Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i3.63156
Rokshana Begum, M. A. Bhuiyan, Sheuly Ferdousi, M. Yesmin, D. Paul, T. Sultana, Md Quddusur Rahman, Md Saiful Islam, Khandoker Abdur Rahim, M. Khaled
Deaths due to coronary artery disease have been increasing in young people aged <40. Studies have reported an association between these deaths with hyperhomocysteinemia. The aim of this study was to compare serum homocysteine levels in middle-aged patients with coronary artery disease. This cross-sectional study was conducted among 52 cardiology inpatients of Bangabandhu Sheikh Mujib Medical University, Dhaka, from March 2021 to February 2022. Among them, 26 were young adults (<40 years, Group I), and 26 were middle-aged (≥40 years, Group II). Serum homocysteine was measured in all of them using an automated immunoassay analyzer. The younger patients had higher (P=0.001) median homocysteine (interquartile range) level, 13.5 (7.7 –28.4 mmol/L) compared to the middle-aged group, 10.0 (5.9 – 38.5 mmol/L). The hyperhomocysteinemia (>15 mmol/L) was 16.2% in Group I compared to 12.4% in Group II (P=0.001). Therefore, control measures for keeping homocysteine levels within the normal range in young people might be useful. BSMMU J 2022; 15(3): 197-200
{"title":"Comparison of serum homocysteine level in young and middle-aged adult patients with coronary artery disease","authors":"Rokshana Begum, M. A. Bhuiyan, Sheuly Ferdousi, M. Yesmin, D. Paul, T. Sultana, Md Quddusur Rahman, Md Saiful Islam, Khandoker Abdur Rahim, M. Khaled","doi":"10.3329/bsmmuj.v15i3.63156","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i3.63156","url":null,"abstract":"Deaths due to coronary artery disease have been increasing in young people aged <40. Studies have reported an association between these deaths with hyperhomocysteinemia. The aim of this study was to compare serum homocysteine levels in middle-aged patients with coronary artery disease. This cross-sectional study was conducted among 52 cardiology inpatients of Bangabandhu Sheikh Mujib Medical University, Dhaka, from March 2021 to February 2022. Among them, 26 were young adults (<40 years, Group I), and 26 were middle-aged (≥40 years, Group II). Serum homocysteine was measured in all of them using an automated immunoassay analyzer. The younger patients had higher (P=0.001) median homocysteine (interquartile range) level, 13.5 (7.7 –28.4 mmol/L) compared to the middle-aged group, 10.0 (5.9 – 38.5 mmol/L). The hyperhomocysteinemia (>15 mmol/L) was 16.2% in Group I compared to 12.4% in Group II (P=0.001). Therefore, control measures for keeping homocysteine levels within the normal range in young people might be useful.\u0000BSMMU J 2022; 15(3): 197-200","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41402525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i2.60869
S. Paul, M. A. Rahman, Shamim Ahmed, R. Chakrabortty, Shuvo Majumder, M. Hamza
Abstract not available BSMMU J 2022; 15(2): 132-137
[摘要][J];15 (2): 132 - 137
{"title":"Multiple arterial and venous thromboses due to protein S deficiency - a case report","authors":"S. Paul, M. A. Rahman, Shamim Ahmed, R. Chakrabortty, Shuvo Majumder, M. Hamza","doi":"10.3329/bsmmuj.v15i2.60869","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i2.60869","url":null,"abstract":"Abstract not available\u0000BSMMU J 2022; 15(2): 132-137","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45291791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i2.60858
Nishat Mahzabin, Md. Raiq Raihan Chowdhury, Md Akhlak Ul Islam, Ismat Ara Islam, Mily Dey, Md Salahuddin Shah, Md Abdul Aziz
The COVID-19 pandemic has had a consequential impact on the global health system. Multisystem involvement is common in COVID-19. Many COVID-19 patients also showed changes in haematological parameters. This cross-sectional study included patients who attended the fever clinic of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, with fever and/or upper respiratory symptoms. Demographic information, information regarding symptoms, exposure and comorbidities were collected. Complete blood count profile and C-reactive protein were done. Patients underwent RT-PCR for Covid-19 at the fever clinic. A total of 350 patients were included in the study. The study revealed that 21.4% of respondents were COVID-19 positive. PCR-positive patients were more likely to be symptomatic and had elevated C reactive protein levels. COVID-19 positive patients also showed higher total leucocyte, neutrophil, lymphocyte, eosinophil, basophil, and platelet count. BSMMU J 2022; 15(2): 75-79
