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Burden of malnutrition among under-five children and elderly population in Southern India: A systematic review and meta-analysis 印度南部五岁以下儿童和老年人的营养不良负担:系统回顾和荟萃分析
IF 0.4 Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_12_23
Lavanya Ayyasamy, PParameshwari Prahalad, S. Chinnaiyan, M. Azarudeen, Janani Kumaresan, Nivedhitha Sekar
Background: Malnutrition remains a leading cause of infant mortality, primarily in low- and middle-income nations such as India. Aim: Based on the existing literature, our systematic review and meta-analysis sought to determine the prevalence of malnutrition among children and the elderly in Southern India. Methods: In accordance with Preferred Reporting Items for Systematic Review and Meta-analysis guidelines, independent researchers searched PubMed, EMBASE, and Web of Science for studies on malnutrition among children and the elderly in Southern India. We estimated the pooled prevalence with confidence intervals (CIs) of 95% using a random-effects model. Results: Twenty studies met the inclusion criteria and were included in the analysis. There were 11,452 children and 1108 elderly population participants included in the review. Thirteen studies reported the prevalence of undernutrition and the pooled number of samples was 8417. The proportion of underweight in under-five children was 41% (95% CI: 36%–46%). Thirteen studies reported wasting, and the pooled sample size was 9789. The pooled proportion of wasting was 25% (95% CI: 20%–31%). Fourteen studies reported stunting, and the pooled sample size was 10,112. The pooled proportion of stunting was 33% among children. Four studies reported malnourishment or undernutrition among the elderly population in southern India. The pooled sample size was 1108 and the pooled proportion of malnourishment among the elderly population was 12% (95% CI: 1%–22%). Conclusion: Combating child malnutrition in India requires public health interventions for cases of mild malnutrition and vulnerable populations, regional strategy implementation and evaluation, investigations on overweight, obesity, and its causes, and socioeconomic development.
背景:营养不良仍然是婴儿死亡的主要原因,主要发生在印度等低收入和中等收入国家。目的:基于现有文献,我们的系统回顾和荟萃分析试图确定印度南部儿童和老年人营养不良的患病率。方法:根据系统评价和荟萃分析指南的首选报告项目,独立研究人员检索了PubMed, EMBASE和Web of Science,以获取印度南部儿童和老年人营养不良的研究。我们使用随机效应模型估计了95%置信区间(ci)的总患病率。结果:20项研究符合纳入标准并被纳入分析。共有11452名儿童和1108名老年人参与了这项研究。13项研究报告了营养不良的患病率,样本总数为8417。五岁以下儿童体重不足的比例为41% (95% CI: 36%-46%)。13项研究报告了消瘦,汇总样本量为9789。浪费的合并比例为25% (95% CI: 20%-31%)。14项研究报告了发育迟缓,汇总样本量为10,112。儿童发育迟缓的总比例为33%。四项研究报告了印度南部老年人营养不良或营养不足的情况。合并样本量为1108例,老年人营养不良的合并比例为12% (95% CI: 1%-22%)。结论:在印度解决儿童营养不良问题需要针对轻度营养不良病例和弱势群体采取公共卫生干预措施,实施和评估区域战略,调查超重、肥胖及其原因,以及社会经济发展。
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引用次数: 0
Role of diaphragmatic breathing exercise in the rehabilitation of chronic low back ache 横膈膜呼吸运动在慢性腰痛康复中的作用
IF 0.4 Pub Date : 2023-04-01 DOI: 10.4103/ajprhc.ajprhc_41_23
S. Nagaraj, KU Dhanesh Kumar, P. Aaron
A 55-year-old male patient who has undergone physiotherapy sessions on and off for about 6 months has been admitted to the hospital for the recurrence of back pain along with it he has slight breathing issues while performing day-to-day activities, especially in forward bending activity and has been treated with pain killers and muscle relaxants during the medication periods. The patient is feeling better again, but his symptoms continue to worsen. Later, he was referred to a pulmonologist for additional evaluation after presenting with decreased diaphragm excursion, which was causing a disordered breathing pattern. He was treated with medication and referred to additional rehabilitation for low back pain management after a thorough physical examination that also included checking the patient's core and deep breathing muscles Activities of Daily Living (ADL) activities.
