Andi Cahyadi, Esthy Poespitaningtyas, Diah Kusuma Arumsari, Maria Christina Shanty Larasati, Mia Ratwita Andarsini, I Dewa Gede Ugrasena
Introduction: The prevalence of childhood cancer in East Java is unevenly associated with differences in exposure to carcinogens in urban-industrial areas, agricultural chemicals, industrial waste along the river, and socio-culture. However, there are no data on regional variations in childhood cancer in East Java. We describe the regional variation of hematological malignancies and solid tumors in East Java. Material and Methods: The study was conducted by cross-sectional on children with cancer aged <18 years in dr. Soetomo General Academic Hospital in 2014-2015. The data evaluated were gender, age, and cancer type (hematological malignancy and solid tumor). They came from Mataraman, Madura Island, industrial-urban areas (Surabaya-Sidoarjo-Gresik), and Tapal Kuda. We used the Chi-square test and Logistic Regression for data analysis (p<0.05 for two-tailed test). Results: During the study period, there were 353 children with cancer, consisting of 56.9% hematological malignancies and 43.1% solid tumors: 60.9% boys, and 82.4% aged <10 years. Hematological malignancies in industries-urban areas are more numerous than in Mataraman, Madura Island, and Tapal Kuda; 67.8%, 52.8%, 47.2%, and 50.9%, respectively (p=0.031). Hematologic malignancies were also more common in aged <10 years (60.5% vs 40.3%; p=0.004 OR=2.265; 95% CI=1.295-3.362) and Javanese race (p=0.025; OR=3.257; 95% CI=1.121-5.263). Children in industrial-urban areas had more hematological malignancies than Mataraman (p=0.027; OR=2.353; 95% CI=1.101-5.030) also Tapal Kuda (p=0.015; OR=1.881; 95% CI=1.132-3.124) and Madura Island (p=0.032; OR=2.033; 95% CI=1.064-3.882). Conclusion: Hematological malignancies in industry and urban areas are more numerous than Mataraman, Madura Island, and Tapal Kuda area. Solid tumors were mostly found on Madura Island.
东爪哇儿童癌症患病率与城市工业区致癌物暴露、农业化学品、沿河工业废物和社会文化的差异有不均匀的关系。然而，没有关于东爪哇儿童癌症区域差异的数据。我们描述了血液恶性肿瘤和实体瘤在东爪哇的区域变化。材料与方法:采用横断面法对2014-2015年dr. Soetomo综合学术医院年龄<18岁的癌症患儿进行研究。评估的数据包括性别、年龄和癌症类型(血液恶性肿瘤和实体瘤)。他们来自Mataraman, Madura岛，工业城市地区(Surabaya-Sidoarjo-Gresik)和Tapal Kuda。资料分析采用卡方检验和Logistic回归(双侧检验p<0.05)。结果:研究期间，儿童癌症353例，其中血液病恶性占56.9%，实体瘤占43.1%，男孩占60.9%，年龄<10岁占82.4%。工业-城市地区的恶性血液病比Mataraman、Madura岛和Tapal Kuda多;分别为67.8%、52.8%、47.2%和50.9% (p = 0.031)。血液系统恶性肿瘤在小于10岁的人群中也更为常见(60.5% vs 40.3%;p = 0.004 = 2.265;95% CI=1.295-3.362)和爪哇人种(p=0.025;或= 3.257;95% CI = 1.121 - -5.263)。工业-城市地区儿童血液系统恶性肿瘤发生率高于Mataraman (p=0.027;或= 2.353;95% CI=1.101-5.030)和Tapal Kuda (p=0.015;或= 1.881;95% CI=1.132-3.124)和Madura Island (p=0.032;或= 2.033;95% CI = 1.064 - -3.882)。结论:工业和城市地区的恶性血液病发病率高于马塔拉曼、马杜拉岛和塔帕尔库达地区。实体瘤主要在马杜拉岛发现。
{"title":"Region Variation of Hematological Malignancies and Solid Tumors in Children in East Java","authors":"Andi Cahyadi, Esthy Poespitaningtyas, Diah Kusuma Arumsari, Maria Christina Shanty Larasati, Mia Ratwita Andarsini, I Dewa Gede Ugrasena","doi":"10.55561/ajhr.v2i1.71","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.71","url":null,"abstract":"Introduction: The prevalence of childhood cancer in East Java is unevenly associated with differences in exposure to carcinogens in urban-industrial areas, agricultural chemicals, industrial waste along the river, and socio-culture. However, there are no data on regional variations in childhood cancer in East Java. We describe the regional variation of hematological malignancies and solid tumors in East Java.\u0000Material and Methods: The study was conducted by cross-sectional on children with cancer aged <18 years in dr. Soetomo General Academic Hospital in 2014-2015. The data evaluated were gender, age, and cancer type (hematological malignancy and solid tumor). They came from Mataraman, Madura Island, industrial-urban areas (Surabaya-Sidoarjo-Gresik), and Tapal Kuda. We used the Chi-square test and Logistic Regression for data analysis (p<0.05 for two-tailed test).