Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp135-138
{"title":"Bluetooth Controlled Car using Arduino","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp135-138","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp135-138","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86349708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p366
Deepak Kumar
Several new substituted thiadiazole pyrazolene anthranilic acid derivatives were synthesized. These compounds also evaluated for their anti-inflammatory and analgesic activities. Compound 2-((5-(3- (2,6-dichloro)acrylamido)-1,3,4-thiadiazol-2-yl)methyl amino)-benzoic acid (5b) and 2-((5-(1-acetyl- 5-(2,6-dichloro)-4,5-dihydro-1H-pyrazol-3-ylamino)-1,3,4-thiadiazol-2-yl)methyl amino)benzoic acid (6b) were found to be most active compounds of this series, which exhibits 38.10 & 48.50% anti-inflammatory activity while, 36.24 & 40.10 % analgesic activity, respectively. The structures of all the compounds were characterized by analytical data, IR, 1H NMR and mass spectrometry.
{"title":"Synthesis and Characterization of Thiadiazole Pyrazolene Anthranilic\u0000Acid Derivatives as Potent Anti-inflammatory Agents","authors":"Deepak Kumar","doi":"10.14233/ajomc.2022.ajomc-p366","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p366","url":null,"abstract":"Several new substituted thiadiazole pyrazolene anthranilic acid derivatives were synthesized. These compounds also evaluated for their anti-inflammatory and analgesic activities. Compound 2-((5-(3- (2,6-dichloro)acrylamido)-1,3,4-thiadiazol-2-yl)methyl amino)-benzoic acid (5b) and 2-((5-(1-acetyl- 5-(2,6-dichloro)-4,5-dihydro-1H-pyrazol-3-ylamino)-1,3,4-thiadiazol-2-yl)methyl amino)benzoic acid (6b) were found to be most active compounds of this series, which exhibits 38.10 & 48.50% anti-inflammatory activity while, 36.24 & 40.10 % analgesic activity, respectively. The structures of all the compounds were characterized by analytical data, IR, 1H NMR and mass spectrometry.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89473591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p361
Anu Sharma, L. Jangid, Nusrat K. Shaikh, J. Bhangale
An innovative sequential step of detecting new medicines or drugs dependent on the information of a target is called drug design. The drug is a small molecule that alters the capacity of a bimolecular, example, protein, receptor or catalyst that leads to restorative incentive for patients. Designing of drug by computational method helped steady use of computational science to find, improve and study drugs as well as biologically related active molecules. The displaying examines like the structure-based plan; ligand-based drugs structure; database looking and restricting partiality dependent on the information of a biological target. In this article, we present the zones where CADD (computer aided drug design) devices uphold the medication disclosure measure.
{"title":"Computer-Aided Drug Design Boon in Drug Discovery","authors":"Anu Sharma, L. Jangid, Nusrat K. Shaikh, J. Bhangale","doi":"10.14233/ajomc.2022.ajomc-p361","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p361","url":null,"abstract":"An innovative sequential step of detecting new medicines or drugs dependent on the information of a target is called drug design. The drug is a small molecule that alters the capacity of a bimolecular, example, protein, receptor or catalyst that leads to restorative incentive for patients. Designing of drug by computational method helped steady use of computational science to find, improve and study drugs as well as biologically related active molecules. The displaying examines like the structure-based plan; ligand-based drugs structure; database looking and restricting partiality dependent on the information of a biological target. In this article, we present the zones where CADD (computer aided drug design) devices uphold the medication disclosure measure.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91544969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp51-66
{"title":"Investigations on Machining and Wear behavior of Hypereutectic Al-20Si-0.5Mg-1.2Fe-0.03Cd alloy","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp51-66","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp51-66","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84774982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p382
V. Marvaniya, H. Joshi, Ujashkumar A. Shah, J. Patel
In search of new anticancer agents with improved efficacy, we designed and synthesized novel hybrid series of isonicotinamide and diaryl urea motifs (R1-R9). Design of series compounds carried out using docking study by Autodock vina tool. Binding energy (more than -9.7 kcal/mol) calculated using Autodock vina against Raf kinase (PDB: 4DBN). All the synthesized compounds were evaluated for them in vitro anticancer activity against MCF-7 cell line. The anticancer activities of the synthesized compounds were also carried. Some of the compounds (R1, R8, R9) showed better activities towards MCF-7 cell line by MTT assay.
