Background: Having a child in hospital is a stressful experience for most parents, especially for mothers. In Bangladesh, the number of hospital admission of under-5 children is gradually increasing. Support from nurses can assist mothers to maintain their parenting role and promote quality nursing care. Objective: The study was conducted to assess the nursing support perceived by the mothers of hospitalized children in Bangladesh. Methods: A Descriptive cross-sectional study was conducted among 112 mothers whose children were admitted at Dhaka Medical College Hospital. Convenience sampling technique was used to select the study participants. Data was collected by using self-administered structured questionnaires including (1) The Demographic Data Questionnaires and (2) Perception of Nursing Support Questionnaire. Data were analyzed by using descriptive and inferential statistics. Results: The total mean of nursing support was 3.68 (SD=.25). The findings showed that there was a statistically significant difference between mothers’education and nursing support (F=2.73, p=.033). There was a statistically significant positive relationship between child age and nursing support (r=.22, p=.019). There were statistically significant differences between a child’s gender and nursing support of mothers (t=1.99, p=.048) which means mothers who had a male child had more nursing support. Conclusion: The findings of the present study provide information for the nurses ‘that help to increase nursing support among mothers of hospitalized children in Bangladesh. Nurses can promote the quality of care and should be aware of the importance of nursing support. Further study is crucial for identifying factors influencing on nursing support perceived by the mothers of hospitalized children. It is important that nurses continue to develop their knowledge about communication and establishing parent support system.
{"title":"Nursing Support Perceived by the Mothers of Hospitalized Children in Bangladesh","authors":"Shanzida Khatun, Kohinur Begom MSN, Happy Bandana Biswas, Mohammad Nurul Anowar","doi":"10.31579/2693-4779/047","DOIUrl":"https://doi.org/10.31579/2693-4779/047","url":null,"abstract":"Background: Having a child in hospital is a stressful experience for most parents, especially for mothers. In Bangladesh, the number of hospital admission of under-5 children is gradually increasing. Support from nurses can assist mothers to maintain their parenting role and promote quality nursing care. Objective: The study was conducted to assess the nursing support perceived by the mothers of hospitalized children in Bangladesh. Methods: A Descriptive cross-sectional study was conducted among 112 mothers whose children were admitted at Dhaka Medical College Hospital. Convenience sampling technique was used to select the study participants. Data was collected by using self-administered structured questionnaires including (1) The Demographic Data Questionnaires and (2) Perception of Nursing Support Questionnaire. Data were analyzed by using descriptive and inferential statistics. Results: The total mean of nursing support was 3.68 (SD=.25). The findings showed that there was a statistically significant difference between mothers’education and nursing support (F=2.73, p=.033). There was a statistically significant positive relationship between child age and nursing support (r=.22, p=.019). There were statistically significant differences between a child’s gender and nursing support of mothers (t=1.99, p=.048) which means mothers who had a male child had more nursing support. Conclusion: The findings of the present study provide information for the nurses ‘that help to increase nursing support among mothers of hospitalized children in Bangladesh. Nurses can promote the quality of care and should be aware of the importance of nursing support. Further study is crucial for identifying factors influencing on nursing support perceived by the mothers of hospitalized children. It is important that nurses continue to develop their knowledge about communication and establishing parent support system.","PeriodicalId":8525,"journal":{"name":"Applied Clinical Research, Clinical Trials and Regulatory Affairs","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81214051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Richmond Ronald Gomes, Shoriful Islam, FM Monjur Hasan
Spontaneous intracerebral hemorrhage (ICH) has remained the least treatable form of stroke despite recent improvements in medical treatment. Treatment usually supportive and medical such as ventilatory support, blood pressure reduction, osmotherapy, fever control, seizure control and nutritional support and treatment of co morbidconditions. This study was carried out to see demographic variability, clinical presentation, causes and outcome of spontaneous intracerebral hemorrhage. Methods and materials: This was a cross sectional observational prospective in study on 50 spontaneous ICH patients admitted in Medicine department of Khulna Medical College Hospital from November 2020 to April, 2021. Result: The study showed that spontaneous ICH was most common in between 41-70 years. Their age frequency were 14 (28%) in 41-50 years, 15 (30%)in 51- 60 years, 12 (24%) in 61-70 years, 5 (10%) in 71- 80 years and 4 (8%) in more than 81 years age group. Among the patients, 64% (32) were male and 36% (18) were female. No of smoker male was 25(50%) and female was 1(2%) and no of nonsmoker male was 7(14%) and female was 17(34%). Headache was present in 56% (28) and absent in 44% (22) of patients. Vomiting was present in 54% (27) and was absent in 46% (23)of patients.Seizure was present in 16% (8) and was absent in 54% (42) of patients. Diabetes mellitus was present in 22% (11) of patients and absent in 78% (39) patients. Range of blood pressure –<140/90 in 24%(12), Systolic BP:140-159/Diastolic BP:90-99 (mm Hg) in 10%(5), Systolic BP:160-179/Diastolic BP:100-109 (mm Hg) in 22%(11),Systolic BP:180 or more/Diastolic BP:110 or more (mm Hg) in 44%(22) patients. Dyslipidemia was present in 30% (15) & absent in 70% (35) patients. Glasgow Coma Scale Score was 8 or less in 42% (21) and 9 or more in 58% (29) patients. Conclusion: Spontaneous ICH is common in Indian subcontinent. As death occur due to ICH itself, associated co morbidities or due to complications, management in stroke care unit, High dependency unit and Intensive care unit is required.
