Pub Date : 2022-08-10DOI: 10.52711/2231-5713.2022.00035
S. Sehar, Mohsin Ali Khan, Amiza Amiza, Touqir Hussain, M. Zahid, Moazina Mobeen, Imran Raza, Minnatullah Minnatullah
The extracted material from Moringa oleifera is used for synthesis of the ZnO nanoparticles. The extracted material from plants is used as stabilizing and reducing agent. Plant extracts are also used for the formation of nanoparticles this is called green synthesis method which decreases the formation of unsafe materials. With the help of various Analytical techniques for example scanning electron microscopy (SEM), Infrared (IR) Spectroscopy and UV (Ultra violet) Spectroscopy, the manufactured ZnO nanoparticles are distinguished. The range of the size of ZnO nanoparticles is from 48nm by SEM and XRD. The peak of ZnO is observed at 500 cm-1 by FTIR. Ultraviolet visible spectroscopy shows the spectrum of ZnO at 290-315nm range. Moringa oleifera mediated ZnO revealed high activity against gram positive and gram negative bacteria. Smaller sized Nanoparticles shows excellent antimicrobial activity.
{"title":"Synthesis of Zinc Oxide Nano particles from Moringa Tree leaves by Green Method and also check its Antibacterial activity against Gram Positive and Gram Negative Bacteria","authors":"S. Sehar, Mohsin Ali Khan, Amiza Amiza, Touqir Hussain, M. Zahid, Moazina Mobeen, Imran Raza, Minnatullah Minnatullah","doi":"10.52711/2231-5713.2022.00035","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00035","url":null,"abstract":"The extracted material from Moringa oleifera is used for synthesis of the ZnO nanoparticles. The extracted material from plants is used as stabilizing and reducing agent. Plant extracts are also used for the formation of nanoparticles this is called green synthesis method which decreases the formation of unsafe materials. With the help of various Analytical techniques for example scanning electron microscopy (SEM), Infrared (IR) Spectroscopy and UV (Ultra violet) Spectroscopy, the manufactured ZnO nanoparticles are distinguished. The range of the size of ZnO nanoparticles is from 48nm by SEM and XRD. The peak of ZnO is observed at 500 cm-1 by FTIR. Ultraviolet visible spectroscopy shows the spectrum of ZnO at 290-315nm range. Moringa oleifera mediated ZnO revealed high activity against gram positive and gram negative bacteria. Smaller sized Nanoparticles shows excellent antimicrobial activity.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76267044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5713.2022.00036
G. Dyade, Pooja Garad, Pallavi Jadhav
Quality by design is applied for the development of various pharmaceutical processes including analytical methods. By applying QbD approach chemometric based analytical method was developed for the estimation of amlodipine besylate and telmisartan by UV-VIS spectrophotometry. Solvent 0.1 N HCl was utilised and 291.2 nm and 365.2 nm was the wavelength for measurement of absorbance. Effect of input variables on spectrum characteristics were studied for selection of critical parameters and developed method was validated as per ICH Q 2 R1 regulatory guidelines. Linearity of both the drugs was ascertained over the conc range 5-40mcg/ml. The accuracy was found 104.46% for TEL and 96.25% for AMD; and the precision study was shown acceptable data as %RSD 2.5416 for TEL and 5.7364 for AMD. The developed method is rigid, robust and efficient for the estimation of AMD and TEL, which are in 1: 8 proportionate in the composition of dosage form. QbD was applied to build rigid robust method through risk assessment at early stage and defining the design space at the later stage.
