Pub Date : 2025-08-01DOI: 10.1016/j.oftal.2025.04.007
L.A. Garza-Garza , A.P. Arizpe , R. Morales-Reyes , R.A. Villafuerte-de la Cruz , M. Garza-León
Introduction and objectives
Kabuki syndrome is a rare congenital malformation syndrome originally described by Niikawa et al. in 1981. A wide array of pathogenic variants and phenotypes have been described ever since. However, cases from Hispanic-Mexican populations evaluated with multimodal imaging are scarce. Therefore, the aim of this study is to report on the multimodal evaluation of a Hispanic-Mexican case with a novel pathogenic variant.
Materials and methods
Next generation sequencing was used to search for pathogenic variants in KMT2D in the proband and her parents and sibling. A full systemic and ophthalmological examination along with ancillary studies were undertaken.
Results
Only the proband had relevant findings and a compatible pathogenic variant in KMT2D. The systemic and ophthalmic phenotype correlates with previous reports of Kabuki syndrome. Ancillary studies of the retina, optic nerve, macular area, macular vascular flow and cornea were within normal limits. The novel detected pathogenic variant in the proband was c.6341del (p.Gly2114Alafs*30) in KMT2D.
Conclusions
The present paper reports on a novel pathogenic variant in Kabuki syndrome. The multimodal imaging evaluation of the ophthalmic phenotype was within normal limits.
{"title":"Variante patogénica de KMT2D c.6341del (p.Gly2114Alafs*30) y evaluación multimodal de su fenotipo en una mujer hispano-mexicana con síndrome de Kabuki: informe de una nueva variante","authors":"L.A. Garza-Garza , A.P. Arizpe , R. Morales-Reyes , R.A. Villafuerte-de la Cruz , M. Garza-León","doi":"10.1016/j.oftal.2025.04.007","DOIUrl":"10.1016/j.oftal.2025.04.007","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Kabuki syndrome is a rare congenital malformation syndrome originally described by Niikawa et al. in 1981. A wide array of pathogenic variants and phenotypes have been described ever since. However, cases from Hispanic-Mexican populations evaluated with multimodal imaging are scarce. Therefore, the aim of this study is to report on the multimodal evaluation of a Hispanic-Mexican case with a novel pathogenic variant.</div></div><div><h3>Materials and methods</h3><div>Next generation sequencing was used to search for pathogenic variants in KMT2D in the proband and her parents and sibling. A full systemic and ophthalmological examination along with ancillary studies were undertaken.</div></div><div><h3>Results</h3><div>Only the proband had relevant findings and a compatible pathogenic variant in KMT2D. The systemic and ophthalmic phenotype correlates with previous reports of Kabuki syndrome. Ancillary studies of the retina, optic nerve, macular area, macular vascular flow and cornea were within normal limits. The novel detected pathogenic variant in the proband was c.6341del (p.Gly2114Alafs*30) in KMT2D.</div></div><div><h3>Conclusions</h3><div>The present paper reports on a novel pathogenic variant in Kabuki syndrome. The multimodal imaging evaluation of the ophthalmic phenotype was within normal limits.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 8","pages":"Pages 452-457"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.1016/j.oftal.2025.03.002
J.C. Escribano Villafruela, A. Fuentes Zamora, L. Gómez Fernández, J.R. Ruiz Batrés, J.L. Urcelay Segura
Peripapillary Intrachoroidal Cavitation (PICC) can be appeared as an orangish lesion located at the outer lower edge of the myopic cone and confined to the intrachoroidal space. It is more common in patients with high myopia, older age, and greater axial length. The most accepted pathophysiological mechanism involves traction over a vulnerable sclera tissue at the myopic cone. PICC may present with visual field defects like mild glaucomatous neuropathy. Differential diagnosis with other choroidal pathologies is essential, and OCT-HD shows distinctive features in PICC. Additionally, OCT-A plays a crucial role in the diagnosis.
We present 3 patients with PICC from our center, all of whom share advanced age, increased axial length, and myopia. All cases exhibit characteristic imaging alterations and visual field defects likely associated with the pathology.
