Pub Date : 2017-01-01DOI: 10.5455/JREIM.82-1457672904
G. Deokar, S. Nagare, P. Deore, S. Kshirsagar, S. Ahirrao, Prasad Kulkurani
Culinary utility of the Coccinia grandis (Cucurbitaceae) indicates the use of fruits in the form of different recepies. Coccinia grandis (Cucurbitaceae) is a perennial plant popularly known as kundru, Tondlee, Ivy gourd, Bimbi and Scarlet gourd etc. This herb is used in folk medicine in the form of intact fruits for healing oral ulcers. So the present work was done with an objective to develop a gel formulation from hydroalcoholic extract of coccinia grandis fruit for the treatment of ulcer and for healing of associated wound and inflammation. Molecular docking study was carried out for lupeol and taraxerone, the chemical constituents contained in the fruits. The dock score values were found to be -51.83 and -35.87 respectively for antiulcer activity. For wound healing activity the values found were -27.25 and -27.17 respectively for the two components, whereas the dock score values obtained for the anti-inflammatory activities were -58.6632 and -58. respectively for lupeol and taraxerone. The negative dock score value shows better affinity to bind receptor site. Application of hydroalcoholic extract gel of (20%w/w) for antiulcer and wound healing activities caused a significant reduction in ulcer and wound area when compared with the untreated controls and marketed formulation. Topical application of gel at 20%w/w concentration showed significant reduction in carrageenan induced rat paw edema. Studies carried out for Antiulcer, Wound Healing and Anti-Inflammatory activities showed promising results proving the standardized utilization of traditional herb having culinary applicability. Moreover the data was also supported by the results of computational studies of major constituents responsible for the said activities. The approach in the present study was fruitful to prove the prospectives of hydroalcoholic extract gel of Coccinia grandis fruit as the effective treatment for ulcer and healing associated with wound and inflammation.
{"title":"COCCINIA GRANDIS FRUIT EXTRACT GEL FOR THE TREATMENT OF MOUTH ULCER ALONG WITH ASSOCIATED WOUND AND INFLAMMATION","authors":"G. Deokar, S. Nagare, P. Deore, S. Kshirsagar, S. Ahirrao, Prasad Kulkurani","doi":"10.5455/JREIM.82-1457672904","DOIUrl":"https://doi.org/10.5455/JREIM.82-1457672904","url":null,"abstract":"Culinary utility of the Coccinia grandis (Cucurbitaceae) indicates the use of fruits in the form of different recepies. Coccinia grandis (Cucurbitaceae) is a perennial plant popularly known as kundru, Tondlee, Ivy gourd, Bimbi and Scarlet gourd etc. This herb is used in folk medicine in the form of intact fruits for healing oral ulcers. So the present work was done with an objective to develop a gel formulation from hydroalcoholic extract of coccinia grandis fruit for the treatment of ulcer and for healing of associated wound and inflammation. Molecular docking study was carried out for lupeol and taraxerone, the chemical constituents contained in the fruits. The dock score values were found to be -51.83 and -35.87 respectively for antiulcer activity. For wound healing activity the values found were -27.25 and -27.17 respectively for the two components, whereas the dock score values obtained for the anti-inflammatory activities were -58.6632 and -58. respectively for lupeol and taraxerone. The negative dock score value shows better affinity to bind receptor site. Application of hydroalcoholic extract gel of (20%w/w) for antiulcer and wound healing activities caused a significant reduction in ulcer and wound area when compared with the untreated controls and marketed formulation. Topical application of gel at 20%w/w concentration showed significant reduction in carrageenan induced rat paw edema. Studies carried out for Antiulcer, Wound Healing and Anti-Inflammatory activities showed promising results proving the standardized utilization of traditional herb having culinary applicability. Moreover the data was also supported by the results of computational studies of major constituents responsible for the said activities. The approach in the present study was fruitful to prove the prospectives of hydroalcoholic extract gel of Coccinia grandis fruit as the effective treatment for ulcer and healing associated with wound and inflammation.","PeriodicalId":85736,"journal":{"name":"The Journal of research and education in Indian medicine","volume":"213 1","pages":"43"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73114829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5455/JREIM.82-1433329990
S. Bhinde, A. Patalia, S. Joshi
