Pub Date : 2023-02-05DOI: 10.3329/bsmmuj.v15i4.63893
Md. Sahidul Islam, M. S. Islam, R. Chowdhury, M. M. Zaman
Impaired growth and development experienced by children, referred to as stunting, is a major impediment to human development. Although the Bangladesh economy has experienced high growth in recent decades, malnutrition still remains a public health problem. This study assesses the prevalence and risk factors associated with stunting among children under-five in Bangladesh. This analysis uses data from the Bangladesh Demographic and Health Survey 2014, a community-based cross-sectional study. A total of 6,965 children were enrolled in the study. The prevalence of stunting was 36.5% [95% confidence interval (CI): 34.8-38.3%] and 40.2% [95% CI: 37.4-43.1%] for children aged 0-59 months and 0-23 months respectively. Multivariate logistic regression revealed that the significant factors for stunting for children aged 0-59 months and 0-23 months were maternal working status, mother education, mothers age at childbirth, birth order, delivery mode, receiving antenatal clinic visit, media habits, perceived size of child at birth, child sex, children having had diarrhea in last two weeks, wealth and geographical region. In order to meet the nutrition indicators under zero hunger sustainable development goal and 2025 target of World Health Assembly, policy interventions are needed to reduce stunting specially focusing on eastern region of Bangladesh. Bangabandhu Sheikh Mujib Medical University Journal 2022;15(4):22-31
{"title":"Stunting and its associated factors in under-five children: evidence from Bangladesh Demographic and Health Survey 2014","authors":"Md. Sahidul Islam, M. S. Islam, R. Chowdhury, M. M. Zaman","doi":"10.3329/bsmmuj.v15i4.63893","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i4.63893","url":null,"abstract":"Impaired growth and development experienced by children, referred to as stunting, is a major impediment to human development. Although the Bangladesh economy has experienced high growth in recent decades, malnutrition still remains a public health problem. This study assesses the prevalence and risk factors associated with stunting among children under-five in Bangladesh. This analysis uses data from the Bangladesh Demographic and Health Survey 2014, a community-based cross-sectional study. A total of 6,965 children were enrolled in the study. The prevalence of stunting was 36.5% [95% confidence interval (CI): 34.8-38.3%] and 40.2% [95% CI: 37.4-43.1%] for children aged 0-59 months and 0-23 months respectively. Multivariate logistic regression revealed that the significant factors for stunting for children aged 0-59 months and 0-23 months were maternal working status, mother education, mothers age at childbirth, birth order, delivery mode, receiving antenatal clinic visit, media habits, perceived size of child at birth, child sex, children having had diarrhea in last two weeks, wealth and geographical region. In order to meet the nutrition indicators under zero hunger sustainable development goal and 2025 target of World Health Assembly, policy interventions are needed to reduce stunting specially focusing on eastern region of Bangladesh.\u0000Bangabandhu Sheikh Mujib Medical University Journal 2022;15(4):22-31","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46051385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-05DOI: 10.3329/bsmmuj.v15i4.64154
L. Banu, M. Masum, Susmita Rahman, Sultana Mahbuba, Mahmud Hosasain, M. J. Hosen, Toufiq Ahmed, S. Banerjee, Dipal Krisna Adhikary, S. Habib, G. Sultana, M. Islam
Hypertrophic cardiomyopathy (HCM) is the most prevalent genetic cardiomyopathy characterized by sudden cardiac death. HCM is caused by the mutation in several genes that encode sarcomere proteins. Beta-Myosin Heavy Chain (β-MHC) gene is the one of the most mutated genes responsible for HCM. Studies on mutation spectrum of β-MHC gene are lacking in the Asian population including Bangladeshi patients. This study was intended to mutational analysis of β-MHC gene in Bangladeshi HCM patients. A cross-sectional study was conducted for mutation analysis of the β-MHC gene on 70 Bengali Bangladeshi HCM probands using nextgeneration sequencing at the Genetic Research Lab of Bangabandhu Sheikh Mujib Medical University. Structural and functional impact of the mutations were further analyzed by in-silico process. Thirty-nine