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Current evidence on the role of fibroblasts in large-vessel vasculitides: From pathogenesis to therapeutics 成纤维细胞在大血管性脉管炎中作用的现有证据:从发病机制到治疗方法。
IF 13.6 1区 医学 Q1 Medicine Pub Date : 2024-05-21 DOI: 10.1016/j.autrev.2024.103574
Shuang Xu , William F. Jiemy , Elisabeth Brouwer , Janette K. Burgess , Peter Heeringa , Kornelis S.M. van der Geest , Roser Alba-Rovira , Marc Corbera-Bellalta , Annemieke H. Boots , Maria C. Cid , Maria Sandovici

Large-vessel vasculitides (LVV) comprise a group of chronic inflammatory diseases of the aorta and its major branches. The most common forms of LVV are giant cell arteritis (GCA) and Takayasu arteritis (TAK). Both GCA and TAK are characterized by granulomatous inflammation of the vessel wall accompanied by a maladaptive immune and vascular response that promotes vascular damage and remodeling. The inflammatory process in LVV starts in the adventitia where fibroblasts constitute the dominant cell population. Fibroblasts are traditionally recognized for synthesizing and renewing the extracellular matrix thereby being major players in maintenance of normal tissue architecture and in tissue repair. More recently, fibroblasts have emerged as a highly plastic cell population exerting various functions, including the regulation of local immune processes and organization of immune cells at the site of inflammation through production of cytokines, chemokines and growth factors as well as cell-cell interaction. In this review, we summarize and discuss the current knowledge on fibroblasts in LVV. Furthermore, we identify key questions that need to be addressed to fully understand the role of fibroblasts in the pathogenesis of LVV.

大血管炎(LVV)是主动脉及其主要分支的一组慢性炎症性疾病。最常见的大血管炎是巨细胞动脉炎(GCA)和高安动脉炎(TAK)。GCA 和 TAK 的特点都是血管壁肉芽肿性炎症,伴有不良的免疫和血管反应,从而促进血管损伤和重塑。左心室血管炎的炎症过程始于前壁,成纤维细胞是前壁的主要细胞群。传统上,成纤维细胞被认为能合成和更新细胞外基质,因此是维持正常组织结构和组织修复的主要角色。最近,成纤维细胞作为一种可塑性极强的细胞群出现,发挥着多种功能,包括通过产生细胞因子、趋化因子和生长因子以及细胞间相互作用,调节局部免疫过程和组织炎症部位的免疫细胞。在这篇综述中,我们总结并讨论了目前有关低密度肺泡中成纤维细胞的知识。此外,我们还指出了需要解决的关键问题,以全面了解成纤维细胞在左心室积液发病机制中的作用。
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引用次数: 0
What have we learned on pre, very early, and early systemic sclerosis microcirculatory pathophysiology? A scoping review 我们对前期、极早期和早期系统性硬化症微循环病理生理学了解多少?范围综述
IF 13.6 1区 医学 Q1 Medicine Pub Date : 2024-04-09 DOI: 10.1016/j.autrev.2024.103540
Joana Caetano , Luís Monteiro Rodrigues , José Delgado Alves

Objective

Microvascular dysfunction is an early event in the pathogenesis of systemic sclerosis (SSc). The objective of this scoping review is to update the current information and the level of knowledge about the mechanisms of microvascular dysfunction in pre-SSc, very early diagnosis of SSc (VEDOSS) and early SSc.

Methods

A PubMed® database search allowed us to include original data from full-length articles in English in which the main topic was microvascular dysfunction in pre-SSC, VEDOSS or early SSc. Data was extracted using a customized form.

Results

In the present review 437 articles were identified, and 42 studies included, reporting data from a total of 1069 patients with pre-SSc, VEDOSS or early-SSc. Distinct mechanisms of microvascular injury were identified comprising, angiogenesis and vasculogenesis, cell surface proteins and adhesion, molecules expression, cytokines profile, inflammatory and oxidation pathways, and skin perfusion determinants. Most of the studies were conducted in early SSc, with a reduced number in pre-disease stages, in which the prompt recognition of specific mechanisms and biomarkers may allow targeted treatment to prevent disease progression.

Conclusions

Although different molecular expression patterns and signaling pathways related to microvascular dysfunction in pre-SSc, VEDOSS, and early SSc were identified, additional prospective longitudinal studies and combined work with functional evaluation of peripheral skin perfusion are needed.