质量设计适用于各种制药工艺的开发，包括分析方法。应用QbD方法，建立了基于化学计量学的紫外-可见分光光度法测定苯磺酸氨氯地平和替米沙坦的分析方法。溶剂为0.1 N HCl，波长为291.2 nm和365.2 nm测定吸光度。研究了输入变量对光谱特征的影响，以选择关键参数，并根据ICH q2 R1监管指南验证了所开发的方法。在5-40mcg/ml范围内确定了两种药物的线性关系。TEL和AMD的准确率分别为104.46%和96.25%;精度研究显示，TEL的%RSD为2.5416,AMD的%RSD为5.7364。该方法在剂型组成中AMD和TEL的比例为1:8，具有刚性、鲁棒性和高效性。通过前期的风险评估和后期的设计空间界定，将QbD应用于构建刚性稳健方法。
{"title":"A QBD Approach in Chemometric assisted Method Development of Telmisartan and Amlodipine besylate by UV-VIS Spectrophotometry","authors":"G. Dyade, Pooja Garad, Pallavi Jadhav","doi":"10.52711/2231-5713.2022.00036","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00036","url":null,"abstract":"Quality by design is applied for the development of various pharmaceutical processes including analytical methods. By applying QbD approach chemometric based analytical method was developed for the estimation of amlodipine besylate and telmisartan by UV-VIS spectrophotometry. Solvent 0.1 N HCl was utilised and 291.2 nm and 365.2 nm was the wavelength for measurement of absorbance. Effect of input variables on spectrum characteristics were studied for selection of critical parameters and developed method was validated as per ICH Q 2 R1 regulatory guidelines. Linearity of both the drugs was ascertained over the conc range 5-40mcg/ml. The accuracy was found 104.46% for TEL and 96.25% for AMD; and the precision study was shown acceptable data as %RSD 2.5416 for TEL and 5.7364 for AMD. The developed method is rigid, robust and efficient for the estimation of AMD and TEL, which are in 1: 8 proportionate in the composition of dosage form. QbD was applied to build rigid robust method through risk assessment at early stage and defining the design space at the later stage.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87643662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5713.2022.00034
B. M. M., Ashwini V. Patil, Ubhale R. J., Barhate S. D., M. Nasir
Purpose- The present study was to develop an oral push-pull osmotic pump tablet of vildagliptin, DPP-IV inhibitor drug; which is BCS class I drug. Method- The tablets were prepared by the wet granulation method using polyox and osmotic agent NaCl. The granules were compressed into bilayered tablet by conventional compression machine. The bilayered core osmotic tablets were coated with cellulose acetate in a conventional pan coating. In-vitro dissolution was evaluated using USP dissolution apparatus II in 0.1 N HCl pH 1.2 buffers for 2 hrs and phosphate buffer pH 7.5 for 22 hrs respectively. The formulated optimized batch VP1 were kept to stability studies for 3 months. Result- The formulated optimized batch VP1 of PPOP tablet shows 2hrs lag time with zero order release kinetic. In –vitro drug release was obtained 91.45 % up to 22hrs respectively. Polyox in push-pull layer along with osmotic agent and cellulose acetate controlled the drug release pattern from formulated PPOP tablet. No significant changes were observed upto the period of 3 months of storage during stability study. Conclusion- The PPOP tablet of vildagliptin was able to deliver the drug in controlled pattern over a long period of time by the process of osmosis. Conventional compression and pan coating method can be used to prepare PPOP tablet successfully.
目的:研制DPP-IV抑制剂维格列汀口服推拉渗透泵片;这是BCS一级药物方法:采用多聚氧剂和渗透剂NaCl湿法制粒。采用常规压缩机将颗粒压缩成双层片剂。用醋酸纤维素包覆双层核心渗透片。体外溶出度采用USP溶出仪II，分别在0.1 N HCl pH 1.2缓冲液和磷酸盐缓冲液pH 7.5中测定2小时和22小时。配制的优化批VP1进行了3个月的稳定性研究。结果-优选的PPOP片剂VP1缓释时间为2h，缓释动力学为零级。22h内释药率为91.45%。推挽层中的聚氧氧与渗透剂和醋酸纤维素共同控制了PPOP片的释药模式。在稳定性研究中，在3个月的储存期间未观察到明显的变化。结论-维格列汀PPOP片能通过渗透作用长期控制给药模式。采用传统的压缩包覆法可成功制备PPOP片剂。
{"title":"Formulation Optimization and Evaluation of Push Pull Osmotic Pump Tablet of Vildagliptin","authors":"B. M. M., Ashwini V. Patil, Ubhale R. J., Barhate S. D., M. Nasir","doi":"10.52711/2231-5713.2022.00034","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00034","url":null,"abstract":"Purpose- The present study was to develop an oral push-pull osmotic pump tablet of vildagliptin, DPP-IV inhibitor drug; which is BCS class I drug. Method- The tablets were prepared by the wet granulation method using polyox and osmotic agent NaCl. The granules were compressed into bilayered tablet by conventional compression machine. The bilayered core osmotic tablets were coated with cellulose acetate in a conventional pan coating. In-vitro dissolution was evaluated using USP dissolution apparatus II in 0.1 N HCl pH 1.2 buffers for 2 hrs and phosphate buffer pH 7.5 for 22 hrs respectively. The formulated optimized batch VP1 were kept to stability studies for 3 months. Result- The formulated optimized batch VP1 of PPOP tablet shows 2hrs lag time with zero order release kinetic. In –vitro drug release was obtained 91.45 % up to 22hrs respectively. Polyox in push-pull layer along with osmotic agent and cellulose acetate controlled the drug release pattern from formulated PPOP tablet. No significant changes were observed upto the period of 3 months of storage during stability study. Conclusion- The PPOP tablet of vildagliptin was able to deliver the drug in controlled pattern over a long period of time by the process of osmosis. Conventional compression and pan coating method can be used to prepare PPOP tablet successfully.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83232857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5713.2022.00042
