Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp121-128
{"title":"A Review of Performance & Application of 6G Wireless Cellular System","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp121-128","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp121-128","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85689031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p359
Periyasamy Sellam, Sundaram Manjunathan, Srinivasan Vasanth Kumar, K. Chithra
Chloroquine derivatives were one of the medications tested against the coronavirus pandemic in 2020 and they appeared to be effective. In this present work, (2E,2′E)-2,2′-(propane-1,2-diylidene)bis(Nmethylhydrazinecarbothioamide) (PMTSC) has been postulated as a possible antiviral for the treatment of COVID-19 by using 1-Click docking. Compound PMTSC has been synthesized by the condensation reaction between pyruvaldehyde and N-methylthiosemicarbazide. The synthesized PMTSC was confirmed by elemental analysis and NMR spectral study. The binding interaction of PMTSC has been performed with SARS-CoV main protease (PDB code: 2GZ7 and 2GZ8). The docking results showed good binding energies and interactions.
{"title":"Synthesis, NMR Studies and Binding Interactions of (2E,2′E)-2,2′-(Propane-1,2-\u0000diylidene)bis(N-methylhydrazinecarbothio-amide) with SARS-CoV Main Protease","authors":"Periyasamy Sellam, Sundaram Manjunathan, Srinivasan Vasanth Kumar, K. Chithra","doi":"10.14233/ajomc.2022.ajomc-p359","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p359","url":null,"abstract":"Chloroquine derivatives were one of the medications tested against the coronavirus pandemic in 2020 and they appeared to be effective. In this present work, (2E,2′E)-2,2′-(propane-1,2-diylidene)bis(Nmethylhydrazinecarbothioamide) (PMTSC) has been postulated as a possible antiviral for the treatment of COVID-19 by using 1-Click docking. Compound PMTSC has been synthesized by the condensation reaction between pyruvaldehyde and N-methylthiosemicarbazide. The synthesized PMTSC was confirmed by elemental analysis and NMR spectral study. The binding interaction of PMTSC has been performed with SARS-CoV main protease (PDB code: 2GZ7 and 2GZ8). The docking results showed good binding energies and interactions.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86022413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p378
Sachin M. Sitapara, J. H. Pandya, C. Pashavan
To synthesize new chemical entities, we have a focus on the aryl or heteroaryl compounds. The current work also relates to the synthesis of pharmaceutical and medicinally active compositions containing these types of compounds and their vast application of treating a wide class of diseases i.e. anticancer, antibacterial, antifungal, antimalarial via administering substituted aryl or heteroaryl compounds. In this work, an efficient synthetic route is developed to explore a wide variety of 1H-1,2,3-triazol-1-yl-N- (4-phenylpyrimidin-2-yl)acetamide derivatives and convergent access a diverse array of triazolopyrimidine analogs via click chemistry approach. The structures elucidation was completed by using 1H & 13C NMR, FT-IR, mass spectroscopy, elemental analysis. The developed morpholino-pyrimidine derivatives were further utilized of a diverse range of their chemotherapeutic value.
{"title":"An Efficient Synthesis of Novel Triazolo-pyrimidine Derivatives using Copper\u0000Catalyzed Click Chemistry (CuAAC) Approach","authors":"Sachin M. Sitapara, J. H. Pandya, C. Pashavan","doi":"10.14233/ajomc.2022.ajomc-p378","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p378","url":null,"abstract":"To synthesize new chemical entities, we have a focus on the aryl or heteroaryl compounds. The current work also relates to the synthesis of pharmaceutical and medicinally active compositions containing these types of compounds and their vast application of treating a wide class of diseases i.e. anticancer, antibacterial, antifungal, antimalarial via administering substituted aryl or heteroaryl compounds. In this work, an efficient synthetic route is developed to explore a wide variety of 1H-1,2,3-triazol-1-yl-N- (4-phenylpyrimidin-2-yl)acetamide derivatives and convergent access a diverse array of triazolopyrimidine analogs via click chemistry approach. The structures elucidation was completed by using 1H & 13C NMR, FT-IR, mass spectroscopy, elemental analysis. The developed morpholino-pyrimidine derivatives were further utilized of a diverse range of their chemotherapeutic value.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76860416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p368
Sheetal Sihag, P. Devi, Rajvir Singh, Sushila Singh
Herein, the conventional method used for β-blocker synthesis is initiated by refluxing biphenyl-2-ol (1) with an epoxy ring (2) in the presence of K2CO3 to obtain 2-[(biphenyl-2-yloxy)methyl]oxirane (3). Compound (3) was then reacted with 99% isopropylamine (4) and various substituted phenols (6a-i) to form 1-(biphenyl-2-yloxy)-3-(propan-2-ylamino)propan-2-ol (5) and 1-(2,6-dimethyl-/4-methoxy- /4-chloro-3-hydroxy-/2,6-dimethoxy-/3,4-dimethyl-/4-amine-/4-bromo/3,4-dinitro-/2,4- dihydroxyphenoxy)-3-(biphenyl-2-yloxy)-propan-2-ols (7a-i), respectively. The synthesized compounds were analyzed by 1H NMR and FTIR spectroscopy to determine their structure and also evaluated for their antifungal activity against Rhizoctonia solani and Aspergillus niger using the food poison technique. From the activity data, it was found that compound 1-(biphenyl-2-yloxy)-3-(propan- 2-ylamino)-propan-2-ol (5) was most active against both the fungi Rhizoctonia solani and Aspergillus niger. The antibacterial activity was also determined against Bacillus species by zone of inhibition method. The compounds (5, 7a-i) were also evaluated for its herbicidal activity.