目的微血管功能障碍是系统性硬化症(SSc)发病机制中的早期事件。本范围综述旨在更新有关系统性硬化前期、极早期系统性硬化诊断(VEDOSS)和早期系统性硬化中微血管功能障碍机制的现有信息和知识水平。方法通过PubMed®数据库检索,我们可以收录以系统性硬化前期、VEDOSS或早期系统性硬化中微血管功能障碍为主题的英文长篇文章的原始数据。结果在本综述中,我们共发现了 437 篇文章,并纳入了 42 项研究,共报告了 1069 名SSC前期、VEDOSS或早期SSC患者的数据。研究发现了微血管损伤的不同机制,包括血管生成和血管生成、细胞表面蛋白和粘附、分子表达、细胞因子谱、炎症和氧化途径以及皮肤灌注决定因素。结论虽然在SSc前期、VEDOSS和SSc早期发现了与微血管功能障碍相关的不同分子表达模式和信号通路,但还需要更多的前瞻性纵向研究以及与外周皮肤灌注功能评估相结合的工作。
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引用次数: 0
Exposure to different occupational chemicals and clinical phenotype of a cohort of patients with systemic sclerosis 接触不同职业化学品与一组系统性硬化症患者的临床表型
IF 13.6 1区 医学 Q1 Medicine Pub Date : 2024-04-08 DOI: 10.1016/j.autrev.2024.103542
Mayka Freire , Bernardo Sopeña , Arturo González-Quintela , Alfredo Guillén del Castillo , Eduardo Callejas Moraga , Gema M. Lledó-Ibañez , Manuel Rubio-Rivas , Luis Trapiella , Ana Argibay , Carles Tolosa , Begoña Marí Alfonso , Jose Antonio Vargas-Hitos , Xavier Pla Salas , Cristina González-Echávarri , Antonio-J Chamorro , Isabel Perales Fraile , Andrés González García , Gloria de la Red Bellvis , David Bernal Bello , Antoni Castro Salomó , Carmen Pilar Simeón-Aznar
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引用次数: 0
Factors associated with incident cardiovascular disease in patients with rheumatoid arthritis: A scoping review 类风湿性关节炎患者发生心血管疾病的相关因素:范围界定综述
IF 13.6 1区 医学 Q1 Medicine Pub Date : 2024-04-04 DOI: 10.1016/j.autrev.2024.103539
Yasaman Hajiesmaeili , Preeti Tamhankar , Saverio Stranges , Lillian Barra

Introduction

Rheumatoid arthritis (RA) is the most common form of autoimmune inflammatory arthritis and is associated with various comorbidities including cardiovascular disease (CVD). This scoping review summarizes the current evidence on longitudinal cohort studies assessing potential factors associated with the incidence of cardiovascular events among patients with RA.

Methods

Scopus, PubMed, Ovid MEDLINE and Cochrane databases were used to identify longitudinal cohort studies investigating the incidence of CVD among RA patients. Using predetermined inclusion and exclusion criteria, two reviewers screened and extracted the relevant studies independently to map the existing literature on this topic. The extracted data included study characteristics, demographics, comorbidities, behavioural and RA-related factors.

Results

Thirty-three research papers were included with a mean follow-up duration of 7.8 years. The sample size of the studies ranged from 182 to 4,311,022 subjects, the mean age from 46.1 to 72.3 years, and on average, 34.6% of the participants were male. The following factors were reported to be associated with a higher incidence of CVD in RA patients: older age, male sex, co-morbid hypertension, diabetes, and/or dyslipidemia, the presence of rheumatoid factor (RF) and/or acute phase reactants. Among RA treatments, glucocorticoids were shown to increase CVD incidence while DMARDs, especially methotrexate, were associated with a lower incidence of CVD.

Conclusion

This review offers a comprehensive summary of the current literature reporting on risk factors for CVD incidence among RA patients. Future research should focus on the less studied factors, including socioeconomic status, physical inactivity, alcohol consumption, sleep habits and dietary patterns as well as some RA-related factors such as anti-citrullinated protein antibodies and functional impairment.

导言类风湿性关节炎(RA)是最常见的自身免疫性炎症性关节炎,与包括心血管疾病(CVD)在内的多种合并症有关。本范围综述总结了目前有关纵向队列研究的证据,这些研究评估了与RA患者心血管事件发生率相关的潜在因素。方法使用Scopus、PubMed、Ovid MEDLINE和Cochrane数据库来确定调查RA患者心血管疾病发生率的纵向队列研究。两位审稿人采用预先确定的纳入和排除标准,独立筛选并提取了相关研究,以绘制该主题的现有文献图谱。提取的数据包括研究特征、人口统计学、合并症、行为和 RA 相关因素。研究样本量从182到4,311,022名受试者不等,平均年龄从46.1岁到72.3岁不等,平均34.6%的受试者为男性。据报道,以下因素与RA患者心血管疾病发病率较高有关:年龄较大、男性、合并高血压、糖尿病和/或血脂异常、存在类风湿因子和/或急性期反应物。结论本综述全面总结了目前有关RA患者心血管疾病发病风险因素的文献。未来的研究应关注研究较少的因素,包括社会经济状况、缺乏运动、饮酒、睡眠习惯和饮食模式,以及一些与 RA 相关的因素,如抗瓜氨酸蛋白抗体和功能障碍。
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引用次数: 0
From autoantibody test results to decision making: Incorporating likelihood ratios within medical practice 从自身抗体检测结果到决策制定:将似然比纳入医疗实践
IF 13.6 1区 医学 Q1 Medicine Pub Date : 2024-03-31 DOI: 10.1016/j.autrev.2024.103537
Kevin D. Deane , Lieve Van Hoovels , Veena E. Joy , Nina Olschowka , Xavier Bossuyt

