Pub Date : 2022-11-22DOI: 10.52711/2231-5713.2022.00058
Shivani Deshmukh, B. Chaudhari, A. Velhal, V. Redasani
Polymeric nanoparticles (NPs) are among the eminently designed organic nanomedicine. There is a lot of elation about polymeric NPs' potential to revolutionize modern medicine. Particle size, morphology, material selection, and processing methods are all being studied to synthesize the perfect nanosystem for effectual and precisely target bioactive. PNPs have the ability to significantly elevate the potency of therapeutic medication by allowing for targeted distribution to a specific location. Drug delivery techniques such as conjugation and trapping of medicines, prodrugs, stimuli-responsive systems, imaging modalities, and theranostics all use polymeric NPs. The review focuses on the array of existing approaches for the producing of polymeric nanoparticles. We want to draw attention to several natural and synthetic biodegradable polymers. Polymers' physiochemical properties can be tweaked to provide distribution through several biological barriers in order to reach distinct organs or cells. The use of biodegradable polymers as nanocarriers is particularly appealing since these materials can be tailored to degrade in physiological system. Additionally, in the next part, the characterization methods for this type of nanoparticles are discussed.
{"title":"A Compendious Review on Biodegradable Polymeric Nanoparticles","authors":"Shivani Deshmukh, B. Chaudhari, A. Velhal, V. Redasani","doi":"10.52711/2231-5713.2022.00058","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00058","url":null,"abstract":"Polymeric nanoparticles (NPs) are among the eminently designed organic nanomedicine. There is a lot of elation about polymeric NPs' potential to revolutionize modern medicine. Particle size, morphology, material selection, and processing methods are all being studied to synthesize the perfect nanosystem for effectual and precisely target bioactive. PNPs have the ability to significantly elevate the potency of therapeutic medication by allowing for targeted distribution to a specific location. Drug delivery techniques such as conjugation and trapping of medicines, prodrugs, stimuli-responsive systems, imaging modalities, and theranostics all use polymeric NPs. The review focuses on the array of existing approaches for the producing of polymeric nanoparticles. We want to draw attention to several natural and synthetic biodegradable polymers. Polymers' physiochemical properties can be tweaked to provide distribution through several biological barriers in order to reach distinct organs or cells. The use of biodegradable polymers as nanocarriers is particularly appealing since these materials can be tailored to degrade in physiological system. Additionally, in the next part, the characterization methods for this type of nanoparticles are discussed.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78960951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-22DOI: 10.52711/2231-5713.2022.00057
Minesh Patel, Anand B. Pithadia, B. Prajapati
Ayurveda is the world’s oldest clinical gadget and the maximum extensively used remedy for alopecia area, mainly in rural India, wherein 68-75% of the populace lives. Ayurveda performed an increasing number of critical functions in Europe and North America because it unfolds to Western international locations withinside the twentieth century. This approach is presently one of the fastest-developing CAM remedies withinside the world. Osteoarthritis is the maximum not unusual place form of arthritis that frequently happens in antique age. Osteoporosis is known as sandy Vata in Ayurveda. It is a joint sickness that reasons pain, swelling, and stiffness whilst the bones are driven into the joint because of abrasion of the cartilage and the bones rub in opposition to every other. The maximum not unusualplace joints are the knee, pelvis, arm, and spine. Osteoarthritis is a main purpose of incapacity withinside the elderly, affecting about 18-26 years of age in adults 22-27 years of age. The occurrence of osteoarthritis is 38tween a long time of forty and forty-five and 76tween a long time of 60 and 65, and the superiority and effect on fitness growth with age. Drug remedy is a complete symptomatic remedy for osteoarthritis of the knee and frequently keeps the person's mobility. This article reviews hints and recommendation on knee implant remedy withinside the new hints of the Asian Medical Association, highlights a few critical aspects, and discusses decision-making considerations. By realistically comparing the effectiveness of remedy, it plans to lessen the threat of clinical mistakes and preventable facet results and take extra meticulous measures.
