Objectives: The objective of this study was to evaluate the outcome of 48 cases of laparoscopic pyeloplasty at a tertiary care hospital of Southern Rajasthan where medical facilities are still evolving. Methods: Data of 48 patients from the medical record department, who underwent laparoscopic pyeloplasty surgery in past 4 years (January 2019– January 2023) for primary ureteropelvic junction (UPJ) obstruction due to intrinsic UPJ abnormality or aberrant vessels, were analyzed retrospectively. Intraoperative findings, success rate, and complications were recorded. Results: Pelvic reduction was required in 30 (62.5%) patients. The mean operative time was 182.4 min and the mean blood loss was 55 mL. The mean hospital stay was of 4.2 days. Success rate of laparoscopic pyeloplasty was 97%. Over all 10.41% of patients had complications. Conclusion: Laparoscopic pyeloplasty deals concomitant secondary stones with less morbidity and complications. It has better cosmetic outcome as compared to open techniques and similar long-term success rates. Hence, it can be concluded that laparoscopic pyeloplasty is an excellent current gold standard for primary UPJ obstruction.
{"title":"EVALUATION OF OUTCOME OF 48 CASES OF LAPAROSCOPIC PYELOPLASTY AT TERTIARY CARE TEACHING HOSPITAL OF SOUTHERN RAJASTHAN","authors":"PANKAJ TRIVEDI, VISHWAS BAHETI, PUSHPENDRA CHOUDHARY","doi":"10.22159/ajpcr.2024v17i7.51884","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.51884","url":null,"abstract":"Objectives: The objective of this study was to evaluate the outcome of 48 cases of laparoscopic pyeloplasty at a tertiary care hospital of Southern Rajasthan where medical facilities are still evolving.\u0000Methods: Data of 48 patients from the medical record department, who underwent laparoscopic pyeloplasty surgery in past 4 years (January 2019– January 2023) for primary ureteropelvic junction (UPJ) obstruction due to intrinsic UPJ abnormality or aberrant vessels, were analyzed retrospectively. Intraoperative findings, success rate, and complications were recorded.\u0000Results: Pelvic reduction was required in 30 (62.5%) patients. The mean operative time was 182.4 min and the mean blood loss was 55 mL. The mean hospital stay was of 4.2 days. Success rate of laparoscopic pyeloplasty was 97%. Over all 10.41% of patients had complications.\u0000Conclusion: Laparoscopic pyeloplasty deals concomitant secondary stones with less morbidity and complications. It has better cosmetic outcome as compared to open techniques and similar long-term success rates. Hence, it can be concluded that laparoscopic pyeloplasty is an excellent current gold standard for primary UPJ obstruction.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141671450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-07DOI: 10.22159/ajpcr.2024v17i7.51029
SWETHA K, Nithin Shetty, V. K., Neeta T Gavimath
Objectives: This study was conducted with an objective to assess the prevalence of prescription errors and to compare the prescription writing skills of the interns’ pre and post-teaching interventions on the appropriateness “prescription writing.” Methods: This research was conducted in a tertiary care teaching hospital Karwar Institute of Medical Sciences, Karwar. All interns posted to the orthopedics department as a part of rotatory internship postings during the 6 months from June 2021 were included in this research after receiving informed permission in writing. We gathered the written prescriptions for three distinct cases and a seminar and hands-on training about “prescription writing” was given. Subsequently, the interns were requested to re-write new prescriptions for the same three situations. Results: A total of 390 prescriptions from 65 interns were gathered and analyzed. In 58%, 36%, 62%, and 78% of the prescriptions, date, diagnosis, prescriber’s name and qualification were absent. In 44% and 12% of the prescriptions, the patient’s age and name were not written, respectively. Following the hands-on teaching intervention, a noteworthy enhancement in the overall prescription writing was noted. Conclusion: Interns often write prescriptions incorrectly because they do not retain the pharmacotherapeutic information that was given in the 2nd year of the undergraduate program. A teaching program of basic prescription writing is necessary to refresh their knowledge and prescription writing skills.