Ketaki Shinde, Sonam Bendre, Niraj Kale, Suhit S. Gilda
Vaccination has had a significant impact on infectious diseases control. However, there are still a number of infectious diseases for which an effective vaccine has yet to be developed. There has been a lot of interest in RNA-based technologies for the creation of therapeutic vaccines over the last two decades. The adaptability of mRNA vaccines, as well as their potential to trigger cellular and humoral responses, are among their benefits. Furthermore, because of their intricate interaction with pattern recognition receptors (PRRs), mRNAs have inherent adjuvant qualities. This identification can be advantageous in terms of stimulating antigen-presenting cells (APCs) or harmful in terms of limiting mRNA translation indirectly. We highlight how numerous innate response mechanisms are triggered by mRNA molecules, and how each element, from the 5' cap to the poly-A tail, interferes with innate/adaptive immune responses. mRNA vaccines have the ability to be developed quickly and to be a strong tool in the fight against infectious illnesses. This article provides a thorough overview of mRNA vaccines, including recommendations for future mRNA vaccine development, as well as safety concerns and personalised vaccines. We focused on mRNA delivery and immunological activation, both which have important role for successful mRNA vaccination.
{"title":"The mRNA Vaccine Heralds a New Era in Vaccinology","authors":"Ketaki Shinde, Sonam Bendre, Niraj Kale, Suhit S. Gilda","doi":"10.52711/2231-5713.2022.00042","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00042","url":null,"abstract":"Vaccination has had a significant impact on infectious diseases control. However, there are still a number of infectious diseases for which an effective vaccine has yet to be developed. There has been a lot of interest in RNA-based technologies for the creation of therapeutic vaccines over the last two decades. The adaptability of mRNA vaccines, as well as their potential to trigger cellular and humoral responses, are among their benefits. Furthermore, because of their intricate interaction with pattern recognition receptors (PRRs), mRNAs have inherent adjuvant qualities. This identification can be advantageous in terms of stimulating antigen-presenting cells (APCs) or harmful in terms of limiting mRNA translation indirectly. We highlight how numerous innate response mechanisms are triggered by mRNA molecules, and how each element, from the 5' cap to the poly-A tail, interferes with innate/adaptive immune responses. mRNA vaccines have the ability to be developed quickly and to be a strong tool in the fight against infectious illnesses. This article provides a thorough overview of mRNA vaccines, including recommendations for future mRNA vaccine development, as well as safety concerns and personalised vaccines. We focused on mRNA delivery and immunological activation, both which have important role for successful mRNA vaccination.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78734105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5713.2022.00045
A. Anamika, Vandita Chauhan, A. Nautiyal
The term "Nutraceutical" comes from "nutrition" and "pharmaceutical". It is defined as a diet or part of a diet that provides health benefits of nutritious foods and helps prevent many diseases. Lifestyles have changed dramatically in the last 50 years as a result of urbanization, industrialization speed, and rapid change. These things have changed people's habits and forced them to eat fast, junk food. These habits directly affect our aspect of healthy eating and gradually reduce the amount and quality of nutrients. As a result of these changed eating habits, the population has increased the incidence of malnutrition, dementia and degenerative diseases. In recent years, people have become more concerned about health and health care. Nutraceuticals play an important role in boosting the immune system without damaging the body's natural immune system. Nutraceuticals are found in dietary supplements that offer additional health benefits also called medical diets, designer foods, active foods, and dietary supplements. Active foods are used to enhance certain bodily functions to prevent or treat infections. The medicinal plant contains many types of active phytochemicals that have therapeutic properties that address various health problems. This review explores the information available in the literature regarding health benefits of nutraceuticals and many other herbal plants. So here, an attempt is made to highlights the significance or importance of nutraceuticals and herbal plants with respect to health diseases and many other problems related to health. Therefore, the future nutraceutical program focuses on specific diagnostic models, clinical studies in humans, understanding the exact mechanism of action that is useful in the prevention and treatment of diseases. Nutraceuticals has demonstrated health benefits and immunity which should be taken as recommended.
