Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp160-164
{"title":"Framework of IOT Based Electricity Monitoring System with Web Application","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp160-164","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp160-164","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75141333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p384
B. Rao, P. Sanjeeva, P. Raman, V. Swamy, V. Prasad, P. Ramana
The growing pharmaceutical relevance of drug-resistant pathogens has necessitated the emergence of new treatment medicines. In this scenario, a novel series of N′-(substituted)-2-(4-(3-nitroimidazo[1,2-b]- pyridazin-6-yl)piperazin-1-yl)acetohydrazides and 1-(2-(substituted)-5-((4-(3-nitroimidazo[1,2- b]pyridazin-6-yl)piperazin-1-yl)methyl)-1,3,4-oxadiazol-3 (2H)-yl)ethan-1-ones have been synthesized and characterized by 1H & 13C NMR spectral data and screened for antimicrobial activity, as well as molecular docking studies. The synthesized compounds were tested against Escherichia coli (1668), Bacillus cereus (1272), Candida albicans (854) by using disc diffusion method. Among all the synthesized compounds 3c and 4c exhibit good potent antimicrobial activity against Escherichia coli, 3a, 4c against Bacillus cereus and 4a, 4c against Candida albicans. The Auto-Dock 4.2/ADT application was performed to investigate the binding interaction of the synthesized compounds with BAX protein. Among all the synthesized compounds 4e, 4a, 3e and 3a showed the highest binding affinity (-8.0, -7.5, -7.0 and -6.9 Kcal/mol) with BAX protein.
{"title":"Synthesis of N'-(Substituted)-2-(4-(3-nitroimidazo[1,2-b]pyridazin-6-yl)piperazin-1-\u0000yl)acetohydrazides and their 1,3,4-Oxadiazole Derivatives: Characterization,\u0000Antimicrobial Activity and Molecular Docking Studies","authors":"B. Rao, P. Sanjeeva, P. Raman, V. Swamy, V. Prasad, P. Ramana","doi":"10.14233/ajomc.2022.ajomc-p384","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p384","url":null,"abstract":"The growing pharmaceutical relevance of drug-resistant pathogens has necessitated the emergence of new treatment medicines. In this scenario, a novel series of N′-(substituted)-2-(4-(3-nitroimidazo[1,2-b]- pyridazin-6-yl)piperazin-1-yl)acetohydrazides and 1-(2-(substituted)-5-((4-(3-nitroimidazo[1,2- b]pyridazin-6-yl)piperazin-1-yl)methyl)-1,3,4-oxadiazol-3 (2H)-yl)ethan-1-ones have been synthesized and characterized by 1H & 13C NMR spectral data and screened for antimicrobial activity, as well as molecular docking studies. The synthesized compounds were tested against Escherichia coli (1668), Bacillus cereus (1272), Candida albicans (854) by using disc diffusion method. Among all the synthesized compounds 3c and 4c exhibit good potent antimicrobial activity against Escherichia coli, 3a, 4c against Bacillus cereus and 4a, 4c against Candida albicans. The Auto-Dock 4.2/ADT application was performed to investigate the binding interaction of the synthesized compounds with BAX protein. Among all the synthesized compounds 4e, 4a, 3e and 3a showed the highest binding affinity (-8.0, -7.5, -7.0 and -6.9 Kcal/mol) with BAX protein.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"191 10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79773152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp147-150
{"title":"An Overview on Image Based Steganography","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp147-150","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp147-150","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81936595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp165-171
R. Pawade, H. Raisoni
One of the popular expressions in the Information Technology is Internet of Things (IoT). What's to come is Internet of Things, which will change this present reality objects into keen virtual articles. The IoT intends to bring together everything in our reality under a typical foundation, giving us not just control of things around us, yet additionally keeping us educated of the condition of the things. In Light of this, introduce ponder addresses IoT ideas through methodical audit of academic research papers, corporate white papers, proficient discourses with specialists and online databases. Besides this examination article centers around definitions, beginnings, fundamental prerequisites, qualities and assumed names of Internet of Things. The fundamental goal of this paper is to give an outline of Internet of Things, models, and imperative innovations and their uses in our everyday life. Notwithstanding, this original copy will give great perception for the new scientists, who need to do explore in this field of Internet of Things (Technological GOD) and encourage information gathering in productively.