{"title":"Excavación intracoroidea peripapilar","authors":"J.C. Escribano Villafruela, A. Fuentes Zamora, L. Gómez Fernández, J.R. Ruiz Batrés, J.L. Urcelay Segura","doi":"10.1016/j.oftal.2025.03.002","DOIUrl":"10.1016/j.oftal.2025.03.002","url":null,"abstract":"<div><div>Peripapillary Intrachoroidal Cavitation (PICC) can be appeared as an orangish lesion located at the outer lower edge of the myopic cone and confined to the intrachoroidal space. It is more common in patients with high myopia, older age, and greater axial length. The most accepted pathophysiological mechanism involves traction over a vulnerable sclera tissue at the myopic cone. PICC may present with visual field defects like mild glaucomatous neuropathy. Differential diagnosis with other choroidal pathologies is essential, and OCT-HD shows distinctive features in PICC. Additionally, OCT-A plays a crucial role in the diagnosis.</div><div>We present 3 patients with PICC from our center, all of whom share advanced age, increased axial length, and myopia. All cases exhibit characteristic imaging alterations and visual field defects likely associated with the pathology.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 8","pages":"Pages 485-491"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.1016/j.oftal.2025.03.005
P. Talavero-González, J. García-Bella, E. Hernández-García, E. Vico-Ruiz, Á. Romo-López, R. Gómez de Liaño-Sánchez
A 73-year-old male with disabling torticollis. He suffered a severe traumatic head injury when he had 36 years old, affecting multiple cranial nerves, including III, IV and VI bilaterally. On actual examination he presented a large torticollis left head turn that compensates the diplopía. In the right eye, -4 limitation of adduction, -1 limitation of elevation and horizontal nystagmus on abduction. In the left eye, -6 limitation of abduction, -2 limitation of adduction, -1 limitation of elevation and -2 limitation of depression (0-8 scale). The right eye underwent Nasal Nishida procedure and the left eye underwent a Temporal Nishida. One year after the surgery the patient was no longer maintaining a head turn but had a mild tilt to the right and inttermitent diplopía.
Nishida procedure can be a good option in cases of complex bilateral oculomotor paralysis.
{"title":"Manejo de las parálisis oculomotoras bilaterales tras un traumatismo craneoencefálico: a propósito de un caso","authors":"P. Talavero-González, J. García-Bella, E. Hernández-García, E. Vico-Ruiz, Á. Romo-López, R. Gómez de Liaño-Sánchez","doi":"10.1016/j.oftal.2025.03.005","DOIUrl":"10.1016/j.oftal.2025.03.005","url":null,"abstract":"<div><div>A 73-year-old male with disabling torticollis. He suffered a severe traumatic head injury when he had 36 years old, affecting multiple cranial nerves, including III, IV and VI bilaterally. On actual examination he presented a large torticollis left head turn that compensates the diplopía. In the right eye, -4 limitation of adduction, -1 limitation of elevation and horizontal nystagmus on abduction. In the left eye, -6 limitation of abduction, -2 limitation of adduction, -1 limitation of elevation and -2 limitation of depression (0-8 scale). The right eye underwent Nasal Nishida procedure and the left eye underwent a Temporal Nishida. One year after the surgery the patient was no longer maintaining a head turn but had a mild tilt to the right and inttermitent diplopía.</div><div>Nishida procedure can be a good option in cases of complex bilateral oculomotor paralysis.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 8","pages":"Pages 504-507"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.1016/j.oftal.2025.02.001
P.B. Blasco Palacio, A. Aramburu-Gonzalez, I. Rodríguez García
We present the case of a 52-year-old man with a stable ophthalmological follow-up for the last 10 years. Clinically asymptomatic, except for floaters in both eyes. In the fundus, bilateral peripheral retinoschisis was observed without associated macular schisis. The electroretinogram (ERG) is electronegative and shows a genetic confirmation of the pathogenic variant c.461A >G; p.(Gln154Arg) of the RS1 gene compatible with the diagnosis of juvenile X-linked retinoschisis (RSLX). The foveal architecture in Optical Coherence Tomography (OCT) presents «inverted roof fovea» not previously described, having found two similar cases in the literature. In males in whom we find the sign of «inverted roof fovea», we should check the fundus, and if we find peripheral retinoschisis, we recommend insisting on the family history, and increase its study with an ERG and molecular genetic analysis, ruling out RSLX.
