficacy profile of the fluocinolone acetonide implant (FAI) in patients with non-infectious posterior segment uveitis over a 60-month follow-up period.

Method

We retrospective conducted a study with a mean follow-up of 47 months (minimum, 18; maximum, 60). The study included 11 eyes (9 patients), with a male-to-female ratio of 1:8. The etiology of uveitis was heterogeneous. Efficacy parameters included visual acuity (VA) and Central macular thickness (CMT), and the ones who needed adjuvant therapy or re-injection. Safety parameters focused on the development of cataracts and intraocular hypertension.

Results

Real-world outcomes were assessed. Both VA recovery and CMT reduction were achieved between 3 to 6 months after FAI implantation and remained stable at the follow-up. All patients but one were pseudophakic prior to implantation. The phakic patient developed early cataract formation, requiring surgery 9 months post-implantation. All cases had previously received intravitreal dexamethasone. Five eyes (45.4%) required topical hypotensive therapy, and none glaucoma surgery. No patient required periodic adjuvant therapy or additional FAI injections, even among those with the longest follow-up periods. Two cases (18.1%) exhibited mild inflammatory activity in the macular area at months 33 and 35 post-implantation. These episodes were successfully resolved with sub-Tenon triamcinolone injections, maintaining clinical stability thereafter.

Conclusions

The FAI, in our series of cases, turned out to be an effective and safe therapy for non-infectious uveitic macular edema, providing sustained and long-lasting effects, in some cases up to 60 months post-implantation. Sub-Tenon triamcinolone proves to be a valuable adjunctive therapy.

目的评价氟西诺酮植入物（FAI）治疗非感染性后段葡萄膜炎患者60个月的安全性和有效性。方法回顾性研究，平均随访47个月（最短18个月，最长60个月）。研究纳入11只眼（9例），男女比例为1:8。葡萄膜炎的病因不同。疗效指标包括视力（VA）、中央黄斑厚度（CMT）及是否需要辅助治疗或再注射。安全性参数集中在白内障和眼内高压的发展。结果评估了真实世界的结果。在植入FAI后3 - 6个月，VA恢复和CMT减少均可实现，并在随访中保持稳定。除1例患者外，所有患者在植入前均为假性晶状体。晶状体患者出现早期白内障形成，在晶状体植入术9个月后需要手术。所有病例均曾接受玻璃体内地塞米松治疗。5只眼（45.4%）需要局部降压治疗，没有青光眼手术。没有患者需要定期辅助治疗或额外的FAI注射，即使是那些随访时间最长的患者。2例（18.1%）在植入后33个月和35个月黄斑区出现轻度炎症活动。这些发作成功地解决了亚tenon曲安奈德注射，此后保持临床稳定。结论：在我们的一系列病例中，FAI被证明是一种有效和安全的治疗非感染性葡萄膜黄斑水肿的方法，具有持续和持久的效果，在某些情况下可达植入后60个月。亚tenon曲安奈德被证明是一种有价值的辅助治疗。

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引用次数: 0

Retinopatía asociada a síndrome de MELAS. A propósito de un caso 与MELAS综合征相关的视网膜病变。关于一个案例

Q3 Medicine

Archivos De La Sociedad Espanola De Oftalmologia

Pub Date : 2025-12-01 Epub Date: 2025-08-22 DOI: 10.1016/j.oftal.2025.06.020

A.B. González Escobar

引用次数: 0

Hamartoma congénito simple del epitelio pigmentario de la retina bilateral 双侧视网膜色素上皮的简单先天性畸形

Q3 Medicine

Archivos De La Sociedad Espanola De Oftalmologia

Pub Date : 2025-12-01 Epub Date: 2025-08-23 DOI: 10.1016/j.oftal.2025.06.017

S. Mejía-Freire , G. De La Mata

Congenital simple hamartoma of the retinal pigment epithelium is a rare, benign retinal lesion, rarely seen bilaterally. This case shows a 46-year-old man initially misdiagnosed with macular dystrophy, whose vision progressively declined over several years due to concomitant cataracts. Multimodal imaging, including OCT, was key in differentiating from more serious conditions such as choroidal melanoma. With no growth or secondary complications, the lesion remains under regular monitoring. This case underscores the importance of imaging in distinguishing CSHRPE from other chorioretinal disorders.