{"title":"Haematological parameters and SARS-CoV-2 RT PCR positivity among patients at fever clinic in a tertiary care hospital in Bangladesh","authors":"Nishat Mahzabin, Md. Raiq Raihan Chowdhury, Md Akhlak Ul Islam, Ismat Ara Islam, Mily Dey, Md Salahuddin Shah, Md Abdul Aziz","doi":"10.3329/bsmmuj.v15i2.60858","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i2.60858","url":null,"abstract":"The COVID-19 pandemic has had a consequential impact on the global health system. Multisystem involvement is common in COVID-19. Many COVID-19 patients also showed changes in haematological parameters. This cross-sectional study included patients who attended the fever clinic of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, with fever and/or upper respiratory symptoms. Demographic information, information regarding symptoms, exposure and comorbidities were collected. Complete blood count profile and C-reactive protein were done. Patients underwent RT-PCR for Covid-19 at the fever clinic. A total of 350 patients were included in the study. The study revealed that 21.4% of respondents were COVID-19 positive. PCR-positive patients were more likely to be symptomatic and had elevated C reactive protein levels. COVID-19 positive patients also showed higher total leucocyte, neutrophil, lymphocyte, eosinophil, basophil, and platelet count.\u0000BSMMU J 2022; 15(2): 75-79","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48644205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i2.60856
Hurjahan Banu, Md Shahed Morshed, S. Tuqan, N. Akhtar, M. Hasanat
Antimullarian hormone (AMH) is found to be a vital tool for the diagnosis of polycystic ovary syndrome (PCOS). AMH may help in the diagnosis of sonographically inconclusive cases of PCOS. This study measured the AMH level in PCOS to assess its impacts on the diagnosis of the syndrome. This cross-sectional study included 160 newly diagnosed females with PCOS who were diagnosed using a modified revised Rotterdam criteria. Fasting blood was collected to measure AMH by enzyme-linked immunosorbent assay and other hormones [total testosterone, luteinizing hormone and follicle-stimulating hormone] were measured by chemiluminescent microparticle immunoassay. Ovarian USG was done in the follicular phase of the menstrual cycle. Serum AMH≥ 3.5 ng/mL and ovarian volume >10 mL was considered as a combined marker of polycystic ovary (PCO). USG-PCO criteria could detect 84.38% PCO, whereas AMH-PCO criteria 67.5%. There was a lack of agreement between USG-PCO and AMH-PCO criteria [κ=-0.004] in PCOS. AMH-PCO criteria identified 68% of PCO patients undiagnosed by USG-PCO criteria [17/25]. Age [β=-0.172, p=0.040], systolic [β =-0.213, p=0.037] and diastolic blood pressure [β=0.301, p=0.004] had significant predictive associations with AMH by linear regression. AMH had a fair discriminating index for combined-PCO [AUC=0.824] in PCOS patients. In conclusion, AMH assessment can help detect PCOS patients who are inconclusively diagnosed by USG-PCO criteria. BSMMU J 2022; 15(2): 65-69
{"title":"Role of antimullarian hormone in the diagnosis of sonographically inconclusive polycystic ovary syndrome","authors":"Hurjahan Banu, Md Shahed Morshed, S. Tuqan, N. Akhtar, M. Hasanat","doi":"10.3329/bsmmuj.v15i2.60856","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i2.60856","url":null,"abstract":"Antimullarian hormone (AMH) is found to be a vital tool for the diagnosis of polycystic ovary syndrome (PCOS). AMH may help in the diagnosis of sonographically inconclusive cases of PCOS. This study measured the AMH level in PCOS to assess its impacts on the diagnosis of the syndrome. This cross-sectional study included 160 newly diagnosed females with PCOS who were diagnosed using a modified revised Rotterdam criteria. Fasting blood was collected to measure AMH