{"title":"ASSESSMENT OF HANDS-ON TRAINING ON INTERNS’ PRESCRIPTION WRITING SKILLS AT A TERTIARY CARE TEACHING HOSPITAL","authors":"SWETHA K, Nithin Shetty, V. K., Neeta T Gavimath","doi":"10.22159/ajpcr.2024v17i7.51029","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.51029","url":null,"abstract":"Objectives: This study was conducted with an objective to assess the prevalence of prescription errors and to compare the prescription writing skills of the interns’ pre and post-teaching interventions on the appropriateness “prescription writing.”\u0000Methods: This research was conducted in a tertiary care teaching hospital Karwar Institute of Medical Sciences, Karwar. All interns posted to the orthopedics department as a part of rotatory internship postings during the 6 months from June 2021 were included in this research after receiving informed permission in writing. We gathered the written prescriptions for three distinct cases and a seminar and hands-on training about “prescription writing” was given. Subsequently, the interns were requested to re-write new prescriptions for the same three situations.\u0000Results: A total of 390 prescriptions from 65 interns were gathered and analyzed. In 58%, 36%, 62%, and 78% of the prescriptions, date, diagnosis, prescriber’s name and qualification were absent. In 44% and 12% of the prescriptions, the patient’s age and name were not written, respectively. Following the hands-on teaching intervention, a noteworthy enhancement in the overall prescription writing was noted.\u0000Conclusion: Interns often write prescriptions incorrectly because they do not retain the pharmacotherapeutic information that was given in the 2nd year of the undergraduate program. A teaching program of basic prescription writing is necessary to refresh their knowledge and prescription writing skills.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-07DOI: 10.22159/ajpcr.2024v17i7.51818
GUGULOTH MANOSRI SOWMYA, A MOUNIKA, B BHANU REKHA
Objectives: The aim of this study was to analyze clinical profile, risk factors, and pulmonary function test (PFT) in patients with obstructive sleep apnea (OSA). Methods: This was a prospective study undertaken in the department of pulmonary medicine of a tertiary care medical institute in which adult patients OSA were included on the basis of a predefined inclusion and exclusion criteria. Demographic details of patients were noted. Gender distribution, age distribution, clinical profile, and risk factors were studied. Severity of OSA was assessed by apnea hypopnea index (AHI). PFTs were done in all the cases. Results: Out of 60 studied cases, there were 39 (65.00%) males and 21 (35.00%) females with a M: F ratio of 1: 0.53. The mean age of the studied cases was 51.58±11.14 years. The most common risk factor present in studied cases was increased neck circumference. Severity of OSA, as determined by AHI, was found to be mild, moderate, and severe in 34 (56.67%), 20 (33.33%), and 6 (10.00%) patients, respectively. Snoring that was bothersome to others was the most common presenting complaints in studied cases and was found in 52 (86.67%) cases. PFT was normal in 23 (38.33%) patients whereas obstructive as well as restrictive features were seen in 16 (26.67%) and 14 (23.33%) patients, respectively. Conclusion: PFTs should be included during workup of patients with OSA and obstructive lung disease may coexist and cause an increase in mortality.
研究目的本研究旨在分析阻塞性睡眠呼吸暂停（OSA）患者的临床概况、风险因素和肺功能测试（PFT）：这是一项在一家三级医疗机构肺内科进行的前瞻性研究，根据预先确定的纳入和排除标准纳入了 OSA 成年患者。研究记录了患者的详细人口统计学资料。对性别分布、年龄分布、临床特征和风险因素进行了研究。通过呼吸暂停低通气指数（AHI）评估 OSA 的严重程度。所有病例均进行了肺功能检查：在 60 例研究病例中，男性 39 例（65.00%），女性 21 例（35.00%），男女比例为 1:0.53。研究病例的平均年龄为（51.58±11.14）岁。研究病例中最常见的危险因素是颈围增大。根据 AHI 确定，34 例（56.67%）、20 例（33.33%）和 6 例（10.00%）患者的 OSA 严重程度分别为轻度、中度和重度。在研究病例中，52 例（86.67%）患者最常见的主诉是鼾声扰人。23例（38.33%）患者的肺活量正常，而16例（26.67%）和14例（23.33%）患者的肺活量分别出现阻塞性和局限性特征：结论：在对 OSA 患者进行检查时，应将 PFT 包括在内，阻塞性肺部疾病可能同时存在，并导致死亡率上升。
{"title":"CLINICAL PROFILE, RISK FACTORS, AND PULMONARY FUNCTION TESTS IN PATIENTS OF OBSTRUCTIVE SLEEP APNEA","authors":"GUGULOTH MANOSRI SOWMYA, A MOUNIKA, B BHANU REKHA","doi":"10.22159/ajpcr.2024v17i7.51818","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.51818","url":null,"abstract":"Objectives: The aim of this study was to analyze clinical profile, risk factors, and pulmonary function test (PFT) in patients with obstructive sleep apnea (OSA).\u0000Methods: This was a prospective study undertaken in the department of pulmonary medicine of a tertiary care medical institute in which adult patients OSA were included on the basis of a predefined inclusion and exclusion criteria. Demographic details of patients were noted. Gender distribution, age distribution, clinical profile, and risk factors were studied. Severity of OSA was assessed by apnea hypopnea index (AHI). PFTs were done in all the cases.