\u0000Results: During the study period, there were 353 children with cancer, consisting of 56.9% hematological malignancies and 43.1% solid tumors: 60.9% boys, and 82.4% aged <10 years. Hematological malignancies in industries-urban areas are more numerous than in Mataraman, Madura Island, and Tapal Kuda; 67.8%, 52.8%, 47.2%, and 50.9%, respectively (p=0.031). Hematologic malignancies were also more common in aged <10 years (60.5% vs 40.3%; p=0.004 OR=2.265; 95% CI=1.295-3.362) and Javanese race (p=0.025; OR=3.257; 95% CI=1.121-5.263). Children in industrial-urban areas had more hematological malignancies than Mataraman (p=0.027; OR=2.353; 95% CI=1.101-5.030) also Tapal Kuda (p=0.015; OR=1.881; 95% CI=1.132-3.124) and Madura Island (p=0.032; OR=2.033; 95% CI=1.064-3.882).\u0000Conclusion: Hematological malignancies in industry and urban areas are more numerous than Mataraman, Madura Island, and Tapal Kuda area. Solid tumors were mostly found on Madura Island.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"35 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73646791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ikatan Dokter, Indonesia Wilayah, Jawa Timur, A. F. Athiyyah, A. Darma, Dwiyanti Puspitasari, K. Sumitro, Ni Nyoman, Metriani Nesa, Steven Christian Susianto, Muhammad Faizi, R. Ranuh, Subijanto Marto, Sudarmo
Introduction: The involvement and ability of health workers in Mandangin Island in early managing acute diarrhea in children to reduce infant mortality due to diarrhea are very important. This study aimed to determine the effect of community development Faculty of Medicine Universitas Airlangga - Dr. Soetomo General Academic Hospital Surabaya in a seminar on Early Management of Acute Diarrhea in Children using video conference to educate health care workers (HCWs) at the Mandangin Community Health Center. Material and Methods: This cross-sectional study was designed on 20 HCWs at the Mandangin community health center. Subjects were evaluated for demographic data (gender, age, occupation, last education), and the knowledge was assessed using a pre-test before the seminar was given. We used questionnaire about acute diarrhea containing 10 questions with maximum score 100. The seminar was given through video conferences with form classical lecturer and a case study on acute diarrhea, and subjects attended the seminar in Community Health Center’s Hall. We assessed knowledge after the seminar using the same questionnaire with randomization in question and answer and compared the pre-and post-test using the Wilcoxon Rank sum test. Results: Most of the subjects were midwifery, with a mean age of 32.4 ± 5.75 years old, 45% with D-3 last education and 80% were female. There was a significant difference between pre-and post-test in acute diarrhea in children (47.89±20.7 vs 64.74±22.94) (p=0.008). Conclusion: Video conference education effectively increased health care workers' knowledge about acute diarrhea in children
简介:Mandangin岛卫生工作者的参与和能力在早期管理儿童急性腹泻，以减少由于腹泻导致的婴儿死亡率是非常重要的。本研究旨在确定社区发展的影响，医学院的埃尔朗加大学-苏托莫博士综合学术医院泗水在Mandangin社区卫生中心的儿童急性腹泻的早期管理研讨会上使用视频会议来教育卫生保健工作者(HCWs)。材料与方法:本横断面研究设计于20名Mandangin社区卫生中心的HCWs。评估受试者的人口统计数据(性别、年龄、职业、上次教育)，并在研讨会开始前使用预测试评估知识。采用急性腹泻问卷，共10题，满分100分。研讨会以视频会议的形式进行，由经典讲师和急性腹泻案例研究组成，受试者在社区卫生中心大厅参加研讨会。我们在研讨会结束后使用相同的随机问卷进行知识评估，并使用Wilcoxon秩和检验比较前后测试。结果:调查对象以助产士居多，平均年龄(32.4±5.75)岁，最后学历为D-3的占45%，女性占80%。患儿急性腹泻检测前与检测后差异有统计学意义(47.89±20.7 vs 64.74±22.94)(p=0.008)。结论:视频会议教育能有效提高医护人员对儿童急性腹泻的认识
