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Hereditary Mesodermal Dystrophy 遗传性中胚皮营养不良症
Pub Date : 1948-04-01 DOI: 10.1136/jech.2.2.71
F. H. Kemp, D. Wilson, W. Fish, W. Stobie
In the course of investigations in Sunningwell parish, Berkshire, certain members of family " H " were found to transmit the dystrophy of mesodermal tissue which is recognized at an early age by' the occurrence of blue sclerotics, laxity of ligaments, and brittle bones, and during adolescence by the onset of deafness (otosclerosis). The mode of heredity is shown in the accompanying diagram, the informants being the widow of No. II 8-since deceased-and No. III 3. When the latter recalled her examination at the Oxford Eye Hospital twentyfour years earlier, contact became possible with the author of a previous paper (Stobie, 1924), describing the syndrome of blue sclerotics, brittle bones, and progressive deafness amongst villagers who have all proved to belong to the " H " kindred. The present communication deals with a recent clinical and social enquiry amongst the " H " family in so far as this affects the prognosis of their familial disorder. The kindred and affinals of family " H " living in-Sunningwell parish number 78. The population of the parish at the last (1937) census was 637.
在伯克郡Sunningwell教区的调查过程中,发现某些家族“H”成员传递中胚层组织营养不良,这在早期通过蓝色硬化,韧带松弛和骨质脆性的发生来识别,并且在青春期通过耳聋(耳硬化)的发作来识别。遗传模式见附图,举报人是第5号的寡妇。II - 8-自死亡以来-和No. 8。三世3。当后者回忆起她24年前在牛津眼科医院的检查时,她与之前一篇论文的作者(Stobie, 1924)取得了联系,该论文描述了在所有被证明属于“H”族的村民中出现的蓝色硬化、骨质脆性和进行性耳聋综合症。本来文涉及最近在“H”家庭中进行的临床和社会调查,因为这影响到他们的家族疾病的预后。住在桑宁维尔教区78号的H家族的亲属和亲戚。在最近一次(1937年)的人口普查中,这个教区的人口是637人。
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引用次数: 1
Textbook of Public Health 公共卫生教材
Pub Date : 1948-04-01 DOI: 10.1136/JECH.2.2.73
Mesodermal Dystrophy
As was mentioned by Stobie, loc. cit., goitre occurred amongst members of family " H " (Nos. III 7; IV 7, 9, 13; V 7, 15). This is probably due to the fact that they lived isolated lives and used well or spring water in an area known to be low in iodine. Recently village communications have been extended, permitting the purchase of sea-fish, a rich dietary source of iodine, and the water has been changed to the main supply of the nearest large town. New cases of goitre are not occurring in the parish, and a recent school survey did not show a high incidence of adolescent hyperplasia of the thyroid gland. Fluorine is present in the former village water supplies, but the amount (about 0 1 parts per million) is unimportant (Murray and others, 1948).
正如斯托比所提到的那样。例如,“H”家族成员(III、7号;Iv 7,9,13;V 7,15)。这可能是因为他们过着与世隔绝的生活,在一个碘含量低的地区饮用井水或泉水。最近,村庄的交通已经扩大,允许购买海鱼,这是一种丰富的碘的膳食来源,水已经改为最近的大城镇的主要供应。教区没有出现甲状腺肿的新病例,最近的一项学校调查也没有显示青少年甲状腺增生的高发病率。以前的村庄供水系统中存在氟,但含量(约为百万分之0.1)并不重要(Murray等人,1948年)。
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引用次数: 86
Tuberculosis in Young Adults: Report on the Prophit Tuberculosis Survey, 1935-44 青壮年结核病:1935-44年结核病调查报告
Pub Date : 1948-04-01 DOI: 10.1136/JECH.2.2.74-A
F. Crew
human and social biology and of human ecology. With the development of social medicine in the universities, and with the expanding recognition in the community of the impossibility of dissociating merely for administrative reasons the medical services and the others which deal with housing, education, and all the rest which promote in one way or another the health of the people, it is probable that in the not too remote future this administrative distinction between the different departments of the central and local authority will gradually be broken down, and with the passing of time the practice of public health in the community will come to mirror the scope and aims of social medicine within the universities. F. A. E. CREw.