Autoantibodies are important laboratory markers to support diagnosis of autoimmune diseases. Interpretation of autoantibodies is classically done in a dichotomous way (positive versus negative). Yet, interpretation of autoantibody test results can be improved by reporting likelihood ratios. Likelihood ratios convey information on how much more/less likely a test result is in individuals with the disease compared to individuals without the disease. It incorporates information on the antibody level (the higher the antibody level, the higher the association with the disease), which is helpful for (differential) diagnosis. Likelihood ratios are unit-independent and allow users to harmonize test result interpretation. When the likelihood ratio is combined with information on the pre-test probability, post-test probability can be appraised. In this review, the applicability of likelihood ratio in autoimmune diagnostics will be reviewed from the perspective of the clinician, the laboratory professional and the in vitro diagnostic industry.

自身抗体是诊断自身免疫性疾病的重要实验室指标。对自身抗体的解释通常采用二分法(阳性与阴性)。然而,通过报告似然比可以更好地解读自身抗体检测结果。似然比传达的信息是,与未患病的人相比,患病者检测结果的可能性有多大/可能性有多小。它包含了抗体水平的信息(抗体水平越高,与疾病的关联度越高),有助于(鉴别)诊断。似然比与单位无关,允许用户统一检验结果的解释。当似然比与检测前的概率信息相结合时,检测后的概率也能得到评估。在本综述中,将从临床医生、实验室专业人员和体外诊断行业的角度对似然比在自身免疫诊断中的适用性进行综述。
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引用次数: 0
The ‘whole landscape’ of research on systemic sclerosis over the past 73 years 过去 73 年系统性硬化症研究的 "全貌"。
IF 13.6 1区 医学 Q1 Medicine Pub Date : 2024-03-29 DOI: 10.1016/j.autrev.2024.103538
Meng-Di Zhang , Wan-Ying Huang , Jia-Yuan Luo , Rong-Quan He , Zhi-Guang Huang , Jian-Di Li , Fang Qin , Gang Chen , Ling Lei

Objective

This study aimed to analyse existing research on systemic sclerosis (SSc) conducted over the past 73 years to develop an essential reference for a comprehensive and objective understanding of this field of inquiry.

Methods

Using the Web of Science Core Collection, PubMed, and Scopus databases as data sources for the bibliometric analysis, we searched for published literature related to SSc over the past 73 years. The Bibliometrix package was used to analyse key bibliometric indicators, such as annual publication volume, countries, journals, author contributions, and research hotspots.

Results

From 1970 to 2022, the number of SSc articles steadily increased, reaching its peak in 2020–2022, with approximately 1200 papers published in each of these three years. Matucci-Cerinic et al.'s team published the most articles (425). The United States (11,282), Italy (7027), and France (5226) were the most predominant contexts. The most influential scholars in the field were Denton, Leroy, Steen, and Khanna, with H-indices of 86, 84, and 83, respectively. Arthritis and Rheumatism was the most influential journal in this field (H-index 142). High-frequency keywords in the SSc field included fibrosis (738), inflammation (242), vasculopathy (145), fibroblasts (120), and autoantibodies (118) with respect to pathogenesis, and interstitial lung disease (ILD, 708), pulmonary arterial hypertension (PAH, 696), and Raynaud's phenomenon (326) with regards to clinical manifestations.

Conclusion

In the past three years, SSc research has entered a period of rapid development, mainly driven by research institutions in Europe and the United States. The most influential journal has been Arthritis and Rheumatism, and autoimmune aspects, vasculopathy, fibrogenesis, PAH, and ILD remain the focus of current research and indicate trends in future research.