{"title":"Clinical Pharmacological Activity of Ayurvedic Treatments in an Osteoarthritis and it’s Benefits Outcomes: Ethnopharmacology Review","authors":"Minesh Patel, Anand B. Pithadia, B. Prajapati","doi":"10.52711/2231-5713.2022.00057","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00057","url":null,"abstract":"Ayurveda is the world’s oldest clinical gadget and the maximum extensively used remedy for alopecia area, mainly in rural India, wherein 68-75% of the populace lives. Ayurveda performed an increasing number of critical functions in Europe and North America because it unfolds to Western international locations withinside the twentieth century. This approach is presently one of the fastest-developing CAM remedies withinside the world. Osteoarthritis is the maximum not unusual place form of arthritis that frequently happens in antique age. Osteoporosis is known as sandy Vata in Ayurveda. It is a joint sickness that reasons pain, swelling, and stiffness whilst the bones are driven into the joint because of abrasion of the cartilage and the bones rub in opposition to every other. The maximum not unusualplace joints are the knee, pelvis, arm, and spine. Osteoarthritis is a main purpose of incapacity withinside the elderly, affecting about 18-26 years of age in adults 22-27 years of age. The occurrence of osteoarthritis is 38tween a long time of forty and forty-five and 76tween a long time of 60 and 65, and the superiority and effect on fitness growth with age. Drug remedy is a complete symptomatic remedy for osteoarthritis of the knee and frequently keeps the person's mobility. This article reviews hints and recommendation on knee implant remedy withinside the new hints of the Asian Medical Association, highlights a few critical aspects, and discusses decision-making considerations. By realistically comparing the effectiveness of remedy, it plans to lessen the threat of clinical mistakes and preventable facet results and take extra meticulous measures.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89549174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-22DOI: 10.52711/2231-5713.2022.00059
Siddiqua Shaikh
On June 23, 2000, the Government of India issued GSR No. 560(E) under Rule 157 of the Drugs and Cosmetic Rules, and on March 7, 2003, GSR No. 198(E) revised Good Manufacturing Practices (GMP). These rules were made necessary for all new ASU drug manufacturing facilities on June 23, 2000, and for existing units on June 23, 2002. (2 years grace period was given for existing ASU units to obtain GMP certification). The criteria for production premises and hygienic conditions are outlined in Schedule T. The fundamental goal of implementing Schedule-T was to ensure that producers maintained a consistent level of hygiene. Good manufacturing practises must be followed at all times. For all the manufacturers of ASU drugs. Compliance to Good manufacturing Practices is mandatory for all the manufacturers of ASU drugs.
{"title":"Schedule T – Good Manufacturing Practice of Indian systems of medicine","authors":"Siddiqua Shaikh","doi":"10.52711/2231-5713.2022.00059","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00059","url":null,"abstract":"On June 23, 2000, the Government of India issued GSR No. 560(E) under Rule 157 of the Drugs and Cosmetic Rules, and on March 7, 2003, GSR No. 198(E) revised Good Manufacturing Practices (GMP). These rules were made necessary for all new ASU drug manufacturing facilities on June 23, 2000, and for existing units on June 23, 2002. (2 years grace period was given for existing ASU units to obtain GMP certification). The criteria for production premises and hygienic conditions are outlined in Schedule T. The fundamental goal of implementing Schedule-T was to ensure that producers maintained a consistent level of hygiene. Good manufacturing practises must be followed at all times. For all the manufacturers of ASU drugs. Compliance to Good manufacturing Practices is mandatory for all the manufacturers of ASU drugs.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80021931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-22DOI: 10.52711/2231-5713.2022.00053
R. Gaikwad, Anilkumar Shinde
Basically Emulsions are liquid–liquid dispersions along with one liquid phase which is dispersed in the other liquid phase as small sized droplets. These days, there is an increasing interest in the utilization of nano emulsions in pharmaceuticals as well as cosmetics industry because of it’ snumerous of potential advantages over conventional and microemulsions. Nanoemulsions are nano-sized emulsions which have sizes range from tens to hundreds of nano meters. Nano emulsion sex hibit useful characteristics due to its small droplet size which leads to high surface area per unit volume, higher stability, optically transparent appearance, flexible fluidity as well as increased bioavailability of lipophilic components. The current review provides a comprehensive overview, starting with an introduction of nano emulsion types, preparation methods, stability study, characterisation, and applications of nano emulsion.