{"title":"Nuevo signo OCT en retinosquisis ligada al X sin esquisis macular: «fovea en tejado invertido»","authors":"P.B. Blasco Palacio, A. Aramburu-Gonzalez, I. Rodríguez García","doi":"10.1016/j.oftal.2025.02.001","DOIUrl":"10.1016/j.oftal.2025.02.001","url":null,"abstract":"<div><div>We present the case of a 52-year-old man with a stable ophthalmological follow-up for the last 10 years. Clinically asymptomatic, except for floaters in both eyes. In the fundus, bilateral peripheral retinoschisis was observed without associated macular schisis. The electroretinogram (ERG) is electronegative and shows a genetic confirmation of the pathogenic variant c.461A<!--> <!-->>G; p.(Gln154Arg) of the RS1 gene compatible with the diagnosis of juvenile X-linked retinoschisis (RSLX). The foveal architecture in Optical Coherence Tomography (OCT) presents «inverted roof fovea» not previously described, having found two similar cases in the literature. In males in whom we find the sign of «inverted roof fovea», we should check the fundus, and if we find peripheral retinoschisis, we recommend insisting on the family history, and increase its study with an ERG and molecular genetic analysis, ruling out RSLX.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 8","pages":"Pages 476-480"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.1016/j.oftal.2025.02.007
J. Noguera Campos, S. Pose Bazarra, N. Castro Casal, A. Urbano Bueno, M.D. Álvarez Díaz
Phthiriasis palpebrarum is defined as the involvement of the eyelids by the Phthirus pubis parasite. It is a pathology considered as a sexually transmitted disease, whose treatment can be challenging in some situations. We present the case of a 4-year-old patient with eyelashes severely affected by this parasite, who cooperated poorly for mechanical removal. Given this situation, we decided to prescribe a single dose of topical permethrin 5% and several applications of vaseline, repeating this treatment a week later, which led to the complete resolution of the condition. This case introduces topical permethrin 5% as an effective, safe and widely available option for the treatment of this pathology, especially for pediatric patients or those who do not cooperate adequately for mechanical removal of the parasites.
{"title":"Permetrina tópica al 5% como tratamiento para pacientes pediátricos con phthiriasis palpebrarum: a propósito de un caso","authors":"J. Noguera Campos, S. Pose Bazarra, N. Castro Casal, A. Urbano Bueno, M.D. Álvarez Díaz","doi":"10.1016/j.oftal.2025.02.007","DOIUrl":"10.1016/j.oftal.2025.02.007","url":null,"abstract":"<div><div>Phthiriasis palpebrarum is defined as the involvement of the eyelids by the <em>Phthirus pubis</em> parasite. It is a pathology considered as a sexually transmitted disease, whose treatment can be challenging in some situations. We present the case of a 4-year-old patient with eyelashes severely affected by this parasite, who cooperated poorly for mechanical removal. Given this situation, we decided to prescribe a single dose of topical permethrin 5% and several applications of vaseline, repeating this treatment a week later, which led to the complete resolution of the condition. This case introduces topical permethrin 5% as an effective, safe and widely available option for the treatment of this pathology, especially for pediatric patients or those who do not cooperate adequately for mechanical removal of the parasites.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 8","pages":"Pages 481-484"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.1016/j.oftal.2025.03.003
P. Merino, A. Fuentes, P. Gómez de Liaño, J. Ruiz
Congenital microcoria is a rare ocular anomaly characterized by pupil smaller than 2 mm with no response to mydriatic agents. It can present in 2 forms: autosomal recessive associated with Pierson syndrome and autosomal dominant isolated (associated with a high incidence of myopia and glaucoma). Studies have identified deletions in the 13q32.1 region of chromosome 13 that include the GPR180 gene, involved in smooth muscle cell growth, as the underlying cause in autosomal dominant cases. We describe 3 members of a family with deletion of the GPR180 gene on chromosome 13. In all, IOP was normal and gonioscopy showed iridocorneal angle dysgenesis with prominent ciliary processes. Congenital microcoria is due to poor development of the iris dilator muscle of genetic cause. Early diagnosis and continuous follow-up for possible complications such as amblyopia, progressive myopia and juvenile glaucoma is essential. Since the diagnoses of glaucoma described in the literature were mainly made in individuals between 20-30 years old.