研究目的本研究旨在分析过去 73 年中有关系统性硬化症(SSc)的现有研究,为全面客观地了解这一研究领域提供重要参考:我们使用 Web of Science Core Collection、PubMed 和 Scopus 数据库作为文献计量分析的数据源,搜索了过去 73 年中与系统性硬化症相关的已发表文献。我们使用 Bibliometrix 软件包分析了关键的文献计量指标,如年出版量、国家、期刊、作者贡献和研究热点:从1970年到2022年,SSc论文数量稳步增长,2020-2022年达到顶峰,这三年每年发表约1200篇论文。Matucci-Cerinic等人的团队发表了最多的文章(425篇)。美国(11282 篇)、意大利(7027 篇)和法国(5226 篇)是发表论文最多的国家。该领域最有影响力的学者是 Denton、Leroy、Steen 和 Khanna,H 指数分别为 86、84 和 83。关节炎与风湿病》是该领域最有影响力的期刊(H 指数为 142)。SSc领域的高频关键词包括与发病机制有关的纤维化(738)、炎症(242)、血管病变(145)、成纤维细胞(120)和自身抗体(118),以及与临床表现有关的间质性肺病(ILD,708)、肺动脉高压(PAH,696)和雷诺现象(326):近三年来,主要在欧洲和美国研究机构的推动下,系统性红斑狼疮研究进入了快速发展期。最具影响力的期刊是《关节炎与风湿病》,而自身免疫方面、血管病变、纤维化、多发性水肿和 ILD 仍是当前研究的重点,并预示着未来研究的趋势。
{"title":"The ‘whole landscape’ of research on systemic sclerosis over the past 73 years","authors":"Meng-Di Zhang ,&nbsp;Wan-Ying Huang ,&nbsp;Jia-Yuan Luo ,&nbsp;Rong-Quan He ,&nbsp;Zhi-Guang Huang ,&nbsp;Jian-Di Li ,&nbsp;Fang Qin ,&nbsp;Gang Chen ,&nbsp;Ling Lei","doi":"10.1016/j.autrev.2024.103538","DOIUrl":"10.1016/j.autrev.2024.103538","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to analyse existing research on systemic sclerosis (SSc) conducted over the past 73 years to develop an essential reference for a comprehensive and objective understanding of this field of inquiry.</p></div><div><h3>Methods</h3><p>Using the Web of Science Core Collection, PubMed, and Scopus databases as data sources for the bibliometric analysis, we searched for published literature related to SSc over the past 73 years. The Bibliometrix package was used to analyse key bibliometric indicators, such as annual publication volume, countries, journals, author contributions, and research hotspots.</p></div><div><h3>Results</h3><p>From 1970 to 2022, the number of SSc articles steadily increased, reaching its peak in 2020–2022, with approximately 1200 papers published in each of these three years. Matucci-Cerinic et al.'s team published the most articles (425). The United States (11,282), Italy (7027), and France (5226) were the most predominant contexts. The most influential scholars in the field were Denton, Leroy, Steen, and Khanna, with H-indices of 86, 84, and 83, respectively. <em>Arthritis and Rheumatism</em> was the most influential journal in this field (H-index 142). High-frequency keywords in the SSc field included fibrosis (738), inflammation (242), vasculopathy (145), fibroblasts (120), and autoantibodies (118) with respect to pathogenesis, and interstitial lung disease (ILD, 708), pulmonary arterial hypertension (PAH, 696), and Raynaud's phenomenon (326) with regards to clinical manifestations.</p></div><div><h3>Conclusion</h3><p>In the past three years, SSc research has entered a period of rapid development, mainly driven by research institutions in Europe and the United States. The most influential journal has been Arthritis and Rheumatism, and autoimmune aspects, vasculopathy, fibrogenesis, PAH, and ILD remain the focus of current research and indicate trends in future research.</p></div>","PeriodicalId":8664,"journal":{"name":"Autoimmunity reviews","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of anti-Ro52-kDa/SSA (TRIM21) antibodies and associated clinical phenotype in systemic sclerosis: Data from a French cohort, a systematic review and meta-analysis 系统性硬化症中抗Ro52-kDa/SSA(TRIM21)抗体的流行率及相关临床表型:来自法国队列的数据、系统回顾和荟萃分析。
IF 13.6 1区 医学 Q1 Medicine Pub Date : 2024-03-28 DOI: 10.1016/j.autrev.2024.103536
Marie-Elise Martel , Amélie Leurs , David Launay , Hélène Behal , Aurélien Chepy , Aurore Collet , Sébastien Sanges , Eric Hachulla , Sylvain Dubucquoi , Luc Dauchet , Vincent Sobanski

Objectives

Estimate the global prevalence of anti-Ro52-kDa/SSA (TRIM21) autoantibodies in systemic sclerosis (SSc), and describe the associated clinical phenotype, through a systematic review and meta-analysis of published reports and new data from our French cohort.

Methods

Anti-TRIM21 seropositivity and associated SSc characteristics were assessed in a cross-sectional study including 300 patients of Lille University Hospital. A systematic review of the literature was performed in Pubmed and Embase, followed by a meta-analysis, using data on prevalence, clinical/demographical/biological characteristics of SSc patients and the type of assay used for anti-TRIM21 antibodies detection (PROSPERO n° CRD42021223719).

