Pub Date : 2022-01-01DOI: 10.14233/ajomc.2022.ajomc-p394
Sharad P. Panchgalle, V. More, A. Bondge, K. I. Momin
Chiral synthesis of centrally acting muscle relaxant (S)-mephenesin was achieved using L-proline catalyzed α-aminoxylation of 3-(2-methyl-phenxoy)propanal as chirality induction step. The chiral synthesis started with commercially available 2-cresol and was accomplished in four steps with overall yield 56%. The enantiomeric excess of final product (S)-mephenesin is >98%. The chiral purity was determined by chiral-HPLC using Chiralcel-OD column. The synthesis involves oxidation of primary alcohol to aldehyde with iodoxybenzoic acid (IBX) as one of the steps.
{"title":"Organocatalytic Chiral Synthesis of Centrally Acting Muscle Relaxant (S)-Mephenesin","authors":"Sharad P. Panchgalle, V. More, A. Bondge, K. I. Momin","doi":"10.14233/ajomc.2022.ajomc-p394","DOIUrl":"https://doi.org/10.14233/ajomc.2022.ajomc-p394","url":null,"abstract":"Chiral synthesis of centrally acting muscle relaxant (S)-mephenesin was achieved using L-proline catalyzed α-aminoxylation of 3-(2-methyl-phenxoy)propanal as chirality induction step. The chiral synthesis started with commercially available 2-cresol and was accomplished in four steps with overall yield 56%. The enantiomeric excess of final product (S)-mephenesin is >98%. The chiral purity was determined by chiral-HPLC using Chiralcel-OD column. The synthesis involves oxidation of primary alcohol to aldehyde with iodoxybenzoic acid (IBX) as one of the steps.","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86143544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.14233/ajomc.2022.7-1-sp4.pp67-75
{"title":"Case Study on Bhakra Dam, Himachal Pradesh","authors":"","doi":"10.14233/ajomc.2022.7-1-sp4.pp67-75","DOIUrl":"https://doi.org/10.14233/ajomc.2022.7-1-sp4.pp67-75","url":null,"abstract":"","PeriodicalId":8544,"journal":{"name":"Asian Journal of Organic & Medicinal Chemistry","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80039480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：