{"title":"A Review: Health Benefits of Herbal Plants in Nutraceuticals","authors":"A. Anamika, Vandita Chauhan, A. Nautiyal","doi":"10.52711/2231-5713.2022.00045","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00045","url":null,"abstract":"The term \"Nutraceutical\" comes from \"nutrition\" and \"pharmaceutical\". It is defined as a diet or part of a diet that provides health benefits of nutritious foods and helps prevent many diseases. Lifestyles have changed dramatically in the last 50 years as a result of urbanization, industrialization speed, and rapid change. These things have changed people's habits and forced them to eat fast, junk food. These habits directly affect our aspect of healthy eating and gradually reduce the amount and quality of nutrients. As a result of these changed eating habits, the population has increased the incidence of malnutrition, dementia and degenerative diseases. In recent years, people have become more concerned about health and health care. Nutraceuticals play an important role in boosting the immune system without damaging the body's natural immune system. Nutraceuticals are found in dietary supplements that offer additional health benefits also called medical diets, designer foods, active foods, and dietary supplements. Active foods are used to enhance certain bodily functions to prevent or treat infections. The medicinal plant contains many types of active phytochemicals that have therapeutic properties that address various health problems. This review explores the information available in the literature regarding health benefits of nutraceuticals and many other herbal plants. So here, an attempt is made to highlights the significance or importance of nutraceuticals and herbal plants with respect to health diseases and many other problems related to health. Therefore, the future nutraceutical program focuses on specific diagnostic models, clinical studies in humans, understanding the exact mechanism of action that is useful in the prevention and treatment of diseases. Nutraceuticals has demonstrated health benefits and immunity which should be taken as recommended.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72857072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5713.2022.00043
Shubhangi Kodag, Swaranjali Gaikwad, Sunayana Mali, A. Mali
Mini Tablets are solid dosage forms with a diameter <= 3 mm and separated into subunits of conventional tablets. Production methods are similar to standard tablets, but the only difference is the use of multiple punches. They have advantageous for use in patients suffering from swallowing difficulty and receiving multiple drug treatment. They provide a more effective treatment by reducing the fluctuation in the drug’s release profile. At the same time, different release systems can be used together. In addition, Mini Tablets have a number of advantages over single unit dosage forms, and in recent years the prominence continues to increase. In the light of this information, the advantages and disadvantages of mini tablets, production equipment, formulation designs, different emission characteristics and evaluation criteria are emphasized in this compilation. Mini tablets represent a new trend in solid dosage form design, with the main goal of overcoming some therapeutic obstacles. Mini tablets are multiple unit dosage forms and are advantageous than pellets or any other oral dosage forms as they are easy to manufacture and stability problems are less.
{"title":"An Overview on Mini Tablets","authors":"Shubhangi Kodag, Swaranjali Gaikwad, Sunayana Mali, A. Mali","doi":"10.52711/2231-5713.2022.00043","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00043","url":null,"abstract":"Mini Tablets are solid dosage forms with a diameter <= 3 mm and separated into subunits of conventional tablets. Production methods are similar to standard tablets, but the only difference is the use of multiple punches. They have advantageous for use in patients suffering from swallowing difficulty and receiving multiple drug treatment. They provide a more effective treatment by reducing the fluctuation in the drug’s release profile. At the same time, different release systems can be used together. In addition, Mini Tablets have a number of advantages over single unit dosage forms, and in recent years the prominence continues to increase. In the light of this information, the advantages and disadvantages of mini tablets, production equipment, formulation designs, different emission characteristics and evaluation criteria are emphasized in this compilation. Mini tablets represent a new trend in solid dosage form design, with the main goal of overcoming some therapeutic obstacles. Mini tablets are multiple unit dosage forms and are advantageous than pellets or any other oral dosage forms as they are easy to manufacture and stability problems are less.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74671340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5713.2022.00041
Ishwar Singh, Jatin Sharma, I. Kumar, Shivali Singla, Amitabh B Chaudhary, Sunny Dhiman
Mucoadhesive formulations, which bind to the vaginal mucosa and play a significant role in drug release, are now being used for controlled release. The vagina is a significant area of the reproductive tract and helps as a potential route of drug administration. it is also of importance for systemic drug delivery, and uterine targeting. Currently, available dosage forms have several limitations, therefore novel concepts and dosage forms are needed. In this field, mucoadhesive polymers will play a major role. This review highlights the most important studies based on mucoadhesive polymer-systems like poly (acrylates), hyaluronic acid derivatives, pectin, chitosan, cellulose derivatives, tragacanth sulfated polysaccharides, carrageenan, Na-alginate, starch, poly (ethylene glycol), and gelatin.