{"title":"Effect on Video Conference’s Education in Mandangin’s Community Health Center’s Healthcare Knowledge about Acute Diarrhea in Children","authors":"Ikatan Dokter, Indonesia Wilayah, Jawa Timur, A. F. Athiyyah, A. Darma, Dwiyanti Puspitasari, K. Sumitro, Ni Nyoman, Metriani Nesa, Steven Christian Susianto, Muhammad Faizi, R. Ranuh, Subijanto Marto, Sudarmo","doi":"10.55561/ajhr.v2i1.61","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.61","url":null,"abstract":"Introduction: The involvement and ability of health workers in Mandangin Island in early managing acute diarrhea in children to reduce infant mortality due to diarrhea are very important. This study aimed to determine the effect of community development Faculty of Medicine Universitas Airlangga - Dr. Soetomo General Academic Hospital Surabaya in a seminar on Early Management of Acute Diarrhea in Children using video conference to educate health care workers (HCWs) at the Mandangin Community Health Center. \u0000Material and Methods: This cross-sectional study was designed on 20 HCWs at the Mandangin community health center. Subjects were evaluated for demographic data (gender, age, occupation, last education), and the knowledge was assessed using a pre-test before the seminar was given. We used questionnaire about acute diarrhea containing 10 questions with maximum score 100. The seminar was given through video conferences with form classical lecturer and a case study on acute diarrhea, and subjects attended the seminar in Community Health Center’s Hall. We assessed knowledge after the seminar using the same questionnaire with randomization in question and answer and compared the pre-and post-test using the Wilcoxon Rank sum test. \u0000Results: Most of the subjects were midwifery, with a mean age of 32.4 ± 5.75 years old, 45% with D-3 last education and 80% were female. There was a significant difference between pre-and post-test in acute diarrhea in children (47.89±20.7 vs 64.74±22.94) (p=0.008). \u0000Conclusion: Video conference education effectively increased health care workers' knowledge about acute diarrhea in children","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"140 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80013866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alfian Nurfaizi, Lelyana Sih Afgriyuspita, Ni Made Adnya Suasti, Ummi Imamatal Muttaqin, Berliana Nur Azizah, Indira Syahraya, Baiq Dwi Hadiatul Azni, Ayuning Tetirah Ramadhani, Crysciando Jefryco Putra, Nyilo Purnami
Introduction: COVID-19 vaccination acceptance by the youth population is still a major problem. Community vaccination programs are needed to immediately achieve immunity so that the goals of good health and well-being can be achieved. This study aims to identify the factors that influence vaccine acceptance in a group of youth non-health professionals. Methods: This cross-sectional, observational questionnaire-based study was conducted among 194 individuals in the age range of 18 to 25 years through online questionnaires. Data was collected using snowball sampling techniques collect data from respondents about their socio-demographics, knowledge, attitudes, and perceptions (KAP). Statistical used descriptive and analytical calculations (Chi-square and Mann-Whitney test). Results: There was a correlation between occupation, comorbid status, and history of COVID-19 with vaccination acceptance. The average score of knowledge among the non-vaccinated group versus the vaccinated group were 52.13 ± 14.556 and 53.68 ± 13.843 (out of 70), respectively (p= 0.509), while the average score for attitude was 6.76 ± 1.781 and 7.44 ± 1.220 (out of 8) respectively (p = 0.004). The occupation, comorbid status, history of COVID-19, perception of dangerous side effects, and willingness to pay were associated with COVID-19 vaccination acceptance. Conclusion: The vaccinated group showed a more positive attitude, though their average knowledge score was not significantly different with the unvaccinated group. Massive health promotion regarding COVID-19 vaccine safety, reassuring the population, especially the unemployed population and COVID-19 survivors should be taken by policymakers to ensure adequate knowledge, positive attitudes, and perceptions against COVID-19 vaccination.