\u0000Results: Out of 60 studied cases, there were 39 (65.00%) males and 21 (35.00%) females with a M: F ratio of 1: 0.53. The mean age of the studied cases was 51.58±11.14 years. The most common risk factor present in studied cases was increased neck circumference. Severity of OSA, as determined by AHI, was found to be mild, moderate, and severe in 34 (56.67%), 20 (33.33%), and 6 (10.00%) patients, respectively. Snoring that was bothersome to others was the most common presenting complaints in studied cases and was found in 52 (86.67%) cases. PFT was normal in 23 (38.33%) patients whereas obstructive as well as restrictive features were seen in 16 (26.67%) and 14 (23.33%) patients, respectively.\u0000Conclusion: PFTs should be included during workup of patients with OSA and obstructive lung disease may coexist and cause an increase in mortality.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-07DOI: 10.22159/ajpcr.2024v17i7.51845
Ravi Shankar, Ajay Kumar, NEHA SHARMA, Raju Ram, Aparajita Kushwaha
Objectives: Metabolic syndrome is the most widely used term for the aggregation of metabolic abnormalities, which leads to an increase in the risk of developing cardiovascular pathology. Protective nutritional antioxidants may benefit defensive antioxidative systems in resolving pro-oxidative dominance and redox imbalance, preventing, or delaying chronic thyroid diseases. Methods: This cross-sectional, observational study was conducted among metabolic syndrome patients in the general population and near and dear patients (350) at the Pacific Institute of Medical Sciences, Udaipur. For the determination of interleukin-6 (IL-6) was done by enzyme-linked immunosorbent assay. Thyroid hormones are determined by chemiluminescence and antioxidant Vitamin C and malondialdehyde (MDA) chromatography and high-performance liquid chromatography, respectively. Results: This study shows a low level of antioxidant Vitamin C and MDA and a high level of inflammatory marker IL-6 in these patients. In this study, the age distribution of patients showed that males in the 35–51 years of age group were most affected, whereas females in the 18–34 years of age group were more prevalent. Conclusion: The present study leads to awareness of antioxidant levels and inflammation in thyroid patients along with other biochemical parameters involved in the development of metabolic syndrome in the Indian population.
目的：代谢综合征是最广泛使用的术语，指代谢异常的聚集，导致心血管病变风险增加。保护性营养抗氧化剂可能有利于防御性抗氧化系统解决促氧化优势和氧化还原失衡问题，预防或延缓慢性甲状腺疾病：这项横断面观察性研究在乌代布尔太平洋医学科学研究所的普通人群代谢综合征患者和近亲患者（350 人）中进行。白细胞介素-6（IL-6）的测定采用酶联免疫吸附法。甲状腺激素通过化学发光法和抗氧化剂维生素 C 及丙二醛（MDA）色谱法和高效液相色谱法分别进行测定：本研究显示，这些患者的抗氧化剂维生素 C 和 MDA 含量较低，炎症标志物 IL-6 含量较高。本研究中，患者的年龄分布显示，35-51 岁年龄组的男性患者最多，而 18-34 岁年龄组的女性患者较多：本研究使人们认识到甲状腺患者的抗氧化水平和炎症以及其他生化指标与印度人群代谢综合征的发展有关。
{"title":"ROLE OF ANTIOXIDANT AND INFLAMMATORY MARKERS WITH METABOLIC SYNDROME AND RISK OF CVD IN THYROID PATIENTS","authors":"Ravi Shankar, Ajay Kumar, NEHA SHARMA, Raju Ram, Aparajita Kushwaha","doi":"10.22159/ajpcr.2024v17i7.51845","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.51845","url":null,"abstract":"Objectives: Metabolic syndrome is the most widely used term for the aggregation of metabolic abnormalities, which leads to an increase in the risk of developing cardiovascular pathology. Protective nutritional antioxidants may benefit defensive antioxidative systems in resolving pro-oxidative dominance and redox imbalance, preventing, or delaying chronic thyroid diseases.\u0000Methods: This cross-sectional, observational study was conducted among metabolic syndrome patients in the general population and near and dear patients (350) at the Pacific Institute of Medical Sciences, Udaipur. For the determination of interleukin-6 (IL-6) was done by enzyme-linked immunosorbent assay. Thyroid hormones are determined by chemiluminescence and antioxidant Vitamin C and malondialdehyde (MDA) chromatography and high-performance liquid chromatography, respectively.\u0000Results: This study shows a low level of antioxidant Vitamin C and MDA and a high level of inflammatory marker IL-6 in these patients. In this study, the age distribution of patients showed that males in the 35–51 years of age group were most affected, whereas females in the 18–34 years of age group were more prevalent.\u0000Conclusion: The present study leads to awareness of antioxidant levels and inflammation in thyroid patients along with other biochemical parameters involved in the development of metabolic syndrome in the Indian population.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-07DOI: 10.22159/ajpcr.2024v17i7.51090
Deepthi Ps, Sathiamma. Pk
