Pub Date : 2023-06-30DOI: 10.22270/ajprd.v11i3.1273
Navya Pabbathi, Haritha Pasupulati, Soni Gaddam, Satyanarayana SV Padi
The world of vaccines has transformed vaccination by saving millions of lives which otherwise would have killed many people and a hurdle for sustainable development world-wide. Indeed, the coronavirus disease 2019 (COVID-19) pandemic is a public health emergency and an important milestone that revealed how vaccines are really turning point for live changing across the world. Owing to extensive human efforts, vaccines for COVID-19 are discovered and developed and approved globally in less than a year, which is the first time in the history of the world of vaccines. Furthermore, one of the strategic goals of WHO’s ‘The Immunization Agenda 2030’ (IA2030) is the clinical development and approval of 500 new vaccines by 2030. Discovery of immunogens that elicit immune responses is a key step or process by which vaccine candidates have been optimized for further preclinical and clinical trials. Clinical evaluation is carried out in Phases (1-3) and is a sequential approach of establishing safety and efficacy in humans. Regulatory requirements for vaccine approval and licensure to bulk manufacturing are another hurdle. Further, post-marketing safety studies and post-marketing surveillance (Phase 4) are essential to collect the real-world data on safety and effectiveness of the approved vaccines. This review work provides a brief outline on timeline of development of traditional and COVID-19 vaccines and summarizes all the six stages of the vaccine development. Furthermore, current status of COVID-19 vaccines is discussed in view of future approvals.
{"title":"The World of Vaccines: Phases of Clinical Trials and Current Status of COVID-19 Vaccines","authors":"Navya Pabbathi, Haritha Pasupulati, Soni Gaddam, Satyanarayana SV Padi","doi":"10.22270/ajprd.v11i3.1273","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1273","url":null,"abstract":"The world of vaccines has transformed vaccination by saving millions of lives which otherwise would have killed many people and a hurdle for sustainable development world-wide. Indeed, the coronavirus disease 2019 (COVID-19) pandemic is a public health emergency and an important milestone that revealed how vaccines are really turning point for live changing across the world. Owing to extensive human efforts, vaccines for COVID-19 are discovered and developed and approved globally in less than a year, which is the first time in the history of the world of vaccines. Furthermore, one of the strategic goals of WHO’s ‘The Immunization Agenda 2030’ (IA2030) is the clinical development and approval of 500 new vaccines by 2030. Discovery of immunogens that elicit immune responses is a key step or process by which vaccine candidates have been optimized for further preclinical and clinical trials. Clinical evaluation is carried out in Phases (1-3) and is a sequential approach of establishing safety and efficacy in humans. Regulatory requirements for vaccine approval and licensure to bulk manufacturing are another hurdle. Further, post-marketing safety studies and post-marketing surveillance (Phase 4) are essential to collect the real-world data on safety and effectiveness of the approved vaccines. This review work provides a brief outline on timeline of development of traditional and COVID-19 vaccines and summarizes all the six stages of the vaccine development. Furthermore, current status of COVID-19 vaccines is discussed in view of future approvals.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139367581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The basic goal of TDDS is to administer medications at a predefined pace into systemic circulation through the skin with little inter- and intrapatient variance. TDDS come in a variety of forms, including reservoir and matrix systems, single-layer drugs in adhesive, and multi-layer drugs in adhesive. With more than 35 items already authorised for sale in the US and around 16 active components authorised for use as TDDSs internationally, the market value of TDDS products is growing quickly. Due to its low likelihood of patient rejection, simplicity of administration, and patients' convenience and perseverance, a transdermal drug delivery system [TDDS] is a desirable substitute for traditional needle injections. However, transdermal administration is complicated and constrained by the physicochemical characteristics of the skin. The many types of TDDS approaches that are now accessible are covered in this study, along with their individual benefits and drawbacks, characterization techniques, and potential. A transdermal patch is an tenacious medical patch that's applied to the skin to administer a particular quantum of drug via the skin and into the bloodstream, constantly accelerating the mending of a damaged body part. Transdermal medicine administration is a fairly new technology that has the implicit to reduce the need for needles when furnishing a wide range of specifics, but the cost is an essential element to take into account.