{"title":"Evaluation of Clinical Presentation and Associated Comorbid Conditions in Patients with Spontaneous Intracerebral Hemorrhage in a Tertiary Care Hospital in Bangladesh","authors":"Richmond Ronald Gomes, Shoriful Islam, FM Monjur Hasan","doi":"10.31579/2693-4779/051","DOIUrl":"https://doi.org/10.31579/2693-4779/051","url":null,"abstract":"Spontaneous intracerebral hemorrhage (ICH) has remained the least treatable form of stroke despite recent improvements in medical treatment. Treatment usually supportive and medical such as ventilatory support, blood pressure reduction, osmotherapy, fever control, seizure control and nutritional support and treatment of co morbidconditions. This study was carried out to see demographic variability, clinical presentation, causes and outcome of spontaneous intracerebral hemorrhage. Methods and materials: This was a cross sectional observational prospective in study on 50 spontaneous ICH patients admitted in Medicine department of Khulna Medical College Hospital from November 2020 to April, 2021. Result: The study showed that spontaneous ICH was most common in between 41-70 years. Their age frequency were 14 (28%) in 41-50 years, 15 (30%)in 51- 60 years, 12 (24%) in 61-70 years, 5 (10%) in 71- 80 years and 4 (8%) in more than 81 years age group. Among the patients, 64% (32) were male and 36% (18) were female. No of smoker male was 25(50%) and female was 1(2%) and no of nonsmoker male was 7(14%) and female was 17(34%). Headache was present in 56% (28) and absent in 44% (22) of patients. Vomiting was present in 54% (27) and was absent in 46% (23)of patients.Seizure was present in 16% (8) and was absent in 54% (42) of patients. Diabetes mellitus was present in 22% (11) of patients and absent in 78% (39) patients. Range of blood pressure –<140/90 in 24%(12), Systolic BP:140-159/Diastolic BP:90-99 (mm Hg) in 10%(5), Systolic BP:160-179/Diastolic BP:100-109 (mm Hg) in 22%(11),Systolic BP:180 or more/Diastolic BP:110 or more (mm Hg) in 44%(22) patients. Dyslipidemia was present in 30% (15) & absent in 70% (35) patients. Glasgow Coma Scale Score was 8 or less in 42% (21) and 9 or more in 58% (29) patients. Conclusion: Spontaneous ICH is common in Indian subcontinent. As death occur due to ICH itself, associated co morbidities or due to complications, management in stroke care unit, High dependency unit and Intensive care unit is required.","PeriodicalId":8525,"journal":{"name":"Applied Clinical Research, Clinical Trials and Regulatory Affairs","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80733970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Total abdominal hysterectomy is a quite common open surgical operation accounting for 54% of all benign diseases. Indications are uterine fibroids, adenomyosis/endometriosis, AUB, chronic pelvic pain, cancer of ovaries, uterus or cervix or cancer phobia. It is relatively an uncomplicated operation and easiest when least required.
