Pub Date : 2023-06-15DOI: 10.22270/ajprd.v11i3.1230
Muzammil Muzaffar, Arifa Hassan Sheikh, Mohd Rafi Reshi
Objective: The objective of the present study was to evaluate the effect of Curcumin on Biochemical markers and Histopathology examination of LPS induced preeclampsia in experimental rats. Materials and Methods: Biochemical examination was done by manual method of kit.Histopathology was done bypathologist. Results: In the LPS treated group, significant increase in SGPT, Albumin, creatinine and CK-BT levels as compared to pregnant control. Also degenerative changes were seen in kidney and liver tissues.Treatment with curcumin (0.36mg/kg)had significant improvement against LPS induced pre-eclampsiachanges in the biochemical markers markers as well as histopathlogical examination. The curcumintreatment ameliorates effect that is induced by LPS. Conclusion: The present study concludes that curcumincan be the treatment of pre-eclamsia as it produced significant effect in biochemical examination as well as decreased the degenerative effect in histopathology examination of kidney and liver.
{"title":"Effect of Curcumin on Biochemical markers and Histopathology examination of LPS induced preeclampsia in experimental rats","authors":"Muzammil Muzaffar, Arifa Hassan Sheikh, Mohd Rafi Reshi","doi":"10.22270/ajprd.v11i3.1230","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1230","url":null,"abstract":"Objective: The objective of the present study was to evaluate the effect of Curcumin on Biochemical markers and Histopathology examination of LPS induced preeclampsia in experimental rats. Materials and Methods: Biochemical examination was done by manual method of kit.Histopathology was done bypathologist. Results: In the LPS treated group, significant increase in SGPT, Albumin, creatinine and CK-BT levels as compared to pregnant control. Also degenerative changes were seen in kidney and liver tissues.Treatment with curcumin (0.36mg/kg)had significant improvement against LPS induced pre-eclampsiachanges in the biochemical markers markers as well as histopathlogical examination. The curcumintreatment ameliorates effect that is induced by LPS. Conclusion: The present study concludes that curcumincan be the treatment of pre-eclamsia as it produced significant effect in biochemical examination as well as decreased the degenerative effect in histopathology examination of kidney and liver.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Traditional medicine (TM) is a collection of skills, knowledge, and practices based on theories, beliefs, and experiences from various cultures that are used to maintain health as well as to prevent, diagnose, improve, or treat physical and mental disorders. There exist a number of non-conventional medicines practices in the world today. Limited documented data exist that addressed the use of traditional medicines among HIV patients in Nigeria. Objectives: To assess the use and the pattern of use of traditional medicines among HIV positive patients. Methods: This study was a cross sectional, descriptive study carried out at the Federal Medical Center Makurdi, Benue State, middle belt, Nigeria for a period of three months. Results: In this study, nearly two-thirds (61.7%) of the participants reported that they had never used Traditional Medicine (TM) along with HIV/AIDS drugs and 16.1% reported that they began TM use after the initiation of ART. The leading forms of TM used by the patients were spiritual therapy (21.9%) and herbal therapy (16.6%). The study showed that most patients use TM without any motivating factor (62.3%) but some had motivating reasons such as religious practices (14.2%) and to deal with ART side effects (14.5%). Conclusions: The use of TM among HIV/AIDS patients on antiretroviral therapy (ART) was unusual. Spiritual and herbal therapies were the most commonly employed TMs among the participants in the study. Although a small percentage of patients reported deteriorated disease condition as a result of using TM with ART, a handful of users reported improvement after treatment.