Findings

In the cross-sectional study, anti-TRIM21 antibodies prevalence was 26% [95%CI: 21; 31]. Anti-centromere antibodies were the most frequent SSc specific autoantibodies coexisting with anti-TRIM21. Patients with anti-TRIM21 antibodies were more frequently women (91% vs 77%, p = 0.006), more likely to present an associated Sjögren's syndrome (19% vs 7%, p < 0.001), had a higher rate of pulmonary arterial hypertension (PAH) (15% vs 6%, p = 0.017) and a greater frequency of digestive complications such as dysphagia (12% vs 5%, p = 0.038) or nausea/vomiting (10% vs 3%, p = 0.009) than anti-TRIM21 negative patients. Thirty-five articles corresponding to a total of 11,751 SSc patients were included in the meta-analysis. In this population, the overall seroprevalence of anti-TRIM21 antibodies was 23% [95%CI: 21; 27] with a high degree of heterogeneity (I2: 93% Phet: <0.0001), partly explained by the methods of detection. Anti-TRIM21 seropositivity was positively associated with female sex (OR: 1.60 [95%CI: 1.25, 2.06]), limited cutaneous subset (OR: 1.29 [1.04, 1.61]), joint manifestations (OR: 1.33 [1.05, 1.68]), pulmonary hypertension (PH) (OR: 1.82 [1.42, 2.33]), and interstitial lung disease (ILD) (OR: 1.31 [1.07, 1.60]).

Interpretation

Anti-TRIM21 antibodies frequently co-exist with usual SSc antibodies, but are independently associated to a higher risk of cardio-pulmonary complications. The presence of these autoantibodies should therefore be considered when assessing the risk of developing PH and ILD, and deserves further studies on appropriate screening and follow-up of patients.

目的通过对已发表的报告和法国队列的新数据进行系统回顾和荟萃分析,估计抗Ro52-kDa/SSA(TRIM21)自身抗体在系统性硬化症(SSc)中的全球流行率,并描述相关的临床表型:在一项横断面研究中评估了抗-TRIM21血清阳性和相关的SSc特征,研究对象包括里尔大学医院的300名患者。我们在Pubmed和Embase上对文献进行了系统性回顾,然后利用SSc患者的患病率、临床/病史/生物学特征以及抗TRIM21抗体检测方法(PROSPERO n° CRD42021223719)等数据进行了荟萃分析:在横断面研究中,抗TRIM21抗体的流行率为26%[95%CI:21;31]。抗中心粒抗体是与抗TRIM21抗体共存的最常见的SSc特异性自身抗体。抗TRIM21抗体患者多为女性(91% vs 77%,P = 0.006),更有可能伴有斯约格伦综合征(31% vs 11%,P 2:93% Phet):解释:抗TRIM21抗体经常与常见的SSc抗体同时存在,但却与较高的心肺并发症风险独立相关。因此,在评估罹患 PH 和 ILD 的风险时,应考虑到这些自身抗体的存在,并对患者的适当筛查和随访进行进一步研究。
{"title":"Prevalence of anti-Ro52-kDa/SSA (TRIM21) antibodies and associated clinical phenotype in systemic sclerosis: Data from a French cohort, a systematic review and meta-analysis","authors":"Marie-Elise Martel ,&nbsp;Amélie Leurs ,&nbsp;David Launay ,&nbsp;Hélène Behal ,&nbsp;Aurélien Chepy ,&nbsp;Aurore Collet ,&nbsp;Sébastien Sanges ,&nbsp;Eric Hachulla ,&nbsp;Sylvain Dubucquoi ,&nbsp;Luc Dauchet ,&nbsp;Vincent Sobanski","doi":"10.1016/j.autrev.2024.103536","DOIUrl":"10.1016/j.autrev.2024.103536","url":null,"abstract":"<div><h3>Objectives</h3><p>Estimate the global prevalence of anti-Ro52-kDa/SSA (TRIM21) autoantibodies in systemic sclerosis (SSc), and describe the associated clinical phenotype, through a systematic review and meta-analysis of published reports and new data from our French cohort.</p></div><div><h3>Methods</h3><p>Anti-TRIM21 seropositivity and associated SSc characteristics were assessed in a cross-sectional study including 300 patients of Lille University Hospital. A systematic review of the literature was performed in Pubmed and Embase, followed by a meta-analysis, using data on prevalence, clinical/demographical/biological characteristics of SSc patients and the type of assay used for anti-TRIM21 antibodies detection (PROSPERO n° CRD42021223719).</p></div><div><h3>Findings</h3><p>In the cross-sectional study, anti-TRIM21 antibodies prevalence was 26% [95%CI: 21; 31]. Anti-centromere antibodies were the most frequent SSc specific autoantibodies coexisting with anti-TRIM21. Patients with anti-TRIM21 antibodies were more frequently women (91% vs 77%, <em>p</em> = 0.006), more likely to present an associated Sjögren's syndrome (19% vs 7%, <em>p</em> &lt; 0.001), had a higher rate of pulmonary arterial hypertension (PAH) (15% vs 6%, <em>p</em> = 0.017) and a greater frequency of digestive complications such as dysphagia (12% vs 5%, <em>p</em> = 0.038) or nausea/vomiting (10% vs 3%, <em>p</em> = 0.009) than anti-TRIM21 negative patients. Thirty-five articles corresponding to a total of 11,751 SSc patients were included in the meta-analysis. In this population, the overall seroprevalence of anti-TRIM21 antibodies was 23% [95%CI: 21; 27] with a high degree of heterogeneity (I<sup>2</sup>: 93% Phet: &lt;0.0001), partly explained by the methods of detection. Anti-TRIM21 seropositivity was positively associated with female sex (OR: 1.60 [95%CI: 1.25, 2.06]), limited cutaneous subset (OR: 1.29 [1.04, 1.61]), joint manifestations (OR: 1.33 [1.05, 1.68]), pulmonary hypertension (PH) (OR: 1.82 [1.42, 2.33]), and interstitial lung disease (ILD) (OR: 1.31 [1.07, 1.60]).</p></div><div><h3>Interpretation</h3><p>Anti-TRIM21 antibodies frequently co-exist with usual SSc antibodies, but are independently associated to a higher risk of cardio-pulmonary complications. The presence of these autoantibodies should therefore be considered when assessing the risk of developing PH and ILD, and deserves further studies on appropriate screening and follow-up of patients.</p></div>","PeriodicalId":8664,"journal":{"name":"Autoimmunity reviews","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1568997224000272/pdfft?md5=1498dd5cfeaa3d0df361ec3ed3b96f8d&pid=1-s2.0-S1568997224000272-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140329588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A critical view on autoantibodies in lupus nephritis: Concrete knowledge based on evidence 狼疮肾炎自身抗体的批判性观点:基于证据的具体知识。
IF 13.6 1区 医学 Q1 Medicine Pub Date : 2024-03-27 DOI: 10.1016/j.autrev.2024.103535
Maurizio Bruschi , Andrea Angeletti , Marco Prunotto , Pier Luigi Meroni , Gian Marco Ghiggeri , for the Zeus consortium, Gabriella Moroni , Renato Alberto Sinico , Franco Franceschini , Micaela Fredi , Augusto Vaglio , Andrea Cavalli , Leonardo Scapozza , Jigar J. Patel , John C. Tan , Ken C. Lo , Lorenzo Cavagna , Andrea Petretto , Federico Pratesi , Paola Migliorini , Enrico Verrina