{"title":"Synthesis, Anticancer Evaluation and Molecular Docking Studies of\u0000Isonicotinamide and Diaryl Urea Hybrid Motifs","authors":"V. Marvaniya, H. Joshi, Ujashkumar A. Shah, J. Patel","doi":"10.14233/ajomc.2022.ajomc-p382","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p382","url":null,"abstract":"In search of new anticancer agents with improved efficacy, we designed and synthesized novel hybrid series of isonicotinamide and diaryl urea motifs (R1-R9). Design of series compounds carried out using docking study by Autodock vina tool. Binding energy (more than -9.7 kcal/mol) calculated using Autodock vina against Raf kinase (PDB: 4DBN). All the synthesized compounds were evaluated for them in vitro anticancer activity against MCF-7 cell line. The anticancer activities of the synthesized compounds were also carried. Some of the compounds (R1, R8, R9) showed better activities towards MCF-7 cell line by MTT assay.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78852020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p377
M. Marimuthu, R. Manikandan
In present study, the presence of bioactive compounds in A. mexicana flowers were analyzed and also evaluated the in vitro antioxidant properties of A. mexicana flowers. The flower extract showed the presence of alkaloids, flavonoids, saponins, tannins, phytosterol, triterpenoids, glycosides, anthraquinones and phenols. The total phenolic and flavonoid content were found to be 25.40 ± 1.20 µg gallic acid equivalents and 14.30 ± 0.20 µg quercetin equivalents, respectively. The carbohydrate and protein content was found to be 4.10 ± 0.24 mg/g and 2.10 ± 0.30 mg/g of the flower extract respectively. HPLC analysis of A. mexicana flower extract revealed the presence of biologically active components such as gallic acid, rutin, caffeic acid, quercetin and ferulic acid. A. mexicana flower extract exhibited 81.33% inhibition in DPPH assay, 85% in ABTS radical assay, 86% superoxide scavenging, 76% NO scavenging, 75% hydroxyl radical scavenging, 77% radicals indicating hydrogen peroxide radical scavenging potential of the flower extract. The antioxidant activity observed in the ethanolic extarct of A. mexicana flower may be related to the presence of significant amounts of total phenolics and flavonoids. Hence, A. mexicana flower extract could serve as natural sources of antioxidants and could be used in the treatment of free radical mediated diseases.
{"title":"Studies on Phytoconstituents and Antioxidant Properties of Argemone mexicana Flower Extract","authors":"M. Marimuthu, R. Manikandan","doi":"10.14233/ajomc.2022.ajomc-p377","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p377","url":null,"abstract":"In present study, the presence of bioactive compounds in A. mexicana flowers were analyzed and also evaluated the in vitro antioxidant properties of A. mexicana flowers. The flower extract showed the presence of alkaloids, flavonoids, saponins, tannins, phytosterol, triterpenoids, glycosides, anthraquinones and phenols. The total phenolic and flavonoid content were found to be 25.40 ± 1.20 µg gallic acid equivalents and 14.30 ± 0.20 µg quercetin equivalents, respectively. The carbohydrate and protein content was found to be 4.10 ± 0.24 mg/g and 2.10 ± 0.30 mg/g of the flower extract respectively. HPLC analysis of A. mexicana flower extract revealed the presence of biologically active components such as gallic acid, rutin, caffeic acid, quercetin and ferulic acid. A. mexicana flower extract exhibited 81.33% inhibition in DPPH assay, 85% in ABTS radical assay, 86% superoxide scavenging, 76% NO scavenging, 75% hydroxyl radical scavenging, 77% radicals indicating hydrogen peroxide radical scavenging potential of the flower extract. The antioxidant activity observed in the ethanolic extarct of A. mexicana flower may be related to the presence of significant amounts of total phenolics and flavonoids. Hence, A. mexicana flower extract could serve as natural sources of antioxidants and could be used in the treatment of free radical mediated diseases.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84750730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p389
P. Sandhya, P. R. Swaran, E. Harikrishnan
Six novel pyrazole compounds were synthesized, characterized and its antimicrobial activity was also evaluated. In vitro antibacterial activity against diverse bacterial and fungal strains was tested and the results were compared to the standard drug. The DNA binding properties of calf thymus DNA (ct-DNA) were investigated using electronic absorption and fluorescence spectroscopies . The software performed computer-aided molecular docking experimentations on proteins and (ct-DNA). Synthesized compounds revealed moderate to satisfactory biological activities both experimentally and theoretically.