Introduction: An intelligence quotient (IQ) is a score derived from a set of standardized tests developed to measure a person’s cognitive abilities (intelligence) in relation to their age group. In Ayurveda it could be considered under the heading of “Medha” which means to have proper correlation and understanding about the knowledge of the existing objects. In present competitive world, children are always forced to get 1st rank in their class by their parents. Even many parents are ready to purchase supplements for their children to “enhance memory” or as “I.Q. Booster” to prepare them for the exams. Objectives: Actually the life style related factors, which are affecting the level of IQ are ignored many of time. So this paper is aimed to explore the factors which affect the IQ in children. Material and Methods: Total 22 children were selected for this study. They were examined thoroughly to find out the specific factors and then IQ score were obtained with the help of “Indian Adaptation of Wechsler’s Intelligence Scale for school children-IV”. Observations and Results: This survey shows that Upper SES (40%), Proper Appetite (80%), adequate sleep (80%), educated parents, and proper growth (100%) have relation with Superior IQ. Conclusion: Kshudha, Nidra, Socio Economical Status, Education of father and Growth showed definitive relation with IQ. Hence proper Medhya Rasayana along with adequate life style modification will help the children to attain the desired IQ.]
{"title":"FACTORS AFFECTING THE IQ OF CHILDREN - A SURVEY STUDY","authors":"S. Bhinde, A. Patalia, S. Joshi","doi":"10.5455/JREIM.82-1433329990","DOIUrl":"https://doi.org/10.5455/JREIM.82-1433329990","url":null,"abstract":"Introduction: An intelligence quotient (IQ) is a score derived from a set of standardized tests developed to measure a person’s cognitive abilities (intelligence) in relation to their age group. In Ayurveda it could be considered under the heading of “Medha” which means to have proper correlation and understanding about the knowledge of the existing objects. In present competitive world, children are always forced to get 1st rank in their class by their parents. Even many parents are ready to purchase supplements for their children to “enhance memory” or as “I.Q. Booster” to prepare them for the exams. Objectives: Actually the life style related factors, which are affecting the level of IQ are ignored many of time. So this paper is aimed to explore the factors which affect the IQ in children. Material and Methods: Total 22 children were selected for this study. They were examined thoroughly to find out the specific factors and then IQ score were obtained with the help of “Indian Adaptation of Wechsler’s Intelligence Scale for school children-IV”. Observations and Results: This survey shows that Upper SES (40%), Proper Appetite (80%), adequate sleep (80%), educated parents, and proper growth (100%) have relation with Superior IQ. Conclusion: Kshudha, Nidra, Socio Economical Status, Education of father and Growth showed definitive relation with IQ. Hence proper Medhya Rasayana along with adequate life style modification will help the children to attain the desired IQ.]","PeriodicalId":85736,"journal":{"name":"The Journal of research and education in Indian medicine","volume":"42 1 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90478246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5455/JREIM.82-1416039719
M. Srivastava, R. Srivastava, S. Singh, Shalini Yadav
Introduction: High blood pressure, is the most common cardiovascular disease and is defined as chronically elevated blood pressure greater than 140/90 mmHg. If not treated this disease is a serious public health problem and significantly increases one’s risk of developing coronary artery disease and stroke. Physical activity is one of the main techniques used to reduce blood pressure and other cardiovascular diseases, reducing morbidity and mortality. Several epidemiological studies have reported an inverse relationship between blood pressure and physical activity. Objective: To assess the prevalence of hypertension and the relationship between physical activity and hypertension among adults. Methodology: The sample size was calculated taking the prevalence of hypertension as 30%, level of significance 5%, with permissible error of 10%, the total sample size to be taken was 92 aged 30 to 69 years including 10% as the non-compliance rate. Blood pressure was measured with the help of WHO recommended digital BP measuring machine (OMRON make model HEM 907) during interview in sitting posture. Physical activity was evaluated by International Physical Activity Questionnaire (IPAQ) recommended by WHO to measure physical activity among adults from 15-69 years. Statistical Analysis: Data was analyzed with the help of statistical software SPSS 16.0 trial version. Physical activity scores were used to categorize the respondents and the relationship with their BP was observed. Results and conclusion:The prevalence of hypertension is 64.0% in physically highly active group and 50.0 % in physically less active group. This shows that physical activity prevent and control hypertension along with some other variables.