Deposition of autoantibodies in glomeruli is a key factor in the development of lupus nephritis (LN). For a long time, anti-dsDNA and anti-C1q antibodies were thought to be the main cause of the kidney damage. However, recent studies have shown that the list of autoantibidies that have renal tropism and deposit in the kidney in LN is increasing and the link between anti-dsDNA and renal pathology is weak due to potential confounders. Aspecific bindings of dsDNA with cationic antibodies and of anti-dsDNA with several renal antigens such as actinin, laminin, entactin, and annexinA2 raised doubts about the specific target of these antibodies in the kidney. Moreover, the isotype of anti-dsDNA in SLE and LN has never received adequate interest until the recent observation that IgG2 are preponderant over IgG1, IgG3 and IgG4.

Based on the above background, recent studies investigated the involvement of anti-dsDNA IgG2 and of other antibodies in LN. It was concluded that circulating anti-dsDNA IgG2 levels do not distinguish between LN versus non-renal SLE, and, in patients with LN, their levels do not change over time. Circulating levels of other antibodies such as anti-ENO1 and anti-H2 IgG2 were, instead, higher in LN vs non-renal SLE at the time of diagnosis and decreased following therapies. Finally, new classes of renal antibodies that potentially modify the anti-inflammatory response in the kidney are emerging as new co-actors in the pathogenetic scenario. They have been defined as ‘second wave antibodies’ for the link with detoxifying mechanisms limiting the oxidative stress in glomeruli that are classically stimulated in a second phase of inflammation.

These findings have important clinical implications that may modify the laboratory approach to LN. Serum levels of anti-ENO1 and anti-H2 IgG2 should be measured in the follow up of patients for designing the length of therapies and identify those patients who respond to treatments. Anti-SOD2 could help to monitor and potentiate the anti-inflammatory response in the kidney.