{"title":"Retained Foreign Body (Gossypiboma) Following Abdominal Hysterectomy; Removed Per Vaginum-2 Case Reports","authors":"Kalyani Singh","doi":"10.31579/2693-4779/046","DOIUrl":"https://doi.org/10.31579/2693-4779/046","url":null,"abstract":"Total abdominal hysterectomy is a quite common open surgical operation accounting for 54% of all benign diseases. Indications are uterine fibroids, adenomyosis/endometriosis, AUB, chronic pelvic pain, cancer of ovaries, uterus or cervix or cancer phobia. It is relatively an uncomplicated operation and easiest when least required.","PeriodicalId":8525,"journal":{"name":"Applied Clinical Research, Clinical Trials and Regulatory Affairs","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88321861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A person cannot stop eating a delicious snack until full of a snack bag of empty without consciousness; most people had this experience. The snack bag of the front of the design, which is attractive to people to buy, a load on the back has detailed the nutrition food label of a claim, and sounds are a perfect snack for us to enjoy our leisure time.
{"title":"Be mindful of eating to be healthy people","authors":"Ying Balch","doi":"10.31579/2693-4779/043","DOIUrl":"https://doi.org/10.31579/2693-4779/043","url":null,"abstract":"A person cannot stop eating a delicious snack until full of a snack bag of empty without consciousness; most people had this experience. The snack bag of the front of the design, which is attractive to people to buy, a load on the back has detailed the nutrition food label of a claim, and sounds are a perfect snack for us to enjoy our leisure time.","PeriodicalId":8525,"journal":{"name":"Applied Clinical Research, Clinical Trials and Regulatory Affairs","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80709760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seed for invasive cardiology was sown in early part of nineties. Cardiac catheterization was actually pioneered by Werner Forssmann in 1929. However, credit for therapeutic interventional cardiology should go to US vascular radiologist, Charles Theodore Dotter for performing first peripheral arterial angioplasty [PTA] in 1964. Subsequently, a German cardiologist by name Andreas Gruentzig adapted the technique in 1974 to suit coronary artery disease and performed the first human coronary balloon angioplasty to treat blockage in coronary artery in 1977.
{"title":"Structural heart disease interventions","authors":"B. Sudhakar","doi":"10.31579/2693-4779/042","DOIUrl":"https://doi.org/10.31579/2693-4779/042","url":null,"abstract":"Seed for invasive cardiology was sown in early part of nineties. Cardiac catheterization was actually pioneered by Werner Forssmann in 1929. However, credit for therapeutic interventional cardiology should go to US vascular radiologist, Charles Theodore Dotter for performing first peripheral arterial angioplasty [PTA] in 1964. Subsequently, a German cardiologist by name Andreas Gruentzig adapted the technique in 1974 to suit coronary artery disease and performed the first human coronary balloon angioplasty to treat blockage in coronary artery in 1977.","PeriodicalId":8525,"journal":{"name":"Applied Clinical Research, Clinical Trials and Regulatory Affairs","volume":"211 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87361895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antioxidants are added to fresh and processed meat to prevent lipid oxidation, retard development of off-flavors, and improve color stability. In the food industry, they can be divided into natural and synthetic antioxidants. Synthetic antioxidants have been confirmed for their toxicological and carcinogenic effects. Thus, the food industry now chooses natural products over synthetic ones. This study was carried out to investigate the effect of Rosemary extract (R.E.) and vitamin E on the quality of fried fillets of Nile tilapia (Oreochromis niloticus) during chilling and frozen storage. Fillets of Nile tilapia were treated with (R.E.) 0.1%, 0.2%, 0.3% and Vitamin E 0.1% then stored for 5,10 and 15 days at 4±1°C and for three months at -18±2°C. Then chemical tests including Peroxide value (PV), Thio-barbituric acid (TBA), Tri-methylamine-nitrogen (TMA-N) and Total volatile base-nitrogen (TVB-N) were done to evaluate the preservative effect of (R.E.) and vitamin E during storage. The TBA and PV increased in all treatments due to lipid peroxidation. Results showed that TMA-N,TVB-N, value of (R.E.) and vitamin E treated samples were significantly lower than those of the control samples (P<0.05). Results of our investigation revealed that R.E. retarded oxidative changes in chilling and frozen fried fillets of Nile tilapia whereas R.E. 0.1%, 0.2% and vitamin E 0.1% were not as effective as R.E. 0.3% on oxidative stability. Best oxidation inhabitation results on chilling and frozen fried fillets of Nile tilapia was obtained when employing of R.E. The obtained results also showed that there was a significant (p<0.05) enhancement in sensory quality attributes of fried fillets of Nile tilapia; samples treated with R.E. and vitamin E Conclusion: The tested R.E. had a high effectiveness as antioxidative and antimicrobial should be utilized for extending the shelf-life through retarded the spoilage and enhancing quality attributes of fried fillets of Nile tilapia during chilling and frozen storage.
