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Bioelectric Medicine: Magicall Tools for Treatment of Many Diseases 生物电医学:治疗多种疾病的神奇工具
Pub Date : 2021-11-26 DOI: 10.52711/2231-5713.2021.00052
Vikram B. Madane, S. N. Mali
Bioelectronic medicine is a relatively new area that focuses on developing methods for treating diseases that do not need medications. Bioelectronic medicine treatments are now possible thanks to a small embedded system that produces and delivers frequent digital doses to nerve bundles, resulting in a disease-fighting effect that can last hours or days and is based on mechanisms similar to drug therapies. Although this may sound like science fiction, electronic brain and nerve stimulators are now presence applicable to treat so many of ailments, including epilepsy, Parkinson's disease, and bladder control. Progress in treating such disorders has opened up possibilities for boosting memory, improving eyesight, strengthening a shaky gait, and even improving a golfer's swing. Those self-improvement dreams may be a long way off, but bioelectronic medicine is gaining traction as a new way to treat difficult diseases. What distinguishes bioelectronic medicine is its biological effect on the body, which goes beyond symptom management to treat the underlying condition by using the body's own mechanisms. With promising early results in many trials and further trials ongoing, bioelectronic therapies are likely to be accepted for clinical use within the next few years. To make this advancement possible, forward-thinking scientists, engineers, doctors, and innovators with specialised talents combined old and new discoveries in ways no one had before.
生物电子医学是一个相对较新的领域,专注于开发治疗不需要药物治疗的疾病的方法。生物电子医学治疗现在成为可能,这要归功于一个小型嵌入式系统,该系统可以产生并频繁地向神经束提供数字剂量,从而产生持续数小时或数天的对抗疾病的效果,其机制与药物治疗相似。虽然这听起来像科幻小说,但电子大脑和神经刺激器现在可用于治疗许多疾病,包括癫痫、帕金森病和膀胱控制。治疗这类疾病的进展为增强记忆力、改善视力、改善摇摇晃晃的步态、甚至改善高尔夫球手的挥杆带来了可能。这些自我完善的梦想可能还有很长的路要走,但生物电子医学作为一种治疗疑难疾病的新方法正在获得关注。生物电子医学的独特之处在于它对身体的生物效应,它超越了症状管理,而是利用身体自身的机制来治疗潜在的疾病。随着许多试验的早期结果和进一步的试验正在进行,生物电子疗法很可能在未来几年内被临床应用。为了使这一进步成为可能,有远见的科学家、工程师、医生和具有专业才能的创新者以前所未有的方式将新旧发现结合起来。
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引用次数: 0
A Short Review on Nasal Drug Delivery System 鼻腔给药系统研究进展综述
Pub Date : 2021-11-26 DOI: 10.52711/2231-5713.2021.00048
Akash H. Mali, Azam Z. Shaikh
Nasal drug delivery has received a great deal of attention as convenient, reliable and promising methods for the systemic administration of drug. It is especially for those molecules which are ineffective oraly and only effective if administration by injection. The nasal route of drug delivery has advantage over the other alternative system of drug administration. The present review is an attempt to provide some information concerning nasal drug delivery system such as limitation, advantage, mechanism drug absorption, anatomy and Physiology Nasal, factor affecting of nasal drug delivery, drug distribution and deposition, Challenges and oppurtunities for Nasal Delivery Systems1. These drug delivery system have the ability to control the rate of drug clearance from the nasal cavity as well as protect the drug from enzymatic degradation in nasal secretions2..
鼻给药作为一种方便、可靠、有发展前景的全身给药方法受到了广泛的关注。特别适用于那些口服无效,只有通过注射才能有效的分子。鼻给药途径比其他可选择的给药系统有优势。本文就鼻给药系统的局限性、优势、药物吸收机制、鼻解剖与生理、影响鼻给药的因素、药物分布与沉积、鼻给药系统面临的挑战与机遇等方面进行综述。这些给药系统有能力控制药物从鼻腔的清除率,并保护药物在鼻腔分泌物中不被酶降解。
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引用次数: 1
Short Review on Novel Dosage Form 新剂型综述
Pub Date : 2021-11-26 DOI: 10.52711/2231-5713.2021.00051
T. N. Sonawane, Pradip D. Dhangar, Sagar D Patil, Azam Z. Shaikh
Novel Drug Delivery Systems are one of the widely use delivery system in the presence scenario. Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of the traditional drug delivery systems. In the form of a Novel Drug Delivery System an existing drug molecule can get a new life. The novel drug delivery system is Increases bioavailability and it Can be used for long-term treatments of chronic illness, Sustained maintenance of plasma drug levels as well as it Decreased adverse drug effects in the total amount of drugs required thus reducing side effects it Improved patient compliance due to reduction in number and frequency of doses required. There is less damage sustained by normal tissue due to targeted drug delivery. In this paper our main focus to give the throughout knowledge of some newer (Novel drug delivery system) to understand the concept of the Novel dossage form.