一名55岁男性患者,断断续续接受物理治疗约6个月,因背部疼痛复发,并在进行日常活动时出现轻微呼吸问题,特别是在前屈活动时,并在服药期间使用止痛药和肌肉松弛剂治疗。病人又感觉好些了,但他的症状继续恶化。后来,他被转介到肺科医生做进一步的评估后,表现为膈肌偏移减少,导致呼吸模式紊乱。他接受了药物治疗,并在全面体检后进行了额外的腰痛康复治疗,其中包括检查患者的核心和深呼吸肌肉的日常生活活动(ADL)活动。
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引用次数: 0
Efficacy of Dienogest on Pelvic Pain and Dyspareunia: Comprehensive Meta-Analysis and Systematic Review Dienogest治疗盆腔疼痛和性交困难的疗效:综合meta分析和系统评价
IF 0.4 Pub Date : 2023-03-30 DOI: 10.55561/ajhr.v2i1.73
S. Sutrisno, Wildan Aulia Firdaus
Introduction: Endometriosis is a severe disorder marked by endometrial tissue outside the uterus and linked to infertility, although typically manifesting as discomfort in the form of dysmenorrhea, dyspareunia, and pelvic pain. Dienogest is indicated as a first-line hormone treatment for endometriosis-related discomfort. The aim of this study is to analyze the efficacy of Dienogest on treating pelvic pain and dyspareunia compared to placebo or combined oral contraceptives (COC) in women with endometriosis.Methods: A systematic search is conducted in PubMed, ScienceDirect, and Google Scholar. The PRISMA 2020 rules were used to screen the articles that were obtained. For the review, studies that examined how using dienogest in improving endometriosis were exposed to were taken into consideration. In a meta-analysis utilizing a random-effects model, odds ratios with their 95% confidence intervals (CI) were provided.Results: Five studies that met the criteria for inclusion were determined to be pertinent to the association between using dienogest in improving endometriosis (n=711). The Dienogest group had substantially improve pelvic pain with a mean difference of 1.01 (95% CI 1.2, 0.82; p<0.00001) and dyspareunia with a mean difference of 0.58 (95% CI 1.09, 0.08; p=0.02) compared to placebo. Compared to combined oral contraceptives, COC had substantially improves dyspareunia with a mean difference of 0.99 (95% CI 0.62, 1.37; p<0.00001) and pelvic pain with a mean difference of 1.15 (95% CI 0.23, 0.83; p=0.01).Conclusion: Dienogest should be considered as an alternate treatment for endometriosis-related symptoms. In double-blind research, DNG efficacy was compared to placebo.
简介:子宫内膜异位症是一种以子宫外子宫内膜组织为特征的严重疾病,与不孕有关,但通常表现为痛经、性交困难和盆腔疼痛等不适。Dienogest是子宫内膜异位症相关不适的一线激素治疗。本研究的目的是分析Dienogest治疗子宫内膜异位症女性盆腔疼痛和性交困难的疗效,并与安慰剂或联合口服避孕药(COC)进行比较。方法:系统检索PubMed、ScienceDirect和b谷歌Scholar。使用PRISMA 2020规则对获得的物品进行筛选。在这篇综述中,研究了如何使用dienogest来改善子宫内膜异位症的研究被考虑在内。在使用随机效应模型的荟萃分析中,提供了具有95%置信区间(CI)的优势比。结果:符合纳入标准的5项研究被确定与使用dienogest改善子宫内膜异位症相关(n=711)。Dienogest组明显改善了盆腔疼痛,平均差异为1.01 (95% CI 1.2, 0.82;p<0.00001)和性交困难,平均差异为0.58 (95% CI 1.09, 0.08;P =0.02)。与联合口服避孕药相比,COC显著改善了性交困难,平均差异为0.99 (95% CI 0.62, 1.37;p<0.00001)和盆腔疼痛,平均差异为1.15 (95% CI 0.23, 0.83;p = 0.01)。结论:Dienogest可作为子宫内膜异位症相关症状的替代治疗方法。在双盲研究中,将DNG疗效与安慰剂进行比较。
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引用次数: 0
Maternal Comorbidities with Full-Term Pregnancy Who Gave Birth to Low Birth Weight Babies at Dr. Saiful Anwar Malang General Hospital 在Saiful Anwar Malang综合医院生下低出生体重婴儿的足月妊娠孕妇合并症
IF 0.4 Pub Date : 2023-03-17 DOI: 10.55561/ajhr.v2i1.85
I Wayan Agung Indrawan, Obi Candra Kapisa
