Objectives: The study aimed to assess follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, and thyroid-stimulating hormone in obese patients with primary infertility and early pregnancy loss (EPL) and compare with normal fertile patients. Methods: Patients were divided into two groups. Group A consists of 50 patients with a history of infertility and EPL with a body mass index of more than 30 kg/m2. Group B consists of 50 normal fertile patients. Informed written consent was taken from all the patients. Blood samples were taken and hormone levels in two groups were measured and compared statistically. Results: Comparison and statistical analysis of FSH levels in obese infertile and normal fertile groups showed the difference to be statistically highly significant. LH levels in both groups were statistically highly significant. When compared statistically, the difference between prolactin levels of both groups was highly significant. Conclusion: This study supports the impact of obesity on infertility and pregnancy outcomes. Obesity affects dysfunction of the hypothalamus, pituitary ovarian axis, and results in a higher risk of infertility and EPL.
{"title":"TO STUDY ASSOCIATION OF OBESITY WITH HORMONAL IMBALANCE IN PRIMARY INFERTILITY AND EARLY PREGNANCY LOSS","authors":"JASVIR SINGH, Seema, MANINDER KAUR, MANJIT KAUR MOHI","doi":"10.22159/ajpcr.2024.v17i6.50667","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i6.50667","url":null,"abstract":"Objectives: The study aimed to assess follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, and thyroid-stimulating hormone in obese patients with primary infertility and early pregnancy loss (EPL) and compare with normal fertile patients.\u0000Methods: Patients were divided into two groups. Group A consists of 50 patients with a history of infertility and EPL with a body mass index of more than 30 kg/m2. Group B consists of 50 normal fertile patients. Informed written consent was taken from all the patients. Blood samples were taken and hormone levels in two groups were measured and compared statistically.\u0000Results: Comparison and statistical analysis of FSH levels in obese infertile and normal fertile groups showed the difference to be statistically highly significant. LH levels in both groups were statistically highly significant. When compared statistically, the difference between prolactin levels of both groups was highly significant.\u0000Conclusion: This study supports the impact of obesity on infertility and pregnancy outcomes. Obesity affects dysfunction of the hypothalamus, pituitary ovarian axis, and results in a higher risk of infertility and EPL.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141371795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.22159/ajpcr.2024.v17i6.51540
Bhavya Shivalingaiah, Mallikarjun, V. J, SPURTHI K
Objectives: The study aimed to find out the prevalence of obstructive sleep apnea (OSA) in individuals with metabolic syndrome (MS). Methods: This was a cross-sectional study conducted in the department of respiratory medicine of a tertiary care medical institute. Eighty patients infected with MS diagnosed on the basis of national cholesterol education program adult treatment panel III criteria were included in this study on the basis of predefined inclusion and exclusion criteria. Demographic details such as age, gender, and socioeconomic status of all the patients were noted. A thorough general and clinical examination was conducted, including the assessment of vital signs. Polysomnography was done in all cases and the diagnosis of OSA was based on polysomnography results. SSPS 21.0 was used for statistical analysis and p<0.05 was taken as statistically significant. Results: Out of 80 patients, there were 58 (72.50%) males and 22 (27.50%) females with a M: F ratio of 1: 0.37. The overall mean age of the studied cases was found to be 44.60±12.92. Mild (apnea-hypopnea index [AHI] 5–14), moderate (AHI=15–30), and severe OSA (AHI >30) was seen in 33 (41.25%), 17 (21.25%) and 9 (11.25%) patients, respectively. Overall prevalence of OSA in cases of MS was found to be 73.75% as the severity of OSA increased there was decreased in mean sleep time and the difference was found to be statistically significant (p<0.05). The most common presenting complaint was loud snoring, observed in 55 patients (93.22%). This was followed by daytime sleepiness in 47 patients (79.66%), waking up tired in 37 patients (62.71%), and disturbed sleep in 36 patients (61.02%). Conclusion: The prevalence of OSA is notably high among individuals with MS. Consequently, routine assessment for OSA should be an integral component of the management strategy for patients with MS.