{"title":"Traditional Medicine Use Among HIV Positive Patients in Markurdi, Benue State of Nigeria","authors":"Maureen Akunne, Chinenye Emerenini, Maureen Anetoh, Eleje Okonta","doi":"10.22270/ajprd.v11i3.1216","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1216","url":null,"abstract":"Background: Traditional medicine (TM) is a collection of skills, knowledge, and practices based on theories, beliefs, and experiences from various cultures that are used to maintain health as well as to prevent, diagnose, improve, or treat physical and mental disorders. There exist a number of non-conventional medicines practices in the world today. Limited documented data exist that addressed the use of traditional medicines among HIV patients in Nigeria. Objectives: To assess the use and the pattern of use of traditional medicines among HIV positive patients. Methods: This study was a cross sectional, descriptive study carried out at the Federal Medical Center Makurdi, Benue State, middle belt, Nigeria for a period of three months. Results: In this study, nearly two-thirds (61.7%) of the participants reported that they had never used Traditional Medicine (TM) along with HIV/AIDS drugs and 16.1% reported that they began TM use after the initiation of ART. The leading forms of TM used by the patients were spiritual therapy (21.9%) and herbal therapy (16.6%). The study showed that most patients use TM without any motivating factor (62.3%) but some had motivating reasons such as religious practices (14.2%) and to deal with ART side effects (14.5%). Conclusions: The use of TM among HIV/AIDS patients on antiretroviral therapy (ART) was unusual. Spiritual and herbal therapies were the most commonly employed TMs among the participants in the study. Although a small percentage of patients reported deteriorated disease condition as a result of using TM with ART, a handful of users reported improvement after treatment.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biopharmaceutical classification system is important for determining the bioavailability of the drug. Drugs that dissolve slowly in water can be effectively solid-dispersed to increase their bioavailability. The bioavailability issue can be due to insufficient solubility of permeability. The poorly water-soluble medication dissolves more quickly when combined with the water-soluble carriers used to make solid dispersion. The review paper concentrates on the preparation techniques, benefits, drawbacks, and characterization of solid dispersion. Pharmaceuticals with sustained release have recently emerged as a very practical tool in medical practise, providing patients with a variety of real and perceived benefits. By minimising fluctuations in Using the therapeutic dose of the medicine in the body, sustained release is another promising reduction technique side effects. The major methods for creating tablets with a sustained release matrix are wet granulation, direct compression, or dispersion. In this review paper got the information about various polymers and different methods which are used for the formulate the sustained release tablet.
{"title":"An Overview Onsustained Release Formulations Using Solid Dispersion as Solubility Enhancement Technique.","authors":"Bhosale Nikita, Velhal Atish, Redasani Vivek Kumar, Raut Poonam, Varda Joshi","doi":"10.22270/ajprd.v11i3.1257","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1257","url":null,"abstract":"Biopharmaceutical classification system is important for determining the bioavailability of the drug. Drugs that dissolve slowly in water can be effectively solid-dispersed to increase their bioavailability. The bioavailability issue can be due to insufficient solubility of permeability. The poorly water-soluble medication dissolves more quickly when combined with the water-soluble carriers used to make solid dispersion. The review paper concentrates on the preparation techniques, benefits, drawbacks, and characterization of solid dispersion. Pharmaceuticals with sustained release have recently emerged as a very practical tool in medical practise, providing patients with a variety of real and perceived benefits. By minimising fluctuations in Using the therapeutic dose of the medicine in the body, sustained release is another promising reduction technique side effects. The major methods for creating tablets with a sustained release matrix are wet granulation, direct compression, or dispersion. In this review paper got the information about various polymers and different methods which are used for the formulate the sustained release tablet.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.22270/ajprd.v11i3.1256
Swarnima Kandari, Ratnakar, A. Chandola
Background: Bronchial asthma is a prevalent inflammatory disease characterized by infiltration with eosinophils, lymphocytes, and mast cells in the airway leading to airway hypersensitivity and increased mucus secretion. T helper (Th) 2-based immune responses drive the inflammatory process. Numerous mechanisms are being studied to understand the progression of allergen induce asthma which subsequently led to the identification of a new population of T cells called the iNKT cells which showed promising results when experimented on murine models. iNKT cells are potent immune modulators involved in a variety of immunoregulations. This potency is the result of their ability to produce prime Th2 cytokines. The recognition of lipid antigens is required for the activation of iNKT cells. When an inflammation occurs due to Th2 cells and ozone, endogenous glycolipids become modified. This causes the activation of various subsets of iNKT cells and initiates airway hyperactivity. Infrequent human studies depict that the number of iNKT cells in BAL fluid ranges from 1 % of lung lymphocytes to 14 % which is a sign of dynamic fluctuation in the number of iNKT cells. Methods: Selective literature review including primary and secondary sources of literature. Eg. Cochrane database, NCBI, MEDLINE database.