新型给药系统是目前应用最广泛的给药系统之一。新型给药系统是一种新的给药方法,解决了传统给药系统的局限性。以一种新型药物传递系统的形式,现有的药物分子可以获得新的生命。这种新型给药系统增加了生物利用度,可用于慢性疾病的长期治疗,持续维持血浆药物水平,并减少了所需药物总量的不良反应,从而减少了副作用。由于减少了所需剂量的数量和频率,提高了患者的依从性。由于靶向药物输送,正常组织遭受的损伤较小。在本文中,我们的主要重点是提供一些较新的(新型给药系统)的全面知识,以理解新型剂型的概念。
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引用次数: 0
Nanotechnology: Overview and its application 纳米技术:概述及其应用
Pub Date : 2021-11-26 DOI: 10.52711/2231-5713.2021.00049
Amit Nikam, A. Patil, C. Magdum
The study of different microscopic or tiny shaped and sized particles is what nanotechnology is all about. These nano-structured compounds have a wide range of strong actions in a variety of disciplines. These are readily carried due to their small size and form. Because of its small size, it may be used in a variety of ways. Nanotechnology improves a variety of businesses, including the pharmaceutical industry, the food industry, environmental protection, and a variety of others. The purpose of this article is to provide an overview of nanotechnology and its applications in different industries and areas.
纳米技术就是研究不同的微观或微小的形状和大小的粒子。这些纳米结构化合物在各种学科中具有广泛的强作用。由于它们的体积和形状小,所以很容易携带。由于它的体积小,它可以以各种方式使用。纳米技术改善了许多行业,包括制药行业、食品行业、环境保护和其他各种行业。本文的目的是概述纳米技术及其在不同行业和领域的应用。
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引用次数: 1
Formulation and Evaluation of Mucoadhesive Buccal Tablets of Anti-Diabetic Drug using 23 Factorial Design 采用23因子设计对抗糖尿病药黏附含片的处方及评价
Pub Date : 2021-11-26 DOI: 10.52711/2231-5713.2021.00043
P. Nagaveni, Sirisha. S, C. A. Rao
The aim of the present study involved the formulation and evaluation of mucoadhesive buccal tablets of anti-diabetic drug gliclazide, Mucoadhesive buccal tablets of Gliclazide are prepared by direct compression method In this present investigational research work the mucoadhesive buccal tablets of gliclazide is prepared separately employing 23 randomized full factorial design by using xanthan gum, carbopol-934, HPMC-E15LV, In this experimental model, target is to determine how the t90% of drug release and mucoadhesive characters can be affected by adjusting three parameters, concentration of polymers xanthan gum, HPMC-E15LV, carbopol-934, of the mucoadhesive buccal tablets. 2 3 full factorial studies were designed to determine the interaction of three independent variables at two levels (low and high level concentration) The tablets were tested for weight variation, hardness, surface pH, drug content uniformity, swelling index, mucoadhesion strength and in-vitro drug release study, Ex- vivo mucoadhesion time. From the drug release studies it was found that formulation H4 containing has good drug release when compared to other formulations.
本研究旨在探讨抗糖尿病药物格列齐特黏附含片的配方及评价,采用直接压缩法制备格列齐特黏附含片。本研究采用23随机全因子设计,分别以黄原胶、carbol -934、HPMC-E15LV为原料制备格列齐特黏附含片,实验模型:目的是考察调整黏附含片中高分子黄原胶、HPMC-E15LV、卡波波-934的浓度对其90%的释药率和黏附特性的影响。2设计3个全因子试验,以确定低、高浓度两个水平下3个自变量的相互作用。测定片剂的重量变化、硬度、表面pH、药物含量均匀性、肿胀指数、黏附强度及体外释药研究、离体黏附时间。从药物释放研究中发现,与其他制剂相比,含有H4的制剂具有较好的药物释放性。
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引用次数: 0
Babchi (Psoralea corylifolia): From a Variety of Traditional Medicinal Application to its Novel Roles in Various Diseases: A Review 补骨脂(Psoralea corylifolia):从多种传统医学应用到其在各种疾病中的新作用:综述
Pub Date : 2021-08-14 DOI: 10.52711/2231-5713.2021.00039
Habeeba Shaikh, Siddiqua Shaikh
Psoralea corylifolia (Leguminosae) commonly known as babchi or babachi has been used in different traditional system of various aliments since, ancient time. Psoralea corylifolia grow throughout Asia and India or many other countries. This article aims to provide a comprehensive review on the phytochemical and pharmacological aspect of Psoralea corylifolia. In traditional medicine, it has been used in treatment of various diseases such as leucoderma skin diseases, cardiovascular diseases, nephritis, osteoporosis, and cancer vitiligo, poisoning, for conception, caries, deafness, filarial. The stem, seeds, leaves, of this plant containe a variety of biologically active compound such as flavonoids, coumarins, phenols, benzofurans, benzopyrans, quinines, sesquiterpenoids, triterpenoids, steroids, and some other components. Those have varuous medicinal properties. The different part of the plant showed the antimicrobial, antipregnancy, estrogenic, antitumor, antioxidant, and many other pharmacological activities. The article focus on traditional as well as modern use and various activities of the plant.