研究目的研究旨在了解代谢综合征（MS）患者中阻塞性睡眠呼吸暂停（OSA）的发病率：这是一项横断面研究，在一家三级医疗机构的呼吸内科进行。根据预先确定的纳入和排除标准，80 名根据国家胆固醇教育计划成人治疗小组 III 标准确诊的 MS 感染者被纳入本研究。研究人员注意到了所有患者的年龄、性别和社会经济状况等人口统计学细节。对患者进行了全面的全身和临床检查，包括生命体征评估。所有病例都进行了多导睡眠图检查，并根据多导睡眠图检查结果确诊为 OSA。采用 SSPS 21.0 进行统计分析，结果显示分别有 33 名（41.25%）、17 名（21.25%）和 9 名（11.25%）患者出现 p30）。随着 OSA 严重程度的增加，平均睡眠时间减少，MS 患者中 OSA 的总体患病率为 73.75%，差异具有统计学意义（P<0.05）。55名患者（93.22%）最常见的主诉是大声打鼾。其次是47名患者（79.66%）白天嗜睡，37名患者（62.71%）疲倦醒来，36名患者（61.02%）睡眠不安：结论：OSA 在多发性硬化症患者中的发病率很高。因此，对 OSA 进行常规评估应成为多发性硬化症患者管理策略的一个组成部分。
{"title":"PREVALENCE OF OBSTRUCTIVE SLEEP APNEA IN CASES OF METABOLIC SYNDROME: A CROSS-SECTIONAL STUDY","authors":"Bhavya Shivalingaiah, Mallikarjun, V. J, SPURTHI K","doi":"10.22159/ajpcr.2024.v17i6.51540","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i6.51540","url":null,"abstract":"Objectives: The study aimed to find out the prevalence of obstructive sleep apnea (OSA) in individuals with metabolic syndrome (MS).\u0000Methods: This was a cross-sectional study conducted in the department of respiratory medicine of a tertiary care medical institute. Eighty patients infected with MS diagnosed on the basis of national cholesterol education program adult treatment panel III criteria were included in this study on the basis of predefined inclusion and exclusion criteria. Demographic details such as age, gender, and socioeconomic status of all the patients were noted. A thorough general and clinical examination was conducted, including the assessment of vital signs. Polysomnography was done in all cases and the diagnosis of OSA was based on polysomnography results. SSPS 21.0 was used for statistical analysis and p<0.05 was taken as statistically significant.\u0000Results: Out of 80 patients, there were 58 (72.50%) males and 22 (27.50%) females with a M: F ratio of 1: 0.37. The overall mean age of the studied cases was found to be 44.60±12.92. Mild (apnea-hypopnea index [AHI] 5–14), moderate (AHI=15–30), and severe OSA (AHI >30) was seen in 33 (41.25%), 17 (21.25%) and 9 (11.25%) patients, respectively. Overall prevalence of OSA in cases of MS was found to be 73.75% as the severity of OSA increased there was decreased in mean sleep time and the difference was found to be statistically significant (p<0.05). The most common presenting complaint was loud snoring, observed in 55 patients (93.22%). This was followed by daytime sleepiness in 47 patients (79.66%), waking up tired in 37 patients (62.71%), and disturbed sleep in 36 patients (61.02%).\u0000Conclusion: The prevalence of OSA is notably high among individuals with MS. Consequently, routine assessment for OSA should be an integral component of the management strategy for patients with MS.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141375392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.22159/ajpcr.2024.v17i6.50762
Rupa Pradhan, Diptimayee Tripathy, S. Jali
Objective: The study aimed to assess the incidence of hyponatremia in cirrhosis of the liver and to evaluate the association between serum sodium levels and the severity of cirrhosis and its complications. Methods: Data on inpatients with cirrhosis of the liver were collected on the date of admission. The serum sodium levels on day 1 and the presence of complications and their severity in 100 patients were analyzed. Results: The incidence of dilutional hyponatremia, which was subdivided into three groups (mmol/L): A-≤130, B-131-135, and C-≥136, were 55%, 25%, and 20%, respectively. The severity of liver cirrhosis was assessed using the CTP score and the MELD score, with a higher score seen in Group A (p=0.011 and p=0.012), respectively. Furthermore in group A, higher grades of complications were seen: grade 3/gross ascites (p=0.001), grade lll/lV hepatic encephalopathy (p=0.007), spontaneous bacterial peritonitis (p=0.049), and hepatorenal syndrome (p=0.022). Even in group B with s.Na+level 131–135 mmol/L, the development of complications was no less common. Conclusion: Serum sodium levels must be closely monitored in cirrhotic patients as they suggest the possibility of a potentially negative impact on the clinical course of the disease.