nucleotide variants were found in both exonic (36%, n= 14) and intronic regions (64%, n=25) of β-MHC gene. We found 14 missense mutations, including the p.Glu965Lys, p.Arg941Pro, p.Lys940Met, p.Glu935Lys, and p.Met922Lys that are associated with inherited HCM. Most variants were heterozygous and one homozygous (p.Val919Leu) was found. The variant with most evidence of causing the disease was p.Glu935Lys. Among the missense variants, nine were not noted in ClinVar, dbSNP, GenomeAD databases. These unreported variants located between myosin head and tail domains might be novel mutations for Bangladeshi population. We found nine novel variants in the β-MHC gene. Findings of this research will help to developing a genetic database of HCM for early diagnosis and proper management of HCM patients in Bangladesh. Bangabandhu Sheikh Mujib Medical University Journal 2022;15(4):2-7
{"title":"Mutation in the beta-myosin heavy chain (β-MHC) gene of adult Bangladeshi patients with hypertrophic cardiomyopathy","authors":"L. Banu, M. Masum, Susmita Rahman, Sultana Mahbuba, Mahmud Hosasain, M. J. Hosen, Toufiq Ahmed, S. Banerjee, Dipal Krisna Adhikary, S. Habib, G. Sultana, M. Islam","doi":"10.3329/bsmmuj.v15i4.64154","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i4.64154","url":null,"abstract":"Hypertrophic cardiomyopathy (HCM) is the most prevalent genetic cardiomyopathy characterized by sudden cardiac death. HCM is caused by the mutation in several genes that encode sarcomere proteins. Beta-Myosin Heavy Chain (β-MHC) gene is the one of the most mutated genes responsible for HCM. Studies on mutation spectrum of β-MHC gene are lacking in the Asian population including Bangladeshi patients. This study was intended to mutational analysis of β-MHC gene in Bangladeshi HCM patients. A cross-sectional study was conducted for mutation analysis of the β-MHC gene on 70 Bengali Bangladeshi HCM probands using nextgeneration sequencing at the Genetic Research Lab of Bangabandhu Sheikh Mujib Medical University. Structural and functional impact of the mutations were further analyzed by in-silico process. Thirty-nine nucleotide variants were found in both exonic (36%, n= 14) and intronic regions (64%, n=25) of β-MHC gene. We found 14 missense mutations, including the p.Glu965Lys, p.Arg941Pro, p.Lys940Met, p.Glu935Lys, and p.Met922Lys that are associated with inherited HCM. Most variants were heterozygous and one homozygous (p.Val919Leu) was found. The variant with most evidence of causing the disease was p.Glu935Lys. Among the missense variants, nine were not noted in ClinVar, dbSNP, GenomeAD databases. These unreported variants located between myosin head and tail domains might be novel mutations for Bangladeshi population. We found nine novel variants in the β-MHC gene. Findings of this research will help to developing a genetic database of HCM for early diagnosis and proper management of HCM patients in Bangladesh.\u0000Bangabandhu Sheikh Mujib Medical University Journal 2022;15(4):2-7","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47988084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i3.62939
M. Zaman, Ananna Zaman, Palash Chandra Banik, S. Numan, Md. Sadekul Islam, J. Ahmed, S. Choudhury, Tanvir Turin Choudhury
Tobacco use in Bangladesh has been high, but there is no report on community-level intervention to reduce tobacco use. The aim of this article is to report the experience of eight years of community intervention to reduce tobacco use in a rural area of Bangladesh. We have done four householdbased surveys (2006, 2008, 2012, and 2014) in Ekhlaspur village of Chandpur district. One man and one woman aged ≥18 years from each of 600 households were selected for each survey randomly to monitor tobacco use in this village concomitant with community interventions. The intervention package included yard meetings, health facility-based counselling, observance of the world no-tobacco days, and periodic lectures in schools. Chi-square for linear trend analysis was done to examine declining trends of prevalence of tobacco use. There were 953 to 1015 participants, approximately half being men in each survey. Their mean age was 44 to 45 years in all surveys. A decline in tobacco use has been observed from 58.8 in 2006 to 43.4% in 2014 (Ptrend=0.000). There has not been any perceivable change in smoking in women because it was either zero or close to zero across surveys. A similar trend was observed in age groups, educational achievements, and hypertension (Ptrend=0.000). Smoking in men declined from 58.3 to 35.2% (Ptrend= 0.000). Community interventions in a sustainable manner can reduce tobacco use in rural communities of Bangladesh. BSMMU J 2022; 15(3): 157-161