{"title":"Overview of Nanoemulsion Preparation Methods, Characterization Techniques and Applications","authors":"R. Gaikwad, Anilkumar Shinde","doi":"10.52711/2231-5713.2022.00053","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00053","url":null,"abstract":"Basically Emulsions are liquid–liquid dispersions along with one liquid phase which is dispersed in the other liquid phase as small sized droplets. These days, there is an increasing interest in the utilization of nano emulsions in pharmaceuticals as well as cosmetics industry because of it’ snumerous of potential advantages over conventional and microemulsions. Nanoemulsions are nano-sized emulsions which have sizes range from tens to hundreds of nano meters. Nano emulsion sex hibit useful characteristics due to its small droplet size which leads to high surface area per unit volume, higher stability, optically transparent appearance, flexible fluidity as well as increased bioavailability of lipophilic components. The current review provides a comprehensive overview, starting with an introduction of nano emulsion types, preparation methods, stability study, characterisation, and applications of nano emulsion.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76304780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-22DOI: 10.52711/2231-5713.2022.00048
Swapnil S Chopade, Esther Gaikwad, N. Patil, A. Manjappa, J. Disouza
Tenoxicam (TNX) is an effective non-steroidal anti-inflammatory drug (NSAIDs) used to treat rheumatoid arthritis. Like other NSAIDs, tenoxicam has the disadvantage of being linked to gastrointestinal side effects. Furthermore, this drug is having weak transdermal penetration, preventing transdermal administration. The goal of this study was to develop a TNX nanogel with a smaller particle size to improve the anti-inflammatory drug's bioavailability and assess its potential in rheumatoid arthritis. The modified emulsification-diffusion method is used to develop nanosized dispersion of TNX using noveon polycarbophil AA-1 as a gelling agent. Moreover, essential oils increase skin penetration by interacting with the stratum corneum (SC). They were found to be successful in increasing skin penetration of both lipophilic and hydrophilic drugs. The rheology, particle size, drug content, % drug release, and in-vitro diffusion study of prepared TNX nanogel were performed. Based on the rheological features of the formulations it was found to be substantial, with the particle size of 125.05nm and zeta potential -8.47mV, drug content of 97.05%, % drug release 97.40% drug diffusion of 97.42%, and pH of 6.2. Tenoxicam nanogel was prepared by using noveon polycarbophil AA-1 and eucalyptus oil as a permeation enhancer was proven to be suitable as a typical topical gel formulation for the treatment of edema and rheumatoid arthritis.
{"title":"Development of Topical Nanogel as a Promising Delivery of NSAID’s Tenoxicam using Natural Permeation Enhancer Essential Oil (Euckolyptus)","authors":"Swapnil S Chopade, Esther Gaikwad, N. Patil, A. Manjappa, J. Disouza","doi":"10.52711/2231-5713.2022.00048","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00048","url":null,"abstract":"Tenoxicam (TNX) is an effective non-steroidal anti-inflammatory drug (NSAIDs) used to treat rheumatoid arthritis. Like other NSAIDs, tenoxicam has the disadvantage of being linked to gastrointestinal side effects. Furthermore, this drug is having weak transdermal penetration, preventing transdermal administration. The goal of this study was to develop a TNX nanogel with a smaller particle size to improve the anti-inflammatory drug's bioavailability and assess its potential in rheumatoid arthritis. The modified emulsification-diffusion method is used to develop nanosized dispersion of TNX using noveon polycarbophil AA-1 as a gelling agent. Moreover, essential oils increase skin penetration by interacting with the stratum corneum (SC). They were found to be successful in increasing skin penetration of both lipophilic and hydrophilic drugs. The rheology, particle size, drug content, % drug release, and in-vitro diffusion study of prepared TNX nanogel were performed. Based on the rheological features of the formulations it was found to be substantial, with the particle size of 125.05nm and zeta potential -8.47mV, drug content of 97.05%, % drug release 97.40% drug diffusion of 97.42%, and pH of 6.2. Tenoxicam nanogel was prepared by using noveon polycarbophil AA-1 and eucalyptus oil as a permeation enhancer was proven to be suitable as a typical topical gel formulation for the treatment of edema and rheumatoid arthritis.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88220807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-22DOI: 10.52711/2231-5713.2022.00046
Aliyu Hamidu. Ahmed, Kabir Yusuf Musa, Abubakar Ahmed, Aisha Faeeza Mahmud