{"title":"Synthesis, Characterization and Bioactivity of Propranolol and it's Derivatives","authors":"Sheetal Sihag, P. Devi, Rajvir Singh, Sushila Singh","doi":"10.14233/ajomc.2022.ajomc-p368","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p368","url":null,"abstract":"Herein, the conventional method used for β-blocker synthesis is initiated by refluxing biphenyl-2-ol (1) with an epoxy ring (2) in the presence of K2CO3 to obtain 2-[(biphenyl-2-yloxy)methyl]oxirane (3). Compound (3) was then reacted with 99% isopropylamine (4) and various substituted phenols (6a-i) to form 1-(biphenyl-2-yloxy)-3-(propan-2-ylamino)propan-2-ol (5) and 1-(2,6-dimethyl-/4-methoxy- /4-chloro-3-hydroxy-/2,6-dimethoxy-/3,4-dimethyl-/4-amine-/4-bromo/3,4-dinitro-/2,4- dihydroxyphenoxy)-3-(biphenyl-2-yloxy)-propan-2-ols (7a-i), respectively. The synthesized compounds were analyzed by 1H NMR and FTIR spectroscopy to determine their structure and also evaluated for their antifungal activity against Rhizoctonia solani and Aspergillus niger using the food poison technique. From the activity data, it was found that compound 1-(biphenyl-2-yloxy)-3-(propan- 2-ylamino)-propan-2-ol (5) was most active against both the fungi Rhizoctonia solani and Aspergillus niger. The antibacterial activity was also determined against Bacillus species by zone of inhibition method. The compounds (5, 7a-i) were also evaluated for its herbicidal activity.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76952973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p390
D. Ramesh, Chatpalliwar Vivekanand Arvind
The present work focuses on indole derivatives due to their promising inhibition activity toward GSK-3β. New compounds based on the indole moiety were synthesized via Japp-Klingemann indole synthesis. The structures of the new compounds were elucidated on the basis of their FTIR, 1H NMR, 13C NMR spectral data, GC-HRMS and elemental analysis. The in vitro GSK-3β inhibitory activity of the new compounds was evaluated using a luminance assay technique in terms of IC50. Compound Aii11 showed excellent inhibitory activity. Compounds Aii2, Aii1 and Aii3 presented promising GSK-3β inhibitory activity.