{"title":"Declining trend of tobacco use in a rural community of Bangladesh: Results of eight years of community interventions","authors":"M. Zaman, Ananna Zaman, Palash Chandra Banik, S. Numan, Md. Sadekul Islam, J. Ahmed, S. Choudhury, Tanvir Turin Choudhury","doi":"10.3329/bsmmuj.v15i3.62939","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i3.62939","url":null,"abstract":"Tobacco use in Bangladesh has been high, but there is no report on community-level intervention to reduce tobacco use. The aim of this article is to report the experience of eight years of community intervention to reduce tobacco use in a rural area of Bangladesh. We have done four householdbased surveys (2006, 2008, 2012, and 2014) in Ekhlaspur village of Chandpur district. One man and one woman aged ≥18 years from each of 600 households were selected for each survey randomly to monitor tobacco use in this village concomitant with community interventions. The intervention package included yard meetings, health facility-based counselling, observance of the world no-tobacco days, and periodic lectures in schools. Chi-square for linear trend analysis was done to examine declining trends of prevalence of tobacco use. There were 953 to 1015 participants, approximately half being men in each survey. Their mean age was 44 to 45 years in all surveys. A decline in tobacco use has been observed from 58.8 in 2006 to 43.4% in 2014 (Ptrend=0.000). There has not been any perceivable change in smoking in women because it was either zero or close to zero across surveys. A similar trend was observed in age groups, educational achievements, and hypertension (Ptrend=0.000). Smoking in men declined from 58.3 to 35.2% (Ptrend= 0.000). Community interventions in a sustainable manner can reduce tobacco use in rural communities of Bangladesh.\u0000BSMMU J 2022; 15(3): 157-161","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49307631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i2.60860
Md Hasanul Haque, A. Huq, Nigar Sultana, Tanvir Ahmed, Abirvab Naha, Md. Abdur Razzak, Mohammad Jahidur Rahman Khan, Md Jaber Al Sayied
Chronic otitis media (COM) is a vital cause of deafness worldwide. Myringoplasty is one of the best treatment options for COM (inactive mucosal variety). Temporalis Fascia is the most favored grafting material among various autografts, which can be used as dry or wet depending upon the Surgeon's choice. The main focus of this study is to compare the graft uptake rate by using dry and wet temporalis fascia by underlay technique. This cross-sectional comparative study was directed from January 2018 to June 2019 at the Department of Otolaryngology-Head & Neck Surgery of BSMMU, Dhaka. All consecutive cases of COM (inactive mucosal) who underwent surgery were randomly assigned either into the dry (Group-A) or wet temporalis fascia group (Group-B). At 12 weeks follow-up, the density of graft failure (4.4% vs. 8.8%) and retraction pocket (0% vs. 2.2%) were higher in the wet procedure. However anterior blunting (2.2% vs. 2.2%) were the same in both procedures, and medialization (2.2% vs. 0%) were more in the dry procedure. Air Bone Gap (ABG) improved significantly in both groups following operation but reduced in Group-A more significantly than Group-B. On the other hand, there was no remarkable difference in successful graft uptake between the groups (Dry group-91.12% vs. wet group-84.44%, p>0.05). No graft material is superior to others in terms of graft uptake. BSMMU J 2022; 15(2): 84-89
慢性中耳炎(COM)是世界范围内耳聋的一个重要原因。鼓膜成形术是COM(无活性粘膜病变)的最佳治疗选择之一。颞筋膜是各种自体移植物中最受欢迎的移植材料，根据外科医生的选择，它可以干式或湿式使用。本研究的主要重点是比较干法和湿法颞筋膜移植术的移植物吸收率。这项横断面比较研究于2018年1月至2019年6月在达卡BSMMU耳鼻喉头颈外科进行。所有连续接受手术的COM(失活粘膜)病例随机分为干性(a组)或湿性颞筋膜组(b组)。在12周的随访中，湿法移植失败的密度(4.4%对8.8%)和回缩袋(0%对2.2%)更高。然而，前路钝化(2.2% vs. 2.2%)在两种手术中是相同的，中间化(2.2% vs. 0%)在干式手术中更多。两组术后空气骨间隙(ABG)均有明显改善，但a组明显低于b组。另一方面，两组间嫁接成功率无显著差异(干组91.12%，湿组84.44%，p < 0.05)。在移植物吸收方面，没有一种移植物材料优于其他材料。Bsmmu j 2022;15 (2): 84 - 89