先天性单纯性视网膜色素上皮错构瘤是一种罕见的良性视网膜病变，罕见于双侧。本病例显示一名46岁男子最初被误诊为黄斑营养不良，由于并发白内障，其视力在几年内逐渐下降。包括OCT在内的多模态成像是区分脉络膜黑色素瘤等更严重疾病的关键。由于没有生长或继发性并发症，病变仍需定期监测。本病例强调了影像学在鉴别CSHRPE与其他绒毛膜视网膜疾病中的重要性。

引用次数: 0

Redes generativas antagónicas para generar imágenes de la progresión de la capa de células ganglionares de pacientes con glaucoma 生成青光眼患者神经节细胞层进展图像的对抗生成网络

Q3 Medicine

Archivos De La Sociedad Espanola De Oftalmologia

Pub Date : 2025-12-01 Epub Date: 2025-08-21 DOI: 10.1016/j.oftal.2025.06.019

A. Peraza , S. Gómez-Perera , R. Arnay , J. Sigut Saavedra , T. Díaz-Alemán

Objective

The main objective of this study is to develop a tool capable of synthesizing images of the ganglion cell layer (GCL) that simulate glaucoma progression using generative antagonistic networks (GANs).

Material and methods

The dataset includes 406 GCL images of 76 eyes with glaucoma and progression, recorded by a spectral domain optical coherence tomograph (OCT). The Pix2Pix model, a conditional antagonistic generative network, was used to transform the current GCL images into images representing glaucoma progression. A total of 70% of the samples were used for training and 30% for model testing. The structural similarity coefficient was used to analyze the similarity between the real and generated images, and finally, an expert's opinion was used to assess the originality of the generated images.

Results

The synthesized images successfully replicate glaucoma lesion patterns, with good generalizability and reproducibility. The results show a mean structural similarity between 0.76 and 0.78 in the different tests. The test with the expert obtained an accuracy of 57% in distinguishing between real and generated images.

Conclusions

The system developed can generate synthetic images of the GCL with a high similarity to the real ones, demonstrating the effectiveness of the model in synthesizing images that represent the evolution of glaucoma.

本研究的主要目的是开发一种能够合成神经节细胞层（GCL）图像的工具，该图像利用生成性拮抗网络（GANs）模拟青光眼的进展。材料和方法数据集包括76只青光眼的406张GCL图像，由光谱域光学相干断层扫描（OCT）记录。使用条件拮抗生成网络Pix2Pix模型将当前GCL图像转换为青光眼进展图像。总共70%的样本用于训练，30%用于模型测试。利用结构相似系数分析真实图像与生成图像的相似度，最后利用专家意见评价生成图像的独创性。结果合成图像成功地复制了青光眼病变模式，具有良好的概括性和重复性。结果表明，不同试验的平均结构相似度在0.76 ~ 0.78之间。专家的测试在区分真实图像和生成图像方面获得了57%的准确率。结论所开发的系统能够生成与真实图像相似度较高的GCL合成图像，证明了该模型在合成代表青光眼演变的图像方面的有效性。

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引用次数: 0

Evaluación de la precisión de una prueba digital de visión del color 评估数字色觉测试的准确性

Q3 Medicine

Archivos De La Sociedad Espanola De Oftalmologia

Pub Date : 2025-12-01 Epub Date: 2025-09-27 DOI: 10.1016/j.oftal.2025.07.011

M. Gobira , M. Gobira , V. Freire , C. Tinoco , G.S. Avelino , P. Carricondo , A. Dias , M.A. Negreiros

Introduction and objectives

The aim of this study was to assess the precision of a web-based tool in measuring color vision in ophthalmic patients, comparing it to the traditional in-clinic evaluation using the Ishihara test, the most used test in clinical context.

Materials and methods

We conducted a prospective validation comparing the Eyecare Colour Vision Test® to the standard Ishihara test, with patients undergoing both tests sequentially. Patients wore their standard spectacles as needed for both tests. Inclusion criteria involved individuals above 18 years with visual acuity equal to or better than + 1 logMAR (20/200) in each eye. Visual acuity measurements were converted from Snellen to LogMAR, and statistical analyses included Bland-Altman and descriptive statistics.

Results

The study, encompassing 330 patients, compared Eyecare Color Vision Test® to conventional Ishihara test, The score for correct responses by the Eyecare Color Vision Test ® was 4073 as compared to 4081 by Ishihara standard test- a concordance rate of 87,88%. Sensitivity of 96.43% (CI 95%, 81.65% to 99.91%), and specificity of 99.34% (CI 95%, 97.63% to 99.92%) for the diagnosis of color vision deficiency.