{"title":"Involvement of iNKT Cells In Bronchial Asthma","authors":"Swarnima Kandari, Ratnakar, A. Chandola","doi":"10.22270/ajprd.v11i3.1256","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1256","url":null,"abstract":"Background: Bronchial asthma is a prevalent inflammatory disease characterized by infiltration with eosinophils, lymphocytes, and mast cells in the airway leading to airway hypersensitivity and increased mucus secretion. T helper (Th) 2-based immune responses drive the inflammatory process. Numerous mechanisms are being studied to understand the progression of allergen induce asthma which subsequently led to the identification of a new population of T cells called the iNKT cells which showed promising results when experimented on murine models. iNKT cells are potent immune modulators involved in a variety of immunoregulations. This potency is the result of their ability to produce prime Th2 cytokines. The recognition of lipid antigens is required for the activation of iNKT cells. When an inflammation occurs due to Th2 cells and ozone, endogenous glycolipids become modified. This causes the activation of various subsets of iNKT cells and initiates airway hyperactivity. Infrequent human studies depict that the number of iNKT cells in BAL fluid ranges from 1 % of lung lymphocytes to 14 % which is a sign of dynamic fluctuation in the number of iNKT cells. Methods: Selective literature review including primary and secondary sources of literature. Eg. Cochrane database, NCBI, MEDLINE database.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.22270/ajprd.v11i3.1259
Poonam Raut, Nikita Bhosale, Varda Joshi
The "Pharmaceutical Nanotechnology" subfield of pharmaceutical sciences, which is now in its infancy, offers new tools, prospects, and horizons with potential applications in the field of therapy and diagnostics of disease. Pharmaceutical nanotechnology consists of items that are nanosized and may be altered in many ways to enhance their properties. According to the administration method, the nanoporous particles are NSs that may entangle a wide variety of materials before being absorbed into a suitable formulation. They delay the drug's release in a regulated manner, stop the drug's protein from degrading, and disperse the drug where it is needed. They can move about the body, connect to the skin, and release the medicine at the intended target spot in a regulated and predictable way. They have excellent aqueous solubility, making them a carrier for medications with poor water solubility. When compared to other nanocarriers, they have greater drug loading capabilities. They are therefore appropriate for addressing issues with active ingredient stability, solubility, and delayed release. The main benefit of nanosponges of weakly water soluble medicines. They can function as biocatalysts in the administration of enzymes, proteins, vaccines, and antibodies and can administer medications via a variety of routes, including oral, topical, parental, etc.
{"title":"Nanosponge: An Overview","authors":"Poonam Raut, Nikita Bhosale, Varda Joshi","doi":"10.22270/ajprd.v11i3.1259","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1259","url":null,"abstract":"The \"Pharmaceutical Nanotechnology\" subfield of pharmaceutical sciences, which is now in its infancy, offers new tools, prospects, and horizons with potential applications in the field of therapy and diagnostics of disease. Pharmaceutical nanotechnology consists of items that are nanosized and may be altered in many ways to enhance their properties. According to the administration method, the nanoporous particles are NSs that may entangle a wide variety of materials before being absorbed into a suitable formulation. They delay the drug's release in a regulated manner, stop the drug's protein from degrading, and disperse the drug where it is needed. They can move about the body, connect to the skin, and release the medicine at the intended target spot in a regulated and predictable way. They have excellent aqueous solubility, making them a carrier for medications with poor water solubility. When compared to other nanocarriers, they have greater drug loading capabilities. They are therefore appropriate for addressing issues with active ingredient stability, solubility, and delayed release. The main benefit of nanosponges of weakly water soluble medicines. They can function as biocatalysts in the administration of enzymes, proteins, vaccines, and antibodies and can administer medications via a variety of routes, including oral, topical, parental, etc.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Beigh, R. Saleem, A. H. Maghrabi, Eman H. Khalifa, Saima Mushtaq, M. Rehman, A. Wali
The most important heterocyclic complexes involved in the manufacture of DNA and RNA are dihydropyrimidines. Through multi-component synthetic procedures like the Biginelli reaction and the Hantzsch dihydropyridine reaction, they were created. Due to their extraordinary biological properties, dihydropyrimidin-2(1H)-ones/thiones (DHPMs) are notable heterocyclic compounds. Dihydropyrimidin-2(1H)-ones/thiones (DHPMs), among the most important heterocyclic compounds, have biologically important properties such as cytotoxic, antibacterial, antiviral, and anti-inflammatory effects. As a result, organic and medicinal chemists are paying increasing attention to the synthesis of DHPMs and their derivatives. Many DHPM compounds have recently been isolated, described, and identified, and they are currently undergoing human usage studies. Dihydrpyrimidines have been discovered to improve the health of cancer patients. We are intrigued by dihydropyrimidine research and its focus on colon cancer. One of the most prevalent kinds of cancer is colorectal cancer (CRC), and it’s also the second commonest fatal malignancy for both sexes combined and the third most frequent diagnosis. With the exception of younger persons, both the incidence of new cases and death have been consistently dropping over the past several years, maybe as a result of increased cancer screening and improved treatment options. Different dihydropyridine calcium channel blockers prevent calcium from entering certain human cancer cells, having anticancer effects. However, to our knowledge, the anticancer impact of dihydropyrimidine on colorectal cancer cells has never been studied (CRC). With an emphasis on colon cancer, we have attempted to discuss the significance of DHPM derivatives for a number of chronic and developmental problems in this article.