Introduction: Stunting is a challenge for children's growth and development in the future, which has long-term impacts in the form of reduced cognitive abilities, decreased productivity, and increased risk of infection and non-communicable diseases. Low birth weight (LBW) is a major determinant of stunting in Indonesia. Various multidimensional factors contribute to low birth weight, including maternal factors.Material and Methods: Quantitative descriptive research was conducted at Dr. Saiful Anwar general hospital from July 2021 to September 2022. The variables studied were age, education, occupation, parity status, medical history, number of antenatal care controls, height, mother's body mass index, and baby's birth weight.Results: Of the 54 full-term pregnant women, the majority who delivered LBW babies were nulliparous (42.6%), aged 20-35 years during pregnancy (79.6%), had a history of hypertension during pregnancy (25.9%), antenatal care visits 1-5 times (48.1%), high school degree (48.1%), housewives (75.9%), height ranging between 151-160 cm (64.8%), and BMI 18.5 to 25 kg/m 2 (51.9%).Conclusion: Maternal factors that contribute to the birth of LBW babies include low parities, age 20 to 35 years during pregnancy, hypertension in pregnancy, infrequent antenatal care visits, high school degree, work as a housewife, height ranging between 151 -160 cm, and had a normal BMI. The representation of the mother's BMI and educational level in this study differs from that in previous studies.
导言:发育迟缓是儿童未来成长和发展面临的挑战,其长期影响表现为认知能力下降、生产力下降以及感染和非传染性疾病风险增加。低出生体重(LBW)是印度尼西亚发育迟缓的主要决定因素。造成出生体重过低的多方面因素,包括产妇因素。材料和方法:定量描述性研究于2021年7月至2022年9月在Dr. Saiful Anwar总医院进行。研究的变量包括年龄、受教育程度、职业、胎次状况、病史、产前保健对照数、身高、母亲体重指数和婴儿出生体重。结果:54例足月孕妇中,产LBW儿的多数为未产(42.6%)、孕期年龄在20 ~ 35岁(79.6%)、孕期有高血压史(25.9%)、产前检查1 ~ 5次(48.1%)、高中学历(48.1%)、家庭主妇(75.9%)、身高151 ~ 160 cm(64.8%)、BMI 18.5 ~ 25 kg/ m2(51.9%)。结论:低胎次、孕期年龄20 ~ 35岁、孕期高血压、产前检查次数少、高中学历、家庭主妇、身高在151 ~ 160 cm之间、BMI正常是导致LBW儿出生的因素。本研究对母亲BMI和受教育程度的表征与以往研究有所不同。
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引用次数: 0
Comparative Study of BAX/BcL2 Expression Ratio in Menstrual Blood between Endometriosis Women and Women without Endometriosis 子宫内膜异位症与非子宫内膜异位症女性经血BAX/BcL2表达比的比较研究
IF 0.4 Pub Date : 2023-03-08 DOI: 10.55561/ajhr.v2i1.83
Arghya Wicaksana, Pande Made Dwijayasa, Rahajeng Rahajeng, Cholid Rohman Riskianto
Introduction: Endometriosis is characterized by the presence of endometrial tissue outside the uterus and is commonly associated with chronic pelvic pain and infertility. One of the endometrial changes that appear in the eutopic and ectopic endometrium of women with endometriosis is the regulation of apoptosis. The proportion value of the BAX/BcL-2 ratio is a crucial factor in determining the ability of cells to stimulate apoptosis. Higher apoptotic activity is linked to an increased BAX/BcL-2 ratio. The aim of this study was to compare the BAX/BcL-2 ratios in menstrual blood of endometriosis and non-endometriosis patients.Material and Methods: This research is a quantitative observational study with a cross-sectional method at dr. Saiful Anwar Malang. The case group was postoperative women with ovarian cysts with anatomical pathology examination results indicating endometriosis. While the control group was patients without endometriosis. Data analysis was carried out by using the Independent T Test with SPSS for Windows 19.0 software.Results: Each group consisted of 17 patients. The normality test for each variable shows p> 0.05. BAX average in patients with endometriosis 4556.29 ± 2338.33 and 6488.06 ± 2649.08 in patients without endometriosis (p = 0.031). The average BcL-2 in endometriosis patients was 6483.82±2489.36 and 4877.18±2023.82 in patients without endometriosis (p=0.047). The average BAX/BcL-2 ratio in patients with endometriosis was 0.698±0.19 and 1.367±0.26 in patients without endometriosis (p=0.000).Conclusion: The BAX/BcL-2 ratio in women with endometriosis cysts has a lower average rate than women without endometriosis cysts.