{"title":"Internet of Things: A Review","authors":"R. Pawade, H. Raisoni","doi":"10.14233/ajomc.2022.7-1-sp4.pp165-171","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp165-171","url":null,"abstract":"One of the popular expressions in the Information Technology is Internet of Things (IoT). What's to come is Internet of Things, which will change this present reality objects into keen virtual articles. The IoT intends to bring together everything in our reality under a typical foundation, giving us not just control of things around us, yet additionally keeping us educated of the condition of the things. In Light of this, introduce ponder addresses IoT ideas through methodical audit of academic research papers, corporate white papers, proficient discourses with specialists and online databases. Besides this examination article centers around definitions, beginnings, fundamental prerequisites, qualities and assumed names of Internet of Things. The fundamental goal of this paper is to give an outline of Internet of Things, models, and imperative innovations and their uses in our everyday life. Notwithstanding, this original copy will give great perception for the new scientists, who need to do explore in this field of Internet of Things (Technological GOD) and encourage information gathering in productively.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78085566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp5-9
{"title":"Mechanical Assets of Metakaolin (MK) and the Steel Fiber (WSF) based Concrete","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp5-9","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp5-9","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81373026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp117-120
{"title":"Deep Learning based Android Application for Real Time Object Detection for Visually Impaired Persons","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp117-120","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp117-120","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87321965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p393
V. Dhumal, S. Shingote, V. Rane, Akshay Bhandare, K. Tayade, A. Kelkar
In present work, Friedal-Craft alkylation of benzene using benzyl alcohol and dibenzyl ether (DBE) has been investigated using Brønsted acidic ionic liquid as a catalyst. It results in 99% conversion of benzyl alcohol, depicting 61% selectivity towards diphenylmethane (DPM) using [CSO3Hmim][La(CF3SO3)4] as a catalyst within 18 h. Using the same catalyst, 62% selectivity towards DPM has been obtained with DBE as benzylating agent within 16 h. Effect of various reaction conditions on the activity and selectivity was investigated using [C3SO3Hmim][La(CF3SO3)4] as a catalyst with DBE as benzylating agent.
{"title":"Exploration on Clean Synthesis of Diphenylmethane Using Ionic Liquid: A Subtle Catalysis","authors":"V. Dhumal, S. Shingote, V. Rane, Akshay Bhandare, K. Tayade, A. Kelkar","doi":"10.14233/ajomc.2022.ajomc-p393","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p393","url":null,"abstract":"In present work, Friedal-Craft alkylation of benzene using benzyl alcohol and dibenzyl ether (DBE) has been investigated using Brønsted acidic ionic liquid as a catalyst. It results in 99% conversion of benzyl alcohol, depicting 61% selectivity towards diphenylmethane (DPM) using [CSO3Hmim][La(CF3SO3)4] as a catalyst within 18 h. Using the same catalyst, 62% selectivity towards DPM has been obtained with DBE as benzylating agent within 16 h. Effect of various reaction conditions on the activity and selectivity was investigated using [C3SO3Hmim][La(CF3SO3)4] as a catalyst with DBE as benzylating agent.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"85 11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77298555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p374
Anupama Chauhan, Ajay Kumar, A. Goel
4-Formyl pyrazole is nitrogen containing heterocyclic aromatic molecule containing isoniazid moiety. The molecule is formed by fusion of two heterocyclic ring i.e. pyrazole and isoniazid. The current paper covers a vast range of methods for synthesis of 4-formyl pyrazole containing isoniazid moiety and its derivatives using variety of catalyst, solvent medium and microwave irridation with a goal of achieving a high yield and rapid separation of products. This work describes 4-formyl pyrazole and isoniazid antimicrobial activity as well as their structural-activity relationship. It also includes the mechanism of action of pyrazole and isoniazid and includes the list of current patents linked to various pharmacological activities in previous past years.