补骨脂(豆科植物)通常被称为babchi或babachi,自古以来一直用于不同的传统系统的各种营养。补骨脂生长在亚洲和印度或许多其他国家。本文就补骨脂的植物化学和药理方面的研究进展作一综述。在传统医学中,它已被用于治疗各种疾病,如白癜风、皮肤病、心血管疾病、肾炎、骨质疏松症、癌症、白癜风、中毒、受孕、龋齿、耳聋、丝虫病等。这种植物的茎、种子、叶含有多种生物活性化合物,如类黄酮、香豆素、酚类、苯并呋喃、苯并吡喃、奎宁、倍半萜类、三萜类、类固醇和其他一些成分。它们有各种各样的药用特性。该植物的不同部位显示出抗菌、抗妊娠、雌激素、抗肿瘤、抗氧化等多种药理活性。本文重点介绍了这种植物的传统和现代用途以及各种活动。
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引用次数: 3
Studies on properties of Novel natural disintegrant after processing of Spray dried and Freez dried technique 新型天然崩解剂喷雾干燥和冷冻干燥后的性能研究
Pub Date : 2021-08-14 DOI: 10.52711/2231-5713.2021.00041
Khairnar Suhas Kishor, Shadab Husain Ashfaque Husain, Patil Pooja Ravsaheb, Gangurde A.B, V. Bairagi
Natural disintegrant are widely used in the development of mouth dissolving tablets and other formulation because of easily available, low cost and rapide onset of action in the mouth dissolving tablet and it enhance the bioavalaibility and disintegration properties as comparaed to synthetic polymer. But aftrer freeze drying and spray drying technique the properties of dsintegrant is increases because its improve the bulkiness and flow property of a powder such as bulk density, tapped density, angle of repose, hausner raio, carrs index etc. by freeze drying the powder are dried and thereby increase the dissolution and disintegration time and highly porous powder is produced by spray drying technique.
天然崩解剂因其易获得、成本低、起效快等优点,与合成聚合物相比,具有较高的生物利用度和崩解性能,被广泛应用于口腔崩解片等制剂的研制。而经过冷冻干燥和喷雾干燥技术后,崩解剂的性能有所提高,因为它改善了粉体的体积性和流动性,如堆积密度、出丝密度、休歇角、豪斯纳比、卡尔斯指数等。通过冷冻干燥,使粉体干燥,从而延长了溶解崩解时间,从而使喷雾干燥技术生产出高多孔粉体。
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引用次数: 0
Formulation development of Temozolomide liposomal formulation in the treatment of Glioma 替莫唑胺脂质体制剂治疗胶质瘤的研制
Pub Date : 2021-08-14 DOI: 10.52711/2231-5713.2021.00033
S. Velivela, N. B. Pati, B. R. Babu
Temozolomide is an anti-cancer drug; it was encapsulated in liposomal intravenous application. To avoid the side effects and to target the drug to the specific site, we have formulated liposomal formulation of Temozolomide. The liposomal were prepared by dried thin film hydration technique using rotary evaporator with drug and Soya phosphatidyl choline as carrier. The prepared liposomes were characterized for size, shape, % entrapment efficiency, in-vitro drug release and physical stability. The evaluated batches showed good physicochemical characteristics. The maximum encapsulation efficiency of Temozolomide was achieved with formulation TMZ 6 with 40.19% and the in-vitro drug release is 64.94%. Based on the results it can be concluded that TMZ 6 was selected as optimized formulation and the optimized formulation Optimized formulation follows zero order release kinetics and follow super case II transport when it applied to Korsmeyer-Pepps model for mechanism of drug release.