简介:子宫内膜异位症的特征是子宫外存在子宫内膜组织,通常与慢性盆腔疼痛和不孕有关。子宫内膜异位症的异位和异位子宫内膜中出现的子宫内膜变化之一是细胞凋亡的调节。BAX/BcL-2比值的比值值是决定细胞刺激凋亡能力的关键因素。较高的凋亡活性与BAX/BcL-2比值升高有关。本研究的目的是比较子宫内膜异位症和非子宫内膜异位症患者月经血中BAX/BcL-2的比值。材料和方法:本研究是Saiful Anwar Malang博士采用横断面方法进行的定量观察研究。病例组为卵巢囊肿术后解剖病理检查提示子宫内膜异位症的女性。对照组为无子宫内膜异位症的患者。数据分析采用SPSS for Windows 19.0软件进行独立T检验。结果:每组17例。各变量正态性检验p> 0.05。子宫内膜异位症患者BAX平均值为4556.29±2338.33,无子宫内膜异位症患者BAX平均值为6488.06±2649.08 (p = 0.031)。子宫内膜异位症患者平均BcL-2为6483.82±2489.36,无子宫内膜异位症患者平均BcL-2为4877.18±2023.82 (p=0.047)。子宫内膜异位症患者平均BAX/BcL-2比值为0.698±0.19,无子宫内膜异位症患者平均BAX/BcL-2比值为1.367±0.26 (p=0.000)。结论:子宫内膜异位症患者BAX/BcL-2的平均比值低于非子宫内膜异位症患者。
{"title":"Comparative Study of BAX/BcL2 Expression Ratio in Menstrual Blood between Endometriosis Women and Women without Endometriosis","authors":"Arghya Wicaksana, Pande Made Dwijayasa, Rahajeng Rahajeng, Cholid Rohman Riskianto","doi":"10.55561/ajhr.v2i1.83","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.83","url":null,"abstract":"Introduction: Endometriosis is characterized by the presence of endometrial tissue outside the uterus and is commonly associated with chronic pelvic pain and infertility. One of the endometrial changes that appear in the eutopic and ectopic endometrium of women with endometriosis is the regulation of apoptosis. The proportion value of the BAX/BcL-2 ratio is a crucial factor in determining the ability of cells to stimulate apoptosis. Higher apoptotic activity is linked to an increased BAX/BcL-2 ratio. The aim of this study was to compare the BAX/BcL-2 ratios in menstrual blood of endometriosis and non-endometriosis patients.\u0000Material and Methods: This research is a quantitative observational study with a cross-sectional method at dr. Saiful Anwar Malang. The case group was postoperative women with ovarian cysts with anatomical pathology examination results indicating endometriosis. While the control group was patients without endometriosis. Data analysis was carried out by using the Independent T Test with SPSS for Windows 19.0 software.\u0000Results: Each group consisted of 17 patients. The normality test for each variable shows p> 0.05. BAX average in patients with endometriosis 4556.29 ± 2338.33 and 6488.06 ± 2649.08 in patients without endometriosis (p = 0.031). The average BcL-2 in endometriosis patients was 6483.82±2489.36 and 4877.18±2023.82 in patients without endometriosis (p=0.047). The average BAX/BcL-2 ratio in patients with endometriosis was 0.698±0.19 and 1.367±0.26 in patients without endometriosis (p=0.000).\u0000Conclusion: The BAX/BcL-2 ratio in women with endometriosis cysts has a lower average rate than women without endometriosis cysts.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85499954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abdominal Epilepsy, A Diagnosis to Consider in Children with Recurrent Vomiting: A Case Report 腹部癫痫,一个诊断考虑儿童反复呕吐:1例报告
IF 0.4 Pub Date : 2023-03-08 DOI: 10.55561/ajhr.v2i1.76
Fatia Murni Chamida, Nirmala Muflihatul Khalida
gastrointestinal complaints and central nervous system involvement, mainly confusion, fatigue, headache, dizziness, syncope, and lethargy resulting during the abdominal seizure activity. Chronic vomitting or other gastrointestinal symptoms often lead to fluid and nutritional deficiencies which resulted in malnutrition. To date, there was no study has been reported on abdominal epilepsy in Indonesia.Case Presentation: We presented a case of two-year-old girl with chief complaint of recurrent profuse vomiting every month for the past year. Patient complained of headaches and abdominal pain and tended to sleep all day during relapse. Physical examination showed sunken eyes and decreased skin turgor. EEG showed abnormal results, diffuse irritative, epileptiform with normal basic rhythm. Esophageal polyps were also found on endoscopy. Patient was given anti-epileptic drugs and histamine H2 receptor antagonists and responded well to those therapies.Conclusion: Abdominal epilepsy is a rare case which may resulted in vomiting and abdominal pain in children. EEG examination is an important test for diagnosing abdominal epilepsy. Treatment with anti-epileptic drugs is known to respond well in this case.