{"title":"Current Trends and Recent Development of Transdermal Drug Delivery System TDDS","authors":"Devbrat Soni, Kartikay Prakash, Kashif Shakeel, Priyanka Kesharawani","doi":"10.22270/ajprd.v11i3.1274","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1274","url":null,"abstract":"The basic goal of TDDS is to administer medications at a predefined pace into systemic circulation through the skin with little inter- and intrapatient variance. TDDS come in a variety of forms, including reservoir and matrix systems, single-layer drugs in adhesive, and multi-layer drugs in adhesive. With more than 35 items already authorised for sale in the US and around 16 active components authorised for use as TDDSs internationally, the market value of TDDS products is growing quickly. Due to its low likelihood of patient rejection, simplicity of administration, and patients' convenience and perseverance, a transdermal drug delivery system [TDDS] is a desirable substitute for traditional needle injections. However, transdermal administration is complicated and constrained by the physicochemical characteristics of the skin. The many types of TDDS approaches that are now accessible are covered in this study, along with their individual benefits and drawbacks, characterization techniques, and potential. A transdermal patch is an tenacious medical patch that's applied to the skin to administer a particular quantum of drug via the skin and into the bloodstream, constantly accelerating the mending of a damaged body part. Transdermal medicine administration is a fairly new technology that has the implicit to reduce the need for needles when furnishing a wide range of specifics, but the cost is an essential element to take into account.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139367628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-21DOI: 10.22270/ajprd.v11i3.1268
P. Bhagat, V. Redasani, Prakash D. Jadhav, Atish B. Velha, R. Mahadik
Human health management has always been the focus area of medical practitioners across the world. Health is maintained with the right kind of food intake, regular exercise, and remedial medications whenever and wherever necessary. Medications have been an integral part of human health management and improvement ever since. Along with medications, the right kind of drug delivery mechanism plays a crucial role in the efficacy of the medications. Dry powder inhalers (DPI) are one of the most efficient and advanced targeted drug delivery mechanisms. Currently, a wide range of inhaler devices are available on the market for pulmonary drug delivery with a view to maximising drug delivery with low variability compared to other drug delivery systems. Compared to other oral, topical, and parenteral drug delivery methods, DPI's efficiency is manifold. It has varied benefits, like rapid drug absorption due to the high density of blood vessels and the large surface area of the lungs (high lung deposition); the lungs have low enzymatic activity, so this route has a minimum risk for enzymatic degradation. Faster absorption, maximum efficiency, site target, minimum wastage, user-friendly, etc. Historically, DPIs were used only for respiratory-related ailments. But now, due to their better utility value, DPIs are also used in other maladies treatments. This research paper focuses on various advancements in the field of dry powder inhalers (DPIs), their advanced manufacturing techniques, challenges, and the evolution of technology that help maintain their versatility, stability, and reliability.
{"title":"Review on a Novel Advancement in Dry Powder Inhaler","authors":"P. Bhagat, V. Redasani, Prakash D. Jadhav, Atish B. Velha, R. Mahadik","doi":"10.22270/ajprd.v11i3.1268","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1268","url":null,"abstract":"Human health management has always been the focus area of medical practitioners across the world. Health is maintained with the right kind of food intake, regular exercise, and remedial medications whenever and wherever necessary. Medications have been an integral part of human health management and improvement ever since. Along with medications, the right kind of drug delivery mechanism plays a crucial role in the efficacy of the medications. Dry powder inhalers (DPI) are one of the most efficient and advanced targeted drug delivery mechanisms. Currently, a wide range of inhaler devices are available on the market for pulmonary drug delivery with a view to maximising drug delivery with low variability compared to other drug delivery systems. Compared to other oral, topical, and parenteral drug delivery methods, DPI's efficiency is manifold. It has varied benefits, like rapid drug absorption due to the high density of blood vessels and the large surface area of the lungs (high lung deposition); the lungs have low enzymatic activity, so this route has a minimum risk for enzymatic degradation. Faster absorption, maximum efficiency, site target, minimum wastage, user-friendly, etc. Historically, DPIs were used only for respiratory-related ailments. But now, due to their better utility value, DPIs are also used in other maladies treatments. This research paper focuses on various advancements in the field of dry powder inhalers (DPIs), their advanced manufacturing techniques, challenges, and the evolution of technology that help maintain their versatility, stability, and reliability.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-21DOI: 10.22270/ajprd.v11i3.1271
Pooja Patil, Vitthal J. Chaware, V. Redasani
The broad theory indicate that neurological ailment is caused by intricate interactions between environmental and genetic factors is supported using animal models to better understand the the cause and pathogenesis of Parkinson's disease (PD), as well as its cellular and molecular mechanisms. The more recent models use genetic manipulations that either introduce mutations similar to those found in familial cases of PD (a-synuclein, DJ-1, PINK1, Parkin, etc.) or selectively disrupt nigrostriatal neurons (MitoPark, Pitx3, Nurr1, etc.). "Classic" models are based on neurotoxins that specifically target catecholaminergic neurons. All of these together each model has its own benefits and drawbacks. The use of medication, deep brain stimulation, and physical therapy has been optimised for the symptomatic treatment of the motor symptoms of Parkinson disease (PD). L-dopa, several dopamine agonists, inhibitors of MAO-B and catechol-o-methyltransferase (COMT), and amantadine are among the pharmacotherapies available.