by enzyme-linked immunosorbent assay and other hormones [total testosterone, luteinizing hormone and follicle-stimulating hormone] were measured by chemiluminescent microparticle immunoassay. Ovarian USG was done in the follicular phase of the menstrual cycle. Serum AMH≥ 3.5 ng/mL and ovarian volume >10 mL was considered as a combined marker of polycystic ovary (PCO). USG-PCO criteria could detect 84.38% PCO, whereas AMH-PCO criteria 67.5%. There was a lack of agreement between USG-PCO and AMH-PCO criteria [κ=-0.004] in PCOS. AMH-PCO criteria identified 68% of PCO patients undiagnosed by USG-PCO criteria [17/25]. Age [β=-0.172, p=0.040], systolic [β =-0.213, p=0.037] and diastolic blood pressure [β=0.301, p=0.004] had significant predictive associations with AMH by linear regression. AMH had a fair discriminating index for combined-PCO [AUC=0.824] in PCOS patients. In conclusion, AMH assessment can help detect PCOS patients who are inconclusively diagnosed by USG-PCO criteria.\u0000BSMMU J 2022; 15(2): 65-69","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41843680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i3.62956
Md Habibul Ghani, Md Shahed Morshed, T. Haq, S. Selim, Murshed Ahamed Khan, M. Mustari, Mostafa Hasan Rajib, A. Yadav, I. Faisal, A. Shah, Md Firoj Hossain, M. Hasanat, M. Fariduddin
Hypovitaminosis D (<20 ng/mL) is thought to increase insulin resistance and meta-inflammation contributing to the pathogenesis of diabetes mellitus (DM). Correcting vitamin D deficiency in people with prediabetes might halt its progression to DM. The aim of this study was to examine the effect of vitamin D supplementation on insulin resistance, glycemic status, and inflammation in prediabetic adults with vitamin D deficiency. This doubleblind randomized placebo-controlled trial was done among 27 newly detected prediabetic adults with hypovitaminosis D randomly assigned to 60,000 IU of vitamin D weekly for eight weeks followed by monthly for the next four months or placebo along with lifestyle modification in both groups [vitamin D (n= 14) vs. Placebo (n=13). They were comparable in terms of sex, age and borlymass index. Glycemic status, fasting plasma glucose (FPG) and Hemoglobin A1C (HbA1C), insulin resistance (homeostasis model assessment of insulin resistance (HOMA-IR) and inflammatory marker high sensitivity C reactive protein (hs-CRP) were measured at baseline and after six months of intervention. Vitamin D levels (ng/mL) increased in both groups from baseline (vitamin D vs. placebo: 12.2±5.9 vs. 3.9±3.5, mean±SD). FPG (mmol/L) significantly decreased in the Vitamin D group (before vs. after: 5.9±0.6 vs. 5.5±0.7, P=0.016, mean±SD), whereas HbA1C (%) and hs- CRP (mg/L) significantly increased in the placebo group (before vs. after- HbA1C: 5.8±0.3 vs. 6.0±0.4, P<0.001; hs-CRP: 5.0±4.4 vs. 5.6±4.9, P=0.039, mean±SD). Percent changes in glycemic status, HOMA-IR, and hs-CRP were statistically similar between the groups. Our study failed to demonstrate the positive effects of vitamin D supplementation on reducing glucose, insulin resistance, or inflammatory marker in prediabetic adult patients with hypovitaminosis D. BSMMU J 2022; 15(3): 167-174
{"title":"Vitamin D supplementation on prediabetic adults with vitamin D deficiency: a double-blind placebo-controlled randomized clinical trial","authors":"Md Habibul Ghani, Md Shahed Morshed, T. Haq, S. Selim, Murshed Ahamed Khan, M. Mustari, Mostafa Hasan Rajib, A. Yadav, I. Faisal, A. Shah, Md Firoj Hossain, M. Hasanat, M. Fariduddin","doi":"10.3329/bsmmuj.v15i3.62956","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i3.62956","url":null,"abstract":"Hypovitaminosis D (<20 ng/mL) is thought to increase insulin resistance and meta-inflammation contributing to the pathogenesis of diabetes mellitus (DM). Correcting vitamin D deficiency in people with prediabetes might halt its progression to DM. The aim of this study was to examine the effect of vitamin D supplementation on insulin resistance, glycemic status, and inflammation in prediabetic adults with vitamin D deficiency. This doubleblind randomized placebo-controlled trial was done among 27 newly detected prediabetic adults with hypovitaminosis D