Conclusion

The Eyecare Color Vision Test® demonstrates accuracy and reliability, with the potential to facilitate remote CVD diagnosis.

本研究的目的是评估一种基于网络的工具在测量眼科患者色视觉方面的准确性，并将其与传统的临床评估方法石原测试进行比较，石原测试是临床上最常用的测试。材料和方法我们进行了前瞻性验证，比较眼保健色觉测试®和标准石原测试，患者依次接受两项测试。患者在两项测试中都需要佩戴标准眼镜。纳入标准为18岁以上、每只眼视力等于或优于+ 1 logMAR（20/200）的个体。视敏度测量由Snellen转换为LogMAR，统计分析包括Bland-Altman和描述性统计。结果该研究包括330名患者，将Eyecare Color Vision Test®与传统的Ishihara测试进行比较，Eyecare Color Vision Test®的正确反应得分为4073，而石原标准测试的正确反应得分为4081，一致性率为87,88%。诊断色觉缺陷的灵敏度为96.43% (CI 95%, 81.65% ~ 99.91%)，特异性为99.34% （CI 95%, 97.63% ~ 99.92%）。结论眼保健色觉测试具有准确性和可靠性，具有促进心血管疾病远程诊断的潜力。

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引用次数: 0

Recuperación de la retinopatía de Purtscher tras un traumatismo craneoencefálico 脑外伤后Purtscher视网膜病变的恢复

Q3 Medicine

Archivos De La Sociedad Espanola De Oftalmologia

Pub Date : 2025-12-01 Epub Date: 2025-08-18 DOI: 10.1016/j.oftal.2025.07.006

I.A. Domínguez-Varela , L.F. Pérez-Villarreal , J. Dalma-Weiszhausz

引用次数: 0

Síndrome de dispersión pigmentaria y glaucoma pigmentario: relevancia diagnóstica de la tríada clásica en una población mediterránea 色散综合征和色素性青光眼：典型三联蛋白在地中海人群中的诊断相关性

Q3 Medicine

Archivos De La Sociedad Espanola De Oftalmologia

Pub Date : 2025-11-01 Epub Date: 2025-08-19 DOI: 10.1016/j.oftal.2025.07.008

J. Benitez-del-Castillo , M. Villalba-Conde , V. Amaya-López , M.D. Pinazo-Duran

Introduction and objectives

To assess prevalence of classic clinical signs of pigment dispersion syndrome (PDS) in PDS and pigmentary glaucoma (PG) in Caucasian patients from Southern Spain.

Materials and methods

Cross-sectional observational case-series study evaluating the prevalence of characteristic clinical signs of PDS: Krukenberg spindle (KS), trabecular meshwork pigmentation (TMP) and iris transillumination defects (ITD). Differences between PDS and PG patients are evaluated and the probability of association with PG of clinical signs with statistically significant differences is also calculated (Odds Ratio [OR] in logistic regression analysis).

Results

144 PDS/PG patients. Prevalence of KS, TMP and ITD is 91%, 88.9% and 24.3%. 48 right eyes (66.7%) were PDS and 24 right eyes (33.3%) were considered PG patients. Prevalence of KS is 95.8% in PDS and 91.7% in PG (P = .47). Prevalence of TMP is 87.5% in PDS and 95.8% in PG (P = .26). Prevalence of ITD is 16.7% in PDS and 41.7% in PG (P = .02). OR of those presenting PG is 3.57 for ITD (95% CI: 1.17 to 10.85) (P = .02).

Conclusions

There are no major differences in the prevalence of KS and TMP in our population of patients with PDS/PG compared to published data in the Caucasian population (91% vs 95% for KS and 88.9% vs 86% for TMP) but there are differences in the prevalence of ITD (24.3% vs 86%).