人类和社会生物学以及人类生态学。随着大学社会医学的发展,随着社会上越来越多的人认识到不能仅仅因为行政原因而把医疗服务与其他处理住房、教育和其他一切以这种或那种方式促进人民健康的部门分开,很可能在不太遥远的将来,中央和地方当局不同部门之间的这种行政区别将逐渐被打破,随着时间的推移,社区公共卫生的实践将反映大学社会医学的范围和目标。空勤人员。
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引用次数: 2
Health Services in England 英格兰的卫生服务
Pub Date : 1948-04-01 DOI: 10.1136/JECH.2.2.75-A
F. Crew
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引用次数: 0
Social and Nutritional Factors in Adolescent Osteochondritis of the Spine 青少年脊柱骨软骨炎的社会和营养因素
Pub Date : 1948-04-01 DOI: 10.1136/jech.2.2.66
F. H. Kemp, D. Wilson, E. Emrys‐Roberts
Introduction The association of endemic dental fluorosis with skeletal changes in the native inhabitants of certain villages in the Madras Presidency was first reported by Shortt and others (1937). Similar bone lesions due to an excess of fluorine in drinking water have been recorded in natives in South Africa (Ockerse, 1941) and in aboriginal tribes in China (Lyth, 1946). The evidence that these changes are caused by fluorine is conclusive, for the radiological appear ances are identical with those found in industrial workers with fluorine (M0ller and Gudjonsson, 1932; Wilkie, 1940) and in the skeletal changes produced experimentally by feeding fluorine to animals (Roholm, 1937). In some cases the clinical features of endemic skeletal fluorosis resemble those seen in the type of ankylosing spondylitis (Marie Strumpell) known in this country as " bamboo spine," which occurs chiefly in young men. Further more, fluorosis tends to affect the spine at a later age and it is common to both sexes. The radiological appearances are totally different (Kemp, 1946). The level of fluorine, about 3 to 4 parts per million (p.p.m.), in the drinking waters associated with bone lesions seen in India and among indigen ous populations in other parts of the world, is often no greater than the amount present in certain English waters, for example at Maldon in Essex, but in this country the social environment is never so unfavourable, and severe skeletal deformity is not seen. As a trace-element, the concentration at which fluorine is effective suggests a catalytic effect and/pr an inhibitor action on certain enzyme systems. Epidemiological studies in the United States combined with standardized grading of dental fluorosis showed less dental caries and more teeth of good structure among people who had used drinking water containing fluorine 0-5 to 1 0 p.p.m. for at least the first eight years of life, that is to say before calcification of the dental enamel is complete (vide Murray and Wilson, 1946). Observations on fluorosis and nutrition in Morocco have made it likely that the effect of fluorine on the development and structure of the dental enamel depends very much on the state of general nutrition (Murray and Wilson, 1948). In certain Oxfordshire villages where severe dental fluorosis is seen amongst the inhabitants, no evidence of developed skeletal fluorosis was found (Kemp and others, 1942), but there was a remarkable incidence of changes in the spines of children of the type described by Scheuremann (1921 and 1936) as kyphosis dorsalis juvenilis! In one school at least a third of the children were affected. The worst cases were seen in the lower social classes, among the younger members of large families, or in children with a history of defective nutrition in the early years. A group of poor Oxford city children examined at this time?the incidence of dental fluorosis in Oxford city as a whole is negligible? showed no such changes. In general the children showi
肖特等人(1937年)首次报道了马德拉斯省某些村庄土著居民的地方性氟牙症与骨骼变化的关系。南非土著居民(Ockerse, 1941年)和中国土著部落(Lyth, 1946年)也记录了由于饮用水中氟过量而造成的类似骨损伤。这些变化是由氟引起的证据是确凿的,因为放射现象与在使用氟的工业工人身上发现的相同(M0ller和Gudjonsson, 1932;Wilkie, 1940),以及通过实验给动物喂食氟而产生的骨骼变化(Roholm, 1937)。在某些情况下,地方性氟骨症的临床特征类似于强直性脊柱炎(Marie Strumpell),在该国被称为“竹棘”,主要发生在年轻男性身上。此外,氟中毒往往会在较晚的年龄影响脊柱,男女都有。放射学表现完全不同(Kemp, 1946)。在印度和世界其他地区的土著居民中,与骨骼损伤有关的饮用水中的氟含量约为百万分之3至4 (p.p.m),通常不高于某些英国水域的氟含量,例如埃塞克斯的马尔登,但在这个国家,社会环境从未如此不利,也没有看到严重的骨骼畸形。作为一种微量元素,氟的有效浓度表明对某些酶系统具有催化作用和/pr抑制剂作用。美国的流行病学研究结合氟斑牙的标准化分级表明,至少在生命的前8年,即在牙釉质钙化完成之前,饮用含氟0-5至10 pm的饮用水的人,龋齿较少,结构良好的牙齿较多(vide Murray和Wilson, 1946)。对摩洛哥氟中毒和营养的观察表明,氟对牙釉质发育和结构的影响很可能在很大程度上取决于一般营养状况(Murray和Wilson, 1948年)。在牛津郡的某些村庄里,居民中出现了严重的氟牙症,但没有发现发展成氟骨症的证据(Kemp等人,1942年),但Scheuremann(1921年和1936年)所描述的儿童脊柱变化的显著发生率为青少年背后畸形!在一所学校,至少有三分之一的孩子受到影响。最严重的情况出现在较低的社会阶层,在大家庭的年轻成员中,或者在早期有营养不良史的儿童中。一群贫穷的牛津城市儿童在这个时候接受检查?整个牛津市氟斑牙的发病率可以忽略不计?没有显示出这样的变化。一般儿童放射学表现为青少年的变化。骨软骨炎没有症状,但很多是畸形的。然而,这些诱发的变化可能在以后的生活中,在紧张或压力的条件下引起疼痛。我们追踪了其中一些病例的发展过程,发现在成年早期发生了进一步的变化。后来,我们提出了进一步的证据,表明该疾病的发生与持续营养不良有关,改善饮食可以带来益处(Kemp和Wilson, 1947)。这种变化并不完全局限于较贫穷阶层的孩子,但在“富裕阶层”的孩子身上发生的频率肯定要低一些。每当我们看到来自高收入群体的案例时,就会有长期持续的健康不良或喂养困难的历史(Kemp和Wilson, 1948)。其他的影响因素是体位紊乱和生长速度。说明该疾病的原始x线照片已在其他地方发表(vide Kemp和Wilson, 1947)。随附的线条图取自一个严重病例,并从正常脊柱进行比较,说明了在这种情况下观察到的变化。
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引用次数: 2
The medical ethnography of the second World War. 第二次世界大战的医学人种志。
Pub Date : 1947-10-01 DOI: 10.1136/jech.1.4.251
L HOGBEN, M M JOHNSTONE, D MULLINGS