{"title":"Potential of naturally occurring Mucoadhesive polymer in Vaginal infection","authors":"Ishwar Singh, Jatin Sharma, I. Kumar, Shivali Singla, Amitabh B Chaudhary, Sunny Dhiman","doi":"10.52711/2231-5713.2022.00041","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00041","url":null,"abstract":"Mucoadhesive formulations, which bind to the vaginal mucosa and play a significant role in drug release, are now being used for controlled release. The vagina is a significant area of the reproductive tract and helps as a potential route of drug administration. it is also of importance for systemic drug delivery, and uterine targeting. Currently, available dosage forms have several limitations, therefore novel concepts and dosage forms are needed. In this field, mucoadhesive polymers will play a major role. This review highlights the most important studies based on mucoadhesive polymer-systems like poly (acrylates), hyaluronic acid derivatives, pectin, chitosan, cellulose derivatives, tragacanth sulfated polysaccharides, carrageenan, Na-alginate, starch, poly (ethylene glycol), and gelatin.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84285941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A solid lipid Microparticle reaches to the target site at controlled rate and show controlled release for better therapeutic result. This drug delivery system are prepare to obtained prolonged sustained or controlled drug delivery, to improves bioavailability, to enhance stability and to reduce toxic effects follows with target drug at specific site. The solid lipid micro particles of curcumin were prepared in a view to achieve high permeability of curcumin in brain through blood-brain-barrier. The solid lipid microspheres are prepared by hot melts microencapsulation technique was used to formulate solid lipid microspheres. Twelve formulations were prepared by varying concentration of surfactants (span 20, span 60, span 80 and Tween 80). The developed formulation were subjected to various parameter such as the particle size, % entrapment efficiency, production yield, % cumulative release, percentage yield and drug loading. Based upon highest entrapment efficiency, drug release and % cumulative release the F3 formulation was considered as the best formulation. The prepared microsphere were subjected to different evaluation parameter such as melting point, thin layer chromatography, solubility, FTIR, compatibility study and In-vitro drug release. The developed formulation shows spherical and smooth surface. The % drug release of F3 formulation was found to be 86.23% after 12 hr.
{"title":"Design and Evaluation of Solid Lipid Microparticles of Curcumin for the Treatment of Alzheimer’s Disease","authors":"Aarti Bhati, Sanjeev Kumar, Renu Chaudhary, Sarvesh Kumar, Alimuddin Saifi","doi":"10.52711/2231-5713.2022.00032","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00032","url":null,"abstract":"A solid lipid Microparticle reaches to the target site at controlled rate and show controlled release for better therapeutic result. This drug delivery system are prepare to obtained prolonged sustained or controlled drug delivery, to improves bioavailability, to enhance stability and to reduce toxic effects follows with target drug at specific site. The solid lipid micro particles of curcumin were prepared in a view to achieve high permeability of curcumin in brain through blood-brain-barrier. The solid lipid microspheres are prepared by hot melts microencapsulation technique was used to formulate solid lipid microspheres. Twelve formulations were prepared by varying concentration of surfactants (span 20, span 60, span 80 and Tween 80). The developed formulation were subjected to various parameter such as the particle size, % entrapment efficiency, production yield, % cumulative release, percentage yield and drug loading. Based upon highest entrapment efficiency, drug release and % cumulative release the F3 formulation was considered as the best formulation. The prepared microsphere were subjected to different evaluation parameter such as melting point, thin layer chromatography, solubility, FTIR, compatibility study and In-vitro drug release. The developed formulation shows spherical and smooth surface. The % drug release of F3 formulation was found to be 86.23% after 12 hr.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83799567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5713.2022.00037
Manojkumar Patil, A. Mali, S. Mali
The main purpose of this research work was to design and process optimization of oral floating drug delivery system of Clarithromycin floating tablets by using the hydrophilic polymer Hydroxylpropyl methyl cellulose and gas generating agent sodium bicarbonate and citric acid. A 32 randomized full factorial design was used to study. In this design 2 factors were evaluated, each at 3 levels and experimental trials were performed at all 9 possible combinations. The independent and dependent variables are selected for optimization study. The radio-labelled floating tablets were prepared by adding barium sulphate in the optimized formulations for in- vivo radiographic study. The Results of multiple regression analysis indicated that both factors X1 and X2 significantly affected on the dependent parameters. The formulation was optimized on the basis of floating ability and in-vitro drug release. It should be concluded that as the time increases, the swelling index was increased, because weight gain by tablet was increased proportionally with rate of hydration. In-vivo radiographic studies of the optimized formulations were performed using New Zeal Albino rabbits by X-ray imaging technique. The in-vivo X-ray imaging and radiographic studies clearly indicated that the prepared optimized floating tablets were retained in the rabbit stomach over a prolonged period of time and had good in-vivo performance. Radiological evidences suggest that the formulated floating tablets of antibiotics were well floated more than 6 h in rabbit stomach.