{"title":"Effect of rosemary extract and vitamin e on lipid peroxidation and the quality during chilling and frozen storage of fried Nile tilapia fillets (Oreochromis niloticus)","authors":"I. Mohamed","doi":"10.31579/2693-4779/029","DOIUrl":"https://doi.org/10.31579/2693-4779/029","url":null,"abstract":"Antioxidants are added to fresh and processed meat to prevent lipid oxidation, retard development of off-flavors, and improve color stability. In the food industry, they can be divided into natural and synthetic antioxidants. Synthetic antioxidants have been confirmed for their toxicological and carcinogenic effects. Thus, the food industry now chooses natural products over synthetic ones. This study was carried out to investigate the effect of Rosemary extract (R.E.) and vitamin E on the quality of fried fillets of Nile tilapia (Oreochromis niloticus) during chilling and frozen storage. Fillets of Nile tilapia were treated with (R.E.) 0.1%, 0.2%, 0.3% and Vitamin E 0.1% then stored for 5,10 and 15 days at 4±1°C and for three months at -18±2°C. Then chemical tests including Peroxide value (PV), Thio-barbituric acid (TBA), Tri-methylamine-nitrogen (TMA-N) and Total volatile base-nitrogen (TVB-N) were done to evaluate the preservative effect of (R.E.) and vitamin E during storage. The TBA and PV increased in all treatments due to lipid peroxidation. Results showed that TMA-N,TVB-N, value of (R.E.) and vitamin E treated samples were significantly lower than those of the control samples (P<0.05). Results of our investigation revealed that R.E. retarded oxidative changes in chilling and frozen fried fillets of Nile tilapia whereas R.E. 0.1%, 0.2% and vitamin E 0.1% were not as effective as R.E. 0.3% on oxidative stability. Best oxidation inhabitation results on chilling and frozen fried fillets of Nile tilapia was obtained when employing of R.E. The obtained results also showed that there was a significant (p<0.05) enhancement in sensory quality attributes of fried fillets of Nile tilapia; samples treated with R.E. and vitamin E Conclusion: The tested R.E. had a high effectiveness as antioxidative and antimicrobial should be utilized for extending the shelf-life through retarded the spoilage and enhancing quality attributes of fried fillets of Nile tilapia during chilling and frozen storage.","PeriodicalId":8525,"journal":{"name":"Applied Clinical Research, Clinical Trials and Regulatory Affairs","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79993996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: In our healthcare setting transmission of hepatitis B is a big challenge to handle for both patients and healthcare providers especially those in frequent contact with blood. Objectives: To determine Hepatitis B knowledge, attitude, and vaccination status among nurses of Tamale Central Hospital. Methods: This study was conducted using a descriptive cross-sectional survey. Data analysis was done with SPSS version 20. Bivariate analysis was done using chi-square to determine the relationships. Results: The study recorded a response rate of 92.5%. Majority (59.6%) had high, 36.4% had moderate and 4.0% had low knowledge hepatitis B. Hepatitis knowledge level was associated with: age X2 (4) = 17.789, P= 0.001, sex, X2(2) = 13.203, P = 0.001, educational level, X2(6) = 17.552, P = 0.007, nursing category, X2(4) = 19.226, P = 0.001, and duration of nursing practice X2(2) = 19.492, P ≤ 0.001. About 42.9% had positive attitude toward hepatitis B prevention and attitude level towards hepatitis B was associated with: marital status X2(1) = 11.090, P = 0.001, residential address X2 (2) = 11.411, P = 0.003 and duration of nursing practice X2(1) = 4.769, P = 0.029. About 84.8% of nurses started vaccination against hepatitis B and 77.3% completed at least three doses of the vaccination. The only factor with a statistically significant relationship with vaccination completeness status was respondent marital status X2(1) = 8.063, P = 0.005. Conclusion: Nurses' knowledge of hepatitis B was very good. And more than half of the nurses had a negative attitude towards hepatitis B prevention. In terms of vaccination more than three-fourth of them started and completed three doses of hepatitis B vaccination.