{"title":"THE CORRELATION BETWEEN SERUM SODIUM LEVELS AND THE SEVERITY OF CIRRHOSIS OF LIVER AND ITS COMPLICATIONS","authors":"Rupa Pradhan, Diptimayee Tripathy, S. Jali","doi":"10.22159/ajpcr.2024.v17i6.50762","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i6.50762","url":null,"abstract":"Objective: The study aimed to assess the incidence of hyponatremia in cirrhosis of the liver and to evaluate the association between serum sodium levels and the severity of cirrhosis and its complications.\u0000Methods: Data on inpatients with cirrhosis of the liver were collected on the date of admission. The serum sodium levels on day 1 and the presence of complications and their severity in 100 patients were analyzed.\u0000Results: The incidence of dilutional hyponatremia, which was subdivided into three groups (mmol/L): A-≤130, B-131-135, and C-≥136, were 55%, 25%, and 20%, respectively. The severity of liver cirrhosis was assessed using the CTP score and the MELD score, with a higher score seen in Group A (p=0.011 and p=0.012), respectively. Furthermore in group A, higher grades of complications were seen: grade 3/gross ascites (p=0.001), grade lll/lV hepatic encephalopathy (p=0.007), spontaneous bacterial peritonitis (p=0.049), and hepatorenal syndrome (p=0.022). Even in group B with s.Na+level 131–135 mmol/L, the development of complications was no less common.\u0000Conclusion: Serum sodium levels must be closely monitored in cirrhotic patients as they suggest the possibility of a potentially negative impact on the clinical course of the disease.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141374427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.22159/ajpcr.2024.v17i6.51658
M. Maghade, Anand Saoji, Abhishek Somani, Abhijeet Faye
Objective: The objective of the study is (1) to analyze the prevalence and severity of depression in cases of pemphigus and (2) to study the association of demographic factors with the presence of depression in cases with pemphigus. Methods: A cross-sectional single-interview study was carried out on 100 consecutively selected patients with pemphigus attending the dermatology out-patient department in a tertiary care hospital. The assessment was done with semi-structured pro forma, Beck depression inventory (BDI), and quality of life (QoL) measure – Skindex-16. The Statistical Package for the Social Sciences 24.0 was used for statistical analysis and p<0.05 was taken as statistically significant. Results: Out of 100 cases, there were 60 (60%) males and 40 (40%) were females with M: F ratio of 1:0.66. The mean age of male and female patients was found to be comparable with no statistically significant difference (p=0.6061). The majority were married, employed, and from rural backgrounds. 22% satisfied the Diagnostic and Statistical Manual for Mental Disorders 5th edition criteria for major depressive disorder. Assessment using BDI in these patients for severity of depression showed mild depression in 12%, moderate depression in 7%, and severe depression in 3%. Patients having a longer duration of illness and a history of frequent hospitalization were found to have significantly high scores on the subscale for depressive symptoms. QoL assessment using the Skindex-16 scale among these patients showed that they experienced more severe emotional and symptomatic effects due to skin disease compared to functional effects, especially during relapse. Those who had poor QoL showed significantly high scores on the subscale for depressive symptoms. Conclusion: More than 20% of patients of pemphigus had diagnosable depression with significant effects on QoL. Therefore, regular screening for depression is important in pemphigus patients as it will help in planning early intervention.