{"title":"An Overview of Animal Models and Symptomatic Treatment of Parkinson’s disease","authors":"Pooja Patil, Vitthal J. Chaware, V. Redasani","doi":"10.22270/ajprd.v11i3.1271","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1271","url":null,"abstract":"The broad theory indicate that neurological ailment is caused by intricate interactions between environmental and genetic factors is supported using animal models to better understand the the cause and pathogenesis of Parkinson's disease (PD), as well as its cellular and molecular mechanisms. The more recent models use genetic manipulations that either introduce mutations similar to those found in familial cases of PD (a-synuclein, DJ-1, PINK1, Parkin, etc.) or selectively disrupt nigrostriatal neurons (MitoPark, Pitx3, Nurr1, etc.). \"Classic\" models are based on neurotoxins that specifically target catecholaminergic neurons. All of these together each model has its own benefits and drawbacks. The use of medication, deep brain stimulation, and physical therapy has been optimised for the symptomatic treatment of the motor symptoms of Parkinson disease (PD). L-dopa, several dopamine agonists, inhibitors of MAO-B and catechol-o-methyltransferase (COMT), and amantadine are among the pharmacotherapies available.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-21DOI: 10.22270/ajprd.v11i3.1272
Rizwan A Bhaijamal, S. P. S. Nayak
Introduction: Despite general acknowledgment of a link between stress and acne, few research have been conducted to evaluate this link. The purpose of this study was to discover the link between stress and acne severity. Method: The research was carried out on adolescent students chosen from Singapore's Choa Chu Kang Secondary School. A total of 94 (59%) of the 160 students invited to participate in the study accepted (43 males and 51 women), and all participants provided parental informed agreement. Mid-year exams at schools were chosen as the stress model for the study. Singaporean children undergo an intensive school examination process. The outcome of such tests has a significant impact on children's long-term employment possibilities. The Perceived Stress Scale (PSS) was utilized in this study to assess acne severity in relation to stress using the global acne grading system (GAGS). The questionnaire also contained some confounding factors related to the severity of acne. Conclusions: According to the findings of this study, it is concluded that stress has a favorable correlation with acne severity.