替莫唑胺是一种抗癌药物;将其包封在脂质体内静脉应用。为了避免副作用和使药物靶向于特定部位,我们配制了替莫唑胺脂质体制剂。以药物和大豆磷脂酰胆碱为载体,采用旋转蒸发器干燥薄膜水化技术制备了该脂质体。对所制备的脂质体的大小、形状、包封率、体外释药和物理稳定性进行了表征。经评价的批次具有良好的理化特性。tmz6包封率最高,为40.19%,体外释放度为64.94%。结果表明,优选tmz6为优化配方,优化后的配方在应用Korsmeyer-Pepps模型研究药物释放机理时,符合零级释放动力学和超case II转运。
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引用次数: 1
Formulation and Evaluation of Transdermal Patches of Benidipine Hydrochloride 盐酸苯地平透皮贴剂的研制及评价
Pub Date : 2021-08-14 DOI: 10.52711/2231-5713.2021.00034
K. Gajbhiye, Nawaz Hakam, Gauri Rathod, M. Tawar
The present research was designed to evaluate matrix type Benidipine Hydrochloride transdermal patches. So, the present work is an attempt to study effect of variation in Methocel E15LV concentration and study effect of hydrophilic and hydrophobic Methocel E15LV and Eudragit RL100 combination on release profile of Benidipine Hydrochloride. All prepared formulations were evaluated for physical and mechanical properties like thickness, moisture uptake, percent flatness, tensile strength, and percent elongation. An attempt was made to get a patch with suitable drug release property as well as physical and mechanical properties. A formulation containing Methocel E15LV 2% has shown good physical, mechanical and in-vitro drug release properties. It also showed good diffusion of Benidipine Hydrochloride across goat skin.
本研究旨在评价基质型盐酸苯尼地平透皮贴剂。因此,本研究旨在研究Methocel E15LV浓度变化的影响,以及亲疏水性Methocel E15LV与乌达吉特RL100联合使用对盐酸苯尼地平释放谱的影响。对所有制备的配方进行了物理和机械性能评估,如厚度、吸湿率、平整度、拉伸强度和伸长率。试图制备出具有合适的释药性能和物理力学性能的贴片。该制剂含有2% Methocel E15LV,具有良好的物理、机械和体外释药性能。盐酸苯地平在山羊皮肤上有良好的扩散。
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引用次数: 3
Formulation, Optimitziation and Evaluation of Polyherbal Anti-Dandruff Shampoo 复方去屑洗发水的配方、优化及评价
Pub Date : 2021-08-14 DOI: 10.52711/2231-5713.2021.00036
Arpit Gawshinde, D. Mishra, Neha Kamalpuria, N. Farooqui, Surbhi Choursiya
Psidium Guajava, family Myrtaceae and Glycyrrhiza glabra family Leguminosae has been reported to possess antioxidant, antimicrobial, antiinflammatory, antibacterial and antifungal properties. Gauva and Liquiorice extracts have been used to treat antimicrobial infections. It contain several chemicals compound such as flavonoids, tannins, phenols, triterpenes, saponins, to take the benefit of the nature of extract. Psidium Guajava and Glycyrrhiza glabra prepare shampoo incorporating in the herbal constituent base and evaluate this natural herbal shampoo. The herbal shampoo formulations comprising of hydroalcoholic extract of Psidium Guajava and Glycyrrhiza glabra (ethanol:water 80:20v/v), coconut oil, castor oil, cymbopogon citrates oil were prepared and evaluated for physicochemical parameters such as visual appearance, pH, viscosity, % of solids content, foaming capacity and the results showed that the formulation F4 of anti-dandruff herbal shampoo contains all good characters of an ideal shampoo and it was found to be harmless, more effective, ease of manufacturing and economical compared to synthetic antidandruff shampoo.
番石榴属番石榴科和甘草属豆科植物具有抗氧化、抗菌、抗炎、抗菌和抗真菌的特性。高瓦和甘草提取物已被用于治疗抗菌感染。它含有黄酮类化合物、单宁类化合物、酚类化合物、三萜化合物、皂苷类化合物等多种化学成分,充分利用天然提取物的优势。番石榴和甘草准备洗发水纳入草药成分的基础和评估这种天然草药洗发水。以番石榴和甘草的水醇提取物(乙醇:水80:20v/v)、椰子油、蓖麻油、枸橼酸香油为主要原料,配制了以番石榴和甘草为主要原料的草药香波配方,并对其外观、pH值、粘度、固相含量百分比、起泡能力等理化参数进行了评价,结果表明:配方F4的去屑草药香波具有理想香波的所有优良特性,且对人体无害。与合成去屑洗发水相比,更有效,更容易制造,更经济。
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引用次数: 1
期刊
Asian Journal of Pharmacy and Technology
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