Objectives: This study aims to assess the clinical features, the impact of coronavirus disease 2019 (COVID-19) infection during pregnancy, and the perinatal and obstetric outcomes in phases I and II. Methods: The current study was performed from January 2020 to August 2021 at the Government T D Medical College, Alappuzha. The pregnant women were registered instantly after each infected woman was known as per the inclusion and exclusion criteria. Demographic parameters, related comorbid disorders, intensive care unit admission, and complete treatment details of each woman were noted. Neonatal outcomes were documented. Results: There were 254 women in wave 1 and 164 women in wave 2 in the obstetric admissions. Still was seen in 3 cases (wave 1) and 2 cases (wave 2). In both phases, most pregnant women fall under the age category between 21 and 30. Multi-parity was found to be 50.8% in wave 1 women and 59.2% in wave 2 women were common in both waves. The period of gestation and obstetric comorbidities were found to be statistically significant with a p=0.007 (phase I) and 0.008 (phase II). Conclusion: Pregnancy-related COVID-19 infection may increase the threat of maternal death but has no influence on the morbidity and death of newborns. It is not possible to totally rule out the possibility of maternal-fetal transfer. Every wave of COVID-19 may have different characteristics and severity; therefore, our treatment plans must change. To confirm this transmission, more research or meta-analysis reports are needed.
{"title":"CLINICAL PROFILE AND PREGNANCY OUTCOMES OF COVID POSITIVE PREGNANT WOMEN IN PHASE I ANDII INFECTION – A COMPARATIVE STUDY","authors":"Deepthi Ps, Sathiamma. Pk","doi":"10.22159/ajpcr.2024v17i7.51090","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.51090","url":null,"abstract":"Objectives: This study aims to assess the clinical features, the impact of coronavirus disease 2019 (COVID-19) infection during pregnancy, and the perinatal and obstetric outcomes in phases I and II.\u0000Methods: The current study was performed from January 2020 to August 2021 at the Government T D Medical College, Alappuzha. The pregnant women were registered instantly after each infected woman was known as per the inclusion and exclusion criteria. Demographic parameters, related comorbid disorders, intensive care unit admission, and complete treatment details of each woman were noted. Neonatal outcomes were documented.\u0000Results: There were 254 women in wave 1 and 164 women in wave 2 in the obstetric admissions. Still was seen in 3 cases (wave 1) and 2 cases (wave 2). In both phases, most pregnant women fall under the age category between 21 and 30. Multi-parity was found to be 50.8% in wave 1 women and 59.2% in wave 2 women were common in both waves. The period of gestation and obstetric comorbidities were found to be statistically significant with a p=0.007 (phase I) and 0.008 (phase II).\u0000Conclusion: Pregnancy-related COVID-19 infection may increase the threat of maternal death but has no influence on the morbidity and death of newborns. It is not possible to totally rule out the possibility of maternal-fetal transfer. Every wave of COVID-19 may have different characteristics and severity; therefore, our treatment plans must change. To confirm this transmission, more research or meta-analysis reports are needed.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-07DOI: 10.22159/ajpcr.2024v17i7.51780
SANJAY D DAKHORE, SAHAN M S, VIDHEY TIRPUDE, SHILPA PANDE, SUNIL B WANKHADE
Objective: The objectives of the study are as follows: (1) To study the clinicopathological profile and outcome of gastrointestinal (GI) perforations. (2) To study the incidence, demographics, etiology, clinical features, management techniques, and factors influencing outcomes in cases of GI perforations. Methods: This was a prospective cohort study conducted in the Department of General Surgery in a tertiary care center in central India. One hundred and twenty cases of GI perforation were included in this study. Demographic data, detailed medical history, and present complaints were recorded for each patient. Clinical features were assessed by thorough physical and systemic examinations. Relevant laboratory tests, imaging, and operative findings were investigated. Management included operative interventions and postoperative analysis with documentation of complications. For statistical purpose, p<0.05 was taken as statistically significant. Results: The study observed a significant male preponderance in cases of GI perforations (M: F ratio 1:0.27). Patients’ age ranged from 18 to 86 years, with the highest incidence in those over 50 years (33.6%). Most patients were from Class IV and V socioeconomic status. Abdominal