ExcepUn so far as the occurrence of large-scale epidemics has provided opportunities for differential observation, there is available little well-accredited information concerning the liability of persons of non-European stock to diseases not commonly current in their normal habitat or of the liability of persons of European stock to diseases prevalent in Africa, Asia, and Oceania. This is necessarily so, because of the paucity of statistical machinery in countries which are not as yet highly industrialized and in countries which have no long tradition of occidental medicine. It is therefore unnecessary to expand the ensuing account by reference to current literature or to emphasize at length the peculiar opportunities which Army hygiene offers for a scientific study of this sort. Information about morbidity and mortality with respect to troops of different ethnic origin supplied by Army medical authorities has evidently two outstanding advantages in so far as:
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引用次数: 2
School medical inspections, their value and limitations. 学校医学检查的价值和局限性。
Pub Date : 1947-10-01 DOI: 10.1136/jech.1.4.238
I GORDON
investigation on 2
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引用次数: 1
Studies on age and wastage in industrial populations; age and incidence. 工业人口年龄与损耗研究;年龄和发病率。
Pub Date : 1947-10-01
R PADLEY
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引用次数: 0
The relation of morbidity to age in an army population. 军队中发病率与年龄的关系。
Pub Date : 1947-07-01 DOI: 10.1136/jech.1.3.149
L HOGBEN, M M JOHNSTONE
Public health statistics provide a wealth of material with reference to the relation of age to mortality risk from individual diseases; and it has long been customary to adjust mortality rates by means of appropriate standardizing factors to forestall erroneous comparisons of crude deaths in populations of different age structure. Within the framework of private practice, civilian medicine provides no comparable opportunities for an exact study of the relation of age to risk of contracting diseases, other than such as are certifiable to public health authorities or such as are speedily fatal. Indeed current medical treatises and articles abound with figures for proportions of cases examined in different age groups cited as an indication of the liability of individuals to contract a particular disease in a given age group. It should be but is not in fact needless to remark that this procedure is highly misleading. Naturally, the physician meets very few cases of peptic ulcer among males between the ages of 95 and 99 inclusive, for the simple reason that there are in fact very few males alive at that age. The practice of putting on record such case-age distributions, in contradistinction to age-incidence distributions exhibiting frequency of onset related to the appropriate population at risk at a given time of life, is a counsel of despair consequent upon the difficulty of delimiting the population from which a civil hospital draws its patients, and hence of defining the relevant demographic data for drawing correct conclusions. Correct information of this sort is of value both because it may furnish clues for an attack on the nature of the ageing process, and because it is a prerequisite of medical man-power planning in a society with a swiftly-changing age-composition. The Army, with an all-in system of social medicine and a complete population census, therefore offers a unique opportunity for studying the relation of age to
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引用次数: 1
Social service for a medical ward. 医疗病房的社会服务
Pub Date : 1947-07-01 DOI: 10.1136/jech.1.3.197
I F BECK, F V GARDNER, L J WITTS
On the eve of new legislation which will affect the results of illness for hospital patients, it seems opportune to discuss the present neecLfor an almoner's services on a medical ward and what it is likely to be in the future. In 1943 a study was carried out in this department of a group of patients admitted to a medical ward during a period of six months, and it was concluded that 70 per cent, of the patients required an almoner's supervision or help (Brown and Carling, 1945). Since that date an almoner has been attached as social worker to the department, and her duties have included the social care and supervision of patients while in the ward and after discharge. A further follow-up study has now been carried out in order to find out what difference this has made. The main questions to be answered are: what proportion of medical patients require the services of an almoner, what are the main social problems with which the almoner has to deal, how much almoning time is needed if medical social supervision is to be effective, and how can the almoner's services be integrated most efficiently with those of the medical staff ?
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引用次数: 0
期刊
British journal of social medicine
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