背景:在我们的医疗保健环境中，乙型肝炎的传播对患者和医疗保健提供者来说都是一个很大的挑战，特别是那些经常接触血液的人。目的:了解塔马勒中心医院护士对乙型肝炎的知识、态度和疫苗接种情况。方法:本研究采用描述性横断面调查法。数据分析使用SPSS version 20。使用卡方进行双变量分析以确定关系。结果:有效率为92.5%。绝大多数(59.6%)的乙肝知识为高，36.4%为中，4.0%为低。乙肝知识水平与年龄X2(4) = 17.789, P= 0.001，性别X2(2) = 13.203, P= 0.001，文化程度X2(6) = 17.552, P= 0.007，护理种类X2(4) = 19.226, P= 0.001，护理时间X2(2) = 19.492, P≤0.001有关。对乙肝预防持积极态度者占42.9%，对乙肝态度的高低与婚姻状况X2(1) = 11.090, P = 0.001;与居住地址X2(2) = 11.411, P = 0.003;与护理实习时间X2(1) = 4.769, P = 0.029有关。约84.8%的护士开始接种乙型肝炎疫苗，77.3%的护士至少接种了三剂疫苗。唯一与疫苗接种完成情况有统计学意义相关的因素为被调查者婚姻状况X2(1) = 8.063, P = 0.005。结论:护士对乙型肝炎知识的了解程度较高。半数以上的护士对乙肝预防持否定态度。在疫苗接种方面，超过四分之三的人开始并完成了三剂乙型肝炎疫苗接种。
{"title":"Hepatitis B Knowledge, Attitude and Vaccination Status among Nurses of Tamale Central Hospital, Ghana","authors":"A. Alhassan","doi":"10.31579/2693-4779/035","DOIUrl":"https://doi.org/10.31579/2693-4779/035","url":null,"abstract":"Background: In our healthcare setting transmission of hepatitis B is a big challenge to handle for both patients and healthcare providers especially those in frequent contact with blood. Objectives: To determine Hepatitis B knowledge, attitude, and vaccination status among nurses of Tamale Central Hospital. Methods: This study was conducted using a descriptive cross-sectional survey. Data analysis was done with SPSS version 20. Bivariate analysis was done using chi-square to determine the relationships. Results: The study recorded a response rate of 92.5%. Majority (59.6%) had high, 36.4% had moderate and 4.0% had low knowledge hepatitis B. Hepatitis knowledge level was associated with: age X2 (4) = 17.789, P= 0.001, sex, X2(2) = 13.203, P = 0.001, educational level, X2(6) = 17.552, P = 0.007, nursing category, X2(4) = 19.226, P = 0.001, and duration of nursing practice X2(2) = 19.492, P ≤ 0.001. About 42.9% had positive attitude toward hepatitis B prevention and attitude level towards hepatitis B was associated with: marital status X2(1) = 11.090, P = 0.001, residential address X2 (2) = 11.411, P = 0.003 and duration of nursing practice X2(1) = 4.769, P = 0.029. About 84.8% of nurses started vaccination against hepatitis B and 77.3% completed at least three doses of the vaccination. The only factor with a statistically significant relationship with vaccination completeness status was respondent marital status X2(1) = 8.063, P = 0.005. Conclusion: Nurses' knowledge of hepatitis B was very good. And more than half of the nurses had a negative attitude towards hepatitis B prevention. In terms of vaccination more than three-fourth of them started and completed three doses of hepatitis B vaccination.","PeriodicalId":8525,"journal":{"name":"Applied Clinical Research, Clinical Trials and Regulatory Affairs","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88393289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Pain management for lower extremity fracture surgeries can be challenging. The purpose of this study is to determine whether the use of ketamine and methadone are more effective than ketamine and morphine to reduce postoperative pain and morphine requirements in patients undergoing lower extremity fracture surgery. Materials and Methods: Seventy-five patients 18-65 years of age, ASA class I-III, were enrolled in this study, which scheduled for elective lower extremity orthopedic surgery involving fracture of femur or tibia were recruited for the study. Thirty-eight randomized to the Methadone group and 37 randomized into the Morphine group. Participants were randomized to either one of the two groups: methadone (2ug/kg fentanyl, 0.2 mg/kg ketamine and 0.2 mg/kg methadone IV) versus control (2 ug/kg fentanyl, 0.2mg/kg ketamine and 0.2 mg/kg morphine IV). The primary outcome was total morphine equivalent (MEQ) during the first 24 and 48 hours after surgery. Secondary outcomes included postoperative pain scores in PACU, at 24 and 48 hours, as well as postoperative nausea and vomiting (PONV). Results: There was no difference in intraoperative consumption of fentanyl between the Methadone group 360mcg and Morphine group 344mcg. In the first 24 hours postoperatively, the Methadone group consumed less MEQ compared with the Morphine group (36.1 mg vs 54.8 mg, p=0.0072), showed lower pain scores than the Morphine group (p=0.0146), and experienced more nausea and vomiting than the Morphine group. There were no differences in sedation in both groups. Conclusion: The intraoperative use of intravenous methadone significantly reduced post-operative opioid requirement in patients undergoing lower extremity fracture surgery. The results also demonstrated the methadone group had a higher rate of PONV.