{"title":"Evaluation of graft uptake in underlay myringoplasty using dry and wet temporalis fascia graft","authors":"Md Hasanul Haque, A. Huq, Nigar Sultana, Tanvir Ahmed, Abirvab Naha, Md. Abdur Razzak, Mohammad Jahidur Rahman Khan, Md Jaber Al Sayied","doi":"10.3329/bsmmuj.v15i2.60860","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i2.60860","url":null,"abstract":"Chronic otitis media (COM) is a vital cause of deafness worldwide. Myringoplasty is one of the best treatment options for COM (inactive mucosal variety). Temporalis Fascia is the most favored grafting material among various autografts, which can be used as dry or wet depending upon the Surgeon's choice. The main focus of this study is to compare the graft uptake rate by using dry and wet temporalis fascia by underlay technique. This cross-sectional comparative study was directed from January 2018 to June 2019 at the Department of Otolaryngology-Head & Neck Surgery of BSMMU, Dhaka. All consecutive cases of COM (inactive mucosal) who underwent surgery were randomly assigned either into the dry (Group-A) or wet temporalis fascia group (Group-B). At 12 weeks follow-up, the density of graft failure (4.4% vs. 8.8%) and retraction pocket (0% vs. 2.2%) were higher in the wet procedure. However anterior blunting (2.2% vs. 2.2%) were the same in both procedures, and medialization (2.2% vs. 0%) were more in the dry procedure. Air Bone Gap (ABG) improved significantly in both groups following operation but reduced in Group-A more significantly than Group-B. On the other hand, there was no remarkable difference in successful graft uptake between the groups (Dry group-91.12% vs. wet group-84.44%, p>0.05). No graft material is superior to others in terms of graft uptake.\u0000BSMMU J 2022; 15(2): 84-89","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41333079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i2.60866
Sarbari Saha, D. Roy, I. Jahan, Mohammad Kamrul Hassan Shabuj, Sadeka Choudhury, M. Mannan, M. Shahidullah, S. Dey
Thrombocytopenia is the commonest hematological abnormality encountered in the neonatal intensive care unit (NICU). This prospective, observational study was conducted among 78 consecutive at-risk neonates admitted in NICU, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from September 2016 to August 2017. Platelet count was measured in all at risk neonates at enrollment and less than 1,50,000/cmm was consiered as the cut off point for determining thrombocytopenia. Platelet count was measured every alternate day till discharge or normalisation of platelet count if the initial platelet count was low. If initial platelet count revealed normal, then the babies were followed up clinically if they develop any further risk condition for developing thrombocytopenia. During the period from enrollment to discharge, if any baby develops thrombocytopenia at any time then baby was defined as thrombocytopenic. Overall 39.7%patients found to be thrombocytopenic among 78 at-risk neonates. Pregnancy induced hypertension (PIH), neonatal sepsis and small for gestational age (SGA), intra uterine growth restriction(IUGR), prematurity, necrotizing enterocolitis (NEC) were significantly associated with thrombocytopenia. Sepsis and NEC were found to be independent risk factor for thrombocytopenia. Regarding outcome, length of hospital stay was significantly more in thrombocytopenic patients than non-thrombocytopenic patients. Death rate was also higher in thrombocytopenic patients in comparison to non-thrombocytopenic patients. BSMMU J 2022; 15(2): 115-120
{"title":"Frequency and outcome of thrombocytopenia in neonates who are at risk of developing thrombocytopenia - a prospective observational study","authors":"Sarbari Saha, D. Roy, I. Jahan, Mohammad Kamrul Hassan Shabuj, Sadeka Choudhury, M. Mannan, M. Shahidullah, S. Dey","doi":"10.3329/bsmmuj.v15i2.60866","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i2.60866","url":null,"abstract":"Thrombocytopenia is the commonest hematological abnormality encountered in the neonatal intensive care unit (NICU). This prospective, observational study was conducted among 78 consecutive at-risk neonates admitted in NICU, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from September 2016 to August 2017. Platelet count was measured in all at risk neonates at enrollment and less than 1,50,000/cmm was consiered as the cut off point for determining thrombocytopenia. Platelet count was measured every alternate day till discharge or normalisation of platelet count if the initial platelet count was low. If