{"title":"Microcoria congénita: descripción de 3 casos en una familia","authors":"P. Merino, A. Fuentes, P. Gómez de Liaño, J. Ruiz","doi":"10.1016/j.oftal.2025.03.003","DOIUrl":"10.1016/j.oftal.2025.03.003","url":null,"abstract":"<div><div>Congenital microcoria is a rare ocular anomaly characterized by pupil smaller than 2<!--> <!-->mm with no response to mydriatic agents. It can present in 2 forms: autosomal recessive associated with Pierson syndrome and autosomal dominant isolated (associated with a high incidence of myopia and glaucoma). Studies have identified deletions in the 13q32.1 region of chromosome 13 that include the GPR180 gene, involved in smooth muscle cell growth, as the underlying cause in autosomal dominant cases. We describe 3 members of a family with deletion of the GPR180 gene on chromosome 13. In all, IOP was normal and gonioscopy showed iridocorneal angle dysgenesis with prominent ciliary processes. Congenital microcoria is due to poor development of the iris dilator muscle of genetic cause. Early diagnosis and continuous follow-up for possible complications such as amblyopia, progressive myopia and juvenile glaucoma is essential. Since the diagnoses of glaucoma described in the literature were mainly made in individuals between 20-30 years old.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 8","pages":"Pages 492-496"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.1016/j.oftal.2025.04.003
N. Castro Casal, N. Olivier Pascual, R. Arroyo Castillo
Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHAD) is a rare but severe genetic disorder that causes pigmentary chorioretinopathy. We present the case of a 20-year-old female patient diagnosed with LCHAD by neonatal screening with alteration of the retinal pigment epithelium (RPE) since the age of 3 years. Fundus examination showed a salt-and-pepper speckled granular pattern and diffuse peripheral chorioretinal atrophy. The patient is stable, visually asymptomatic and with good systemic control after more than 15 years of follow-up with retinography, optical coherence tomography (OCT), autofluorescence (FAF) and electroretinogram (ERG), essential for control. This case highlights the importance of early diagnosis and treatment to prevent decompensation and improve survival and progression.
{"title":"Coriorretinopatía pigmentaria por déficit de 3-hidroxiacil-CoA-deshidrogenasa de cadena larga (LCHAD): un caso clínico con seguimiento a largo plazo","authors":"N. Castro Casal, N. Olivier Pascual, R. Arroyo Castillo","doi":"10.1016/j.oftal.2025.04.003","DOIUrl":"10.1016/j.oftal.2025.04.003","url":null,"abstract":"<div><div>Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHAD) is a rare but severe genetic disorder that causes pigmentary chorioretinopathy. We present the case of a 20-year-old female patient diagnosed with LCHAD by neonatal screening with alteration of the retinal pigment epithelium (RPE) since the age of 3 years. Fundus examination showed a salt-and-pepper speckled granular pattern and diffuse peripheral chorioretinal atrophy. The patient is stable, visually asymptomatic and with good systemic control after more than 15 years of follow-up with retinography, optical coherence tomography (OCT), autofluorescence (FAF) and electroretinogram (ERG), essential for control. This case highlights the importance of early diagnosis and treatment to prevent decompensation and improve survival and progression.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 8","pages":"Pages 497-503"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.1016/j.oftal.2025.04.001
E. Marín-Payá , L. Zanón-Moreno , I. Andrés-Blasco , J. Marín-Montiel , M.D. Pinazo-Durán , V. Zanón-Moreno
{"title":"Actualización en biotecnología oftalmológica. Técnicas de identificación de biomarcadores moleculares y genéticos","authors":"E. Marín-Payá , L. Zanón-Moreno , I. Andrés-Blasco , J. Marín-Montiel , M.D. Pinazo-Durán , V. Zanón-Moreno","doi":"10.1016/j.oftal.2025.04.001","DOIUrl":"10.1016/j.oftal.2025.04.001","url":null,"abstract":"","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 8","pages":"Pages 441-443"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.1016/j.oftal.2024.12.010
N. Kahuam-López , J.G. Serrano-Robles , G.R. Vera-Duarte , J.R. Bermeo-Escalona , C.A. Müller-Morales , A. Ramirez-Miranda , A. Navas , E.O. Graue-Hernandez
Objective
Translate, culturally adapt, and validate the Ocular Surface Disease Index (OSDI) into Spanish for the Mexican population.
Methods
To ensure fluency and comprehensibility, we employed the Crawford and INFLEZS indexes. The Content Validity Coefficient was used to assess coherence, relevance, clarity, and sufficiency. Internal consistency was evaluated using Cronbach's Alpha Coefficient.