介绍与目的评估西班牙南部高加索患者色素弥散综合征（PDS）和色素性青光眼（PG）典型临床体征的患病率。材料和方法通过横断面观察性病例系列研究评估PDS的特征性临床体征：Krukenberg纺锤体（KS）、小梁网色素沉着（TMP）和虹膜透射缺陷（ITD）的患病率。评估PDS与PG患者之间的差异，并计算有统计学差异的临床体征与PG相关的概率（logistic回归分析中的Odds Ratio [OR]）。结果144例PDS/PG患者。KS、TMP和ITD患病率分别为91%、88.9%和24.3%。48只右眼（66.7%）为PDS， 24只右眼（33.3%）为PG。PDS患者KS患病率为95.8%，PG患者为91.7% （P = 0.47）。PDS患者TMP患病率为87.5%，PG患者为95.8% （P = 0.26）。PDS的ITD患病率为16.7%，PG为41.7% （P = 0.02）。ITD患者PG的OR为3.57 (95% CI: 1.17 ~ 10.85) （P = 0.02）。结论：与已发表的高加索人群数据相比，PDS/PG患者中KS和TMP的患病率无显著差异（KS为91%对95%，TMP为88.9%对86%），但ITD的患病率存在差异（24.3%对86%）。

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引用次数: 0

El papel de la luz en el manejo de la miopía: un análisis de redes de citación 光在近视管理中的作用：引文网络分析

Q3 Medicine

Archivos De La Sociedad Espanola De Oftalmologia

Pub Date : 2025-11-01 Epub Date: 2025-10-06 DOI: 10.1016/j.oftal.2025.07.012

C. Martínez-Pérez , C. Álvarez-Peregrina , M.Á. Sánchez-Tena , Á. Arance-Gil , C. Villa-Collar

This study explores the interconnections between various publications and authors, identifies distinct research domains concerning light's role in myopia control, and pinpoints the most referenced study within citation networks. A systematic literature search was conducted in the Web of Science database using the keywords «(Myopia OR ‘Refractive error’) AND (Control OR Treatment OR Therapy OR Management) AND (Light OR Ultraviolet OR Solar OR Outdoors)» covering the period from 1990 to December 2024. Citation Network Explorer, VOSviewer, and CiteSpace were used to analyze the publications. A total of 1,468 publications and 5,473 citation networks were identified, with the highest publication volume in 2023 (153 papers). The most cited article, by He et al. in JAMA 2015, focused on the effect of outdoor time on myopia development among children, receiving 588 citations. The analysis clustered the findings into 5 key research areas: dopamine's role, outdoor exposure time, red light therapy, scleral cross-linking efficacy, and intrastromal cross-linking benefits. Overall, the citation network provides a comprehensive assessment of significant studies on sunlight and monochromatic light in myopia prevention and management, emphasizing the importance of preventing axial eye growth.

本研究探讨了各种出版物和作者之间的相互联系，确定了关于光在近视控制中的作用的不同研究领域，并在引文网络中确定了被引用最多的研究。使用关键词“（近视或屈光不正”）和（控制或治疗或治疗或管理）和（光或紫外线或太阳能或户外）”在Web of Science数据库中进行了系统的文献检索，检索时间为1990年至2024年12月。使用Citation Network Explorer、VOSviewer和CiteSpace对出版物进行分析。共发现1468篇论文和5473个引文网络，其中2023年的论文发表量最高（153篇）。被引用最多的文章是He等人在2015年JAMA上发表的一篇关于户外时间对儿童近视发展的影响的文章，被引用588次。该分析将这些发现集中在5个关键研究领域：多巴胺的作用、户外暴露时间、红光疗法、巩膜交联疗效和眼内交联益处。总的来说，引文网络全面评估了日光和单色光在近视预防和管理中的重要研究，强调了防止轴眼生长的重要性。

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引用次数: 0

Análisis de los factores asociados a la formación de cataratas posvitrectomía en pacientes fáquicos sometidos a vitrectomía por desprendimiento de retina regmatógeno 分析因regmatargenin脱落而进行玻璃切除术的咽部患者产生白内障的因素

Q3 Medicine

Archivos De La Sociedad Espanola De Oftalmologia

Pub Date : 2025-11-01 Epub Date: 2025-08-23 DOI: 10.1016/j.oftal.2025.07.009

A. Gibelalde, S. Pinar-Sueiro, I. Martínez-Soroa

Introductions and objetives

This study assesses risk factors for developing cataracts after vitrectomy with tamponade for rhegmatogenous retinal detachment (RRD) in phakic patients and explores the potencial causal relationship between RRD surgery and the development of cataracts.

Materials and methods

This was a retrospective study analysing the medical records of patients undergoing RRD surgery between 2012 and 2020 (9 years) at Donostia University Hospital (HUD). We collected data on the date of phacoemulsification surgery after vitrectomy surgery for RRD, as well as the type of vitrectomy and patient characteristics.