{"title":"Dihydropyrimidinones: Recent Synthetic and Pharmacological Perspectives with Special Focus on Colon Cancer","authors":"S. Beigh, R. Saleem, A. H. Maghrabi, Eman H. Khalifa, Saima Mushtaq, M. Rehman, A. Wali","doi":"10.47485/2694-5614.1017","DOIUrl":"https://doi.org/10.47485/2694-5614.1017","url":null,"abstract":"The most important heterocyclic complexes involved in the manufacture of DNA and RNA are dihydropyrimidines. Through multi-component synthetic procedures like the Biginelli reaction and the Hantzsch dihydropyridine reaction, they were created. Due to their extraordinary biological properties, dihydropyrimidin-2(1H)-ones/thiones (DHPMs) are notable heterocyclic compounds. Dihydropyrimidin-2(1H)-ones/thiones (DHPMs), among the most important heterocyclic compounds, have biologically important properties such as cytotoxic, antibacterial, antiviral, and anti-inflammatory effects. As a result, organic and medicinal chemists are paying increasing attention to the synthesis of DHPMs and their derivatives. Many DHPM compounds have recently been isolated, described, and identified, and they are currently undergoing human usage studies.\u0000\u0000Dihydrpyrimidines have been discovered to improve the health of cancer patients. We are intrigued by dihydropyrimidine research and its focus on colon cancer. One of the most prevalent kinds of cancer is colorectal cancer (CRC), and it’s also the second commonest fatal malignancy for both sexes combined and the third most frequent diagnosis. With the exception of younger persons, both the incidence of new cases and death have been consistently dropping over the past several years, maybe as a result of increased cancer screening and improved treatment options. Different dihydropyridine calcium channel blockers prevent calcium from entering certain human cancer cells, having anticancer effects. However, to our knowledge, the anticancer impact of dihydropyrimidine on colorectal cancer cells has never been studied (CRC). With an emphasis on colon cancer, we have attempted to discuss the significance of DHPM derivatives for a number of chronic and developmental problems in this article.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81490797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.22270/ajprd.v10i6.1210
N. Padole, Himanshu Chandankhede, R. Deshmukh, Prajakta Chatakwar, S. Dandekar, J. Baheti
Now a day’s major population over the world is facing the issue of allopathic drug and their adverse effect in treatment of various diseases. Ayurveda is one of the traditional medicinal systems of India. The philosophy behind Ayurveda is preventing unnecessary suffering and living a long healthy life. Herbal medicines have existed world-wide with long recorded history and they were used in ancient Chinese, Greek, and Indian medicine for various therapies purposes.Herbals are one of the best alternativesin treatment of acute and chronic diseases. In this review different herb has been studied due to its medicinal, pharmacognostic and therapeutic application. This article enlists some commercial and non-commercial Polyherbal all around the world. In which plants, fruits, leaves, seeds and powder of Momordica dioica, Lantana camara L., Curcuma longa,Carthamustinctorius and Acacia catechu has been studied. This article provides a general idea about different herbs, their phytochemical contents, method of extraction and applications in treatment of various diseases.