pain (100%) and vomiting (76.2%) were common symptoms. Hypertension (17.2%) and diabetes (14.7%) were prevalent comorbidities, with alcohol consumption (40.16%) as a notable risk factor. Gastroduodenal perforations were most frequent (63.93%). Common surgical interventions included modified Graham’s patch (62.3%) and appendicectomy (12.3%). Surgical site infections (20.4%) were common complications. Mortality was 11.4%, primarily due to sepsis. Conclusion: Early diagnosis and proper interventions are the cornerstone of management in cases of GI perforation. Prognosis depends on symptom duration, perforation site, peritoneal contamination, preoperative hypotension, and need for preoperative abdominal drainage. Chances of mortality increase in patients who present late after perforation.
{"title":"A STUDY ON CLINICOPATHOLOGICAL PROFILE AND OUTCOME OF GASTROINTESTINAL PERFORATIONS: A PROSPECTIVE OBSERVATIONAL STUDY","authors":"SANJAY D DAKHORE, SAHAN M S, VIDHEY TIRPUDE, SHILPA PANDE, SUNIL B WANKHADE","doi":"10.22159/ajpcr.2024v17i7.51780","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.51780","url":null,"abstract":"Objective: The objectives of the study are as follows:\u0000(1) To study the clinicopathological profile and outcome of gastrointestinal (GI) perforations. (2) To study the incidence, demographics, etiology, clinical features, management techniques, and factors influencing outcomes in cases of GI perforations.\u0000Methods: This was a prospective cohort study conducted in the Department of General Surgery in a tertiary care center in central India. One hundred and twenty cases of GI perforation were included in this study. Demographic data, detailed medical history, and present complaints were recorded for each patient. Clinical features were assessed by thorough physical and systemic examinations. Relevant laboratory tests, imaging, and operative findings were investigated. Management included operative interventions and postoperative analysis with documentation of complications. For statistical purpose, p<0.05 was taken as statistically significant.\u0000Results: The study observed a significant male preponderance in cases of GI perforations (M: F ratio 1:0.27). Patients’ age ranged from 18 to 86 years, with the highest incidence in those over 50 years (33.6%). Most patients were from Class IV and V socioeconomic status. Abdominal pain (100%) and vomiting (76.2%) were common symptoms. Hypertension (17.2%) and diabetes (14.7%) were prevalent comorbidities, with alcohol consumption (40.16%) as a notable risk factor. Gastroduodenal perforations were most frequent (63.93%). Common surgical interventions included modified Graham’s patch (62.3%) and appendicectomy (12.3%). Surgical site infections (20.4%) were common complications. Mortality was 11.4%, primarily due to sepsis.\u0000Conclusion: Early diagnosis and proper interventions are the cornerstone of management in cases of GI perforation. Prognosis depends on symptom duration, perforation site, peritoneal contamination, preoperative hypotension, and need for preoperative abdominal drainage. Chances of mortality increase in patients who present late after perforation.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141671317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-07DOI: 10.22159/ajpcr.2024v17i7.51781
PRANAB DAS, Nivedita Saha, Dolly Roy
Objective: The objective of this study was to evaluate the drug utilization pattern of psychotropic drugs prescribed in patients as per the World Health Organization core prescribing indicators. Methods: The investigation examined all patient medical records who visited the outpatient department of the Department of Psychiatry, Silchar Medical College and Hospital between September 2023 and March 2024. The prescriptions were analyzed for indicators of drug use such as the quantity of drugs prescribed, generic name prescriptions, essential drug list prescriptions, antibiotics prescribed, injection prescribed, and the percentage of polypharmacy. Results: A total of 600 prescriptions were examined. The most common type of psychotropic drug administered was antidepressants. Psychotropic drugs were administered on an average of 1.64 times per prescription. The proportion of generic names was 98.88%; the proportion of prescription encounters involving an injection was 3.33%; the proportion of psychiatric medications prescribed from the National List of Essential Medicines (NLEM) was 62.53%; and the proportion of polypharmacy was 5.5%. Conclusion: This study setting performed well in terms of the proportion of prescriptions that included injections and antibiotics; nevertheless, it fell short of recommendations in terms of NLEM drugs, generic drugs, and minimizing polypharmacy.