randomly assigned to 60,000 IU of vitamin D weekly for eight weeks followed by monthly for the next four months or placebo along with lifestyle modification in both groups [vitamin D (n= 14) vs. Placebo (n=13). They were comparable in terms of sex, age and borlymass index. Glycemic status, fasting plasma glucose (FPG) and Hemoglobin A1C (HbA1C), insulin resistance (homeostasis model assessment of insulin resistance (HOMA-IR) and inflammatory marker high sensitivity C reactive protein (hs-CRP) were measured at baseline and after six months of intervention. Vitamin D levels (ng/mL) increased in both groups from baseline (vitamin D vs. placebo: 12.2±5.9 vs. 3.9±3.5, mean±SD). FPG (mmol/L) significantly decreased in the Vitamin D group (before vs. after: 5.9±0.6 vs. 5.5±0.7, P=0.016, mean±SD), whereas HbA1C (%) and hs- CRP (mg/L) significantly increased in the placebo group (before vs. after- HbA1C: 5.8±0.3 vs. 6.0±0.4, P<0.001; hs-CRP: 5.0±4.4 vs. 5.6±4.9, P=0.039, mean±SD). Percent changes in glycemic status, HOMA-IR, and hs-CRP were statistically similar between the groups. Our study failed to demonstrate the positive effects of vitamin D supplementation on reducing glucose, insulin resistance, or inflammatory marker in prediabetic adult patients with hypovitaminosis D.\u0000BSMMU J 2022; 15(3): 167-174","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47388493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i3.62958
Md Ahad Murshid, A. M. Hossain, M. A. Rahman, Shamim Ahmed, S. Islam, R. Chakrabortty
In this cross-sectional study from October 2020 to September 2021, pulmonary function was assessed in 40 (24 severe and 16 non-severe) post- COVID-19 patients at three months following hospital discharge by convenient sampling in post-COVID follow-up clinic at Department of Respiratory Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka. Among 40 subjects, 17 (42.5%) had restrictive defect, 1 (2.5%) had obstructive defect and 22 (55%) had normal spirometry. There was reduced total lung capacity (TLC) in 17 (42.5%) subjects and reduced diffusing lung capacity for carbon monoxide (DLCO) in 20 (50%) subjects. Mean six minutes walking distance (6MWD) was low (387.6±99.4 meters). Oxygen desaturation was in 4 (10%) cases. Frequency of restrictive defect was higher in severe than non-severe subjects (54.2% vs. 25%). Reduced TLC was in 62.5% of severe and 12.5% of non-severe cases. There was higher frequency of reduced DLCO in severe than non-severe casese (62.5% vs. 31.3%). 6MWD was lower in severe than non-severe group (354.0±134.9 vs. 438.2±51.4 meters, P=0.02). Pulmonary function was found significantly impaired in post-COVID patients which was more prominent in severe disease group. BSMMU J 2022; 15(3): 192-196
{"title":"Assessment of pulmonary function of post-COVID-19 patients of a tertiary hospital at three months following discharge","authors":"Md Ahad Murshid, A. M. Hossain, M. A. Rahman, Shamim Ahmed, S. Islam, R. Chakrabortty","doi":"10.3329/bsmmuj.v15i3.62958","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i3.62958","url":null,"abstract":"In this cross-sectional study from October 2020 to September 2021, pulmonary function was assessed in 40 (24 severe and 16 non-severe) post- COVID-19 patients at three months following hospital discharge by convenient sampling in post-COVID follow-up clinic at Department of Respiratory Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka. Among 40 subjects, 17 (42.5%) had restrictive defect, 1 (2.5%) had obstructive defect and 22 (55%) had normal spirometry. There was reduced total lung capacity (TLC) in 17 (42.5%) subjects and reduced diffusing lung capacity for carbon monoxide (DLCO) in 20 (50%) subjects. Mean six minutes walking distance (6MWD) was low (387.6±99.4 meters). Oxygen desaturation was in 4 (10%) cases. Frequency of restrictive defect was higher in severe than non-severe subjects (54.2% vs. 25%). Reduced TLC was in 62.5% of severe and 12.5% of non-severe cases. There was higher frequency of reduced DLCO in severe than non-severe casese (62.5% vs. 31.3%). 6MWD was lower in severe than non-severe group (354.0±134.9 vs. 438.2±51.4 meters, P=0.02). Pulmonary function was found significantly impaired in post-COVID patients which was more prominent in severe disease group.\u0000BSMMU J 2022; 15(3): 192-196","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47596640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i3.63445