{"title":"DEPRESSION AND QUALITY OF LIFE IN PATIENTS WITH PEMPHIGUS: A CROSS-SECTIONAL STUDY","authors":"M. Maghade, Anand Saoji, Abhishek Somani, Abhijeet Faye","doi":"10.22159/ajpcr.2024.v17i6.51658","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i6.51658","url":null,"abstract":"Objective: The objective of the study is (1) to analyze the prevalence and severity of depression in cases of pemphigus and (2) to study the association of demographic factors with the presence of depression in cases with pemphigus.\u0000Methods: A cross-sectional single-interview study was carried out on 100 consecutively selected patients with pemphigus attending the dermatology out-patient department in a tertiary care hospital. The assessment was done with semi-structured pro forma, Beck depression inventory (BDI), and quality of life (QoL) measure – Skindex-16. The Statistical Package for the Social Sciences 24.0 was used for statistical analysis and p<0.05 was taken as statistically significant.\u0000Results: Out of 100 cases, there were 60 (60%) males and 40 (40%) were females with M: F ratio of 1:0.66. The mean age of male and female patients was found to be comparable with no statistically significant difference (p=0.6061). The majority were married, employed, and from rural backgrounds. 22% satisfied the Diagnostic and Statistical Manual for Mental Disorders 5th edition criteria for major depressive disorder. Assessment using BDI in these patients for severity of depression showed mild depression in 12%, moderate depression in 7%, and severe depression in 3%. Patients having a longer duration of illness and a history of frequent hospitalization were found to have significantly high scores on the subscale for depressive symptoms. QoL assessment using the Skindex-16 scale among these patients showed that they experienced more severe emotional and symptomatic effects due to skin disease compared to functional effects, especially during relapse. Those who had poor QoL showed significantly high scores on the subscale for depressive symptoms.\u0000Conclusion: More than 20% of patients of pemphigus had diagnosable depression with significant effects on QoL. Therefore, regular screening for depression is important in pemphigus patients as it will help in planning early intervention.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141371335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.22159/ajpcr.2024.v17i6.50809
Archana Tiwari, Avinash Tiwari, Archana Tiwari
Objective: Plant-based polyphenolic compounds are important phytonutrients found in many meals such as fruits, vegetables, tea, coffee, and red wine. The literature study has gathered enough evidence confirming the existence of the same substance in the bark of Acacia catechu plants. The literature review verified that the dense forest with comparable plant life in Guna district of Central India has not been systematically studied. This research aims to analyze the total polyphenolic content of A. catechu bark from this location. Methods: Thirty samples of test plants were collected from the research area in different seasons for this investigation. Each sample was made using six distinct solvents. Subsequently, quantitative testing was conducted using a standardized laboratory approach. Bibliographic analysis was conducted to confirm and establish a connection between the current study and previous research. Results: The results indicated that the test parameter was present in large quantities in all polar extraction systems, but only insignificant amounts were seen in chloroform and benzene. The comparative bibliographic investigation was confirmed the advantageous uses of the same. Conclusion: This exploratory investigation potentially identified novel, cost-effective, and easily accessible sources of polyphenolic chemicals from the local flora of Guna region and serve as the foundation for future researches on the same.
{"title":"A COMPARATIVE STUDY OF POLYPHENOLIC CONTENT IN ACACIA CATECHU BARK EXTRACTS AND BIBLIOGRAPHIC ANALYSIS WITH REFERENCE TO GUNA (MADHYA PRADESH), INDIA","authors":"Archana Tiwari, Avinash Tiwari, Archana Tiwari","doi":"10.22159/ajpcr.2024.v17i6.50809","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i6.50809","url":null,"abstract":"Objective: Plant-based polyphenolic compounds are important phytonutrients found in many meals such as fruits, vegetables, tea, coffee, and red wine. The literature study has gathered enough evidence confirming the existence of the same substance in the bark of Acacia catechu plants. The literature review verified that the dense forest with comparable plant life in Guna district of Central India has not been systematically studied. This research aims to analyze the total polyphenolic content of A. catechu bark from this location.\u0000Methods: Thirty samples of test plants were collected from the research area in different seasons for this investigation. Each sample was made using six distinct solvents. Subsequently, quantitative testing was conducted using a standardized laboratory approach. Bibliographic analysis was conducted to confirm and establish a connection between the current study and previous research.\u0000Results: The results indicated that the test parameter was present in large quantities in all polar extraction systems, but only insignificant amounts were seen in chloroform and benzene. The comparative bibliographic investigation was confirmed the advantageous uses of the same.\u0000Conclusion: This exploratory investigation potentially identified novel, cost-effective, and easily accessible sources of polyphenolic chemicals from the local flora of Guna region and serve as the foundation for future researches on the same.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141372188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.22159/ajpcr.2024.v17i6.50595