{"title":"A Retrospective Study of Synthesis, Structure-Activity Relationship and\u0000Antimicrobial Activity of 4-Formyl Pyrazole Containing Isoniazid Moiety","authors":"Anupama Chauhan, Ajay Kumar, A. Goel","doi":"10.14233/ajomc.2022.ajomc-p374","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p374","url":null,"abstract":"4-Formyl pyrazole is nitrogen containing heterocyclic aromatic molecule containing isoniazid moiety. The molecule is formed by fusion of two heterocyclic ring i.e. pyrazole and isoniazid. The current paper covers a vast range of methods for synthesis of 4-formyl pyrazole containing isoniazid moiety and its derivatives using variety of catalyst, solvent medium and microwave irridation with a goal of achieving a high yield and rapid separation of products. This work describes 4-formyl pyrazole and isoniazid antimicrobial activity as well as their structural-activity relationship. It also includes the mechanism of action of pyrazole and isoniazid and includes the list of current patents linked to various pharmacological activities in previous past years.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90012354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p376
Swati Udugade, H. Tare, B. Udugade, Vijaykumar Wakale, Chetan Pulate
Existing study involves effort to forecast absorption, distribution, metabolism, excretion, toxicity and polypharmacological profile of 4-((1-(3-nitrophenyl)-5-oxo-3-phenyl-4,5-dihydro-1H-pyrazol-4-yl)- methyl)benzoic acid (NPOPPBA), a 3CLpro non-peptidic inhibitors with the aid of by means of in silico methods. In the beginning, PASS online computational software’s utilized to investigate pharmacological action of NPOPPBA. Followed by, Swiss ADME online tool utilized to estimate of physical parameters, chemical properties, log P, solubility, absorption, distribution, metabolism, excretion, drug like property and medicinal chemistry. Lastly, XUNDRUG eMolTox online tool utilized to forecast toxicity. End result of PASS online prediction tool confirmed that NPOPPBA may be used as Fusarinine-C ornithinesterase inhibitor, which may be beneficial in most cancers treatment; Swiss ADME end outcome confirmed molecule may orally absorbable but not able to pass lipophilic membrane of brain and hence will not able to show undesirable effect centrally. Observations of bioavailability study shows NPOPPBA may be taken into consideration as a drug like because it shows all parameters falls inside red location of graph. The log P become observed about 3.7 signifying NPOPPBA may absorb on oral administration, solubility in water was found to be poor demonstrating need of attempts to enhance it in formulation development. This molecule can also additionally inhibits CYP2C19 which performs an essential function in metabolism of drugs live omeprazole, which are utilized to cure of gastrointestinal disorder and need to take precaution in the course of use of proton pump inhibitors. It is also CYP2C9 inhibitor therefore due care need to be taken for drugs undergoing phase I metabolism. XUNDRUG online resource outcomes confirmed hepatic and nephron toxicity possibility of NPOPPBA. Here from this existing analysis, it may be confirmed that the beneficial absorption, distribution, metabolism, excretion, drug like property and easy in synthesis of current molecule recommended that NPOPPBA may be an amazing medicinal agent in upcoming COVID-19 treatment.