胃肠道主诉和中枢神经系统受累,主要是在腹部癫痫发作时引起的意识不清、疲劳、头痛、头晕、晕厥和嗜睡。慢性呕吐或其他胃肠道症状常导致体液和营养缺乏,从而导致营养不良。迄今为止,没有关于印度尼西亚腹部癫痫的研究报告。病例介绍:我们报告一名两岁女童,主诉为过去一年来每月反复呕吐。患者主诉头痛、腹痛,复发期间常睡一整天。体格检查显示眼窝凹陷,皮肤肿胀减轻。脑电图显示异常,弥漫性刺激,癫痫样,基本节律正常。内镜检查还发现食管息肉。患者给予抗癫痫药物和组胺H2受体拮抗剂治疗,反应良好。结论:腹部癫痫是一种罕见的病例,可导致儿童呕吐和腹痛。脑电图检查是诊断腹部癫痫的一项重要检查。在这种情况下,抗癫痫药物治疗效果良好。
{"title":"Abdominal Epilepsy, A Diagnosis to Consider in Children with Recurrent Vomiting: A Case Report","authors":"Fatia Murni Chamida, Nirmala Muflihatul Khalida","doi":"10.55561/ajhr.v2i1.76","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.76","url":null,"abstract":"gastrointestinal complaints and central nervous system involvement, mainly confusion, fatigue, headache, dizziness, syncope, and lethargy resulting during the abdominal seizure activity. Chronic vomitting or other gastrointestinal symptoms often lead to fluid and nutritional deficiencies which resulted in malnutrition. To date, there was no study has been reported on abdominal epilepsy in Indonesia.\u0000Case Presentation: We presented a case of two-year-old girl with chief complaint of recurrent profuse vomiting every month for the past year. Patient complained of headaches and abdominal pain and tended to sleep all day during relapse. Physical examination showed sunken eyes and decreased skin turgor. EEG showed abnormal results, diffuse irritative, epileptiform with normal basic rhythm. Esophageal polyps were also found on endoscopy. Patient was given anti-epileptic drugs and histamine H2 receptor antagonists and responded well to those therapies.\u0000Conclusion: Abdominal epilepsy is a rare case which may resulted in vomiting and abdominal pain in children. EEG examination is an important test for diagnosing abdominal epilepsy. Treatment with anti-epileptic drugs is known to respond well in this case.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87288820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Red Bean Extract (Phaseolus vulgaris L. Sp) on Interleukin-1, Inhibin Β and PCNA Expression in Systemic Lupus Erythematosus Mice Model 红豆提取物对系统性红斑狼疮小鼠模型白细胞介素-1、抑制素Β及PCNA表达的影响
IF 0.4 Pub Date : 2023-03-08 DOI: 10.55561/ajhr.v2i1.81
Albert Novriadi, Muhammad Nooryanto, I Wayan Agung Indrawan, Puspita Handayani
Introduction: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by multiple organ involvement. Chronic inflammation due to oxidative stress and autoimmune causes damage to related organs, one of which is the ovary which leads to Premature Ovarian Failure (POF) . Red bean (Phaseolus vulgaris L. Sp.) is an anti-inflammatory and antioxidant agent. This study aims to examine the effect of red beans on IL-1, Inhibin B, and PCNA.Methods: This is a true experimental study with a post-test-only controlled group design in vivo. The sample in this study were female Balb/c mice treated with red bean extract (Phaseolus vulgaris L. sp.) at doses of 50 mg/KgBW (P1), 75 mg/KgBW (P2), and 100 mg/KgBW (P3). IL-1, Inhibin B, and PCNA levels in each group were statistically analyzed using the SPSS 16 for Windows software program.Results: Red bean extract (Phaseolus vulgaris L. Sp.) administration at various doses was statistically proven to significantly reduce IL-1 levels (p<0,05) and increase Inhibin levels in all groups (p<0,05). The highest average Inhibin B levels were found in the 100 mg/KgBW dose group (P3), significant increase in PCNA expression in all groups given various doses of red bean extract (p<0,05).Conclusion: Administration of red bean extract (Phaseoulus vulgaris L. Sp.) can reduce levels of Interleukin-1, increase levels of Inhibin B and PCNA expression in SLE mice.