Results

Patients who underwent cataract surgery were on average older (mean age of 60.79 years old ± 9.49) than those who did not undergo this type of surgery during follow-up (52.97 years old ± 13.59), the difference being statistically significant (P < .0001). Classifying patients by age at the date of the vitrectomy (≤ 50 years or > 50 years of age), we found between-group differences in phacoemulsification rates after vitrectomy in the follow-up period, cataract surgery being performed in a third of the younger group and three-quarters of the older group (P < .0001).

Conclusions

Patients with phakic RRD under 50 years old have a lower risk of cataract development after vitrectomy with tamponade than those over 50 years old. The use of long-acting tamponade gases such as C3F8 and silicone oil in phakic patients seems to increase the likelihood of needing early cataract surgery after RRD surgery with PPV.

介绍和目的本研究评估晶状体切除术合并填塞治疗孔源性视网膜脱离（RRD）后白内障发生的危险因素，并探讨RRD手术与白内障发生之间的潜在因果关系。材料和方法本研究是一项回顾性研究，分析了2012年至2020年（9年）在多诺斯蒂亚大学医院（HUD）接受RRD手术的患者的医疗记录。我们收集了RRD玻璃体切除术后超声乳化手术的资料，以及玻璃体切除术的类型和患者的特征。结果随访期间，行白内障手术的患者平均年龄（60.79岁±9.49岁）大于未行白内障手术的患者（52.97岁±13.59岁），差异有统计学意义（P < .0001）。根据患者在玻璃体切除术时的年龄（≤50岁或≤50岁）对患者进行分类，我们发现随访期间玻璃体切除术后的超声乳化率在组间存在差异，三分之一的年轻组和四分之三的老年组进行了白内障手术（P < .0001）。结论50岁以下白内障患者玻璃体切除术合并填塞后白内障发展风险低于50岁以上患者。在有晶状体的患者中使用长效填塞气体，如C3F8和硅油，似乎增加了在有PPV的RRD手术后需要早期白内障手术的可能性。

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引用次数: 0

Implante intravítreo de acetónido de fluocinolona (ILUVIEN®) para el tratamiento del xantogranuloma ocular juvenil 静脉注射氟喹诺酮类丙酮（ILUVIEN®），用于治疗幼年眼黄肉芽肿

Q3 Medicine

Archivos De La Sociedad Espanola De Oftalmologia

Pub Date : 2025-11-01 Epub Date: 2025-07-26 DOI: 10.1016/j.oftal.2024.09.007

M. Larrañaga Cores , M. Asencio Durán , J. Peralta Calvo , M. Feito Rodríguez , G. Amorena Santesteban , A. del Hierro Zarzuelo , A. Boto-de-los-Bueis

This is the case of a 14-years-old woman referred to our ophthalmology department with suspected iris juvenile xanthogranuloma, with reported bilateral, hematic recurrent uveitis as soon as she discontinued treatment with topical prednisolone acetate eye drops. After numerous treatments at the 3-year follow-up, including oral steroids, repeated injections of subtenon triamcinolone acetonide and intracameral and intravitreal anti-VEGF, treatment with intravitreal fluocinolone acetonide implant (ILUVIEN®) in both eyes was decided. Evolution since then and at the 10-month follow-up has been satisfactory; the patient has not exhibited any new episodes of ocular inflammation or hyphema despite the progressive withdrawal of topical corticosteroids, and vision has remained at 20/20 in both eyes. As far as we know, this is the first case of bilateral ocular juvenile xanthogranuloma successfully treated with an intravitreal fluocinolone implant.

这是一名14岁的女性，因疑似虹膜幼年黄色肉芽肿而转诊至我们的眼科，她在停止使用醋酸泼尼松龙眼药水治疗后立即报告双侧出血性复发性葡萄膜炎。经过3年随访期间的多次治疗，包括口服类固醇、反复注射曲安奈德次坦、眼内和玻璃体内抗vegf，最终决定双眼使用玻璃体内醋酸氟西诺酮种植体（ILUVIEN®）治疗。此后和10个月随访的进展令人满意；尽管局部皮质类固醇逐渐停用，但患者未出现任何新的眼部炎症或前房积血发作，双眼视力保持在20/20。据我们所知，这是首例通过玻璃体内氟西诺酮植入成功治疗双侧幼年性眼黄色肉芽肿的病例。

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引用次数: 0

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