Monica Diana, Nuveen Ak, Panamparambil Remith, Bini Markose
Objective: Foramen magnum is an oval opening present in the median region of the posterior cranial fossa of the occipital bone. The lower end of the medulla, meninges, spinal arteries, and spinal roots of accessory nerve pass through the foramen. Morphometry of the foramen magnum is studied for better learning of the structure, but this study helps in planning a safe surgery and exploration in the head-and-neck region. Various surgical approaches of the foramen provide access to the foramina on the base of the skull and prevent broad retraction of the neurovascular structures passing through them, so the morphometric study plays an important role in transcondylar approach. Methods: Fifty dry human skulls available in the Department of Anatomy, Amala Medical College and Hospital, and also at Jubilee Medical College and Hospital, Thrissur were studied for this research work, and results were statistically analyzed. Results: The most common shape of the foramen magnum was oval, the mean of anteroposterior diameter was greater than the mean of transverse diameter, p-value of the diameters was found to be significant, p-value of the mean of foramen magnum index was significant. Conclusion: This study will help the surgeons to effectively plan a surgery at the head and neck site
目的：枕骨大孔是枕骨后颅窝正中区域的一个椭圆形开口。髓质下端、脑膜、脊髓动脉和附属神经的脊髓根均通过该孔。对枕骨大孔形态的研究是为了更好地了解其结构，但这一研究有助于规划头颈部的安全手术和探查。对枕骨大孔的各种手术方法都能进入颅底的枕骨大孔，并防止穿过枕骨大孔的神经血管结构广泛回缩，因此形态测量研究在经髁入路中起着重要作用：方法：研究了阿马拉医学院和医院解剖学系以及特里苏尔朱比利医学院和医院的 50 个干燥人类头骨，并对结果进行了统计分析：结果：最常见的枕骨大孔形状为椭圆形，前后径的平均值大于横径的平均值，直径的 p 值显著，枕骨大孔指数的平均值的 p 值显著：这项研究将帮助外科医生有效地制定头颈部手术计划。
{"title":"FORAMEN MAGNUM – A STUDY ON ITS MORPHOMETRY AMONG THE SOUTH INDIAN POPULATION","authors":"Monica Diana, Nuveen Ak, Panamparambil Remith, Bini Markose","doi":"10.22159/ajpcr.2024.v17i6.50595","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i6.50595","url":null,"abstract":"Objective: Foramen magnum is an oval opening present in the median region of the posterior cranial fossa of the occipital bone. The lower end of the medulla, meninges, spinal arteries, and spinal roots of accessory nerve pass through the foramen. Morphometry of the foramen magnum is studied for better learning of the structure, but this study helps in planning a safe surgery and exploration in the head-and-neck region. Various surgical approaches of the foramen provide access to the foramina on the base of the skull and prevent broad retraction of the neurovascular structures passing through them, so the morphometric study plays an important role in transcondylar approach.\u0000Methods: Fifty dry human skulls available in the Department of Anatomy, Amala Medical College and Hospital, and also at Jubilee Medical College and Hospital, Thrissur were studied for this research work, and results were statistically analyzed.\u0000Results: The most common shape of the foramen magnum was oval, the mean of anteroposterior diameter was greater than the mean of transverse diameter, p-value of the diameters was found to be significant, p-value of the mean of foramen magnum index was significant.\u0000Conclusion: This study will help the surgeons to effectively plan a surgery at the head and neck site","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141374730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.22159/ajpcr.2024.v17i6.50812
A. M. K. AL-TUMA
Objectives: Methotrexate (MTX) is a disease-modifying ant-rheumatic drug that has been used commonly in patients with rheumatoid arthritis (RA) with a goal of reducing RA activity or RA remission. Response to MTX varied among patients and side effects including liver impairment are not uncommon. The study aimed to compare oral and parenteral MTX intake regarding the efficacy and risk of liver impairment in patients with RA. Subject: Thirty patients who were newly diagnosed with RA according to EULAR/ASAR were included in the study. MTX was given for them for 6 months in a dose ranging between 2 and 25 mg either orally or parenterally intramuscular and subcutaneously once weekly. Patients were assessed depending on clinical disease activity index (CDAI) score and liver enzymes were measured before and after the start of the treatment. Results: The study showed that parenteral MTX intake significantly improves the CDAI score more than oral intake, CDAI reduced from 13.15±3.25 to 5.57±2.34 following 6 months of treatment in comparison to its’ insignificant reduction from 12.72±3.13 to 8.90±3.08 following oral treatment. Regarding liver enzymes, the impairment in alanine aminotransferase and aspartate aminotransferase is significantly less than that with oral ones with the same effect on alkaline phosphatase. Conclusion: Parenteral MTX intake tends to be more efficacious in attaining low disease activity than oral intake with a lower rate of impaired liver function.