{"title":"The Impact of Stress on Acne","authors":"Rizwan A Bhaijamal, S. P. S. Nayak","doi":"10.22270/ajprd.v11i3.1272","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1272","url":null,"abstract":"Introduction: Despite general acknowledgment of a link between stress and acne, few research have been conducted to evaluate this link. The purpose of this study was to discover the link between stress and acne severity. Method: The research was carried out on adolescent students chosen from Singapore's Choa Chu Kang Secondary School. A total of 94 (59%) of the 160 students invited to participate in the study accepted (43 males and 51 women), and all participants provided parental informed agreement. Mid-year exams at schools were chosen as the stress model for the study. Singaporean children undergo an intensive school examination process. The outcome of such tests has a significant impact on children's long-term employment possibilities. The Perceived Stress Scale (PSS) was utilized in this study to assess acne severity in relation to stress using the global acne grading system (GAGS). The questionnaire also contained some confounding factors related to the severity of acne. Conclusions: According to the findings of this study, it is concluded that stress has a favorable correlation with acne severity.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayurveda the science of life is the most ancient medical science which has focused primarily on preventive aspect rather than curative aspect, marma science is one of the exclusive and unique concepts of ayurveda, marma are vital and vulnarable areas of our body these areas or points are situated all over the body i.e. head, neck, trunk and extremeties, so knowledge of marma areas is not only essential for individuals for proctecting their vital and vulnerable areas of body from any injury but also for physician and surgeons to save these areas during surgical procedure or any medical interventation. Many references can be found in Vedic literature regarding injury at marma region of soldiers of enemies and protection of one's marma by wearing guards. Marmas are formed by the conglomeration of muscles, vessels, ligaments, tendons, bones and their joints. These marma areas have tridosha, triguna, bhutatma and chetana dhatu, so any injury to these points may cause pain or even death, other symptoms which appear on injury of marma are giddiness, syncope, delusion, semiconciousness, numbness etc Demanding lifestyle has boosted the incidence of trauma/soft tissue injury. One among such conditions is sprain with site predominance as Ankle accounting for 75%. Most sprains are sports related injuries and treatment for which is PRICE (pain killers, rest, icepack, compression and elevation) in allied science. In the United States it is estimated that 23,000 people per day, necessitate medical care for ankle sprains including athletes and non-athletes. AchayraSushruta in the context of BhagnaChikitsa explained ManjisthadiLepa to combat Vedana (pain). In this case study a patient diagnosed with rujakarmarmkshat of gulphasandhi was treated with a manjisthadilepa application twice a day daily for seven days.assessment of patient was done by scorring pattern. After completion of manjisthadilepa treatment significant relief was observed in symptopms.
阿育吠陀生命科学是一门最古老的医学科学，它主要侧重于预防而非治疗，玛尔玛科学是阿育吠陀独有的独特概念之一，玛尔玛是我们身体的重要和脆弱部位，这些部位或穴位遍布全身，即头部、颈部、躯干和四肢。因此，了解玛尔玛区不仅对个人保护身体重要和易受伤害的部位至关重要，而且对内科医生和外科医生在外科手术或任何医疗干预中保护这些部位也至关重要。在吠陀文献中可以找到许多关于敌人士兵在玛尔玛区域受伤以及佩戴护具保护自己玛尔玛的记载。玛玛区由肌肉、血管、韧带、肌腱、骨骼及其关节组成。这些穴位部位有三焦、三叉、膀胱经和膻中穴，因此任何对这些穴位的伤害都可能导致疼痛甚至死亡，其他因穴位受伤而出现的症状包括眩晕、晕厥、妄想、半知觉、麻木等。扭伤就是其中之一，扭伤部位以脚踝为主，占 75%。大多数扭伤都与运动有关，治疗方法是联合科学中的 PRICE（止痛药、休息、冰袋、加压和抬高）。据估计，在美国，每天有 23 000 人因踝关节扭伤而需要就医，其中包括运动员和非运动员。Achayra-Sushruta在Bhagna-Chikitsa中解释了Manjisthadi-Lepa对抗Vedana（疼痛）的方法。 在本病例研究中，一名被诊断出患有茹加卡玛克沙特（rujakarmkshat of gulphasandhi）的患者接受了曼吉斯他地利帕治疗，每天两次，连续七天。曼吉斯塔迪勒帕治疗结束后，症状明显缓解。
{"title":"A Single Case Study of Manjisthadi Lepa on Gulpharujakarmarmasandhighata W.S.R to Ankle Sprain","authors":"Sonal Panchal, Harshitshah, Rajesh Kumar sharma, Wasim Kazi, Divyabahen S. Ninama","doi":"10.22270/ajprd.v11i3.1269","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1269","url":null,"abstract":"Ayurveda the science of life is the most ancient medical science which has focused primarily on preventive aspect rather than curative aspect, marma science is one of the exclusive and unique concepts of ayurveda, marma are vital and vulnarable areas of our body these areas or points are situated all over the body i.e. head, neck, trunk and extremeties, so knowledge of marma areas is not only essential for individuals for proctecting their vital and vulnerable areas of body from any injury but also for physician and surgeons to save these areas during surgical procedure or any medical interventation. Many references can be found in Vedic literature regarding injury at marma region of soldiers of enemies and protection of one's marma by wearing guards. Marmas are formed by the conglomeration of muscles, vessels, ligaments, tendons, bones and their joints. These marma areas have tridosha, triguna, bhutatma and chetana dhatu, so any injury to these points may cause pain or even death, other symptoms which appear on injury of marma are giddiness, syncope, delusion, semiconciousness, numbness etc Demanding