{"title":"Knowledge, Attitude, and Perception of Youth Population in Indonesia toward COVID-19 Vaccination","authors":"Alfian Nurfaizi, Lelyana Sih Afgriyuspita, Ni Made Adnya Suasti, Ummi Imamatal Muttaqin, Berliana Nur Azizah, Indira Syahraya, Baiq Dwi Hadiatul Azni, Ayuning Tetirah Ramadhani, Crysciando Jefryco Putra, Nyilo Purnami","doi":"10.55561/ajhr.v2i1.63","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.63","url":null,"abstract":"Introduction: COVID-19 vaccination acceptance by the youth population is still a major problem. Community vaccination programs are needed to immediately achieve immunity so that the goals of good health and well-being can be achieved. This study aims to identify the factors that influence vaccine acceptance in a group of youth non-health professionals.\u0000Methods: This cross-sectional, observational questionnaire-based study was conducted among 194 individuals in the age range of 18 to 25 years through online questionnaires. Data was collected using snowball sampling techniques collect data from respondents about their socio-demographics, knowledge, attitudes, and perceptions (KAP). Statistical used descriptive and analytical calculations (Chi-square and Mann-Whitney test).\u0000Results: There was a correlation between occupation, comorbid status, and history of COVID-19 with vaccination acceptance. The average score of knowledge among the non-vaccinated group versus the vaccinated group were 52.13 ± 14.556 and 53.68 ± 13.843 (out of 70), respectively (p= 0.509), while the average score for attitude was 6.76 ± 1.781 and 7.44 ± 1.220 (out of 8) respectively (p = 0.004). The occupation, comorbid status, history of COVID-19, perception of dangerous side effects, and willingness to pay were associated with COVID-19 vaccination acceptance.\u0000Conclusion: The vaccinated group showed a more positive attitude, though their average knowledge score was not significantly different with the unvaccinated group. Massive health promotion regarding COVID-19 vaccine safety, reassuring the population, especially the unemployed population and COVID-19 survivors should be taken by policymakers to ensure adequate knowledge, positive attitudes, and perceptions against COVID-19 vaccination.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"19 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76964011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Colorectal cancer is the fourth most common cancer in the world. Stage IV colorectal cancer are often late for treatment and have poor prognosis. Knowledge and attitude factors are known to play a role in treatment delay. Therefore, this study aims to determine the relationship between knowledge and attitudes on treatment delay of stage IV colorectal cancer patients at Saiful Anwar Hospital, Malang (RSSA). Material and Methods: The research design was a cause-effect retrospective study conducted at RSSA from June 2021 to December 2021. Measurement of patient knowledge and attitudes using questionnaires while patient delays in seeking treatment are obtained from medical records. Statistical analysis using structural equation modelling (SEM) using the WarpPLS application with a significance level of p<0.05. Results: The result of this research indicated that the knowledge of symptoms is associated with the patient's anxiety attitude (p<0.01; r=-0.31) and attitude to screening (p=0.03; r=0.21). Knowledge of a healthy lifestyle was associated with attitudes to screening (p<0.01; r=0.27). Screening attitude was associated with treatment delay in colorectal cancer patients (p<0.01; r=-0.42). Conclusion: The conclusion is the knowledge and attitudes of patients about colorectal cancer are associated with the treatment delay. Increasing knowledge and attitudes of patients can reduce the treatment delay on stage IV colorectal cancer patients to come to RSSA.
{"title":"Relationship between Knowledge and Attitude with Treatment Delay in Stadium IV Colorectal Cancer Patients","authors":"Zaki Yamani, Aries Budianto, Solimun Solimun","doi":"10.55561/ajhr.v2i1.64","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.64","url":null,"abstract":"Introduction: Colorectal cancer is the fourth most common cancer in the world. Stage IV colorectal cancer are often late for treatment and have poor prognosis. Knowledge and attitude factors are known to play a role in treatment delay. Therefore, this study aims to determine the relationship between knowledge and attitudes on treatment delay of stage IV colorectal cancer patients at Saiful Anwar Hospital, Malang (RSSA).\u0000Material and Methods: The research design was a cause-effect retrospective study conducted at RSSA from June 2021 to December 2021. Measurement of patient knowledge and attitudes using questionnaires while patient delays in seeking treatment are obtained from medical records. Statistical analysis using structural equation modelling (SEM) using the WarpPLS application with a significance level of p<0.05.\u0000Results: The result of this research indicated that the knowledge of symptoms is associated with the patient's anxiety attitude (p<0.01; r=-0.31) and attitude to screening (p=0.03; r=0.21). Knowledge of a healthy lifestyle was associated with attitudes to screening (p<0.01; r=0.27). Screening attitude was associated with treatment delay in colorectal cancer patients (p<0.01; r=-0.42).\u0000Conclusion: The conclusion is the knowledge and attitudes of patients about colorectal cancer are associated with the treatment delay. Increasing knowledge and attitudes of patients can reduce the treatment delay on stage IV colorectal cancer patients to come to RSSA.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"5 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78649630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Achmad Januar Er Putra, Sutji Kuswarini, Nurmawati Fatimah, Wening Hapsari
Introduction: Infectious diseases have always been a problem, especially in the third-world countries. Due to the uncontrolled prescription of antibiotics, several bacteria developed resistance to some antimicrobial agents. One of them is Staphylococcus aureus. There is local wisdom in Indonesia to use natural products as potent antimicrobial agents. Curcuma heyneana and Graptophyllum pictum had been used by the locals in past centuries and seemed to be an effective agent for combatting infectious diseases. Therefore, we want to evaluate the activity of the combined extract of Curcuma heyneana and Graptophyllum pictum against Staphylococcus aureus.. Material and Methods: An in-vitro test by using the test tube dilution. The test tubes consisted of seven tubes; 2 control tubes and 5 experimental tubes. We used 1000mg/ml of each extract component at the highest (i.e., 1000mg/ml for Curcuma heyneana and Graptophyllum pictum, respectively). Five-times replication was conducted for each treatment. MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bactericidal Concentration) were investigated after being streaked at the agar plate and incubated at 370C for 24 hours. Results: We could not determine the MIC because the colour of the combination of the extract was cloudy. The bacteria grew at all concentrations from five-times replication, except for the negative control, therefore MBC could not be obtained. Conclusion: Staphylococcus aureus was not inhibited effectively by combined extract of Curcuma heyneana and Graptophyllum pictum.