{"title":"A Review: Phytochemical Investigation and Medicinal Applications of Herb’s","authors":"N. Padole, Himanshu Chandankhede, R. Deshmukh, Prajakta Chatakwar, S. Dandekar, J. Baheti","doi":"10.22270/ajprd.v10i6.1210","DOIUrl":"https://doi.org/10.22270/ajprd.v10i6.1210","url":null,"abstract":"Now a day’s major population over the world is facing the issue of allopathic drug and their adverse effect in treatment of various diseases. Ayurveda is one of the traditional medicinal systems of India. The philosophy behind Ayurveda is preventing unnecessary suffering and living a long healthy life. Herbal medicines have existed world-wide with long recorded history and they were used in ancient Chinese, Greek, and Indian medicine for various therapies purposes.Herbals are one of the best alternativesin treatment of acute and chronic diseases. \u0000In this review different herb has been studied due to its medicinal, pharmacognostic and therapeutic application. This article enlists some commercial and non-commercial Polyherbal all around the world. In which plants, fruits, leaves, seeds and powder of Momordica dioica, Lantana camara L., Curcuma longa,Carthamustinctorius and Acacia catechu has been studied. This article provides a general idea about different herbs, their phytochemical contents, method of extraction and applications in treatment of various diseases. \u0000 \u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73396476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.22270/ajprd.v10i6.1209
Iis Solihah
Background: Heart disease is no longer affecting the elderly, but more and more young people are getting heart disease. An educational approach in health promotion by using attractive media is one of the most necessary ways to invite teenagers to behave in a healthy life. The purpose of this study was to determine the effect of the education module on knowledge of risk factors for cardiovascular disease prevention. The research method used a quasi-experimental design with a control group. The research sample is students at SMK Era Pembangunan 3, West Jakarta. Sampling was done by simple random sampling and a total sample of 68 people were selected. Data were analyzed using chi square test and multiple logistic regression. The results showed that the education module given to respondents could increase students' knowledge in preventing cardiovascular disease risk factors with a p value of 0.000:OR 51.83 (95% CI 9.84-273.05). Conclusion: the education module has an effect on increasing knowledge about the prevention of cardiovascular disease risk factors. Recommendations are expected that future research will develop more instruments on risk factors for cardiovascular disease.
背景:心脏病不再影响老年人，但越来越多的年轻人患心脏病。利用有吸引力的媒体进行促进健康的教育是邀请青少年健康生活的最必要途径之一。本研究的目的是确定教育模块对心血管疾病预防危险因素知识的影响。研究方法采用准实验设计，设对照组。研究样本是雅加达西部SMK Era Pembangunan 3的学生。抽样采用简单随机抽样，共选取68人。数据分析采用卡方检验和多元逻辑回归。结果显示，给予被调查者的教育模块可以增加学生对心血管疾病危险因素的预防知识，p值为0.000:OR 51.83 (95% CI 9.84-273.05)。结论:教育模块对提高心血管疾病危险因素预防知识有一定作用。预计未来的研究将开发更多关于心血管疾病危险因素的仪器。
{"title":"Educational modules as an effort to increase knowledge of cardiovascular disease risk prevention","authors":"Iis Solihah","doi":"10.22270/ajprd.v10i6.1209","DOIUrl":"https://doi.org/10.22270/ajprd.v10i6.1209","url":null,"abstract":"Background: Heart disease is no longer affecting the elderly, but more and more young people are getting heart disease. An educational approach in health promotion by using attractive media is one of the most necessary ways to invite teenagers to behave in a healthy life. The purpose of this study was to determine the effect of the education module on knowledge of risk factors for cardiovascular disease prevention. The research method used a quasi-experimental design with a control group. The research sample is students at SMK Era Pembangunan 3, West Jakarta. Sampling was done by simple random sampling and a total sample of 68 people were selected. Data were analyzed using chi square test and multiple logistic regression. The results showed that the education module given to respondents could increase students' knowledge in preventing cardiovascular disease risk factors with a p value of 0.000:OR 51.83 (95% CI 9.84-273.05). Conclusion: the education module has an effect on increasing knowledge about the prevention of cardiovascular disease risk factors. Recommendations are expected that future research will develop more instruments on risk factors for cardiovascular disease. \u0000 \u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73021393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.22270/ajprd.v10i6.1208
Hussein Ali Hussein Al-Sa'idy, Hussein Kamil Hamid
Around seven species of the genous lolium poisonous grasses belonging to the family Poaceae are mutually grown in corps field over the world. In Iraq the prennel ryegrass is locally called “rewatta”.The toxicity of these gasses are related to three chemically distinct alkaloids groups; the aminopyrrolizidine; lolines, indole-diterpenes (ergots, loliterms, and paxillines) as well as peramine alkaloids mostly concentrated in their seeds although indole-diterpene alkaloids loliterm B and paxilline biosynthesis requires endophytes symbiosis. The level of loline alkaloids enhances in both late summer-autumn of the year as well as in the infected dry plant materials up to 10 fold. However, paxilline and ergovaline are believed to be the precursor of the most toxic lolium species alkaloids, loliterm B, although, indole-diterpene alkaloids paxillines, loliterms and ergovaline are the actual indicators of Lolium species. In this review we summarize chemical characteristics, biological and toxicological influences as well as their interrelation of the plant of lolium genus. Central as well as peripheral biological/toxicological manifestations are summarized for both loline and indole-diterpene alkaloids. Finally, toxic influences of lolium alkaloids are function of their biological influences mostly exhibited via resembling molecular mechansims centrally as well as peripherallyare concluded.