系统性红斑狼疮(SLE)是一种复杂的自身免疫性疾病,以多器官受累为特征。氧化应激和自身免疫引起的慢性炎症会损害相关器官,其中之一是卵巢,导致卵巢早衰(POF)。红豆(Phaseolus vulgaris L. Sp.)是一种抗炎和抗氧化剂。本研究旨在探讨红豆对IL-1、抑制素B和PCNA的影响。方法:这是一项真正的实验研究,在体内采用仅限测试后的对照组设计。本研究采用红豆提取物(Phaseolus vulgaris L. sp.)分别以50 mg/KgBW (P1)、75 mg/KgBW (P2)和100 mg/KgBW (P3)处理Balb/c雌性小鼠。采用SPSS 16软件对各组IL-1、抑制素B、PCNA水平进行统计学分析。结果:不同剂量红豆提取物均能显著降低各组IL-1水平(p< 0.05),提高抑制素水平(p< 0.05)。抑制素B平均水平以100 mg/KgBW剂量组最高(P3),各剂量红豆提取物各组PCNA表达均显著升高(p< 0.05)。结论:红豆提取物(Phaseoulus vulgaris L. Sp.)可降低SLE小鼠白细胞介素-1水平,增加抑制素B水平和PCNA表达。
{"title":"Effect of Red Bean Extract (Phaseolus vulgaris L. Sp) on Interleukin-1, Inhibin Β and PCNA Expression in Systemic Lupus Erythematosus Mice Model","authors":"Albert Novriadi, Muhammad Nooryanto, I Wayan Agung Indrawan, Puspita Handayani","doi":"10.55561/ajhr.v2i1.81","DOIUrl":"https://doi.org/10.55561/ajhr.v2i1.81","url":null,"abstract":"Introduction: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by multiple organ involvement. Chronic inflammation due to oxidative stress and autoimmune causes damage to related organs, one of which is the ovary which leads to Premature Ovarian Failure (POF) . Red bean (Phaseolus vulgaris L. Sp.) is an anti-inflammatory and antioxidant agent. This study aims to examine the effect of red beans on IL-1, Inhibin B, and PCNA.\u0000Methods: This is a true experimental study with a post-test-only controlled group design in vivo. The sample in this study were female Balb/c mice treated with red bean extract (Phaseolus vulgaris L. sp.) at doses of 50 mg/KgBW (P1), 75 mg/KgBW (P2), and 100 mg/KgBW (P3). IL-1, Inhibin B, and PCNA levels in each group were statistically analyzed using the SPSS 16 for Windows software program.\u0000Results: Red bean extract (Phaseolus vulgaris L. Sp.) administration at various doses was statistically proven to significantly reduce IL-1 levels (p<0,05) and increase Inhibin levels in all groups (p<0,05). The highest average Inhibin B levels were found in the 100 mg/KgBW dose group (P3), significant increase in PCNA expression in all groups given various doses of red bean extract (p<0,05).\u0000Conclusion: Administration of red bean extract (Phaseoulus vulgaris L. Sp.) can reduce levels of Interleukin-1, increase levels of Inhibin B and PCNA expression in SLE mice.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":null,"pages":null},"PeriodicalIF":0.4,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86813715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Vertical Rectus Abdominis Myocutaneous Flap for Complex Abdominal Wall Reconstruction on a Relapse Case of Monophasic Synovial Sarcoma 垂直腹直肌肌皮瓣复合腹壁重建术治疗单相滑膜肉瘤复发1例
IF 0.4 Pub Date : 2023-03-08 DOI: 10.55561/ajhr.v2i1.70
Alfadz Kholifah Akbar, Muhammad Pratama Mandala Putra, Denny Irwansyah