initial platelet count revealed normal, then the babies were followed up clinically if they develop any further risk condition for developing thrombocytopenia. During the period from enrollment to discharge, if any baby develops thrombocytopenia at any time then baby was defined as thrombocytopenic. Overall 39.7%patients found to be thrombocytopenic among 78 at-risk neonates. Pregnancy induced hypertension (PIH), neonatal sepsis and small for gestational age (SGA), intra uterine growth restriction(IUGR), prematurity, necrotizing enterocolitis (NEC) were significantly associated with thrombocytopenia. Sepsis and NEC were found to be independent risk factor for thrombocytopenia. Regarding outcome, length of hospital stay was significantly more in thrombocytopenic patients than non-thrombocytopenic patients. Death rate was also higher in thrombocytopenic patients in comparison to non-thrombocytopenic patients.\u0000BSMMU J 2022; 15(2): 115-120","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41373054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i2.60871
G. Kundu, Sk Serjina Anwar, Noor-A-Sabah Liza, S. T. Alam, Sanjida Ahmed, Mohammad Arbab Sarker, Meher Nigar Nishi, Sharmina Afrin, M. Quddus
Niemann Pick Disease (NPD) is a rare autosomal recessive lysosomal storage disease characterized by lysosomal lipid storage. The disease is caused by deficiency of enzyme, acid sphingomyelinase (ASM) which leads to accumulation of sphingomyelin & other lipids in reticuloendothelial cells of various organs like liver, spleen, bone marrow, lymph node, brain, nerves and kidney. Four types of the disease have been identified i.e. A, B, C and D. We report a case of Niemann Pick Disease type C. The patient was a 2.5 years female child who presented with developmental regression, recurrent seizures, failure to thrive and hepatospleenomegaly. Bone marrow (BM) aspiration was performed which showed hypercelluler marrow with few fat laden macrophage resembling foam cell that are characteristics of this disease. BSMMU J 2022; 15(2): 141-144
{"title":"Niemann Pick disease: a rare lysosomal storage disease","authors":"G. Kundu, Sk Serjina Anwar, Noor-A-Sabah Liza, S. T. Alam, Sanjida Ahmed, Mohammad Arbab Sarker, Meher Nigar Nishi, Sharmina Afrin, M. Quddus","doi":"10.3329/bsmmuj.v15i2.60871","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i2.60871","url":null,"abstract":"Niemann Pick Disease (NPD) is a rare autosomal recessive lysosomal storage disease characterized by lysosomal lipid storage. The disease is caused by deficiency of enzyme, acid sphingomyelinase (ASM) which leads to accumulation of sphingomyelin & other lipids in reticuloendothelial cells of various organs like liver, spleen, bone marrow, lymph node, brain, nerves and kidney. Four types of the disease have been identified i.e. A, B, C and D. We report a case of Niemann Pick Disease type C. The patient was a 2.5 years female child who presented with developmental regression, recurrent seizures, failure to thrive and hepatospleenomegaly. Bone marrow (BM) aspiration was performed which showed hypercelluler marrow with few fat laden macrophage resembling foam cell that are characteristics of this disease.\u0000BSMMU J 2022; 15(2): 141-144","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48435211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i3.62930
A. H. Z. H. Shikder, Muhiuddin Mahmud Galib, Fahmida Siddiqua, Dilara Jahan
Odontoma are the most common benign odontogenic tumor of epithelial and mesenchymal origin. Usually a conservative approach is the standard treatment protocol for this. Odontoma associated with unerupted tooth andodontogenic cyst aggravates the existing condition. Generally, expansible nature of cystic lesions require surgical excision which is different from isolated non-symptomatic odontomas that can be monitored by periodic radiological examination. There is inadequate evidence on the presence of odontoma-associated cystic lesions in the oral cavity. Therefore, the present case report is aimed at describing the diagnostic clinical, radiological, and histological features together with the surgical management of a dentigerous cyst associated with a compound odontoma. The lesion was surgically removed. No recurrence was observed after 12 months of follow-up. BSMMU J 2022; 15(3): 201-203