lifestyle has boosted the incidence of trauma/soft tissue injury. One among such conditions is sprain with site predominance as Ankle accounting for 75%. Most sprains are sports related injuries and treatment for which is PRICE (pain killers, rest, icepack, compression and elevation) in allied science. In the United States it is estimated that 23,000 people per day, necessitate medical care for ankle sprains including athletes and non-athletes. AchayraSushruta in the context of BhagnaChikitsa explained ManjisthadiLepa to combat Vedana (pain). In this case study a patient diagnosed with rujakarmarmkshat of gulphasandhi was treated with a manjisthadilepa application twice a day daily for seven days.assessment of patient was done by scorring pattern. After completion of manjisthadilepa treatment significant relief was observed in symptopms.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: To Evaluate the clinical efficacy of Amrutadi tablet (Anubhuta)as palliative care management in oral squamous cell carcinoma. Background: The disease arbuda was prevalent during the Vedic period. In athar-vaveda2 there is reference of arbuda and its management. Arbuda is one of the surgical diseases and was explained in detailed by sushruta the pioneer of in ancient ayurvedic texts that have remarkable similarities with modern interpretation of cancer. Cancer is one of the most dreaded diseases of the 20th century and spreading further with continuance and increasing incidence in 21st century. Cancer is a disease caused by uncontrolled division of abnormal cells in any part of the body.More than 90% of cancer of the tobacco induced oral cancer are squamous cell carcinoma. Results and Discussion: A case of pain in oral cavity and mouth ulceration after biopsy and mri diagnosed as oral squamous cell carcinoma was given Amrutadi tablet for a period of 30 days. Symptom of pain in oral cavity mouth ulceration and associated symtoms dysphagia, anorexia has been improved moderately within a month. Assesement of patient has been done based on subjective and objective criteria before and after treatment, which shows improvement in patient condition.
{"title":"Evaluate the clinical efficacy of Amrutadi tablet(Anubhut) as palliative care management in oral squamous cell carcinoma w.s.r to tobacco induced oral cancer -a single case study","authors":"Damini Parmar, Rajesh Kumar sharma, Vipulkumar V Sangani, Dhruval Padadhariya, Divya Bahen Ninama","doi":"10.22270/ajprd.v11i3.1266","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1266","url":null,"abstract":"Aim: To Evaluate the clinical efficacy of Amrutadi tablet (Anubhuta)as palliative care management in oral squamous cell carcinoma. Background: The disease arbuda was prevalent during the Vedic period. In athar-vaveda2 there is reference of arbuda and its management. Arbuda is one of the surgical diseases and was explained in detailed by sushruta the pioneer of in ancient ayurvedic texts that have remarkable similarities with modern interpretation of cancer. Cancer is one of the most dreaded diseases of the 20th century and spreading further with continuance and increasing incidence in 21st century. Cancer is a disease caused by uncontrolled division of abnormal cells in any part of the body.More than 90% of cancer of the tobacco induced oral cancer are squamous cell carcinoma. Results and Discussion: A case of pain in oral cavity and mouth ulceration after biopsy and mri diagnosed as oral squamous cell carcinoma was given Amrutadi tablet for a period of 30 days. Symptom of pain in oral cavity mouth ulceration and associated symtoms dysphagia, anorexia has been improved moderately within a month. Assesement of patient has been done based on subjective and objective criteria before and after treatment, which shows improvement in patient condition.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Urethral stricture disease is the common problem occurred in the patients after chronic urinary tract infection, urethral injury or post-surgical interventions performed through per urethra. In Ayurvedic literature urethral stricture may be correlated as mutrotsanga mentioned in Sushruta Samhita. There are advance surgeries available as the science advances with technology various surgeries like Urethroplasty, Visual Internal Urethrotomy, and Dilatation of urethra. The way to overcome this problem is surgery i.e. urethroplasty. But the recurrence rate is high enough to think the alternative. In this case study, 40 years old Male patient suffering from recurrent urethral stricture was came to Shalya Tantra OPD. Patient also undergone repeated urethral dilatations two times but not relieved. So after clinical examination and investigations the case diagnosed as urethral stricture and treated with Ayurvedic Para-surgical procedure i.e uttarbasti to avoid recurrent urethral stricture. In Ayurvedic literature Uttarbasti is the procedure in which some medicinal preparations are introduced per urethra. (As per reference given in sushruta samhita) Uttarbasti was done at 3 days interval for 4 weeks. In this particular study urethral dilatation done by urethral dilatators After that Uttarbasti has been given. After 3rd sitting patient got 70% relief. Thus we can conclude that uttarbasti can be considered as a golden choice of treatment for urethral stricture in Ayurved.