背景:下肢骨折手术的疼痛管理具有挑战性。本研究的目的是确定氯胺酮和美沙酮是否比氯胺酮和美沙酮更有效地减少下肢骨折手术患者的术后疼痛和吗啡需求。材料和方法:本研究招募了75例18-65岁的ASA I-III级患者，这些患者计划进行选择性下肢骨科手术，包括股骨或胫骨骨折。38例随机分为美沙酮组，37例随机分为吗啡组。参与者被随机分为两组:美沙酮组(2ug/kg芬太尼，0.2mg/kg氯胺酮和0.2mg/kg美沙酮IV)与对照组(2ug/kg芬太尼，0.2mg/kg氯胺酮和0.2mg/kg吗啡IV)。主要结局是术后前24小时和48小时的总吗啡当量(MEQ)。次要结局包括术后24小时和48小时PACU疼痛评分，以及术后恶心和呕吐(PONV)。结果:术中芬太尼用量美沙酮组(360mcg)与吗啡组(344mcg)无显著差异。术后24小时内，美沙酮组MEQ用量低于吗啡组(36.1 mg vs 54.8 mg, p=0.0072)，疼痛评分低于吗啡组(p=0.0146)，恶心呕吐发生率高于吗啡组。两组患者镇静效果无差异。结论:术中静脉注射美沙酮可显著降低下肢骨折患者术后阿片类药物需求。结果还表明，美沙酮组有较高的PONV率。
{"title":"Intraoperative Intravenous Methadone and Ketamine Combination versus Intravenous Morphine and Ketamine Combination for Post-Operative Analgesia in Patients Undergoing Lower Extremity Fracture Surgery","authors":"A. Wadhwa","doi":"10.31579/2693-4779/026","DOIUrl":"https://doi.org/10.31579/2693-4779/026","url":null,"abstract":"Background: Pain management for lower extremity fracture surgeries can be challenging. The purpose of this study is to determine whether the use of ketamine and methadone are more effective than ketamine and morphine to reduce postoperative pain and morphine requirements in patients undergoing lower extremity fracture surgery. Materials and Methods: Seventy-five patients 18-65 years of age, ASA class I-III, were enrolled in this study, which scheduled for elective lower extremity orthopedic surgery involving fracture of femur or tibia were recruited for the study. Thirty-eight randomized to the Methadone group and 37 randomized into the Morphine group. Participants were randomized to either one of the two groups: methadone (2ug/kg fentanyl, 0.2 mg/kg ketamine and 0.2 mg/kg methadone IV) versus control (2 ug/kg fentanyl, 0.2mg/kg ketamine and 0.2 mg/kg morphine IV). The primary outcome was total morphine equivalent (MEQ) during the first 24 and 48 hours after surgery. Secondary outcomes included postoperative pain scores in PACU, at 24 and 48 hours, as well as postoperative nausea and vomiting (PONV). Results: There was no difference in intraoperative consumption of fentanyl between the Methadone group 360mcg and Morphine group 344mcg. In the first 24 hours postoperatively, the Methadone group consumed less MEQ compared with the Morphine group (36.1 mg vs 54.8 mg, p=0.0072), showed lower pain scores than the Morphine group (p=0.0146), and experienced more nausea and vomiting than the Morphine group. There were no differences in sedation in both groups. Conclusion: The intraoperative use of intravenous methadone significantly reduced post-operative opioid requirement in patients undergoing lower extremity fracture surgery. The results also demonstrated the methadone group had a higher rate of PONV.","PeriodicalId":8525,"journal":{"name":"Applied Clinical Research, Clinical Trials and Regulatory Affairs","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73751588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: periodontal disease with alveoli bone degeneration and losing teeth is seen in many people, including those with arthritis rheumatoid. Objective This study aims to evaluate the effect of non-surgical periodontal treatments on the severity of arthritis rheumatoid. Methods: this randomized control clinical trial was conducted on 60 patients who concurrently had arthritis and mild to moderate periodontitis. Patients divided into three groups of 20 subjects (group C had tooth cleaning and antibiotic therapy, group B had only tooth cleaning and group A was control). DAS28 questionnaire was filled out for all three groups at the beginning of the study. After ending the treatment and improvement, patients were examined in days 45 and 90 in terms of improvement indicators for arthritis rheumatoid. Data were finally analyzed by SPSS18. Results: the highest reduction rate of ESR, DAS28, CRP and RF was in different time periods in tooth cleaning intervention +antibiotic group and then, teeth cleaning group. The lowest reduction was seen in control group. RF, CRP and DAS28 indices showed significant differences in different time periods in tooth cleaning group and tooth cleaning+ antibiotic group (P<0.05). Conclusion: non-surgery periodontal treatment and RA indices, without considering the medicines used for treatment, had positive effect on the treatment of this disease.