{"title":"Activities of Curcuma heyneana Rhizome and Graptophyllum pictum Leaves Combination against Staphylococcus aureus","authors":"Achmad Januar Er Putra, Sutji Kuswarini, Nurmawati Fatimah, Wening Hapsari","doi":"10.55561/ajhr.v2i1.33","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.33","url":null,"abstract":"Introduction: Infectious diseases have always been a problem, especially in the third-world countries. Due to the uncontrolled prescription of antibiotics, several bacteria developed resistance to some antimicrobial agents. One of them is Staphylococcus aureus. There is local wisdom in Indonesia to use natural products as potent antimicrobial agents. Curcuma heyneana and Graptophyllum pictum had been used by the locals in past centuries and seemed to be an effective agent for combatting infectious diseases. Therefore, we want to evaluate the activity of the combined extract of Curcuma heyneana and Graptophyllum pictum against Staphylococcus aureus..\u0000Material and Methods: An in-vitro test by using the test tube dilution. The test tubes consisted of seven tubes; 2 control tubes and 5 experimental tubes. We used 1000mg/ml of each extract component at the highest (i.e., 1000mg/ml for Curcuma heyneana and Graptophyllum pictum, respectively). Five-times replication was conducted for each treatment. MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bactericidal Concentration) were investigated after being streaked at the agar plate and incubated at 370C for 24 hours.\u0000Results: We could not determine the MIC because the colour of the combination of the extract was cloudy. The bacteria grew at all concentrations from five-times replication, except for the negative control, therefore MBC could not be obtained.\u0000Conclusion: Staphylococcus aureus was not inhibited effectively by combined extract of Curcuma heyneana and Graptophyllum pictum.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"11 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84379615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The transboundary disease, Covid-19, which has been ongoing since 2020, crosses borders and affects many parts of society. The ensuing health issues have weakened the nation’s economy, workforce, quality of life, and overall resiliency. Based on information from the Covid-19 Task Force and Emerging Infections of the Ministry of Health, the Cumulative Situation of Covid-19 in Indonesia as of July 18, 2022, shows 6,138,953 confirmed cases, 27,550 active cases, 156,849 deaths, and 5,950,554 recoveries from a total of 102,088,388 specimens tested. This cumulative mortality rate is 2.6% greater than the global average of 1.14%. Current evidence from epidemiology and transmission demonstrates that Covid-19 has mutational traits that make it a community spreader, demonstrated by an uptick in asymptomatic positive cases, mobilization, and international migration. However, keeping an eye out for comorbid groups with varying clinical signs and organ problems is still important. The government has to re-encapsulate the upstream and downstream techniques into a single integration if it is to cope with the present situation. Hospital emergency plans and the notion of “High Vigilance” (also known as “High Alert”) are both included in this plan as a means of making the shift from a pandemic to an endemic. High Vigilance’s strategy is to build organizational awareness and community participation by empowering Leadership, Best Practices, and Environmental Without Error as an integrated policy with measuring tools for the dynamic implementation of the rapid – detect- respond and prevention program.