M. J. Shams, Sajib Kumar Talukdhar, Mst Hasnahena Nargis, M. Ghosh, Md Masudur Rahman, Md Zakir Hasan, S. Alam, Md. Zillur Rahman Bhuiyan
Chemotherapy is the primary therapeutic choice for advanced gastric cancer. The goal of this study was to assess the effectiveness and toxicity of the cisplatin-capecitabine regimen versus the oxaliplatin-capecitabine regimen in treating advanced gastric cancer. Between February 2021 and March 2022, this quasi-experimental study was conducted on 64 advanced gastric cancer patients. Purposive sampling was used to include those who met the inclusion criteria and distributed them evenly between the two arms. Arm A got an injection of cisplatin (80 mg/m2 on day 1) with oral capecitabine (1000 mg/m2 b.i.d. on days 1–14), whereas arm B received an injection of oxaliplatin (130 mg/m2 on day 1) plus oral capecitabine (1000 mg/m2 b.i.d. on days 1–14), every 3 weeks for 6 cycles. A final check-up was done at 12 weeks after the treatment. In arm A, 18 (56.2%) patients exhibited partial response compared to 15 (46.9%) in arm B. Stable diseases were also reported in both arms (18.8% in arm A and 21.9% in arm B). There were 8 (25.0%) cases of progressive disease in arm A and 10 (31.2%) cases in Arm B. The median progression-free survival in arms A (5.6 months) was almost similar to arm B (5.9 months). The most prevalent toxicities in both arms were vomiting, diarrhea, anemia, neutropenia, oral mucositis, paresthesia, handfoot syndrome, and renal toxicity. There were no statistically significant variations in outcomes between the two arms. In conclusion, the cisplatincapecitabine regimen is as effective as the oxaliplatin-capecitabine regimen in advanced gastric cancer. BSMMU J 2022; 15(3): 180-185
{"title":"Comparative outcome of cisplatin-capecitabine regimen with oxaliplatincapecitabine regimen in advanced gastric carcinoma: a quasi-experimental study","authors":"M. J. Shams, Sajib Kumar Talukdhar, Mst Hasnahena Nargis, M. Ghosh, Md Masudur Rahman, Md Zakir Hasan, S. Alam, Md. Zillur Rahman Bhuiyan","doi":"10.3329/bsmmuj.v15i3.63445","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i3.63445","url":null,"abstract":"Chemotherapy is the primary therapeutic choice for advanced gastric cancer. The goal of this study was to assess the effectiveness and toxicity of the cisplatin-capecitabine regimen versus the oxaliplatin-capecitabine regimen in treating advanced gastric cancer. Between February 2021 and March 2022, this quasi-experimental study was conducted on 64 advanced gastric cancer patients. Purposive sampling was used to include those who met the inclusion criteria and distributed them evenly between the two arms. Arm A got an injection of cisplatin (80 mg/m2 on day 1) with oral capecitabine (1000 mg/m2 b.i.d. on days 1–14), whereas arm B received an injection of oxaliplatin (130 mg/m2 on day 1) plus oral capecitabine (1000 mg/m2 b.i.d. on days 1–14), every 3 weeks for 6 cycles. A final check-up was done at 12 weeks after the treatment. In arm A, 18 (56.2%) patients exhibited partial response compared to 15 (46.9%) in arm B. Stable diseases were also reported in both arms (18.8% in arm A and 21.9% in arm B). There were 8 (25.0%) cases of progressive disease in arm A and 10 (31.2%) cases in Arm B. The median progression-free survival in arms A (5.6 months) was almost similar to arm B (5.9 months). The most prevalent toxicities in both arms were vomiting, diarrhea, anemia, neutropenia, oral mucositis, paresthesia, handfoot syndrome, and renal toxicity. There were no statistically significant variations in outcomes between the two arms. In conclusion, the cisplatincapecitabine regimen is as effective as the oxaliplatin-capecitabine regimen in advanced gastric cancer.\u0000BSMMU J 2022; 15(3): 180-185","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42542319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i2.60861