{"title":"Assessment of Physical Activity and Hypertension among Educated Adults","authors":"M. Srivastava, R. Srivastava, S. Singh, Shalini Yadav","doi":"10.5455/JREIM.82-1416039719","DOIUrl":"https://doi.org/10.5455/JREIM.82-1416039719","url":null,"abstract":"Introduction: High blood pressure, is the most common cardiovascular disease and is defined as chronically elevated blood pressure greater than 140/90 mmHg. If not treated this disease is a serious public health problem and significantly increases one’s risk of developing coronary artery disease and stroke. Physical activity is one of the main techniques used to reduce blood pressure and other cardiovascular diseases, reducing morbidity and mortality. Several epidemiological studies have reported an inverse relationship between blood pressure and physical activity. Objective: To assess the prevalence of hypertension and the relationship between physical activity and hypertension among adults. Methodology: The sample size was calculated taking the prevalence of hypertension as 30%, level of significance 5%, with permissible error of 10%, the total sample size to be taken was 92 aged 30 to 69 years including 10% as the non-compliance rate. Blood pressure was measured with the help of WHO recommended digital BP measuring machine (OMRON make model HEM 907) during interview in sitting posture. Physical activity was evaluated by International Physical Activity Questionnaire (IPAQ) recommended by WHO to measure physical activity among adults from 15-69 years. Statistical Analysis: Data was analyzed with the help of statistical software SPSS 16.0 trial version. Physical activity scores were used to categorize the respondents and the relationship with their BP was observed. Results and conclusion:The prevalence of hypertension is 64.0% in physically highly active group and 50.0 % in physically less active group. This shows that physical activity prevent and control hypertension along with some other variables.","PeriodicalId":85736,"journal":{"name":"The Journal of research and education in Indian medicine","volume":"25 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79191785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5455/JREIM.82-1496627623
Ayman Aboda, Wafaa Taha, I. Abdelgawad, N. Alieldin, J. Kanwar
Background: Cancer cachexia is characterized as a multi-factorial syndrome, identified by the continuing decline of skeletal muscle mass where nutritional support does not completely reverse the effects. Finding a cure for cachexia will impact cancer patients� worldwide, improving quality of life and potentially increasing survival in response to standard care. In turn, an accurate diagnostic tool would assist in the identification and translation of therapeutic targets to the clinic. The Glasgow Prognostic Score (GPS), is determined from combining circulating albumin and C-reactive protein (CRP) concentrations to form a score of 0 (normal) and 1 or 2 (abnormal) (albumin 10mg/L=1). The GPS has been used as an indicator in various cancer types, due to the presence of systemic inflammation, but not in cancer cachexia. The GPS has been validated in a wide range of clinical situation for a systemic inflammatory response so it may be beneficial in assessing the prognosis of cancer cachexia patients. Method/Design:A retrospective cohort study was conducted to assess the GPS as a valuable tool for diagnosing cancer cachexia. The relationship between BMI and the GPS was examined, along with other parameters for controls and cases. Clinical audit data was collected for 357 participants, 185 cases and 172 controls. Results: The GPS was abnormal (2; with albumin 10mg/L) in 123 (66.5%) cases and in 13 (7.6) controls. The GPS scored was also abnormal (1; with albumin 10 mg/L) in 53 (28.6%) cases and 89 (51.7%) controls. It was normal (0) in 9 (4.9%) cases and in 70 (40.7%) controls. There was a significant correlation between the GPS and a decrease in BMI as P value was 0.019. Conclusion: The GPS could be a useful indicator for the onset of cancer cachexia as advanced cancer is usually associated with a marked systemic inflammatory response which is manifested by an increase in CRP which led to a decrease in albumin. It would be beneficial to investigate if the GPS could be used for early diagnosis of cancer cachexia so it must be included in the basic assessment for all patients with cancer.