{"title":"in silico Analysis of 4-((1-(3-Nitrophenyl)-5-oxo-3-phenyl-4,5-dihydro-1H-pyrazol-4-\u0000yl)methyl)benzoic Acid: An Emerging 3-CLpro Non-peptidic Inhibitors for COVID-19","authors":"Swati Udugade, H. Tare, B. Udugade, Vijaykumar Wakale, Chetan Pulate","doi":"10.14233/ajomc.2022.ajomc-p376","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p376","url":null,"abstract":"Existing study involves effort to forecast absorption, distribution, metabolism, excretion, toxicity and polypharmacological profile of 4-((1-(3-nitrophenyl)-5-oxo-3-phenyl-4,5-dihydro-1H-pyrazol-4-yl)- methyl)benzoic acid (NPOPPBA), a 3CLpro non-peptidic inhibitors with the aid of by means of in silico methods. In the beginning, PASS online computational software’s utilized to investigate pharmacological action of NPOPPBA. Followed by, Swiss ADME online tool utilized to estimate of physical parameters, chemical properties, log P, solubility, absorption, distribution, metabolism, excretion, drug like property and medicinal chemistry. Lastly, XUNDRUG eMolTox online tool utilized to forecast toxicity. End result of PASS online prediction tool confirmed that NPOPPBA may be used as Fusarinine-C ornithinesterase inhibitor, which may be beneficial in most cancers treatment; Swiss ADME end outcome confirmed molecule may orally absorbable but not able to pass lipophilic membrane of brain and hence will not able to show undesirable effect centrally. Observations of bioavailability study shows NPOPPBA may be taken into consideration as a drug like because it shows all parameters falls inside red location of graph. The log P become observed about 3.7 signifying NPOPPBA may absorb on oral administration, solubility in water was found to be poor demonstrating need of attempts to enhance it in formulation development. This molecule can also additionally inhibits CYP2C19 which performs an essential function in metabolism of drugs live omeprazole, which are utilized to cure of gastrointestinal disorder and need to take precaution in the course of use of proton pump inhibitors. It is also CYP2C9 inhibitor therefore due care need to be taken for drugs undergoing phase I metabolism. XUNDRUG online resource outcomes confirmed hepatic and nephron toxicity possibility of NPOPPBA. Here from this existing analysis, it may be confirmed that the beneficial absorption, distribution, metabolism, excretion, drug like property and easy in synthesis of current molecule recommended that NPOPPBA may be an amazing medicinal agent in upcoming COVID-19 treatment.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85541202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p365
Nancy, Sakshi Chaudhary, Deepak Kumar, Archana.
Various 5-substituted aryl-3-(2′-carboxy-5′-methoxyindolyl)-2-pyrazolines (9-15) and 5-substituted aryl-3-(2′-carboxy-5′-methoxyindolyl)isoxazolines (16-22) have been synthesized by the cyclization of compounds 1-(2′-carboxyl-5′-methoxyindolyl-3-arylidenyl chalcones (2-8) by treating them with hydrazine hydrate/glacial acetic acid and hydroxylamine hydrochloride/2% NaOH, respectively and TLC checked for their purity. Structure of all these newly synthesized compounds was characterized by elemental (C, H, N) analysis and IR and 1H NMR spectroscopy. All the synthesized compounds were tested for their anti-inflammatory and ulcerogenic activities and acute toxicity and found to possess varying degrees of these activities. Compound 15 is 5-(3′′-methoxy-4′′-hydroxyphenyl)-3- (2′-carboxy-5′-methoxyindolyl)-2-pyrazoline found to be the most potent compound of the series, more potent than the standard drug phenylbutazone.
{"title":"Synthesis and Anti-inflammatory Activity of Newer Indolyl\u0000Pyrazolines and Indolyl Isoxazolines","authors":"Nancy, Sakshi Chaudhary, Deepak Kumar, Archana.","doi":"10.14233/ajomc.2022.ajomc-p365","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p365","url":null,"abstract":"Various 5-substituted aryl-3-(2′-carboxy-5′-methoxyindolyl)-2-pyrazolines (9-15) and 5-substituted aryl-3-(2′-carboxy-5′-methoxyindolyl)isoxazolines (16-22) have been synthesized by the cyclization of compounds 1-(2′-carboxyl-5′-methoxyindolyl-3-arylidenyl chalcones (2-8) by treating them with hydrazine hydrate/glacial acetic acid and hydroxylamine hydrochloride/2% NaOH, respectively and TLC checked for their purity. Structure of all these newly synthesized compounds was characterized by elemental (C, H, N) analysis and IR and 1H NMR spectroscopy. All the synthesized compounds were tested for their anti-inflammatory and ulcerogenic activities and acute toxicity and found to possess varying degrees of these activities. Compound 15 is 5-(3′′-methoxy-4′′-hydroxyphenyl)-3- (2′-carboxy-5′-methoxyindolyl)-2-pyrazoline found to be the most potent compound of the series, more potent than the standard drug phenylbutazone.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81726022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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