Md Ehteshamul Choudhury, M. Hossen, A. Z. Chowdhury, Indrojit Kumar Kundu, Mohammad Suman Sutar, Obaidur Rahman, Md Yakub Ali, Md. Sayedul Islam
Olecranon fracture is relatively common and accounts for approximately 40% of elbow joint fractures. It is an intra-articular fracture, so the aim of treatment is anatomic reduction, stable fixation and early mobilization. Tension band wiring (TBW) may be a popular and widely practiced method using either single knot or two knots techniques. Now two knots TBW are widely accepted by AO foundation as well as various countries. But single knot technique is commonly practiced in Bangladesh. The present study was done to see the clinical, radiologi- cal and functional outcome of two knots Tension band wiring (TBW) in Mayo type IIA olecranon fracture. This observational study was carried out by the National Institute of Traumatology and Orthopaedic Rehabilitation (NITOR), Dhaka, Bangladesh. A total of 32 patients with Mayo type IIA olecranon fractures were treated with two knots TBW, out of which 30 cases had completed at least 24 weeks of follow-up and analyzed for final functional outcome with Mayo Elbow Performance Score (MEPS). The mean age was 32.58±14.21 years and the male to female ratio was 2.6:1. The mean radiological union time was 8.15±2.25 weeks. In 6 (18.75%) cases, it took 6 weeks, in 18 (56.25%) cases, it took 8 weeks and in 8 (25.0%), it took 12 weeks. Complications were found in 21.9% of patients. At first follow-up after the operation showed that 21 (70.0%) had moderate pain and the final follow-up showed 21 (70.0%) had no pain. The mean arc of elbow motion at first follow-up and final follow-up were 61.090±16.2340 and 122.820±15.2870, respectively. The mean functional score at 1st follow-up was 6.75±5.63 and the last follow-up was 24.76±1.69. The mean total Mayo Elbow Performance Score (MEPS) scores at first and last follow-up were 40.65±14.48 and 94.13±8.35, respectively. Excellent and good outcomes were found among 21 (70.0%) and 9 (30.0%) patients, respectively. Two knots TBW technique is safe regarding overall complication rate, pain status and excellent outcome. BSMMU J 2022; 15(2): 90-95
{"title":"Outcome of two knots tension band wiring (TBW) in Mayo type-IIA olecranon fracture","authors":"Md Ehteshamul Choudhury, M. Hossen, A. Z. Chowdhury, Indrojit Kumar Kundu, Mohammad Suman Sutar, Obaidur Rahman, Md Yakub Ali, Md. Sayedul Islam","doi":"10.3329/bsmmuj.v15i2.60861","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i2.60861","url":null,"abstract":"Olecranon fracture is relatively common and accounts for approximately 40% of elbow joint fractures. It is an intra-articular fracture, so the aim of treatment is anatomic reduction, stable fixation and early mobilization. Tension band wiring (TBW) may be a popular and widely practiced method using either single knot or two knots techniques. Now two knots TBW are widely accepted by AO foundation as well as various countries. But single knot technique is commonly practiced in Bangladesh. The present study was done to see the clinical, radiologi- cal and functional outcome of two knots Tension band wiring (TBW) in Mayo type IIA olecranon fracture. This observational study was carried out by the National Institute of Traumatology and Orthopaedic Rehabilitation (NITOR), Dhaka, Bangladesh. A total of 32 patients with Mayo type IIA olecranon fractures were treated with two knots TBW, out of which 30 cases had completed at least 24 weeks of follow-up and analyzed for final functional outcome with Mayo Elbow Performance Score (MEPS). The mean age was 32.58±14.21 years and the male to female ratio was 2.6:1. The mean radiological union time was 8.15±2.25 weeks. In 6 (18.75%) cases, it took 6 weeks, in 18 (56.25%) cases, it took 8 weeks and in 8 (25.0%), it took 12 weeks. Complications were found in 21.9% of patients. At first follow-up after the operation showed that 21 (70.0%) had moderate pain and the final follow-up showed 21 (70.0%) had no pain. The mean arc of elbow motion at first follow-up and final follow-up were 61.090±16.2340 and 122.820±15.2870, respectively. The mean functional score at 1st follow-up was 6.75±5.63 and the last follow-up was 24.76±1.69. The mean total Mayo Elbow Performance Score (MEPS) scores at first and last follow-up were 40.65±14.48 and 94.13±8.35, respectively. Excellent and good outcomes were found among 21 (70.0%) and 9 (30.0%) patients, respectively. Two knots TBW technique is safe regarding overall complication rate, pain status and excellent outcome.\u0000BSMMU J 2022; 15(2): 90-95","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41420789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i2.60868