自身抗体在肾小球的沉积是狼疮肾炎(LN)发病的关键因素。长期以来,抗dsDNA和抗C1q抗体被认为是肾脏损伤的主要原因。然而,最近的研究表明,在狼疮性肾炎患者中,具有肾脏滋养特性并沉积于肾脏的自身抗体越来越多,而由于潜在的混杂因素,抗dsDNA与肾脏病理之间的联系很弱。dsDNA与阳离子抗体的特异性结合,以及抗dsDNA与多种肾脏抗原(如肌动蛋白、层粘连蛋白、entactin和annexinA2)的特异性结合,使人对这些抗体在肾脏中的特异性靶点产生怀疑。此外,系统性红斑狼疮和 LN 中抗dsDNA 的同种型一直没有引起足够的重视,直到最近发现 IgG2 比 IgG1、IgG3 和 IgG4 占优势。基于上述背景,最近的研究调查了抗dsDNA IgG2和其他抗体在LN中的参与情况。研究得出的结论是,循环中的抗dsDNA IgG2水平并不能区分LN和非肾性系统性红斑狼疮,而且在LN患者中,其水平不会随着时间的推移而改变。相反,其他抗体如抗ENO1和抗H2 IgG2的循环水平在LN和非肾性系统性红斑狼疮诊断时较高,在接受治疗后下降。最后,有可能改变肾脏抗炎反应的新型肾脏抗体正在成为新的致病因素。它们被定义为 "第二波抗体",因为它们与限制肾小球氧化应激的解毒机制有联系,而这种机制在炎症的第二阶段通常会受到刺激。这些发现具有重要的临床意义,可能会改变实验室检测 LN 的方法。在对患者进行随访时,应测量血清中抗 ENO1 和抗 H2 IgG2 的水平,以设计治疗时间的长短,并确定对治疗有反应的患者。抗 SOD2 有助于监测和增强肾脏的抗炎反应。
{"title":"A critical view on autoantibodies in lupus nephritis: Concrete knowledge based on evidence","authors":"Maurizio Bruschi ,&nbsp;Andrea Angeletti ,&nbsp;Marco Prunotto ,&nbsp;Pier Luigi Meroni ,&nbsp;Gian Marco Ghiggeri ,&nbsp;for the Zeus consortium,&nbsp;Gabriella Moroni ,&nbsp;Renato Alberto Sinico ,&nbsp;Franco Franceschini ,&nbsp;Micaela Fredi ,&nbsp;Augusto Vaglio ,&nbsp;Andrea Cavalli ,&nbsp;Leonardo Scapozza ,&nbsp;Jigar J. Patel ,&nbsp;John C. Tan ,&nbsp;Ken C. Lo ,&nbsp;Lorenzo Cavagna ,&nbsp;Andrea Petretto ,&nbsp;Federico Pratesi ,&nbsp;Paola Migliorini ,&nbsp;Enrico Verrina","doi":"10.1016/j.autrev.2024.103535","DOIUrl":"10.1016/j.autrev.2024.103535","url":null,"abstract":"<div><p>Deposition of autoantibodies in glomeruli is a key factor in the development of lupus nephritis (LN). For a long time, anti-dsDNA and anti-C1q antibodies were thought to be the main cause of the kidney damage. However, recent studies have shown that the list of autoantibidies that have renal tropism and deposit in the kidney in LN is increasing and the link between anti-dsDNA and renal pathology is weak due to potential confounders. Aspecific bindings of dsDNA with cationic antibodies and of anti-dsDNA with several renal antigens such as actinin, laminin, entactin, and annexinA2 raised doubts about the specific target of these antibodies in the kidney. Moreover, the isotype of anti-dsDNA in SLE and LN has never received adequate interest until the recent observation that IgG2 are preponderant over IgG1, IgG3 and IgG4.</p><p>Based on the above background, recent studies investigated the involvement of anti-dsDNA IgG2 and of other antibodies in LN. It was concluded that circulating anti-dsDNA IgG2 levels do not distinguish between LN versus non-renal SLE, and, in patients with LN, their levels do not change over time. Circulating levels of other antibodies such as anti-ENO1 and anti-H2 IgG2 were, instead, higher in LN vs non-renal SLE at the time of diagnosis and decreased following therapies. Finally, new classes of renal antibodies that potentially modify the anti-inflammatory response in the kidney are emerging as new co-actors in the pathogenetic scenario. They have been defined as ‘second wave antibodies’ for the link with detoxifying mechanisms limiting the oxidative stress in glomeruli that are classically stimulated in a second phase of inflammation.</p><p>These findings have important clinical implications that may modify the laboratory approach to LN. Serum levels of anti-ENO1 and anti-H2 IgG2 should be measured in the follow up of patients for designing the length of therapies and identify those patients who respond to treatments. Anti-SOD2 could help to monitor and potentiate the anti-inflammatory response in the kidney.</p></div>","PeriodicalId":8664,"journal":{"name":"Autoimmunity reviews","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140326311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Redox mechanisms in autoimmune thyroid eye disease 自身免疫性甲状腺眼病的氧化还原机制
IF 13.6 1区 医学 Q1 Medicine Pub Date : 2024-03-26 DOI: 10.1016/j.autrev.2024.103534
Francesco Buonfiglio , Katharina A. Ponto , Norbert Pfeiffer , George J. Kahaly , Adrian Gericke