{"title":"IS THE GLASGOW PROGNOSTIC SCORE A USEFUL TOOL FOR DIAGNOSIS OF CANCER CACHEXIA","authors":"Ayman Aboda, Wafaa Taha, I. Abdelgawad, N. Alieldin, J. Kanwar","doi":"10.5455/JREIM.82-1496627623","DOIUrl":"https://doi.org/10.5455/JREIM.82-1496627623","url":null,"abstract":"Background: Cancer cachexia is characterized as a multi-factorial syndrome, identified by the continuing decline of skeletal muscle mass where nutritional support does not completely reverse the effects. Finding a cure for cachexia will impact cancer patients� worldwide, improving quality of life and potentially increasing survival in response to standard care. In turn, an accurate diagnostic tool would assist in the identification and translation of therapeutic targets to the clinic. The Glasgow Prognostic Score (GPS), is determined from combining circulating albumin and C-reactive protein (CRP) concentrations to form a score of 0 (normal) and 1 or 2 (abnormal) (albumin 10mg/L=1). The GPS has been used as an indicator in various cancer types, due to the presence of systemic inflammation, but not in cancer cachexia. The GPS has been validated in a wide range of clinical situation for a systemic inflammatory response so it may be beneficial in assessing the prognosis of cancer cachexia patients. Method/Design:A retrospective cohort study was conducted to assess the GPS as a valuable tool for diagnosing cancer cachexia. The relationship between BMI and the GPS was examined, along with other parameters for controls and cases. Clinical audit data was collected for 357 participants, 185 cases and 172 controls. Results: The GPS was abnormal (2; with albumin 10mg/L) in 123 (66.5%) cases and in 13 (7.6) controls. The GPS scored was also abnormal (1; with albumin 10 mg/L) in 53 (28.6%) cases and 89 (51.7%) controls. It was normal (0) in 9 (4.9%) cases and in 70 (40.7%) controls. There was a significant correlation between the GPS and a decrease in BMI as P value was 0.019. Conclusion: The GPS could be a useful indicator for the onset of cancer cachexia as advanced cancer is usually associated with a marked systemic inflammatory response which is manifested by an increase in CRP which led to a decrease in albumin. It would be beneficial to investigate if the GPS could be used for early diagnosis of cancer cachexia so it must be included in the basic assessment for all patients with cancer.","PeriodicalId":85736,"journal":{"name":"The Journal of research and education in Indian medicine","volume":"126 1","pages":"77-83"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87645053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5455/JREIM.82-1498286036
Konica Gera, N. Siddique, B. Kumar, Nia Jaipur
{"title":"A Clinical Analysis to Elicit the Sadhya-Asadhyata of Prameha in Diagnosed Cases of Type-II DM","authors":"Konica Gera, N. Siddique, B. Kumar, Nia Jaipur","doi":"10.5455/JREIM.82-1498286036","DOIUrl":"https://doi.org/10.5455/JREIM.82-1498286036","url":null,"abstract":"","PeriodicalId":85736,"journal":{"name":"The Journal of research and education in Indian medicine","volume":"4 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90788938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5455/JREIM.82-1378902288
R. Kulkarni, Abhimanyu Kumar, Savita Hp
Children and academics are not exempted from stress. Academic stress is referred to as elements related to school, studies, family and others that potentially disrupt the physical and psychological homeostasis, besides hampers the performance in academics. It can even be detrimental if not well managed. Despite the loss of lives consequent upon poor academic stress management and resultant academic under achievement, academic stress is less researched.Psychotherapy is the current gold standard. Moreover, now-a-day, there is increase in number of children with stress manifestations seeking Ayurveda treatment at office practice and the reports show encouraging results. Many herbal drugs have been researched and established for anti stress activity.Thus understanding of stress through Ayurveda fundamentals is a step ahead in conceptualising academic stress that is not explicitly described in Ayurveda classics. This would pave way for better understanding of the condition and improvised management strategies. This article adapts concept of manas (mind) and medha (higher mental functions) as constructs to arrive at Chittodvega- entitle ofthe academic stress. Attempts are made to understand etiopathological basis of the condition based on concepts of prajnaparadha and of course tridosha to arrive at disease mapping through nidana(etiology), purvarupa (prodromata), rupa (clinical manifestation), upashayanupashaya (factors increase or decrease the conditions) and samprapti (pathogenesis). Researches on the same are used as evidences for the facts. Based on these, sadhyasadhyata (prognosis) of the condition, chikitsa siddhanta (management principles) and preventions could be derived.