{"title":"Pharmacognostic Characteristics, Chemistry, Biological Activity And Toxicity of Lolium Species","authors":"Hussein Ali Hussein Al-Sa'idy, Hussein Kamil Hamid","doi":"10.22270/ajprd.v10i6.1208","DOIUrl":"https://doi.org/10.22270/ajprd.v10i6.1208","url":null,"abstract":"Around seven species of the genous lolium poisonous grasses belonging to the family Poaceae are mutually grown in corps field over the world. In Iraq the prennel ryegrass is locally called “rewatta”.The toxicity of these gasses are related to three chemically distinct alkaloids groups; the aminopyrrolizidine; lolines, indole-diterpenes (ergots, loliterms, and paxillines) as well as peramine alkaloids mostly concentrated in their seeds although indole-diterpene alkaloids loliterm B and paxilline biosynthesis requires endophytes symbiosis. The level of loline alkaloids enhances in both late summer-autumn of the year as well as in the infected dry plant materials up to 10 fold. However, paxilline and ergovaline are believed to be the precursor of the most toxic lolium species alkaloids, loliterm B, although, indole-diterpene alkaloids paxillines, loliterms and ergovaline are the actual indicators of Lolium species. In this review we summarize chemical characteristics, biological and toxicological influences as well as their interrelation of the plant of lolium genus. Central as well as peripheral biological/toxicological manifestations are summarized for both loline and indole-diterpene alkaloids. Finally, toxic influences of lolium alkaloids are function of their biological influences mostly exhibited via resembling molecular mechansims centrally as well as peripherallyare concluded. \u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81530485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rheumatoid arthritis is a persistent, painful inflammatory condition characterized by serious destruction of the bone marrow and cartilage in the joints. It can also affect the body as a whole, including the tissues, leading to disorders of the heart, lungs, nervous system, and eyes. It is an extremely painful inflammatory condition that significantly limits movement due to pain and joint deterioration. Systemic disease rheumatoid arthritis usually affects tissues that constrict. Age, race, inheritance, aberrant immunological functioning, and stress are risk factors. Early rheumatoid arthritis appears to have a unique cytokine profile for the production of interleukin-4, 13, and 15,52, which later show in chronic rheumatoid arthritis. The main objectives of rheumatoid arthritis treatment are to minimize pain and stop or slow the disease's progression. Therefore, early disease detection and correct diagnosis and treatment are crucial. Low-dose GCs combined with Awards are a safe and effective therapy choice for radiographic progression, symptom reduction, and high rates of clinical remission.
{"title":"Areview On Rheumatoid Arthiritis","authors":"Lalitha Sumathi, Manimekalai Pichaivel, Sabarinath, Thilagasundari Kandasamy","doi":"10.22270/ajprd.v10i6.1200","DOIUrl":"https://doi.org/10.22270/ajprd.v10i6.1200","url":null,"abstract":"Rheumatoid arthritis is a persistent, painful inflammatory condition characterized by serious destruction of the bone marrow and cartilage in the joints. It can also affect the body as a whole, including the tissues, leading to disorders of the heart, lungs, nervous system, and eyes. It is an extremely painful inflammatory condition that significantly limits movement due to pain and joint deterioration. Systemic disease rheumatoid arthritis usually affects tissues that constrict. Age, race, inheritance, aberrant immunological functioning, and stress are risk factors. Early rheumatoid arthritis appears to have a unique cytokine profile for the production of interleukin-4, 13, and 15,52, which later show in chronic rheumatoid arthritis. The main objectives of rheumatoid arthritis treatment are to minimize pain and stop or slow the disease's progression. Therefore, early disease detection and correct diagnosis and treatment are crucial. Low-dose GCs combined with Awards are a safe and effective therapy choice for radiographic progression, symptom reduction, and high rates of clinical remission. \u0000 ","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88058548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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