Antioxidants are believed to play a role in preventing the development of some chronic diseases. Medicinal plants with antioxidant activity have continuously been utilized both in traditional and contemporary medicine for management of free radical related diseases. There is need to search for medicinal plants with antioxidant potentials and to isolate compounds responsible for the activity. The aim of this research was to carry out the phytochemical and antioxidant studies on stem bark extract of Aubrevillea kerstingii. The powdered stem bark of Aubrevillea kerstingii (1.5kg) was extracted with n-hexane, ethyl acetate and methanol using sequential maceration. Qualitative screening for antioxidant activity was carried out using thin layer chromatographic TLC autographic screening on pre-coated silica plate. The determination of 2,2-diphenyl-1- picrylhydrazyl (DPPH) radical scavenging activity of the 3 stem bark extracts was carried out according to a standard method. The ethyl acetate extract (5g) was pre-adsorbed on silica gel and loaded into a column pre-packed with 100g silica gel (60-120 Merck). The extract was eluted with n-hexane: ethyl acetate in a gradient elution starting from n-hexane (100%) to ethyl acetate methanol (90:10). The DPPH scavenging activity of the extracts revealed a concentration dependent increase in free radical scavenging activity. The n-hexane, ethyl acetate and methanol extracts showed IC50 values of 98.58μg/ml, 36.79μg/ml and 49.27μg/ml respectively compared with ascorbic acid which had IC50 of 17.89μg/ml. The isolated compound was identified as oleanolic acid using NMR. The 1H-NMR and13C-NMR spectra obtained in CDCl3 with NMR spectrometer showed chemical shifts characteristic of oleanolic acid. The methanol extract and ethyl acetate extracts showed significant antioxidant activity. Oleanolic acid isolated from the ethyl acetate extract may be responsible for the antioxidant activity.
{"title":"Phytochemical and Antioxidant studies on Stem Bark of Aubrevillea kerstingii","authors":"Aliyu Hamidu. Ahmed, Kabir Yusuf Musa, Abubakar Ahmed, Aisha Faeeza Mahmud","doi":"10.52711/2231-5713.2022.00046","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00046","url":null,"abstract":"Antioxidants are believed to play a role in preventing the development of some chronic diseases. Medicinal plants with antioxidant activity have continuously been utilized both in traditional and contemporary medicine for management of free radical related diseases. There is need to search for medicinal plants with antioxidant potentials and to isolate compounds responsible for the activity. The aim of this research was to carry out the phytochemical and antioxidant studies on stem bark extract of Aubrevillea kerstingii. The powdered stem bark of Aubrevillea kerstingii (1.5kg) was extracted with n-hexane, ethyl acetate and methanol using sequential maceration. Qualitative screening for antioxidant activity was carried out using thin layer chromatographic TLC autographic screening on pre-coated silica plate. The determination of 2,2-diphenyl-1- picrylhydrazyl (DPPH) radical scavenging activity of the 3 stem bark extracts was carried out according to a standard method. The ethyl acetate extract (5g) was pre-adsorbed on silica gel and loaded into a column pre-packed with 100g silica gel (60-120 Merck). The extract was eluted with n-hexane: ethyl acetate in a gradient elution starting from n-hexane (100%) to ethyl acetate methanol (90:10). The DPPH scavenging activity of the extracts revealed a concentration dependent increase in free radical scavenging activity. The n-hexane, ethyl acetate and methanol extracts showed IC50 values of 98.58μg/ml, 36.79μg/ml and 49.27μg/ml respectively compared with ascorbic acid which had IC50 of 17.89μg/ml. The isolated compound was identified as oleanolic acid using NMR. The 1H-NMR and13C-NMR spectra obtained in CDCl3 with NMR spectrometer showed chemical shifts characteristic of oleanolic acid. The methanol extract and ethyl acetate extracts showed significant antioxidant activity. Oleanolic acid isolated from the ethyl acetate extract may be responsible for the antioxidant activity.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76544476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-22DOI: 10.52711/2231-5713.2022.00061
Ajay I. Patel, Pooja K. Khunti, Amit J. Vyas, Ashok B. Patel
Artificial intelligence (AI) is a broad word that refers to the theory and development of computer systems that can do tasks that would ordinarily require human cognition, such as perception, comprehension, reasoning, learning, planning, and problem solving. Understanding the terminology and methodologies used in AI can help you communicate more effectively with data scientists to work together to design models that will improve patient care. The healthcare and pharmaceutical industries have long been early adopters of technological developments, reaping major benefits as a result. AI is being applied in a range of health-related sectors, including the discovery of novel medications, the invention of new medical treatments, and the management of patient data and records. This review identifies and examines the fundamentals and applications of artificial intelligence in medicine and pharmacy.