{"title":"ACADEMIC STRESS: A CONCEPTUAL UNDERSTANDING BASED ON AYURVEDIC PRINCIPLES","authors":"R. Kulkarni, Abhimanyu Kumar, Savita Hp","doi":"10.5455/JREIM.82-1378902288","DOIUrl":"https://doi.org/10.5455/JREIM.82-1378902288","url":null,"abstract":"Children and academics are not exempted from stress. Academic stress is referred to as elements related to school, studies, family and others that potentially disrupt the physical and psychological homeostasis, besides hampers the performance in academics. It can even be detrimental if not well managed. Despite the loss of lives consequent upon poor academic stress management and resultant academic under achievement, academic stress is less researched.Psychotherapy is the current gold standard. Moreover, now-a-day, there is increase in number of children with stress manifestations seeking Ayurveda treatment at office practice and the reports show encouraging results. Many herbal drugs have been researched and established for anti stress activity.Thus understanding of stress through Ayurveda fundamentals is a step ahead in conceptualising academic stress that is not explicitly described in Ayurveda classics. This would pave way for better understanding of the condition and improvised management strategies. This article adapts concept of manas (mind) and medha (higher mental functions) as constructs to arrive at Chittodvega- entitle ofthe academic stress. Attempts are made to understand etiopathological basis of the condition based on concepts of prajnaparadha and of course tridosha to arrive at disease mapping through nidana(etiology), purvarupa (prodromata), rupa (clinical manifestation), upashayanupashaya (factors increase or decrease the conditions) and samprapti (pathogenesis). Researches on the same are used as evidences for the facts. Based on these, sadhyasadhyata (prognosis) of the condition, chikitsa siddhanta (management principles) and preventions could be derived.","PeriodicalId":85736,"journal":{"name":"The Journal of research and education in Indian medicine","volume":"35 1","pages":"165-172"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88428746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5455/JREIM.82-1426656034
Janmejaya Samal, Suresh Kumar
{"title":"THE CRAFT OF CAREER PLANNING FOR AYUSH PROFESSIONALS","authors":"Janmejaya Samal, Suresh Kumar","doi":"10.5455/JREIM.82-1426656034","DOIUrl":"https://doi.org/10.5455/JREIM.82-1426656034","url":null,"abstract":"","PeriodicalId":85736,"journal":{"name":"The Journal of research and education in Indian medicine","volume":"43 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82599139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5455/JREIM.82-1435295257
S. Porte, A. Malviya
{"title":"Drug Addiction and Its Ayurvedic Method of De-Addiction","authors":"S. Porte, A. Malviya","doi":"10.5455/JREIM.82-1435295257","DOIUrl":"https://doi.org/10.5455/JREIM.82-1435295257","url":null,"abstract":"","PeriodicalId":85736,"journal":{"name":"The Journal of research and education in Indian medicine","volume":"20 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83489785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5455/JREIM.82-1335952638
Y. Deole, A. Thakar, H. Chandola, B. Ravishankar
{"title":"A CROSS SECTIONAL SURVEY STUDY ON DIETETIC CAUSATIVE FACTORS OF PREMATURE AGEING DESCRIBED IN AYURVEDA","authors":"Y. Deole, A. Thakar, H. Chandola, B. Ravishankar","doi":"10.5455/JREIM.82-1335952638","DOIUrl":"https://doi.org/10.5455/JREIM.82-1335952638","url":null,"abstract":"","PeriodicalId":85736,"journal":{"name":"The Journal of research and education in Indian medicine","volume":"36 1","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88828451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.5455/JREIM.82-1450870178
S. Khedekar, G. Ruknuddin, B. Patgiri, P. Prajapati