{"title":"High Vigilance Concept: Preventive Transition Strategy Toward the Covid-19 Endemic","authors":"Soroy Lardo","doi":"10.55561/ajhr.v2i1.94","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.94","url":null,"abstract":"The transboundary disease, Covid-19, which has been ongoing since 2020, crosses borders and affects many parts of society. The ensuing health issues have weakened the nation’s economy, workforce, quality of life, and overall resiliency. Based on information from the Covid-19 Task Force and Emerging Infections of the Ministry of Health, the Cumulative Situation of Covid-19 in Indonesia as of July 18, 2022, shows 6,138,953 confirmed cases, 27,550 active cases, 156,849 deaths, and 5,950,554 recoveries from a total of 102,088,388 specimens tested. This cumulative mortality rate is 2.6% greater than the global average of 1.14%. Current evidence from epidemiology and transmission demonstrates that Covid-19 has mutational traits that make it a community spreader, demonstrated by an uptick in asymptomatic positive cases, mobilization, and international migration. However, keeping an eye out for comorbid groups with varying clinical signs and organ problems is still important. The government has to re-encapsulate the upstream and downstream techniques into a single integration if it is to cope with the present situation. Hospital emergency plans and the notion of “High Vigilance” (also known as “High Alert”) are both included in this plan as a means of making the shift from a pandemic to an endemic. High Vigilance’s strategy is to build organizational awareness and community participation by empowering Leadership, Best Practices, and Environmental Without Error as an integrated policy with measuring tools for the dynamic implementation of the rapid – detect- respond and prevention program.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"22 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85694584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Condylomata accuminata (CA) is one of the most common sexually transmitted infections in the genital area caused by Human Papilloma Virus (HPV) variants 6 and 11. This disease is also known as genital warts. The potential for recurrence is relatively high and the risk for malignancy is high, therefore it requires appropriate treatment and therapy. There is no clear evidence regarding the best treatment choice for patients with CA. Case Presentation: Female, 24 years old with complaints of genital warts that have grown bigger since 1 month before. Physiological examination of the labia minora showed multiple papules with mucosal-like color and verrucous surfaces, varying in shape and size. The acetowhite test result was positive. Patients were treated with 25% podophyllin tincture, with an interval of one week one time. Conclusion: Podophyllin usage as a therapy for CA provides excellent therapeutic response and is relatively affordable, simple, and has minimal side effects. Patients treated with 25% podophyllin tincture, with an interval of one week one time, for two weeks showed significant improvement of the lesions.
{"title":"Case Report: The Effect of 25% Podophyllin Tincture in Condylomata Accuminata","authors":"Lita Setyowatie, Ayunita Mayasari","doi":"10.55561/ajhr.v2i1.55","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.55","url":null,"abstract":"Introduction: Condylomata accuminata (CA) is one of the most common sexually transmitted infections in the genital area caused by Human Papilloma Virus (HPV) variants 6 and 11. This disease is also known as genital warts. The potential for recurrence is relatively high and the risk for malignancy is high, therefore it requires appropriate treatment and therapy. There is no clear evidence regarding the best treatment choice for patients with CA.\u0000Case Presentation: Female, 24 years old with complaints of genital warts that have grown bigger since 1 month before. Physiological examination of the labia minora showed multiple papules with mucosal-like color and verrucous surfaces, varying in shape and size. The acetowhite test result was positive. Patients were treated with 25% podophyllin tincture, with an interval of one week one time.\u0000Conclusion: Podophyllin usage as a therapy for CA provides excellent therapeutic response and is relatively affordable, simple, and has minimal side effects. Patients treated with 25% podophyllin tincture, with an interval of one week one time, for two weeks showed significant improvement of the lesions.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"36 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81992740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajprhc.ajprhc_10_23
Shanthi Vanka, Dalya Afandi, Rana Otaif, Anan Sharbatly, Raghad Hejazi, R. Aljohani, O. Wali, A. Vanka
Introduction: A major cause of death on a global scale is tobacco and in fact the biggest preventable cause of mortality and illness worldwide. The World Health Organization estimates that there are 1100 million regular smokers worldwide and they are increasing alarmingly. Dentists play a pivotal role in the prevention of tobacco use as patients approach dentists for cosmetic reasons. We planned this study to find the experience of dentists on tobacco cessation and counseling. Methods: We designed the study as an analytical cross-sectional study. The data were collected through a questionnaire using Google Forms targeting all the dentists in Jeddah. The questionnaire Google link was sent to their WhatsApp and other electronic means. Consent from the dentists was obtained prior to collecting information from the dentists. Results: 89.9% of dentists agreed that it is the duty of every dentist to advise the patient on tobacco cessation and 10.1% disagreed. 81.7% of dentists agreed that all dentists have the capability of doing tobacco cessation practices. Seventy-eight percent of dentists agreed that dentists are not presently well prepared to assist patients with tobacco cessation in contrast with 22% who disagree. The scientific evidence relating to the burden of oral diseases has always been attributable to tobacco use, and a well-structured dental teaching curriculum for the dentists and the auxiliaries concentrating on oral cancer education and tobacco cessation interventions has to be emphasized in the Kingdom for the dentists (28). Dentists require formal training to do tobacco cessation successfully to reach a major goal of a “tobacco-free society.” Conclusion: There should be an emphasis on formal training being an effective tool to provide guidelines to the dentist and auxiliaries in tobacco cessation and counseling of the patients in the dental clinic.