{"title":"The Effect of non-Surgical Periodontal Treatments on the Severity of Arthritis Rheumatoid","authors":"E. Atabati","doi":"10.31579/2693-4779/038","DOIUrl":"https://doi.org/10.31579/2693-4779/038","url":null,"abstract":"Background: periodontal disease with alveoli bone degeneration and losing teeth is seen in many people, including those with arthritis rheumatoid. Objective This study aims to evaluate the effect of non-surgical periodontal treatments on the severity of arthritis rheumatoid. Methods: this randomized control clinical trial was conducted on 60 patients who concurrently had arthritis and mild to moderate periodontitis. Patients divided into three groups of 20 subjects (group C had tooth cleaning and antibiotic therapy, group B had only tooth cleaning and group A was control). DAS28 questionnaire was filled out for all three groups at the beginning of the study. After ending the treatment and improvement, patients were examined in days 45 and 90 in terms of improvement indicators for arthritis rheumatoid. Data were finally analyzed by SPSS18. Results: the highest reduction rate of ESR, DAS28, CRP and RF was in different time periods in tooth cleaning intervention +antibiotic group and then, teeth cleaning group. The lowest reduction was seen in control group. RF, CRP and DAS28 indices showed significant differences in different time periods in tooth cleaning group and tooth cleaning+ antibiotic group (P<0.05). Conclusion: non-surgery periodontal treatment and RA indices, without considering the medicines used for treatment, had positive effect on the treatment of this disease.","PeriodicalId":8525,"journal":{"name":"Applied Clinical Research, Clinical Trials and Regulatory Affairs","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76397176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to subculture human skeletal muscle cells (HSkMC) using a culture medium with different compositions to determine the most efficient medium for the growth of the human skeletal muscle cells. The culture media was divided into three groups: Group1. An HSkMC growth medium. Group 2. An HSkMC growth medium + with 10% high glucose (GH). Group 3. An HSkMC growth medium + 10% fetal bovine serum (FBS). HSkMC from groups 1 to 3 gradually became round in shape and gathered in clusters. These changes differed between the groups. In group 3, the HSkMC clusters were more in numbers and gathered as significantly more prominent than in the other groups under the EVOS-Microscope shown. We concluded that by manipulating the composition of the culture medium, it is possible to induce HSkMC to promote the best growth.
{"title":"Subculture human skeletal muscle cells to produce the cells with different Culture medium compositions","authors":"Ying Balch","doi":"10.31579/2693-4779/036","DOIUrl":"https://doi.org/10.31579/2693-4779/036","url":null,"abstract":"This study aimed to subculture human skeletal muscle cells (HSkMC) using a culture medium with different compositions to determine the most efficient medium for the growth of the human skeletal muscle cells. The culture media was divided into three groups: Group1. An HSkMC growth medium. Group 2. An HSkMC growth medium + with 10% high glucose (GH). Group 3. An HSkMC growth medium + 10% fetal bovine serum (FBS). HSkMC from groups 1 to 3 gradually became round in shape and gathered in clusters. These changes differed between the groups. In group 3, the HSkMC clusters were more in numbers and gathered as significantly more prominent than in the other groups under the EVOS-Microscope shown. We concluded that by manipulating the composition of the culture medium, it is possible to induce HSkMC to promote the best growth.","PeriodicalId":8525,"journal":{"name":"Applied Clinical Research, Clinical Trials and Regulatory Affairs","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85694582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：