{"title":"Synthesis, Characterization and in vitro Studies of Some Ethyl 2-Carboxylate-5-\u0000monosubstitued 1H-indole Derivatives as Potential GSK-3β Inhibitors","authors":"D. Ramesh, Chatpalliwar Vivekanand Arvind","doi":"10.14233/ajomc.2022.ajomc-p390","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p390","url":null,"abstract":"The present work focuses on indole derivatives due to their promising inhibition activity toward GSK-3β. New compounds based on the indole moiety were synthesized via Japp-Klingemann indole synthesis. The structures of the new compounds were elucidated on the basis of their FTIR, 1H NMR, 13C NMR spectral data, GC-HRMS and elemental analysis. The in vitro GSK-3β inhibitory activity of the new compounds was evaluated using a luminance assay technique in terms of IC50. Compound Aii11 showed excellent inhibitory activity. Compounds Aii2, Aii1 and Aii3 presented promising GSK-3β inhibitory activity.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75138566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp14-16
{"title":"Soil Nailing Technique for Slope Stabilization- A Review","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp14-16","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp14-16","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75151404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p383
Sanjukta Muhuri, H. Rahaman
In a large number of biologically active natural products and pharmaceuticals, the important substructures are sulfur containing heterocycles. Thioethers and other sulphur-rich molecules commonly occur in chemical biology, organic synthesis and material chemistry. In case of the formation of carbon-heteroatom bonds, copper catalyzed cross-coupling reactions provide a powerful tool as its cost is low and here the readily accessible and stable ligands are used. It has been recognized that copper catalyzed C–S coupling reactions are an efficacious strategy for synthesizing sulfur-rich heterocyclic compounds and so the strategy has gained worldwide attention. This review sums up recent research developments in the field of synthesis of sulfur-containing heterocycles using copper-catalyst.
{"title":"Recent Developments in Synthesis of Sulfur Heterocycles via\u0000Copper-Catalyzed C-S Bond Formation Reaction","authors":"Sanjukta Muhuri, H. Rahaman","doi":"10.14233/ajomc.2022.ajomc-p383","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p383","url":null,"abstract":"In a large number of biologically active natural products and pharmaceuticals, the important substructures are sulfur containing heterocycles. Thioethers and other sulphur-rich molecules commonly occur in chemical biology, organic synthesis and material chemistry. In case of the formation of carbon-heteroatom bonds, copper catalyzed cross-coupling reactions provide a powerful tool as its cost is low and here the readily accessible and stable ligands are used. It has been recognized that copper catalyzed C–S coupling reactions are an efficacious strategy for synthesizing sulfur-rich heterocyclic compounds and so the strategy has gained worldwide attention. This review sums up recent research developments in the field of synthesis of sulfur-containing heterocycles using copper-catalyst.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80305403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p380
D. Satheesh, A. Rajendran, K. Chithra
Breast cancer is the most foremost cause of the most cancer demises in women. In normal cells, BRCA1 and BRCA2 make certain the stability of DNA and also preclude hysterical cell progression. Metamorphosis of these genes is related to the expansion of hereditary breast and ovarian cancers. Bearing in mind the lacunae of consistent and prospective medications to remedy the lifetime intimidating most breast cancers, the present work has attention on molecular docking evaluation to ascertain the prospective binding sites and binding energies of 1-substituted-2-methyl-4-nitroimidazoles, nine protonated 4-nitroimidazolium cations and five aromatic carboxylate anions. Doxorubicin and vinorelbine were also docked with breast cancer protein (PDB code: 3K0K) and the protein binding sites of these standard drugs were also identified. The results exposed that among the docked 4-nitroimdazoles, 4-nitroimidazolium cations and organic anions were found efficient in binding interactions and in wrecking the protein liable towards breast cancer.
{"title":"Protein-Ligand Binding Interactions of 4-Nitroimidazolium Salts with\u0000Breast Cancer Protein: A Computational Biology Study","authors":"D. Satheesh, A. Rajendran, K. Chithra","doi":"10.14233/ajomc.2022.ajomc-p380","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p380","url":null,"abstract":"Breast cancer is the most foremost cause of the most cancer demises in women. In normal cells, BRCA1 and BRCA2 make certain the stability of DNA and also preclude hysterical cell progression. Metamorphosis of these genes is related to the expansion of hereditary breast and ovarian cancers. Bearing in mind the lacunae of consistent and prospective medications to remedy the lifetime intimidating most breast cancers, the present work has attention on molecular docking evaluation to ascertain the prospective binding sites and binding energies of 1-substituted-2-methyl-4-nitroimidazoles, nine protonated 4-nitroimidazolium cations and five aromatic carboxylate anions. Doxorubicin and vinorelbine were also docked with breast cancer protein (PDB code: 3K0K) and the protein binding sites of these standard drugs were also identified. The results exposed that among the docked 4-nitroimdazoles, 4-nitroimidazolium cations and organic anions were found efficient in binding interactions and in wrecking the protein liable towards breast cancer.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85994076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp10-13
{"title":"Bamboo as a Building Material - A Review","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp10-13","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp10-13","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83651261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp143-146
{"title":"RFID Attendance System using Node MCU","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp143-146","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp143-146","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90746544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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