{"title":"DRUG UTILIZATION STUDY OF PSYCHOTROPIC DRUGS IN PSYCHIATRY OUTDOOR PATIENTS AT A TERTIARY CARE HOSPITAL","authors":"PRANAB DAS, Nivedita Saha, Dolly Roy","doi":"10.22159/ajpcr.2024v17i7.51781","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.51781","url":null,"abstract":"Objective: The objective of this study was to evaluate the drug utilization pattern of psychotropic drugs prescribed in patients as per the World Health Organization core prescribing indicators.\u0000Methods: The investigation examined all patient medical records who visited the outpatient department of the Department of Psychiatry, Silchar Medical College and Hospital between September 2023 and March 2024. The prescriptions were analyzed for indicators of drug use such as the quantity of drugs prescribed, generic name prescriptions, essential drug list prescriptions, antibiotics prescribed, injection prescribed, and the percentage of polypharmacy.\u0000Results: A total of 600 prescriptions were examined. The most common type of psychotropic drug administered was antidepressants. Psychotropic drugs were administered on an average of 1.64 times per prescription. The proportion of generic names was 98.88%; the proportion of prescription encounters involving an injection was 3.33%; the proportion of psychiatric medications prescribed from the National List of Essential Medicines (NLEM) was 62.53%; and the proportion of polypharmacy was 5.5%.\u0000Conclusion: This study setting performed well in terms of the proportion of prescriptions that included injections and antibiotics; nevertheless, it fell short of recommendations in terms of NLEM drugs, generic drugs, and minimizing polypharmacy.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141671443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-07DOI: 10.22159/ajpcr.2024v17i7.50998
Meghna Sharma, Sapna Soneja, L. Oberoi, Anuradha Malhotra
Objectives: The aim of this study is to determine the seroprevalence of herpes simplex virus (HSV) in a population of human immunodeficiency virus (HIV) positive and non-HIV patients and its association with CD-4 count. Methods: 200 HIV-positive individuals attending antiretroviral treatment clinic and 100 HIV-negative individuals from the clinical departments of Government Medical College, Amritsar, were enrolled in the study. The sera were tested in parallel using anti-HSV-1 immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA) (calbiotech), anti-HSV-2-IgG (calbiotech), and HSV-1/2 pool IgM ELISA (calbiotech) assays as per the manufacturer’s instructions. Sysmex partec CyFlow counter IVD flow cytometer. CD4+ reagents are used for measuring absolute counts of CD4+ T lymphocytes. Results: For anti-HSV-2 IgG, seroprevalence was positively associated with HIV-positive status. The mean CD4+ T lymphocyte counts for anti- HSV-2 IgG patients were 400.45±122.92 cells/μL in the HIV-positive group (n=163). Mean CD4+ counts in HSV-2 IgG-negative cases were 350.05±160.46 cells/μL. This association was statistically significant. Conclusion: HSV-1 and 2 are common lifelong infections that often are asymptomatic. African studies have highlighted HSV synergism with HIV infection. Seroprevalence of this common infection and the studies covering the Northern India region are scarce. Our study has confirmed this coinfection synergism. Increasing awareness of HSV-HIV synergy can contribute to better informed decisions regarding safe sex practices.