目的：甲氨蝶呤（MTX）是一种改变病情的抗风湿药物，常用于类风湿性关节炎（RA）患者，目的是减少 RA 活动或使 RA 缓解。不同患者对MTX的反应各不相同，包括肝功能损害在内的副作用也不少见。该研究旨在比较口服和肠外MTX对RA患者的疗效和肝功能损害风险：研究纳入了 30 名根据 EULAR/ASAR 新确诊的 RA 患者。在为期6个月的时间里，他们口服或皮下注射MTX，剂量从2毫克到25毫克不等，每周一次。根据临床疾病活动指数（CDAI）评分对患者进行评估，并在治疗开始前后测量肝酶：研究显示，肠外注射 MTX 比口服 MTX 更能明显改善 CDAI 评分，治疗 6 个月后 CDAI 从（13.15±3.25）分降至（5.57±2.34）分，而口服治疗后 CDAI 从（12.72±3.13）分降至（8.90±3.08）分，降幅不明显。在肝酶方面，丙氨酸氨基转移酶和天门冬氨酸氨基转移酶的损害明显低于口服治疗，对碱性磷酸酶的影响相同：结论：与口服药物相比，肠外MTX对达到低疾病活动度更有效，且肝功能受损率更低。
{"title":"A COMPARISON BETWEEN ENTERAL AND PARENTERAL METHOTREXATE INTAKE IN IRAQI PATIENTS WITH RHEUMATOID ARTHRITIS REGARDING EFFICACY AND LIVER FUNCTION IMPAIRMENT","authors":"A. M. K. AL-TUMA","doi":"10.22159/ajpcr.2024.v17i6.50812","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i6.50812","url":null,"abstract":"Objectives: Methotrexate (MTX) is a disease-modifying ant-rheumatic drug that has been used commonly in patients with rheumatoid arthritis (RA) with a goal of reducing RA activity or RA remission. Response to MTX varied among patients and side effects including liver impairment are not uncommon. The study aimed to compare oral and parenteral MTX intake regarding the efficacy and risk of liver impairment in patients with RA.\u0000Subject: Thirty patients who were newly diagnosed with RA according to EULAR/ASAR were included in the study. MTX was given for them for 6 months in a dose ranging between 2 and 25 mg either orally or parenterally intramuscular and subcutaneously once weekly. Patients were assessed depending on clinical disease activity index (CDAI) score and liver enzymes were measured before and after the start of the treatment.\u0000Results: The study showed that parenteral MTX intake significantly improves the CDAI score more than oral intake, CDAI reduced from 13.15±3.25 to 5.57±2.34 following 6 months of treatment in comparison to its’ insignificant reduction from 12.72±3.13 to 8.90±3.08 following oral treatment. Regarding liver enzymes, the impairment in alanine aminotransferase and aspartate aminotransferase is significantly less than that with oral ones with the same effect on alkaline phosphatase.\u0000Conclusion: Parenteral MTX intake tends to be more efficacious in attaining low disease activity than oral intake with a lower rate of impaired liver function.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141373833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.22159/ajpcr.2024.v17i6.51242
Yugal Chandrakar
We present a detailed case report of a 22-year-old male patient admitted with severe back pain who experienced an unexpected complication following tramadol administration. Despite initial investigations showing no abnormalities, the patient developed convulsions shortly after receiving tramadol. This case underscores the importance of considering rare adverse reactions when administering medications, even in patients without a predisposing medical history.
{"title":"UNFORESEEN COMPLICATION OF TRAMADOL ADMINISTRATION: A CASE REPORT","authors":"Yugal Chandrakar","doi":"10.22159/ajpcr.2024.v17i6.51242","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i6.51242","url":null,"abstract":"We present a detailed case report of a 22-year-old male patient admitted with severe back pain who experienced an unexpected complication following tramadol administration. Despite initial investigations showing no abnormalities, the patient developed convulsions shortly after receiving tramadol. This case underscores the importance of considering rare adverse reactions when administering medications, even in patients without a predisposing medical history.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141372611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.22159/ajpcr.2024.v17i6.50275
Rinu Jonsan, Santhi Ks
Objective: The objective of the study is to determine the dose of propofol required for induction when fentanyl was administered just before, 3 min, and 5 min before propofol administration. Furthermore, to determine changes in heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), when fentanyl was given at varying time intervals. Methods: A prospective observational study was conducted in a tertiary care teaching hospital for 12 months. A total of 150 patients belonging to ASA 1 and 2 in the age group of 18–60 years scheduled for elective surgery under general anesthesia were allocated into three groups. Group 1 received propofol immediately after a 2 mcg/kg fentanyl injection and Group 2 and Group 3 received propofol 3 and 5 min, respectively, after the administration of fentanyl. The total dose of propofol required for induction is noted. Heart rate, systolic, diastolic, and MAPs after induction were also noted. Data analysis was done using SPSS version 25. Results: All three groups were comparable concerning demographic variables. The total dose of propofol required for induction was highest in Group 1, where propofol was given immediately after fentanyl, followed by Group 2, and lowest in Group 3 where propofol was given 5 min after fentanyl. Fall in heart rate, SBP, DBP, and MAP after propofol administration was highest in Group 1, followed by Group 2, and least in Group 3 where fentanyl was administered 5 min before propofol. The results were statistically significant. Conclusion: Administering fentanyl 5 min before propofol causes a marked reduction in the dose requirement of propofol along with a significantly decreased incidence of hypotension after induction.