{"title":"Dentists' perspective on tobacco cessation and counseling in Jeddah","authors":"Shanthi Vanka, Dalya Afandi, Rana Otaif, Anan Sharbatly, Raghad Hejazi, R. Aljohani, O. Wali, A. Vanka","doi":"10.4103/ajprhc.ajprhc_10_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_10_23","url":null,"abstract":"Introduction: A major cause of death on a global scale is tobacco and in fact the biggest preventable cause of mortality and illness worldwide. The World Health Organization estimates that there are 1100 million regular smokers worldwide and they are increasing alarmingly. Dentists play a pivotal role in the prevention of tobacco use as patients approach dentists for cosmetic reasons. We planned this study to find the experience of dentists on tobacco cessation and counseling. Methods: We designed the study as an analytical cross-sectional study. The data were collected through a questionnaire using Google Forms targeting all the dentists in Jeddah. The questionnaire Google link was sent to their WhatsApp and other electronic means. Consent from the dentists was obtained prior to collecting information from the dentists. Results: 89.9% of dentists agreed that it is the duty of every dentist to advise the patient on tobacco cessation and 10.1% disagreed. 81.7% of dentists agreed that all dentists have the capability of doing tobacco cessation practices. Seventy-eight percent of dentists agreed that dentists are not presently well prepared to assist patients with tobacco cessation in contrast with 22% who disagree. The scientific evidence relating to the burden of oral diseases has always been attributable to tobacco use, and a well-structured dental teaching curriculum for the dentists and the auxiliaries concentrating on oral cancer education and tobacco cessation interventions has to be emphasized in the Kingdom for the dentists (28). Dentists require formal training to do tobacco cessation successfully to reach a major goal of a “tobacco-free society.” Conclusion: There should be an emphasis on formal training being an effective tool to provide guidelines to the dentist and auxiliaries in tobacco cessation and counseling of the patients in the dental clinic.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"64 1","pages":"91 - 96"},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79364040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajprhc.ajprhc_93_22
Manas Sahoo, M. Umashankar
Background: Medicinal herbs are well known for their therapeutic effects and are traditionally used in the treatment and prevention of numerous diseases. Further plant-derived natural products have also been a valuable source of lead compounds for drug discovery and development. As the bioactivity of natural extracts is due to synergism between hundreds of metabolites present in the plant extract, the complete metabolomic analysis can be used for the quality control of phytomedicine. The 1H-nuclear magnetic resonance (NMR) fingerprint of the herbal extract can be used as a promising approach for comprehensive analysis of secondary metabolites to obtain a holistic view. The 1H-NMR spectroscopy has the advantage that it requires little quantity of samples and simple sample preparation method. Objectives: The study aimed to study the secondary metabolites of seven selected herbs, namely Abies webbiana, Cuminum cyminum, Elettaria cardamomum, Zingiber officinale, Glycyrrhiza glabra, Piper longum, and Terminalia chebula. Materials and Methods: The secondary metabolites of the herbal extracts were studied by recording the 1H-NMR spectra using NMR spectrometer in suitable solvent. Results: The putative metabolites that have been identified were 4-methoxy quercetin, luteolin, cuminaldehyde, 1,8-cineole, elettarins, gingerol, shogaol, glycyrrhizin, liquiritigenin, glabridin, betulinic acid, oleanolic acid, arabinogalactan, chebulagic acid, and gallic acid. Conclusion: The study highlighted the potential of NMR metabolomics in the study of plant extracts and their application for the quality control of phytomedicine.