{"title":"Efficacy of Urethral dilatation with Uttarbasti in the management of Recurrent Urethral Stricture-A Single Case Study","authors":"Wasim Kazi, Rajesh Kumar sharma, Harshit Shah, Varsha Sharma, Sonal Panchal","doi":"10.22270/ajprd.v11i3.1267","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1267","url":null,"abstract":"Urethral stricture disease is the common problem occurred in the patients after chronic urinary tract infection, urethral injury or post-surgical interventions performed through per urethra. In Ayurvedic literature urethral stricture may be correlated as mutrotsanga mentioned in Sushruta Samhita. There are advance surgeries available as the science advances with technology various surgeries like Urethroplasty, Visual Internal Urethrotomy, and Dilatation of urethra. The way to overcome this problem is surgery i.e. urethroplasty. But the recurrence rate is high enough to think the alternative. In this case study, 40 years old Male patient suffering from recurrent urethral stricture was came to Shalya Tantra OPD. Patient also undergone repeated urethral dilatations two times but not relieved. So after clinical examination and investigations the case diagnosed as urethral stricture and treated with Ayurvedic Para-surgical procedure i.e uttarbasti to avoid recurrent urethral stricture. In Ayurvedic literature Uttarbasti is the procedure in which some medicinal preparations are introduced per urethra. (As per reference given in sushruta samhita) Uttarbasti was done at 3 days interval for 4 weeks. In this particular study urethral dilatation done by urethral dilatators After that Uttarbasti has been given. After 3rd sitting patient got 70% relief. Thus we can conclude that uttarbasti can be considered as a golden choice of treatment for urethral stricture in Ayurved.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pilus meaning hair and nidus meaning nest.A pilonidal sinus is an acquired condition.It is also termed as jeep disease. Mostly affected to males cause they have more hair growth. Hair containing cyst located just below the coccyx PNS occurs in the cleft between the buttocks. when buttocks moves and hair breaks off by friction and collect in the cleft makes local inflammation turns to sinus formation. PNS can be correlated with Nadivrana as per Ayurveda classic.Management of Nadi vrana is described by Susruta along with Chedana (excision) of the total tract (Su.Chi-17/18). After Chedana karma (excision) the big wound (6cm length*3cm width) was treated with local application of tikshna ApamargaKshara and Jatyadi Ghrita after cleaning wound with Panchvalkala kwath along with internal Ayurveda medicine (TriphalaGuggulu 1gm three times a day). Aim:To evaluate the efficacy of Chedana Karma and Apamarg Kshara Application in the management of shalyaja nadivrana w.s.r to Pilonidal Sinus. Methodology: here we present a case discussion of Chhedan karma and Application of tikshna Apamarga Kshara in the management of shalyaja nadivrana. Result: Patient got symptomatic relief. Conclusion: The prevalence of Nadivrana increasing day by day.Ayurvedic management is effective in slow down the disease progression and breakdown the pathology.