{"title":"A 15-year-old boy with an unerupted tooth enclosed by dentigerous cyst associated with odontome","authors":"A. H. Z. H. Shikder, Muhiuddin Mahmud Galib, Fahmida Siddiqua, Dilara Jahan","doi":"10.3329/bsmmuj.v15i3.62930","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i3.62930","url":null,"abstract":"Odontoma are the most common benign odontogenic tumor of epithelial and mesenchymal origin. Usually a conservative approach is the standard treatment protocol for this. Odontoma associated with unerupted tooth andodontogenic cyst aggravates the existing condition. Generally, expansible nature of cystic lesions require surgical excision which is different from isolated non-symptomatic odontomas that can be monitored by periodic radiological examination. There is inadequate evidence on the presence of odontoma-associated cystic lesions in the oral cavity. Therefore, the present case report is aimed at describing the diagnostic clinical, radiological, and histological features together with the surgical management of a dentigerous cyst associated with a compound odontoma. The lesion was surgically removed. No recurrence was observed after 12 months of follow-up.\u0000BSMMU J 2022; 15(3): 201-203 ","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41555432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i2.60863
Tasmia Islam, S. G. Banu, B. P. Dey, M. M. Rahman, Papiya Rahman, Ummey Salma Shabnam, Syeeda Shiraj Um Mahmuda
Hirschsprung disease is one of the most common and problematic infancy and childhood maladies. Early and accurate diagnosis is a fundamental step in proper management and prevention of complications. The most reliable method for diagnosis is the histopathological analysis of colorectal biopsies and the typical finding of Hirschsprung disease is the absence of ganglion cells. Toluidine blue stain can act as a double check along with conventional H&E stain for ganglion cell detection. Neuron-specific enolase is an immune-histochemical marker that can also aid in better identifying ganglion cells, especially for small and immature ones. This study aimed to evaluate Toluidine blue stain and Neuron specific enolase immunostain along with conventional H&E stain as a panel for the diagnosis of Hirschsprung disease. This cross-sectional study was conducted from September 2019 to August 2021, involving 55 clinically suspected Hirschsprung disease cases. Paraffin blocks of colorectal biopsy samples were collected from the Department of Pathology, BSMMU. Hematoxylin & Eosin, Toluidine blue stain, and Neuron specific enolase immunohistochemical stain for Hirschsprung disease detection were performed on the sections from the paraffin blocks. Then the sections were examined and an evaluation of the stains was done. Statistical analysis was performed on the tabulated data by chi-square test. Among 55 cases, conventional H&E stain detected ganglion cells in 31 cases, that is 56.4%. Later, Toluidine blue stain and Neuron specific enolase immu- nohistochemical stain detected ganglion cells in 35 cases, that is 63.6%. So, these two addition- al stains were able to detect ganglion cells in four more cases compared to conventional H&E stain. In conclusion, conventional H&E stain, Toluidine blue stain, and NSE immunohisto- chemical stain can improve the diagnostic accuracy of Hirschsprung disease. BSMMU J 2022; 15(2): 102-106
{"title":"Application of toluidine blue stain and neuron specific enolase immunohistochemical stain in the diagnosis of hirschsprung disease","authors":"Tasmia Islam, S. G. Banu, B. P. Dey, M. M. Rahman, Papiya Rahman, Ummey Salma Shabnam, Syeeda Shiraj Um Mahmuda","doi":"10.3329/bsmmuj.v15i2.60863","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i2.60863","url":null,"abstract":"Hirschsprung disease is one of the most common and problematic infancy and childhood maladies. Early and accurate diagnosis is a fundamental step in proper management and prevention of complications. The most reliable method for diagnosis is the histopathological analysis of colorectal biopsies and the typical finding of Hirschsprung disease is the absence of ganglion cells. Toluidine blue stain can act as a double check along with conventional H&E stain for ganglion cell detection. Neuron-specific enolase is an immune-histochemical marker that can also aid in better identifying ganglion cells, especially for small and immature ones. This study aimed to evaluate Toluidine blue stain and Neuron specific enolase immunostain along with