Background: Mercurial preparations are used as medicines in Ayurveda. Many procedures are mentioned in the texts to purify and detoxify mercury before its use as a medicine. Gandhaka Jarana viz. treating Parada with Gandhaka is one of them. It is claimed that, it not only implants the property of bioavailability to Parada but also increases its therapeutic efficacy. As per textual claims of Rasashastra, there is difference in the products of respective Gandhaka Jarana. To know details and rationality of Gandhaka Jarana, it was decided to screen and review the studies related with it. Materials and Methods: Few studies were carried out in the department of Rasashastra and Bhaishajya Kalpana of our institute like concept of Gandhaka Jarana, pharmaceutical procedures, chemical characterization, experimental and toxicity studies, study of therapeutic efficacy, etc for dissertation and thesis work. These studies were collected through departmental library, screened and reviewed. Along with this published research articles related with Gandhaka Jarana were reviewed. Results and Conclusion: Gandhaka Jarana having definite role in the mercurial preparations. The screened and reviewed studies showed that increase in number and quantity of Gandhaka Jarana induces major differences in the finished mercurial products. Rasasindura prepared Samaguna Gandhaka Jarana and Shadguna Gandhaka Jarana shows major difference in the analysis of finished product. Analytical studies of Makaradhwaja revealed that Makaradhwaja prepared by Triguna Balijarana shows 300.1 ppm of gold in finished product, whereas 12131 ppm of gold in Shadguna Balijarita Makaradhwaja. Scholars have also mentioned that increase in the number of Gandhaka Jarana of Makaradhwaja reduces the concentration of Parada (Mercury) in the finished product. Clinical and experimental studies of the same products also indicate that increase in number of Gandhaka Jarana increases the efficacy of product. All reviewed studies in different aspects viz. analytical, experimental, and clinical shows that Gandhaka Jarana has a definite role in the mercurial medicinal preparations.
{"title":"Role of Gandhaka Jarana in the Mercurial preparations of Indian Medicinal Alchemy (Rasashastra)","authors":"S. Khedekar, G. Ruknuddin, B. Patgiri, P. Prajapati","doi":"10.5455/JREIM.82-1450870178","DOIUrl":"https://doi.org/10.5455/JREIM.82-1450870178","url":null,"abstract":"Background: Mercurial preparations are used as medicines in Ayurveda. Many procedures are mentioned in the texts to purify and detoxify mercury before its use as a medicine. Gandhaka Jarana viz. treating Parada with Gandhaka is one of them. It is claimed that, it not only implants the property of bioavailability to Parada but also increases its therapeutic efficacy. As per textual claims of Rasashastra, there is difference in the products of respective Gandhaka Jarana. To know details and rationality of Gandhaka Jarana, it was decided to screen and review the studies related with it. Materials and Methods: Few studies were carried out in the department of Rasashastra and Bhaishajya Kalpana of our institute like concept of Gandhaka Jarana, pharmaceutical procedures, chemical characterization, experimental and toxicity studies, study of therapeutic efficacy, etc for dissertation and thesis work. These studies were collected through departmental library, screened and reviewed. Along with this published research articles related with Gandhaka Jarana were reviewed. Results and Conclusion: Gandhaka Jarana having definite role in the mercurial preparations. The screened and reviewed studies showed that increase in number and quantity of Gandhaka Jarana induces major differences in the finished mercurial products. Rasasindura prepared Samaguna Gandhaka Jarana and Shadguna Gandhaka Jarana shows major difference in the analysis of finished product. Analytical studies of Makaradhwaja revealed that Makaradhwaja prepared by Triguna Balijarana shows 300.1 ppm of gold in finished product, whereas 12131 ppm of gold in Shadguna Balijarita Makaradhwaja. Scholars have also mentioned that increase in the number of Gandhaka Jarana of Makaradhwaja reduces the concentration of Parada (Mercury) in the finished product. Clinical and experimental studies of the same products also indicate that increase in number of Gandhaka Jarana increases the efficacy of product. All reviewed studies in different aspects viz. analytical, experimental, and clinical shows that Gandhaka Jarana has a definite role in the mercurial medicinal preparations.","PeriodicalId":85736,"journal":{"name":"The Journal of research and education in Indian medicine","volume":"14 1","pages":"101-108"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91392270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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