{"title":"A Case Discussion On Pilonidal Sinus(Nadivrana): Case Report","authors":"Varsha Sharma, Rajesh Kumar sharma, Harshit Shah, Dhruval Padadhria, Wasim Kazi","doi":"10.22270/ajprd.v11i3.1265","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1265","url":null,"abstract":"Pilus meaning hair and nidus meaning nest.A pilonidal sinus is an acquired condition.It is also termed as jeep disease. Mostly affected to males cause they have more hair growth. Hair containing cyst located just below the coccyx PNS occurs in the cleft between the buttocks. when buttocks moves and hair breaks off by friction and collect in the cleft makes local inflammation turns to sinus formation. PNS can be correlated with Nadivrana as per Ayurveda classic.Management of Nadi vrana is described by Susruta along with Chedana (excision) of the total tract (Su.Chi-17/18). After Chedana karma (excision) the big wound (6cm length*3cm width) was treated with local application of tikshna ApamargaKshara and Jatyadi Ghrita after cleaning wound with Panchvalkala kwath along with internal Ayurveda medicine (TriphalaGuggulu 1gm three times a day). Aim:To evaluate the efficacy of Chedana Karma and Apamarg Kshara Application in the management of shalyaja nadivrana w.s.r to Pilonidal Sinus. Methodology: here we present a case discussion of Chhedan karma and Application of tikshna Apamarga Kshara in the management of shalyaja nadivrana. Result: Patient got symptomatic relief. Conclusion: The prevalence of Nadivrana increasing day by day.Ayurvedic management is effective in slow down the disease progression and breakdown the pathology.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-15DOI: 10.22270/ajprd.v11i3.1224
Savitri Patidar
Indigenous knowledge is a valuable knowledge that has been facilitated local ethno- groups of people for survival in all over the world. This knowledge is unique tactic knowledge that originates from the interaction between members of the community and the environment in which they live. It passes through elder generations to younger generations orally or verbally. Knowledge about ethno-medicinal plants and practices make it a survival strategy of livelihood in tribal community of Dungarpur district. However, Dungarpur district is enriched with Deciduous forest covered thus abundant of medicinal plants are identified by these group of people for healthcare purposes. This study is an attempt to identify the ethno-medicinal plants and documentations it with special case studies of the persons who authentically treat and cure community. The field survey was carried out during January 2022 to March 2022 and in July 2022 for identification of plants and know about their story. Outcomes from the field survey revealed that abundant of ethno-medicinal species are found in this area due to its Geographical and Climatic conditions. Since, lack of awareness, lesser interest of Government and local politicians and integument of modernity over younger generation this knowledge has been extinct gradually from the society. There should me need to conserve and protect their traditional legacy of survival with nature.
{"title":"Indigenous Knowledge of Medicinal Plants in Tribal Community of Antri and Mewara Forest Range of Dungarpur District, Rajasthan","authors":"Savitri Patidar","doi":"10.22270/ajprd.v11i3.1224","DOIUrl":"https://doi.org/10.22270/ajprd.v11i3.1224","url":null,"abstract":"Indigenous knowledge is a valuable knowledge that has been facilitated local ethno- groups of people for survival in all over the world. This knowledge is unique tactic knowledge that originates from the interaction between members of the community and the environment in which they live. It passes through elder generations to younger generations orally or verbally. Knowledge about ethno-medicinal plants and practices make it a survival strategy of livelihood in tribal community of Dungarpur district. However, Dungarpur district is enriched with Deciduous forest covered thus abundant of medicinal plants are identified by these group of people for healthcare purposes. This study is an attempt to identify the ethno-medicinal plants and documentations it with special case studies of the persons who authentically treat and cure community. The field survey was carried out during January 2022 to March 2022 and in July 2022 for identification of plants and know about their story. Outcomes from the field survey revealed that abundant of ethno-medicinal species are found in this area due to its Geographical and Climatic conditions. Since, lack of awareness, lesser interest of Government and local politicians and integument of modernity over younger generation this knowledge has been extinct gradually from the society. There should me need to conserve and protect their traditional legacy of survival with nature.","PeriodicalId":8526,"journal":{"name":"Asian Journal of Pharmaceutical Research and Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139369779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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