Bhajan Kumar Saha, Md. Habibur Rahman, T. S. Hossain, Faruk Hossain, K. Ghosh
A kidney transplant (KT) offers a significant survival benefit and is the only curative treatment for patients with ESRD. Infectious complications are still a leading cause of morbidity and death among transplant patients. This study aimed to assess the organisms and risk factors responsible for urinary tract and surgical site infection in allograft live-related renal transplant recipients during the early post-transplant period. This observational follow-up study was conducted among 20 purposively selected patients who underwent renal allograft transplant surgery from July 2019 to December 2020 in the Department of Urology, BSMMU, Dhaka. Patients with a history of renal transplant recipients or congenital renal anomalies and any urological malignancy were excluded from the study. After kidney transplant, UTI developed in 6 (30%) renal transplant recipients where all were complicated types and occurred between 10 to 14 days postoperatively. UTI was caused by E. coli in 3 (15%) patients, while Klebsiella and Enterococci were causative organisms for 1 (5%) and 2 (10.0%) patients, respectively. SSI developed in 3 (15%) renal transplant recipients where two were superficial, and one was deep. SSI occurred between 5-8 days postoperatively. SSI was caused by S. aureus in 2 (10%) patients and Pseudomonas in 1 (5%) patient. UTI was significantly more in older patients and the patients with a longer duration of catheterization. Older patients and overweight patients had significantly higher rates of SSI. In total, 33% of the recipient during the early hospital stay developed UTIs, all of which were complicated types. SSI developed in 15%, where 2/3rd was superficial and 1/3rd was deep. Older age with a longer duration of catheterization and DJ stent was found to be associated with the occurrence of UTI, while older age and high BMI were related to the event of SSI. BSMMU J 2022; 15(2): 127-131
{"title":"Pattern of urinary tract and surgical site infection in allograft renal recipient during early postoperative period","authors":"Bhajan Kumar Saha, Md. Habibur Rahman, T. S. Hossain, Faruk Hossain, K. Ghosh","doi":"10.3329/bsmmuj.v15i2.60868","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i2.60868","url":null,"abstract":"A kidney transplant (KT) offers a significant survival benefit and is the only curative treatment for patients with ESRD. Infectious complications are still a leading cause of morbidity and death among transplant patients. This study aimed to assess the organisms and risk factors responsible for urinary tract and surgical site infection in allograft live-related renal transplant recipients during the early post-transplant period. This observational follow-up study was conducted among 20 purposively selected patients who underwent renal allograft transplant surgery from July 2019 to December 2020 in the Department of Urology, BSMMU, Dhaka. Patients with a history of renal transplant recipients or congenital renal anomalies and any urological malignancy were excluded from the study. After kidney transplant, UTI developed in 6 (30%) renal transplant recipients where all were complicated types and occurred between 10 to 14 days postoperatively. UTI was caused by E. coli in 3 (15%) patients, while Klebsiella and Enterococci were causative organisms for 1 (5%) and 2 (10.0%) patients, respectively. SSI developed in 3 (15%) renal transplant recipients where two were superficial, and one was deep. SSI occurred between 5-8 days postoperatively. SSI was caused by S. aureus in 2 (10%) patients and Pseudomonas in 1 (5%) patient. UTI was significantly more in older patients and the patients with a longer duration of catheterization. Older patients and overweight patients had significantly higher rates of SSI. In total, 33% of the recipient during the early hospital stay developed UTIs, all of which were complicated types. SSI developed in 15%, where 2/3rd was superficial and 1/3rd was deep. Older age with a longer duration of catheterization and DJ stent was found to be associated with the occurrence of UTI, while older age and high BMI were related to the event of SSI.\u0000BSMMU J 2022; 15(2): 127-131","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44260977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i3.63038