研究目的本研究旨在确定人类免疫缺陷病毒（HIV）阳性和非 HIV 患者中单纯疱疹病毒（HSV）的血清流行率及其与 CD-4 细胞计数的关系。方法：本研究从阿姆利则政府医学院临床科室招募了 200 名接受抗逆转录病毒治疗的 HIV 阳性患者和 100 名 HIV 阴性患者。按照制造商的说明，使用抗 HSV-1 免疫球蛋白 G (IgG) 酶联免疫吸附试验 (ELISA)（calbiotech）、抗 HSV-2 免疫球蛋白 G (IgG)（calbiotech）和 HSV-1/2 池 IgM 酶联免疫吸附试验（calbiotech）对血清进行平行检测。Sysmex partec CyFlow counter IVD 流式细胞仪。CD4+ 试剂用于测量 CD4+ T 淋巴细胞的绝对计数：抗 HSV-2 IgG 血清阳性率与 HIV 阳性状态呈正相关。HIV 阳性组（n=163）抗 HSV-2 IgG 患者的平均 CD4+ T 淋巴细胞计数为 400.45±122.92 cells/μL。HSV-2 IgG 阴性病例的平均 CD4+ 细胞数为 350.05±160.46 cells/μL。这一关联具有统计学意义：结论：HSV-1 和 HSV-2 是常见的终身感染疾病，通常没有症状。非洲的研究强调了 HSV 与 HIV 感染的协同作用。关于这种常见感染的血清流行率以及印度北部地区的研究却很少。我们的研究证实了这种合并感染的协同作用。提高对 HSV 与 HIV 协同作用的认识有助于在安全性行为方面做出更明智的决定。
{"title":"SEROPREVALENCE OF HERPES SIMPLEX VIRUS INFECTION TYPE 1 AND 2 IN A POPULATION OF HIV-POSITIVE AND HIV-NEGATIVE INDIVIDUALS IN A TERTIARY CARE HOSPITAL","authors":"Meghna Sharma, Sapna Soneja, L. Oberoi, Anuradha Malhotra","doi":"10.22159/ajpcr.2024v17i7.50998","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.50998","url":null,"abstract":"Objectives: The aim of this study is to determine the seroprevalence of herpes simplex virus (HSV) in a population of human immunodeficiency virus (HIV) positive and non-HIV patients and its association with CD-4 count.\u0000Methods: 200 HIV-positive individuals attending antiretroviral treatment clinic and 100 HIV-negative individuals from the clinical departments of Government Medical College, Amritsar, were enrolled in the study. The sera were tested in parallel using anti-HSV-1 immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA) (calbiotech), anti-HSV-2-IgG (calbiotech), and HSV-1/2 pool IgM ELISA (calbiotech) assays as per the manufacturer’s instructions. Sysmex partec CyFlow counter IVD flow cytometer. CD4+ reagents are used for measuring absolute counts of CD4+ T lymphocytes.\u0000Results: For anti-HSV-2 IgG, seroprevalence was positively associated with HIV-positive status. The mean CD4+ T lymphocyte counts for anti- HSV-2 IgG patients were 400.45±122.92 cells/μL in the HIV-positive group (n=163). Mean CD4+ counts in HSV-2 IgG-negative cases were 350.05±160.46 cells/μL. This association was statistically significant.\u0000Conclusion: HSV-1 and 2 are common lifelong infections that often are asymptomatic. African studies have highlighted HSV synergism with HIV infection. Seroprevalence of this common infection and the studies covering the Northern India region are scarce. Our study has confirmed this coinfection synergism. Increasing awareness of HSV-HIV synergy can contribute to better informed decisions regarding safe sex practices.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141671279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-07DOI: 10.22159/ajpcr.2024v17i7.51092
Pavan K Singh, Kanishk U Kaushik, Rahul Bhargava
Objective: Systemic inflammatory markers are often raised in comorbid metabolic syndrome (MetS) and vitiligo. Why some patients with vitiligo develop MetS while others do not remain to be elucidated. This study aimed to identify independent risk factors for MetS development in vitiligo patients. Methods: In this prospective study, disease characteristics (disease duration, severity, and subtype) and high-sensitivity C-reactive protein (hs-CRP) were compared between vitiligo patients (n=100) with and without MetS. Multivariate logistic regression of potential risk factors for MetS was done after adjusting for potential confounders (such as waist circumference, basal metabolic rate, serum lipids, blood pressure, and fasting blood sugar). The performance of these parameters (hs-CRP, age, disease duration, and severity) in predicting MetS development was ascertained by the area under the receiver operating characteristic curve (ROC). Results: Vitiligo patients with MetS had a significantly longer (p<0.001) disease duration as compared to those without MetS (56±16 versus 14±12 months). On regression analysis, inflammatory markers (hs-CRP) had significantly higher odds (odds ratio [OR]=5.1) as compared to demographic factors such as gender (OR=3.1) and disease factors such as disease duration (OR=2.4) and disease severity (OR=1.8) of developing MetS. On ROC curve analysis, the performance of these parameters for MetS was hs-CRP>Vitiligo Area Scoring Index score>disease duration >increasing age (Area under the curve=0.952, 0.905, 0.851, and 0.697, respectively). The cutoff value of hs-CRP was 6.42 ug/mL. Conclusion: Elevated hs-CRP has the highest predictive value for MetS development in vitiligo. Systemic inflammation may be the driving force for MetS development.