Introduction: Vertical Rectus Abdominis Myocutaneous (VRAM) flap is a chosen method for a large wound closure instead of Anterolateral Thigh (ALT) flap. Both versatile and highly vascularized flaps share almost similar advantages for large wound closure. In our case, the site and size of the wound are the points of consideration.Case Presentation: A 16-year-old girl with a chief complaint of a large progressive lower abdominal mass enlarged since January 2021 that has grown back from the same site. Abdominal CT-Scan shows a tumor in the right lower abdomen infiltrated to the pelvic cavity and spanning from the lower abdominal area all the way to the groin area. Histopathology interpretation suggests a Monophasic Synovial Sarcoma. The patient underwent a second tumor resection with VRAM flap as the wound closure. The benefits of this versatile flap are excellent dead space obliteration and low Surgical Site Occurrence (SSO’s).Conclusion: As postulated in many studies VRAM flap is an excellent flap for a CAWR procedure. The expected SSO’s is non-existence during the postoperative follow-up
简介:垂直腹直肌肌皮瓣(VRAM)是一种替代大腿前外侧皮瓣(ALT)的大伤口闭合方法。多功能和高度血管化皮瓣在大伤口闭合方面几乎具有相似的优势。在我们的病例中,伤口的位置和大小是考虑的重点。病例介绍:一名16岁的女孩,主诉为自2021年1月起扩大的下腹大进行性肿块,该肿块已从同一部位生长回来。腹部ct示右下腹部肿瘤浸润至盆腔,并从下腹部一直延伸至腹股沟区。组织病理学解释提示为单相滑膜肉瘤。患者行第二次肿瘤切除术,用VRAM皮瓣缝合伤口。这种多功能皮瓣的优点是良好的死腔消除和低手术部位发生率(SSO)。结论:在许多研究中,VRAM皮瓣是一种很好的用于car手术的皮瓣。术后随访中未出现预期的SSO
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引用次数: 0
Efficacy and Safety Comparison Between Lorazepam and Diazepam in Treating Convulsive Status Epilepticus in Children: An Evidence-Based Case Report 劳拉西泮与地西泮治疗儿童惊厥性癫痫持续状态的疗效和安全性比较:一份循证病例报告
IF 0.4 Pub Date : 2023-03-08 DOI: 10.55561/ajhr.v2i1.62
Muhammad Habiburrahman, Widya Khairunnisa Sarkowi
Introduction: Indonesia still recommends diazepam for epilepsy, but the International League Against Epilepsy increasingly favours lorazepam. Some reports indicate diazepam being less effective and causing side effects. This report presents a difficult-to-treat convulsive status epilepticus (CSE) case in a 10-month infant who received diazepam, questioning if intravenous/rectal lorazepam is a better initial therapy than diazepam for hospitalized children with CSE.Methods: Following the patient-intervention-comparison-outcome (PICO) formula, we searched for evidence in four journal databases (Pubmed, Proquest, EBSCOHost, and Cochrane). Studies meeting inclusion and exclusion criteria were appraised.Results: Through three systematic reviews and meta-analyses, our clinical query was addressed. One study revealed that rectal lorazepam was more effective in stopping seizures than rectal diazepam (RR 2.86). Meanwhile, two studies found that intravenous lorazepam exhibited similar efficacy in seizure cessation compared to intravenous diazepam (RR 1.04 and OR 1.03, respectively). Both drugs showed no significant difference in the time required to stop seizures or the necessity for additional doses or adjunctive medications to achieve such cessation, nor in the likelihood of refractory seizure within 24 hours. Two studies indicated that intravenous lorazepam had a reduced risk of respiratory depression (RR 0.71 and OR 0.62, respectively). Regardless of the administration route, lorazepam was linked to a lower probability of ICU admission (RR 0.15) than diazepam.Conclusion: Intravenous lorazepam and diazepam are equally effective for treating CSE, but rectal lorazepam is considered better at stopping seizures and preventing their recurrence compared to diazepam. Furthermore, lorazepam is deemed safer, especially when given intravenously.