{"title":"Metabolite fingerprinting and profiling of selected medicinal plants using nuclear magnetic resonance","authors":"Manas Sahoo, M. Umashankar","doi":"10.4103/ajprhc.ajprhc_93_22","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_93_22","url":null,"abstract":"Background: Medicinal herbs are well known for their therapeutic effects and are traditionally used in the treatment and prevention of numerous diseases. Further plant-derived natural products have also been a valuable source of lead compounds for drug discovery and development. As the bioactivity of natural extracts is due to synergism between hundreds of metabolites present in the plant extract, the complete metabolomic analysis can be used for the quality control of phytomedicine. The 1H-nuclear magnetic resonance (NMR) fingerprint of the herbal extract can be used as a promising approach for comprehensive analysis of secondary metabolites to obtain a holistic view. The 1H-NMR spectroscopy has the advantage that it requires little quantity of samples and simple sample preparation method. Objectives: The study aimed to study the secondary metabolites of seven selected herbs, namely Abies webbiana, Cuminum cyminum, Elettaria cardamomum, Zingiber officinale, Glycyrrhiza glabra, Piper longum, and Terminalia chebula. Materials and Methods: The secondary metabolites of the herbal extracts were studied by recording the 1H-NMR spectra using NMR spectrometer in suitable solvent. Results: The putative metabolites that have been identified were 4-methoxy quercetin, luteolin, cuminaldehyde, 1,8-cineole, elettarins, gingerol, shogaol, glycyrrhizin, liquiritigenin, glabridin, betulinic acid, oleanolic acid, arabinogalactan, chebulagic acid, and gallic acid. Conclusion: The study highlighted the potential of NMR metabolomics in the study of plant extracts and their application for the quality control of phytomedicine.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"35 1","pages":"47 - 58"},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79778947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajprhc.ajprhc_8_23
Y. Ingale, S. Chandanwale, Payal Patel, R. Rashmi, Narendra C Kale, Tushar Kambale, V. Vikhe
Background: COVID-19 epidemic causes destructive consequences on human beings and on the global economy. Aim: The purpose of this study was to evaluate the severe acute respiratory syndrome coronavirus 2 antibodies response in COVID-19 patients and health-care providers to them in different categories and with respect to age, sex, and symptoms. Materials and Methods: Analysis of immunoglobulin (Ig) G and total COVID antibodies was done by chemiluminescent microparticle immunoassay (CMIA) and IgM antibodies by rapid card test method in 300 cases. Results: Out of 300 cases, asymptomatic were 29%, mild 26.66%, moderate 17.66%, and severe were 28.33%; percentage of males were higher than females in all. The most common age group involved was 30–40 years (20%). The most common symptom was fever (51.33%), followed by cough (38.66%), and the most common comorbidity was hypertension (16.33%). We observed that severe category had a higher percentage of symptoms as well as comorbidities. Out of 300 cases, 56.66% were IgG positive, and 89.6% were total COVID antibody positive. In rapid IgM antibodies, out of 50 cases, 13 were positive. We observed that IgM was positive mainly in severe cases compared to mild cases, while IgG level was lower in severe cases than those of mild cases. In our study, majority of cases (97 cases) are IgG positive approximately in 8–14 days after onset of symptoms. Conclusion: Quantitative analysis of antibodies is a simple, quick, and cheap method and could play major role in diagnosis and prognosis of COVID-19, and also used to pick up silent carriers (asymptomatic patients) who missed in false-negative reverse transcription polymerase chain reaction in such epidemic.
{"title":"Analysis of severe acute respiratory syndrome coronavirus 2 antibodies response in COVID-19 patients and health-care workers","authors":"Y. Ingale, S. Chandanwale, Payal Patel, R. Rashmi, Narendra C Kale, Tushar Kambale, V. Vikhe","doi":"10.4103/ajprhc.ajprhc_8_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_8_23","url":null,"abstract":"Background: COVID-19 epidemic causes destructive consequences on human beings and on the global economy. Aim: The purpose of this study was to evaluate the severe acute respiratory syndrome coronavirus 2 antibodies response in COVID-19 patients and health-care providers to them in different categories and with respect to age, sex, and symptoms. Materials and Methods: Analysis of immunoglobulin (Ig) G and total COVID antibodies was done by chemiluminescent microparticle immunoassay (CMIA) and IgM antibodies by rapid card test method in 300 cases. Results: Out of 300 cases, asymptomatic were 29%, mild 26.66%, moderate 17.66%, and severe were 28.33%; percentage of males were higher than females in all. The most common age group involved was 30–40 years (20%). The most common symptom was fever (51.33%), followed by cough (38.66%), and the most common comorbidity was hypertension (16.33%). We observed that severe category had a higher percentage of symptoms as well as comorbidities. Out of 300 cases, 56.66% were IgG positive, and 89.6% were total COVID antibody positive. In rapid IgM antibodies, out of 50 cases, 13 were positive. We observed that IgM was positive mainly in severe cases compared to mild cases, while IgG level was lower in severe cases than those of mild cases. In our study, majority of cases (97 cases) are IgG positive approximately in 8–14 days after onset of symptoms. Conclusion: Quantitative analysis of antibodies is a simple, quick, and cheap method and could play major role in diagnosis and prognosis of COVID-19, and also used to pick up silent carriers (asymptomatic patients) who missed in false-negative reverse transcription polymerase chain reaction in such epidemic.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"66 1","pages":"70 - 75"},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90734587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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