Thyroid eye disease (TED) is an autoimmune condition affecting the orbit and the eye with its adnexa, often occurring as an extrathyroidal complication of Graves' disease (GD). Orbital inflammatory infiltration and the stimulation of orbital fibroblasts, triggering de novo adipogenesis, an overproduction of hyaluronan, myofibroblast differentiation, and eventual tissue fibrosis are hallmarks of the disease. Notably, several redox signaling pathways have been shown to intensify inflammation and to promote adipogenesis, myofibroblast differentiation, and fibrogenesis by upregulating potent cytokines, such as interleukin (IL)-1β, IL-6, and transforming growth factor (TGF)-β. While existing treatment options can manage symptoms and potentially halt disease progression, they come with drawbacks such as relapses, side effects, and chronic adverse effects on the optic nerve. Currently, several studies shed light on the pathogenetic contributions of emerging factors within immunological cascades and chronic oxidative stress. This review article provides an overview on the latest advancements in understanding the pathophysiology of TED, with a special focus of the interplay between oxidative stress, immunological mechanisms and environmental factors. Furthermore, cutting-edge therapeutic approaches targeting redox mechanisms will be presented and discussed.

甲状腺眼病(TED)是一种影响眼眶和眼球及其附件的自身免疫性疾病,通常是巴塞杜氏病(GD)的甲状腺外并发症。眼眶炎症浸润、刺激眼眶成纤维细胞、引发新生脂肪生成、透明质酸过度产生、肌成纤维细胞分化以及最终的组织纤维化是该病的特征。值得注意的是,一些氧化还原信号通路已被证明会加剧炎症,并通过上调白细胞介素(IL)-1β、IL-6 和转化生长因子(TGF)-β 等强效细胞因子促进脂肪生成、肌成纤维细胞分化和纤维化。虽然现有的治疗方案可以控制症状,并有可能阻止疾病的发展,但它们也存在复发、副作用和对视神经的慢性不良影响等缺点。目前,一些研究揭示了免疫级联和慢性氧化应激中新出现因素的致病作用。这篇综述文章概述了在了解 TED 病理生理学方面的最新进展,特别关注氧化应激、免疫机制和环境因素之间的相互作用。此外,文章还将介绍和讨论针对氧化还原机制的前沿治疗方法。
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引用次数: 0
The management of patients with inflammatory bowel disease-associated spondyloarthritis: Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD) and Italian Society of Rheumatology (SIR) recommendations based on a pseudo-Delphi consensus 炎症性肠病相关脊柱关节炎患者的治疗:意大利炎症性肠病研究小组(IG-IBD)和意大利风湿病学会(SIR)根据伪德尔菲共识提出的建议。
IF 13.6 1区 医学 Q1 Medicine Pub Date : 2024-03-22 DOI: 10.1016/j.autrev.2024.103533
Fabio Salvatore Macaluso , Flavio Caprioli , Laura Benedan , Cristina Bezzio , Roberto Caporali , Alberto Cauli , Maria Sole Chimenti , Francesco Ciccia , Salvatore D'Angelo , Massimo Claudio Fantini , Stefano Festa , Florenzo Iannone , Ennio Lubrano , Paolo Mariani , Claudio Papi , Giuseppe Provenzano , Daniela Pugliese , Antonio Rispo , Simone Saibeni , Carlo Salvarani , Roberto Gerli

Spondyloarthritis (SpA) is the most frequent extraintestinal manifestation in patients with inflammatory bowel diseases (IBD). When IBD and spondyloarthritis coexist, musculoskeletal and intestinal disease features should be considered when planning a therapeutic strategy. Treatment options for IBD and SpA have expanded enormously over the last few years, but randomized controlled trials with specific endpoints focused on SpA are not available in the IBD setting. To address this important clinical topic, the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD) and the Italian Society of Rheumatology (SIR) jointly planned to draw updated therapeutic recommendations for IBD-associated SpA using a pseudo-Delphi method. This document presents the official recommendations of IG-IBD and SIR on the management of IBD-associated SpA in the form of 34 statements and 4 therapeutic algorithms. It is intended to be a reference guide for gastroenterologists and rheumatologists dealing with IBD-associated SpA.

脊柱关节炎(Spondyloarthritis,SPA)是炎症性肠病(IBD)患者最常见的肠外表现。当 IBD 和脊柱关节炎同时存在时,在制定治疗策略时应考虑肌肉骨骼和肠道疾病的特征。在过去几年中,IBD 和脊柱关节炎的治疗方案有了很大的扩展,但在 IBD 环境中,还没有针对脊柱关节炎的特定终点的随机对照试验。为了解决这一重要的临床课题,意大利炎症性肠病研究小组(IG-IBD)和意大利风湿病学会(SIR)共同计划采用伪德尔菲法,为 IBD 相关性 SpA 制定最新的治疗建议。本文件以 34 项声明和 4 种治疗算法的形式,介绍了 IG-IBD 和 SIR 对 IBD 相关性 SpA 治疗的官方建议。它旨在为消化内科医生和风湿病学家处理 IBD 相关性 SpA 提供参考指南。
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Autoimmunity reviews
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