conventional H&E stain as a panel for the diagnosis of Hirschsprung disease. This cross-sectional study was conducted from September 2019 to August 2021, involving 55 clinically suspected Hirschsprung disease cases. Paraffin blocks of colorectal biopsy samples were collected from the Department of Pathology, BSMMU. Hematoxylin & Eosin, Toluidine blue stain, and Neuron specific enolase immunohistochemical stain for Hirschsprung disease detection were performed on the sections from the paraffin blocks. Then the sections were examined and an evaluation of the stains was done. Statistical analysis was performed on the tabulated data by chi-square test. Among 55 cases, conventional H&E stain detected ganglion cells in 31 cases, that is 56.4%. Later, Toluidine blue stain and Neuron specific enolase immu- nohistochemical stain detected ganglion cells in 35 cases, that is 63.6%. So, these two addition- al stains were able to detect ganglion cells in four more cases compared to conventional H&E stain. In conclusion, conventional H&E stain, Toluidine blue stain, and NSE immunohisto- chemical stain can improve the diagnostic accuracy of Hirschsprung disease.\u0000BSMMU J 2022; 15(2): 102-106","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43563685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i3.62929
Samira Mahjabeen, S. Selim, M. Mustari
Impact of gestational diabetes mellitus (GDM) on the coagulation system still remains unclear and there is limited data available regarding haemostatic changes in GDM in Bangladesh. This study was aimed at determining plasmaprothrombin time (PT), activated partial thromboplastin time (APTT) in women with GDM. This cross sectional study encompassed 44 GDM (age: 28.5±3.8 years, BMI: 27.2±4.0kg/m2; mean±SD) and equal number of pregnant women with normal glucose tolerance (NGT) diagnosed on the basis of WHO criterion 2013 at or after 24 weeks of gestation to see PT and APTT. Plasma glucose was measured by glucose oxidase method, PT and APTT by automated coagulation analyzer. There was no statistically significant difference between the GDM and NGT groups for PT (12.3±0.5 vs. 12.2±0.4 sec, mean±SD; P=0.40) or APTT (30.53±1.01 vs. 30.9±4.5 sec, mean±SD; P=0.56). In conclusion, PT and APTT do not differ between women with or without GDM. BSMMU J 2022; 15(3): 146-150
{"title":"Prothrombin time and activated partial thromboplastin time in women with gestational diabetes mellitus","authors":"Samira Mahjabeen, S. Selim, M. Mustari","doi":"10.3329/bsmmuj.v15i3.62929","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i3.62929","url":null,"abstract":"Impact of gestational diabetes mellitus (GDM) on the coagulation system still remains unclear and there is limited data available regarding haemostatic changes in GDM in Bangladesh. This study was aimed at determining plasmaprothrombin time (PT), activated partial thromboplastin time (APTT) in women with GDM. This cross sectional study encompassed 44 GDM (age: 28.5±3.8 years, BMI: 27.2±4.0kg/m2; mean±SD) and equal number of pregnant women with normal glucose tolerance (NGT) diagnosed on the basis of WHO criterion 2013 at or after 24 weeks of gestation to see PT and APTT. Plasma glucose was measured by glucose oxidase method, PT and APTT by automated coagulation analyzer. There was no statistically significant difference between the GDM and NGT groups for PT (12.3±0.5 vs. 12.2±0.4 sec, mean±SD; P=0.40) or APTT (30.53±1.01 vs. 30.9±4.5 sec, mean±SD; P=0.56). In conclusion, PT and APTT do not differ between women with or without GDM.\u0000BSMMU J 2022; 15(3): 146-150","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43828399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-16DOI: 10.3329/bsmmuj.v15i2.60870
P. Das, Mozammal Hosain, Shuvendu Saha, Md Ali Asgor Moral
Abstract not available BSMMU J 2022; 15(2): 138-140
摘要不可用SMMU J 2022；15（2）:138-140
{"title":"A 19-year-old boy with intra-oral discharging sinus for 28 days","authors":"P. Das, Mozammal Hosain, Shuvendu Saha, Md Ali Asgor Moral","doi":"10.3329/bsmmuj.v15i2.60870","DOIUrl":"https://doi.org/10.3329/bsmmuj.v15i2.60870","url":null,"abstract":"Abstract not available\u0000BSMMU J 2022; 15(2): 138-140","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":"122 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41309715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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