{"title":"In-Vitro, In-Vivo Evaluation of Floating Tablets of Clarithromycin.","authors":"Manojkumar Patil, A. Mali, S. Mali","doi":"10.52711/2231-5713.2022.00037","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00037","url":null,"abstract":"The main purpose of this research work was to design and process optimization of oral floating drug delivery system of Clarithromycin floating tablets by using the hydrophilic polymer Hydroxylpropyl methyl cellulose and gas generating agent sodium bicarbonate and citric acid. A 32 randomized full factorial design was used to study. In this design 2 factors were evaluated, each at 3 levels and experimental trials were performed at all 9 possible combinations. The independent and dependent variables are selected for optimization study. The radio-labelled floating tablets were prepared by adding barium sulphate in the optimized formulations for in- vivo radiographic study. The Results of multiple regression analysis indicated that both factors X1 and X2 significantly affected on the dependent parameters. The formulation was optimized on the basis of floating ability and in-vitro drug release. It should be concluded that as the time increases, the swelling index was increased, because weight gain by tablet was increased proportionally with rate of hydration. In-vivo radiographic studies of the optimized formulations were performed using New Zeal Albino rabbits by X-ray imaging technique. The in-vivo X-ray imaging and radiographic studies clearly indicated that the prepared optimized floating tablets were retained in the rabbit stomach over a prolonged period of time and had good in-vivo performance. Radiological evidences suggest that the formulated floating tablets of antibiotics were well floated more than 6 h in rabbit stomach.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90293688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.52711/2231-5713.2022.00038
B. Hemalatha, T. P. Priya, K. Manasa, Ch. Greeshmika, P. Kavya, Shaik Sayeeda Sarah, K. Padmalatha
Emulgel is one of the promising topical drug delivery system for the delivery of hydrophobic drugs which overcome a variety of disadvantages of ointments and creams like greasiness as well as phase inversion. The aim of present work was to develop and evaluate Oxiconazole emulgel. Oxiconazole emulgel was prepared by using polymers like Carbopol 934 and HPMC K4M at different concentrations. Oxiconazole is a broad spectrum anti - fungal agent used in treat of various skin infections such as athlete’s foot, jock itch and ring worm. The prepared emulgels were evaluated in terms of physical appearance, measurement of pH, viscosity, spreadability, drug content and in vitro diffusion studies and skin irritation study. Formulation F1 containing carbapol 934 is considered as optimized formulation because it showed highest drug release i.e., 58.57% in 8 hrs.
{"title":"Optimization of Oxiconazole Topical Emulgel Formulation for the Treatment of Skin Infections","authors":"B. Hemalatha, T. P. Priya, K. Manasa, Ch. Greeshmika, P. Kavya, Shaik Sayeeda Sarah, K. Padmalatha","doi":"10.52711/2231-5713.2022.00038","DOIUrl":"https://doi.org/10.52711/2231-5713.2022.00038","url":null,"abstract":"Emulgel is one of the promising topical drug delivery system for the delivery of hydrophobic drugs which overcome a variety of disadvantages of ointments and creams like greasiness as well as phase inversion. The aim of present work was to develop and evaluate Oxiconazole emulgel. Oxiconazole emulgel was prepared by using polymers like Carbopol 934 and HPMC K4M at different concentrations. Oxiconazole is a broad spectrum anti - fungal agent used in treat of various skin infections such as athlete’s foot, jock itch and ring worm. The prepared emulgels were evaluated in terms of physical appearance, measurement of pH, viscosity, spreadability, drug content and in vitro diffusion studies and skin irritation study. Formulation F1 containing carbapol 934 is considered as optimized formulation because it showed highest drug release i.e., 58.57% in 8 hrs.","PeriodicalId":8527,"journal":{"name":"Asian Journal of Pharmacy and Technology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90711579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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