{"title":"SYSTEMIC INFLAMMATION IN COMORBID METABOLIC SYNDROME AND VITILIGO: A REGRESSION ANALYSIS OF RISK FACTORS!","authors":"Pavan K Singh, Kanishk U Kaushik, Rahul Bhargava","doi":"10.22159/ajpcr.2024v17i7.51092","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.51092","url":null,"abstract":"Objective: Systemic inflammatory markers are often raised in comorbid metabolic syndrome (MetS) and vitiligo. Why some patients with vitiligo develop MetS while others do not remain to be elucidated. This study aimed to identify independent risk factors for MetS development in vitiligo patients.\u0000Methods: In this prospective study, disease characteristics (disease duration, severity, and subtype) and high-sensitivity C-reactive protein (hs-CRP) were compared between vitiligo patients (n=100) with and without MetS. Multivariate logistic regression of potential risk factors for MetS was done after adjusting for potential confounders (such as waist circumference, basal metabolic rate, serum lipids, blood pressure, and fasting blood sugar). The performance of these parameters (hs-CRP, age, disease duration, and severity) in predicting MetS development was ascertained by the area under the receiver operating characteristic curve (ROC).\u0000Results: Vitiligo patients with MetS had a significantly longer (p<0.001) disease duration as compared to those without MetS (56±16 versus 14±12 months). On regression analysis, inflammatory markers (hs-CRP) had significantly higher odds (odds ratio [OR]=5.1) as compared to demographic factors such as gender (OR=3.1) and disease factors such as disease duration (OR=2.4) and disease severity (OR=1.8) of developing MetS. On ROC curve analysis, the performance of these parameters for MetS was hs-CRP>Vitiligo Area Scoring Index score>disease duration >increasing age (Area under the curve=0.952, 0.905, 0.851, and 0.697, respectively). The cutoff value of hs-CRP was 6.42 ug/mL.\u0000Conclusion: Elevated hs-CRP has the highest predictive value for MetS development in vitiligo. Systemic inflammation may be the driving force for MetS development.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141671038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-07DOI: 10.22159/ajpcr.2024v17i7.51486
SHIVIKA NATH, SHARMISTHA SINGHA
For upper extremity surgery involving wrist and hand, ultrasound (US) guide distal nerve block produces sufficient anesthesia with patient satisfaction. Here, we report a case study of adult with a proximal interphalangeal joint fracture and planned for US-guided wrist block involving media and ulnar using 0.5% bupivacaine + 2% lidocaine. Patient had maintenance of motor function with no complication of nerve injury. Wrist distal block produces safe anesthesia and effective patient satisfaction.
对于涉及腕部和手部的上肢手术，超声（US）引导的远端神经阻滞可产生充分的麻醉效果，并令患者满意。在此，我们报告了一例成人近端指间关节骨折的病例研究，患者计划在 US 引导下使用 0.5% 布比卡因 + 2% 利多卡因进行腕部中轴和尺神经阻滞。患者的运动功能得以维持，未出现神经损伤并发症。腕部远端阻滞麻醉安全有效，患者满意度高。
{"title":"EFFECTIVENESS OF WRIST BLOCK FOR SURGERY OF FRACTURE PROXIMAL INTERPHALANGEAL JOINT: A CASE REPORT","authors":"SHIVIKA NATH, SHARMISTHA SINGHA","doi":"10.22159/ajpcr.2024v17i7.51486","DOIUrl":"https://doi.org/10.22159/ajpcr.2024v17i7.51486","url":null,"abstract":"For upper extremity surgery involving wrist and hand, ultrasound (US) guide distal nerve block produces sufficient anesthesia with patient satisfaction. Here, we report a case study of adult with a proximal interphalangeal joint fracture and planned for US-guided wrist block involving media and ulnar using 0.5% bupivacaine + 2% lidocaine. Patient had maintenance of motor function with no complication of nerve injury. Wrist distal block produces safe anesthesia and effective patient satisfaction.","PeriodicalId":8528,"journal":{"name":"Asian Journal of Pharmaceutical and Clinical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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