{"title":"Explicating Artificial Intelligence: Applications in Medicine and Pharmacy","authors":"Ajay I. Patel, Pooja K. Khunti, Amit J. Vyas, Ashok B. Patel","doi":"10.52711/2231-5713.2022.00061","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00061","url":null,"abstract":"Artificial intelligence (AI) is a broad word that refers to the theory and development of computer systems that can do tasks that would ordinarily require human cognition, such as perception, comprehension, reasoning, learning, planning, and problem solving. Understanding the terminology and methodologies used in AI can help you communicate more effectively with data scientists to work together to design models that will improve patient care. The healthcare and pharmaceutical industries have long been early adopters of technological developments, reaping major benefits as a result. AI is being applied in a range of health-related sectors, including the discovery of novel medications, the invention of new medical treatments, and the management of patient data and records. This review identifies and examines the fundamentals and applications of artificial intelligence in medicine and pharmacy.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75716811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Solid dispersion is one of the method, which was most widely and successfully applied to improve the solubility, dissolution rates and consequently the bioavailability of poorly soluble drugs. The solid dispersion based on the concept that the drug is dispersed in an inert water- soluble carrier at solid state. Several water-soluble carriers such as methyl cellulose, urea, lactose, citric acid, polyvinyl pyrrolidone and HPMC, cyclodextrin, polyethylene glycols 4000 and 6000 are used as carriers for solid dispersion. In the current research work, the solid dispersion technique can be successfully used for the improvement of dissolution of piperine and sulfamethaoxazole. In this regards, solid dispersions of these drugs were prepared by using HPMC E 100 and 2-Hydroxyproplyl beta cyclodextrin as a carrier in 1:1 ratio by solvent evaporation method. The saturation solubility and in-vitro dissolution studies of prepared solid dispersions were examined against pure piperine and sulfamethaoxazole. Faster dissolution was exhibited by piperine-2 hydroxypropyl beta cyclodextrin solid dispersion containing 1:1 ratio.