Afsana Sharmin Anika, Md. Abdul Bari, S. Alam, Md. Nazir Uddin Mollah, Md. Zillur Rahman Bhuiyan, Sadia Sharmin, Rokaya Sultana Ruma, Md. Hafizul Islam, Sajib Kumar Talukdhar
Cervical cancer is one of the most prevalent gynecological cancers in women in Bangladesh. The objective of this study was to assess the clincoepidemiological association with the histology of locally advanced cervical cancer. We have done this observational study in the department of Clinical Oncology at Bangabandhu Sheikh Mujib Medical University from July to December 2019. Sixty-six biopsy-proven locally advanced (stage IIB to IVA) squamous cell carcinoma of uterine cervix were included in this study. The mean age of patients at diagnosis was 48.5 (±8.6) years. Commonly observed epidemiological characteristics of locally advanced carcinoma cervix were illiteracy (46.9%), oral contraceptive use (62.1%), multi para (78.7%) and early marriage (74.2%). Most frequent clinical presentation was post-coital bleeding (37.87%). Most patients presented in stage IIB (65.1%). The association of the stages of the disease with age, parity, oral contraceptive use, age at marriage and clinical presentation were statistically nonsignificant, whereas illiteracy was statistically significant. Most women had poor awareness regarding their need for routine check-up and screening as indicated by the late medical care seeking. Social stigma might have played some role. Relevant programmes should create awareness among women, especially those with socioeconomic deprivation. BSMMU J 2022; 15(3): 175-179
{"title":"Association of clinico-epidemiological features with locally advanced stage of cervical cancer patients presenting at Bangabandhu Sheikh Mujib Medical University, Bangladesh","authors":"Afsana Sharmin Anika, Md. Abdul Bari, S. Alam, Md. Nazir Uddin Mollah, Md. Zillur Rahman Bhuiyan, Sadia Sharmin, Rokaya Sultana Ruma, Md. Hafizul Islam, Sajib Kumar Talukdhar","doi":"10.3329/bsmmuj.v15i3.63038","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i3.63038","url":null,"abstract":"Cervical cancer is one of the most prevalent gynecological cancers in women in Bangladesh. The objective of this study was to assess the clincoepidemiological association with the histology of locally advanced cervical cancer. We have done this observational study in the department of Clinical Oncology at Bangabandhu Sheikh Mujib Medical University from July to December 2019. Sixty-six biopsy-proven locally advanced (stage IIB to IVA) squamous cell carcinoma of uterine cervix were included in this study. The mean age of patients at diagnosis was 48.5 (±8.6) years. Commonly observed epidemiological characteristics of locally advanced carcinoma cervix were illiteracy (46.9%), oral contraceptive use (62.1%), multi para (78.7%) and early marriage (74.2%). Most frequent clinical presentation was post-coital bleeding (37.87%). Most patients presented in stage IIB (65.1%). The association of the stages of the disease with age, parity, oral contraceptive use, age at marriage and clinical presentation were statistically nonsignificant, whereas illiteracy was statistically significant. Most women had poor awareness regarding their need for routine check-up and screening as indicated by the late medical care seeking. Social stigma might have played some role. Relevant programmes should create awareness among women, especially those with socioeconomic deprivation.\u0000BSMMU J 2022; 15(3): 175-179","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41820109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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