印度尼西亚仍然推荐安定治疗癫痫,但国际抗癫痫联盟越来越倾向于劳拉西泮。一些报告指出安定的效果较差并会产生副作用。本报告报道了一例难治性惊厥性癫痫持续状态(CSE)病例,患者为10个月大的婴儿,接受地西泮治疗,质疑静脉/直肠劳拉西泮是否比地西泮更好地治疗住院的CSE患儿。方法:遵循患者-干预-比较-结果(PICO)公式,我们在四个期刊数据库(Pubmed, Proquest, EBSCOHost和Cochrane)中检索证据。对符合纳入和排除标准的研究进行评价。结果:通过三个系统综述和荟萃分析,我们的临床问题得到了解决。一项研究显示,直肠用劳拉西泮比直肠用地西泮更有效地阻止癫痫发作(RR 2.86)。同时,两项研究发现静脉注射劳拉西泮与静脉注射地西泮在癫痫发作停止方面具有相似的疗效(RR分别为1.04和OR分别为1.03)。两种药物在停止癫痫发作所需的时间、额外剂量或辅助药物的必要性以及24小时内难治性癫痫发作的可能性方面均无显著差异。两项研究表明,静脉注射劳拉西泮可降低呼吸抑制的风险(RR分别为0.71和0.62)。无论何种给药途径,劳拉西泮比地西泮入院的概率更低(RR 0.15)。结论:静脉注射劳拉西泮和地西泮治疗CSE的效果相同,但直肠注射劳拉西泮比地西泮更能有效地阻止癫痫发作和防止复发。此外,劳拉西泮被认为更安全,尤其是静脉注射时。
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引用次数: 0
Case Report: Combination Therapy of Electrocautery and Zinc Sulfate in Perianal Giant Condylomata Acuminata with Human Immunodeficiency Virus (HIV) 电灼加硫酸锌联合治疗肛周尖锐湿疣合并HIV病例报告
IF 0.4 Pub Date : 2023-03-08 DOI: 10.55561/ajhr.v2i1.57
Lita Setyowatie, Rizky Devitasari
Introduction: Giant Condylomata Acuminata (GCA) or Buschke-Lowenstein tumours are rare variations of anogenital warts. Immunocompromising conditions are closely related to the development of GCA. There is no standard therapy in the management of GCA. Its large size allows malignant transformation and high recurrence.Case Presentation: A male, 26 years old, with a complaint of wart in the anal in the last 11 months. The lump was getting bigger and sometimes bleed. The patient had been diagnosed with HIV 1 year ago and had received routine antiretroviral therapy (ARV). On physical examination of the perianal region showed stalked vegetation which was hypopigmented, partly erythema, verrucous surface, in the form of cauliflower, multiple, measuring 1.5x1.5x4 cm. A positive acetowhite test and histopathological examination showed condylomata acuminata. Patients were given combination electrocautery therapy and zinc sulfate 5-10 mg/kg/day for 2 months. Significant improvement appears and GCA disappears entirely.Conclusion: Electrocautery and zinc sulfate as an immunomodulator can be considered as a treatment of GCA with HIV because they can work synergistically to achieve resolution of the lesion and prevent recurrence of GCA.
简介:巨大尖锐湿疣(GCA)或布施克-洛温斯坦肿瘤是肛门生殖器疣的罕见变异。免疫损害条件与GCA的发展密切相关。GCA的治疗没有标准的治疗方法。它的大体积允许恶性转化和高复发率。病例介绍:男性,26岁,在过去的11个月抱怨在肛门疣。肿块越来越大,有时还出血。该患者1年前被诊断为HIV,并接受了常规抗逆转录病毒治疗(ARV)。肛周查体示茎状植物,色素减退,部分红斑,疣状表面,菜花状,多个,1.5x1.5x4 cm。乙酰白试验和组织病理学检查呈阳性,显示为尖锐湿疣。患者给予电灼联合硫酸锌5 ~ 10 mg/kg/天,疗程2个月。显著改善出现,GCA完全消失。结论:电灼和硫酸锌作为免疫调节剂可作为治疗GCA合并HIV的一种方法,因为它们可以协同作用,达到病变的消退和防止GCA复发的目的。
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引用次数: 0
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Asian Journal of Pharmaceutical Research and Health Care
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