{"title":"Formulation and Evaluation of Solid Dispersion of Poorly Soluble Drugs","authors":"Komal Chandrakant Jadhav, Sourabh Sukumar Hegaje, Sadhana Uttam Jadhav, Rupesh Sopanrao Vaidhya, Mayuresh Ramesh Redkar","doi":"10.52711/2231-5713.2022.00050","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00050","url":null,"abstract":"Solid dispersion is one of the method, which was most widely and successfully applied to improve the solubility, dissolution rates and consequently the bioavailability of poorly soluble drugs. The solid dispersion based on the concept that the drug is dispersed in an inert water- soluble carrier at solid state. Several water-soluble carriers such as methyl cellulose, urea, lactose, citric acid, polyvinyl pyrrolidone and HPMC, cyclodextrin, polyethylene glycols 4000 and 6000 are used as carriers for solid dispersion. In the current research work, the solid dispersion technique can be successfully used for the improvement of dissolution of piperine and sulfamethaoxazole. In this regards, solid dispersions of these drugs were prepared by using HPMC E 100 and 2-Hydroxyproplyl beta cyclodextrin as a carrier in 1:1 ratio by solvent evaporation method. The saturation solubility and in-vitro dissolution studies of prepared solid dispersions were examined against pure piperine and sulfamethaoxazole. Faster dissolution was exhibited by piperine-2 hydroxypropyl beta cyclodextrin solid dispersion containing 1:1 ratio.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81437848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5713.2022.00040
Sonam Bendre, Ketaki Shinde, Niraj Kale, Suhit S. Gilda
Artificial intelligence (AI) is that the theory and development of computer systems ready to perform tasks normally requiring human intelligence. With teeming competition and increasing demand within the food industry, has begun to embrace AI technologies during a bid to maximize profits and explore new ways to succeed in serve the consumers. AI has recently began to fix its application in various sector of the society with food industry as like pharmaceutical industry. This review highlights the impactful use of AI in diverse area of food sector including Sorting, Grading, Food Quality, Cleaning, Efficient Supply chain management, Microbial internal control and various method of food analysis. Chemical and Biological Sensor are used for food quality monitoring as well as application of AI to provide best quality food products. Planning of ordinary reliable procedures to regulate the standard of products may be a major objective. Despite these obstacles, research into optimizing production processes using AI is ongoing. It is crucial to emphasize, however, that the benefit of AI application in the food industry far outweigh the limitations.
{"title":"Artificial Intelligence in Food Industry: A Current Panorama","authors":"Sonam Bendre, Ketaki Shinde, Niraj Kale, Suhit S. Gilda","doi":"10.52711/2231-5713.2022.00040","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00040","url":null,"abstract":"Artificial intelligence (AI) is that the theory and development of computer systems ready to perform tasks normally requiring human intelligence. With teeming competition and increasing demand within the food industry, has begun to embrace AI technologies during a bid to maximize profits and explore new ways to succeed in serve the consumers. AI has recently began to fix its application in various sector of the society with food industry as like pharmaceutical industry. This review highlights the impactful use of AI in diverse area of food sector including Sorting, Grading, Food Quality, Cleaning, Efficient Supply chain management, Microbial internal control and various method of food analysis. Chemical and Biological Sensor are used for food quality monitoring as well as application of AI to provide best quality food products. Planning of ordinary reliable procedures to regulate the standard of products may be a major objective. Despite these obstacles, research into optimizing production processes using AI is ongoing. It is crucial to emphasize, however, that the benefit of AI application in the food industry far outweigh the limitations.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81723469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5713.2022.00033
N. Deshmukh
Oral controlled drug delivery systems represent the foremost widespread kind of sustained drug delivery systems for the plain blessings of oral route of drug administration. Suchsystemsrelease the drug with constant or variable unleash rates. The oral controlled releasesystems show a typical pattern of drug unleash within which the drug concentration is maintained inthe therapeutic window for a chronic amount of your time (sustained release), thereby guaranteeingsustained therapeutic action. They are used as single dosage form. Present work involvespreparation and analysis of sustained release beads of beads of Meclizine Hydrochloride using Sodium alginate as natural polymer as well as Hydroxyl Propyl Methyl Cellulose K15, Sodium CMC. The technique employed for preparation of beads of the drug is ionotropic gelation.
{"title":"Preparation and Evaluation of Sustained Release Hydrogel Alginate Beads of Meclizine Hydrochloride","authors":"N. Deshmukh","doi":"10.52711/2231-5713.2022.00033","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00033","url":null,"abstract":"Oral controlled drug delivery systems represent the foremost widespread kind of sustained drug delivery systems for the plain blessings of oral route of drug administration. Suchsystemsrelease the drug with constant or variable unleash rates. The oral controlled releasesystems show a typical pattern of drug unleash within which the drug concentration is maintained inthe therapeutic window for a chronic amount of your time (sustained release), thereby guaranteeingsustained therapeutic action. They are used as single dosage form. Present work involvespreparation and analysis of sustained release beads of beads of Meclizine Hydrochloride using Sodium alginate as natural polymer as well as Hydroxyl Propyl Methyl Cellulose K15, Sodium CMC. The technique employed for preparation of beads of the drug is ionotropic gelation.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84339215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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