Results
A total of 372 participants were included in the study (63.4%, women; age ranged from 17 to 86 years). According to the INFLEZS readability index, symptom-related items achieved scores of 82.56, 72.69, 85.81, 73.24, and 74.24. Lifestyle-related items obtained scores of 71.39, 76.90, 58.27, and 72.56, while in the environmental domain, scores of 83.61, 74.03, and 58.93 were recorded. Using the Crawford index, symptom scores were 3.6, 4.6, 3.5, 4.1, and 3.8, lifestyle scores were 4.7, 4.1, 5.1, and 4.6, and environmental scores were 3.7, 4.4, and 5.7. The Cronbach's alpha coefficient was 0.868. Based on the scores from the OSDI questionnaire, patients were categorized as having no dry eye (n = 129), mild dry eye (n = 99), moderate (n = 45), and severe dry eye (n = 99).
Conclusions
This study developed and validated the Mexican version of the OSDI, while assessing its reliability and internal consistency. With this tool, ophthalmologists and researchers alike will be able to assess and monitor Mexican-Spanish-speaking patients with dry eye in their routine clinical practice and future research.
{"title":"Adaptación cultural y validación del cuestionario del Índice de Enfermedades de la Superficie Ocular (OSDI) en la población mexicana","authors":"N. Kahuam-López , J.G. Serrano-Robles , G.R. Vera-Duarte , J.R. Bermeo-Escalona , C.A. Müller-Morales , A. Ramirez-Miranda , A. Navas , E.O. Graue-Hernandez","doi":"10.1016/j.oftal.2024.12.010","DOIUrl":"10.1016/j.oftal.2024.12.010","url":null,"abstract":"<div><h3>Objective</h3><div>Translate, culturally adapt, and validate the Ocular Surface Disease Index (OSDI) into Spanish for the Mexican population.</div></div><div><h3>Methods</h3><div>To ensure fluency and comprehensibility, we employed the Crawford and INFLEZS indexes. The Content Validity Coefficient was used to assess coherence, relevance, clarity, and sufficiency. Internal consistency was evaluated using Cronbach's Alpha Coefficient.</div></div><div><h3>Results</h3><div>A total of 372 participants were included in the study (63.4%, women; age ranged from 17 to 86<!--> <!-->years). According to the INFLEZS readability index, symptom-related items achieved scores of 82.56, 72.69, 85.81, 73.24, and 74.24. Lifestyle-related items obtained scores of 71.39, 76.90, 58.27, and 72.56, while in the environmental domain, scores of 83.61, 74.03, and 58.93 were recorded. Using the Crawford index, symptom scores were 3.6, 4.6, 3.5, 4.1, and 3.8, lifestyle scores were 4.7, 4.1, 5.1, and 4.6, and environmental scores were 3.7, 4.4, and 5.7. The Cronbach's alpha coefficient was 0.868. Based on the scores from the OSDI questionnaire, patients were categorized as having no dry eye (n<!--> <!-->=<!--> <!-->129), mild dry eye (n<!--> <!-->=<!--> <!-->99), moderate (n<!--> <!-->=<!--> <!-->45), and severe dry eye (n<!--> <!-->=<!--> <!-->99).</div></div><div><h3>Conclusions</h3><div>This study developed and validated the Mexican version of the OSDI, while assessing its reliability and internal consistency. With this tool, ophthalmologists and researchers alike will be able to assess and monitor Mexican-Spanish-speaking patients with dry eye in their routine clinical practice and future research.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 8","pages":"Pages 444-451"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-01DOI: 10.1016/j.oftal.2025.01.012
V.M. Asensio-Sánchez
Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect almost every organ. This article describes a middle-aged woman, previously diagnosed with untreated SLE, who during a severe SLE flare simultaneously presented with a superior nasal artery occlusion in the right eye and a central retinal artery occlusion (CRAO) in the left eye. Severe ocular complications, such as CRAO, can occur during an acute flare of the disease in previously asymptomatic SLE.
{"title":"Oclusión bilateral y simultánea de arterias retinianas en mujer con lupus eritematoso sistémico","authors":"V.M. Asensio-Sánchez","doi":"10.1016/j.oftal.2025.01.012","DOIUrl":"10.1016/j.oftal.2025.01.012","url":null,"abstract":"<div><div>Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect almost every organ. This article describes a middle-aged woman, previously diagnosed with untreated SLE, who during a severe SLE flare simultaneously presented with a superior nasal artery occlusion in the right eye and a central retinal artery occlusion (CRAO) in the left eye. Severe ocular complications, such as CRAO, can occur during an acute flare of the disease in previously asymptomatic SLE.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"100 8","pages":"Pages 473-475"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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