{"title":"Synthesis, DNA Binding, DFT Calculations and Molecular Docking Studies of Biologically\u0000Active N-((3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)naphthyl Derivatives","authors":"P. Sandhya, P. R. Swaran, E. Harikrishnan","doi":"10.14233/ajomc.2022.ajomc-p389","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p389","url":null,"abstract":"Six novel pyrazole compounds were synthesized, characterized and its antimicrobial activity was also evaluated. In vitro antibacterial activity against diverse bacterial and fungal strains was tested and the results were compared to the standard drug. The DNA binding properties of calf thymus DNA (ct-DNA) were investigated using electronic absorption and fluorescence spectroscopies . The software performed computer-aided molecular docking experimentations on proteins and (ct-DNA). Synthesized compounds revealed moderate to satisfactory biological activities both experimentally and theoretically.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87214791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p379
Priyal Sukhwal, S. Pathan, N. S. Chundawat, Amit Bhargav, Repale Anil Vithal, G. Singh
Cystathionine-γ-lyase (CSE) 1-(1H-tetrazol-5-yl) but-3-yn-1-amine) is co-enzyme play an important role in in situ production of H2S. In this study, herein reported the synthesis of a new molecule, which is inhibitors of CSE. Hydrogen sulfide is a signaling molecule in the form of gas, also it modulates a large number of mammalian physiological processes. Cystathionine-γ-lyase (CSE) catalyzes hydrogen sulfide synthesis and is a target for modulating under pathophysiological conditions. CSE is inhibited by propargylglycine (PPG), thus this study disclosed that it is useful for CSE inhibitors in the treatment of diseases where CSE inhibition provides therapeutic advantage to the patient having the disease.
{"title":"Synthesis and Characterization of Cystathionine-y-lyase (CSE)\u0000Inhibitors 1-(1H-Tetrazol-5-yl)but-3-yn-1-amine","authors":"Priyal Sukhwal, S. Pathan, N. S. Chundawat, Amit Bhargav, Repale Anil Vithal, G. Singh","doi":"10.14233/ajomc.2022.ajomc-p379","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p379","url":null,"abstract":"Cystathionine-γ-lyase (CSE) 1-(1H-tetrazol-5-yl) but-3-yn-1-amine) is co-enzyme play an important role in in situ production of H2S. In this study, herein reported the synthesis of a new molecule, which is inhibitors of CSE. Hydrogen sulfide is a signaling molecule in the form of gas, also it modulates a large number of mammalian physiological processes. Cystathionine-γ-lyase (CSE) catalyzes hydrogen sulfide synthesis and is a target for modulating under pathophysiological conditions. CSE is inhibited by propargylglycine (PPG), thus this study disclosed that it is useful for CSE inhibitors in the treatment of diseases where CSE inhibition provides therapeutic advantage to the patient having the disease.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77417270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p392
Archana Ratnakar Baraskar, Ratnamala P. Sonawane, Nilesh Kshirsagar, S. Pathan
The functionalization of organic molecules with the Schiff bases having benzothiazole moiety has grown rapidly due to its multiple therapeutic and pharmacological properties. They have driven enormous studies on their stereochemistry, bioactivity and synthetic attempts. The benzothiazole moiety is infinitesimal but broadly used for industrial purposes and also exhibits a broad range of biological activities. Study carried out on Schiff bases having benzothiazole had well-known promising activities like antimicrobial, antimalarial, antifungal, antitubercular, antiviral, antitumor, analgesic, anti-inflammatory and many more. This review brings forward a systematic and comprehensive survey of the reactivity and biological properties associated with the Schiff bases-benzothiazole derivatives and their analogs.
{"title":"Biological Activities of Schiff Bases Incorporating Benzothiazole Moiety","authors":"Archana Ratnakar Baraskar, Ratnamala P. Sonawane, Nilesh Kshirsagar, S. Pathan","doi":"10.14233/ajomc.2022.ajomc-p392","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p392","url":null,"abstract":"The functionalization of organic molecules with the Schiff bases having benzothiazole moiety has grown rapidly due to its multiple therapeutic and pharmacological properties. They have driven enormous studies on their stereochemistry, bioactivity and synthetic attempts. The benzothiazole moiety is infinitesimal but broadly used for industrial purposes and also exhibits a broad range of biological activities. Study carried out on Schiff bases having benzothiazole had well-known promising activities like antimicrobial, antimalarial, antifungal, antitubercular, antiviral, antitumor, analgesic, anti-inflammatory and many more. This review brings forward a systematic and comprehensive survey of the reactivity and biological properties associated with the Schiff bases-benzothiazole derivatives and their analogs.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81643585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp100-109
{"title":"Iris Recognition Detection System based on Various Techniques: A Review","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp100-109","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp100-109","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81969034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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