{"title":"EFFECT OF VARYING TIME INTERVALS BETWEEN FENTANYL AND PROPOFOL ADMINISTRATION ON PROPOFOL REQUIREMENT FOR INDUCTION OF ANESTHESIA - AN OBSERVATIONAL STUDY","authors":"Rinu Jonsan, Santhi Ks","doi":"10.22159/ajpcr.2024.v17i6.50275","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i6.50275","url":null,"abstract":"Objective: The objective of the study is to determine the dose of propofol required for induction when fentanyl was administered just before, 3 min, and 5 min before propofol administration. Furthermore, to determine changes in heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), when fentanyl was given at varying time intervals.\u0000Methods: A prospective observational study was conducted in a tertiary care teaching hospital for 12 months. A total of 150 patients belonging to ASA 1 and 2 in the age group of 18–60 years scheduled for elective surgery under general anesthesia were allocated into three groups. Group 1 received propofol immediately after a 2 mcg/kg fentanyl injection and Group 2 and Group 3 received propofol 3 and 5 min, respectively, after the administration of fentanyl. The total dose of propofol required for induction is noted. Heart rate, systolic, diastolic, and MAPs after induction were also noted. Data analysis was done using SPSS version 25.\u0000Results: All three groups were comparable concerning demographic variables. The total dose of propofol required for induction was highest in Group 1, where propofol was given immediately after fentanyl, followed by Group 2, and lowest in Group 3 where propofol was given 5 min after fentanyl. Fall in heart rate, SBP, DBP, and MAP after propofol administration was highest in Group 1, followed by Group 2, and least in Group 3 where fentanyl was administered 5 min before propofol. The results were statistically significant.\u0000Conclusion: Administering fentanyl 5 min before propofol causes a marked reduction in the dose requirement of propofol along with a significantly decreased incidence of hypotension after induction.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141374422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-07DOI: 10.22159/ajpcr.2024.v17i6.50642
Keziah K Viju, MAYURI R SHAH
Objectives: The study aimed to determine the knowledge of delayed healing in postoperative fracture conditions in osteoporotic patients. Method: In this observational study, 60 subjects were taken between the age group 50–80 years, which consisted of 52% of females and 48% of males. The study was done with self-made questionnaires. Result: A sample of 60 people was taken; out of this, only 11% were aware of the relationship between osteoporosis and fracture healing, and the other 89% lacked the awareness of the relationship between osteoporosis and fracture healing. Conclusion: In this study, it was found that there was 11% of people aware of fracture healing and osteoporosis.
{"title":"AWARENESS OF DELAYED HEALING IN POST-OPERATIVE FRACTURE CONDITIONS IN OSTEOPOROTIC PATIENTS","authors":"Keziah K Viju, MAYURI R SHAH","doi":"10.22159/ajpcr.2024.v17i6.50642","DOIUrl":"https://doi.org/10.22159/ajpcr.2024.v17i6.50642","url":null,"abstract":"Objectives: The study aimed to determine the knowledge of delayed healing in postoperative fracture conditions in osteoporotic patients.\u0000Method: In this observational study, 60 subjects were taken between the age group 50–80 years, which consisted of 52% of females and 48% of males. The study was done with self-made questionnaires.\u0000Result: A sample of 60 people was taken; out of this, only 11% were aware of the relationship between osteoporosis and fracture healing, and the other 89% lacked the awareness of the relationship between osteoporosis and fracture healing.\u0000Conclusion: In this study, it was found that there was 11% of people aware of fracture healing and osteoporosis.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141374032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：