Pub Date : 2023-09-03DOI: 10.3329/bsmmcj.v1i1.68414
Md. Shafiq-Ur Rahman, N. N. Biswas, Shabub Alam, Debabrata Roy
Lymphadenopathy is a very common clinical manifestation of many diseases. It is a disease of the lymph nodes, inwhich they are abnormal in size or consistency. The study intends to find out systematically the various pathologicalconditions presenting with enlarged lymph nodes in the neck, also the various nodes of clinical presentations andbehavior of these conditions. This study consisted of 200 consecutive cases and diagnosis was made on the basis ofclinical, fine needle aspiration cytology and histopathological findings. Out of 200 cases in the study 30.0% werenon-specific lymphadenopathy, 47% were tuberculosis, 15% were secondary metastatic lymphadenopathy due toprimary malignant lesion in head-neck region, 5% were primary malignant lesion that is lymphoma (Hodgkins andnon-Hodgkins lymphoma), rest 3% were due to other lesions like Kikuchi's disease, histiocytosis. After swelling inthe neck, pain and fever were the most common presentations. Some patients presented with suppurativelymphadenopathy. In this study, fine needle aspiration cytology was found to be so reliable. Bangabandhu Sheikh Mujib Med. Coll. J. 2022;1(1):29-32
{"title":"A Clinicopathological Study of Cervical Lymphadenopathy","authors":"Md. Shafiq-Ur Rahman, N. N. Biswas, Shabub Alam, Debabrata Roy","doi":"10.3329/bsmmcj.v1i1.68414","DOIUrl":"https://doi.org/10.3329/bsmmcj.v1i1.68414","url":null,"abstract":"Lymphadenopathy is a very common clinical manifestation of many diseases. It is a disease of the lymph nodes, inwhich they are abnormal in size or consistency. The study intends to find out systematically the various pathologicalconditions presenting with enlarged lymph nodes in the neck, also the various nodes of clinical presentations andbehavior of these conditions. This study consisted of 200 consecutive cases and diagnosis was made on the basis ofclinical, fine needle aspiration cytology and histopathological findings. Out of 200 cases in the study 30.0% werenon-specific lymphadenopathy, 47% were tuberculosis, 15% were secondary metastatic lymphadenopathy due toprimary malignant lesion in head-neck region, 5% were primary malignant lesion that is lymphoma (Hodgkins andnon-Hodgkins lymphoma), rest 3% were due to other lesions like Kikuchi's disease, histiocytosis. After swelling inthe neck, pain and fever were the most common presentations. Some patients presented with suppurativelymphadenopathy. In this study, fine needle aspiration cytology was found to be so reliable.\u0000Bangabandhu Sheikh Mujib Med. Coll. J. 2022;1(1):29-32","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80681955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Salt intake knowledge, attitude and behaviour in a rural population of Bangladesh","authors":"Md Abbas Ibn Karim, Rijwan Bhuiyan, Md Nahid Sarkar, Shafia Shaheen","doi":"10.3329/bsmmuj.v16i2.67238","DOIUrl":"https://doi.org/10.3329/bsmmuj.v16i2.67238","url":null,"abstract":"Abstract not available\u0000Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 124-125","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43297388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Swyer syndrome: A rare case","authors":"H. Pradhan, G. Dangal, M. K. Shrestha","doi":"10.3329/bsmmuj.v16i2.67241","DOIUrl":"https://doi.org/10.3329/bsmmuj.v16i2.67241","url":null,"abstract":"Abstract not available\u0000Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 128-130","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48109936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-25DOI: 10.3329/bsmmuj.v16i2.67209
Muhammad Ibrahim Ibne Towhid, Raisa Nuzhat, Md Atiqul Haque
Background: Online sexual abuse is a growing concern in Bangladesh, particularly as children are increasingly accessing the internet and social media. This paper examines the prevalence and impact of online sexual abuse on children in Bangladesh, and provides policy recommendations to protect children from this type of abuse. Methods: This policy brief was prepared after reviewing findings of the research works conducted on online child sexual abuse. Results: Around 86% female and 91% male children of Bangladesh use the internet. Among the internet users, about one in two children are sexually abused. In addition to the Children Act 2013, the government of Bangladesh enacted the ICT Act 2006 and the Digital Security Act 2018 to address cybercrimes. However, these acts do not specifically address the issue of online child sexual abuse. In addition, the legal provisions lack strict enforcement and the media at times discloses the identities of child victims including images. Policy recommendations: The government, civil society organizations, and other stakeholders need to take a comprehensive approach to protect children from online sexual abuse including improving the legal framework, strengthening child protection mechanisms, increasing awareness and education on safe internet use, and empowering children and their families to report incidents of online sexual abuse. Anonymous reporting system needs to be developed and strict legal measures must be enforced. Conclusion: Protecting children from online sexual abuse requires a sustained multi-stakeholder approach that involves the government, civil society organizations, parents, educators, and children themselves. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 111-117
{"title":"Protecting children from online sexual abuse in Bangladesh: A policy brief","authors":"Muhammad Ibrahim Ibne Towhid, Raisa Nuzhat, Md Atiqul Haque","doi":"10.3329/bsmmuj.v16i2.67209","DOIUrl":"https://doi.org/10.3329/bsmmuj.v16i2.67209","url":null,"abstract":"Background: Online sexual abuse is a growing concern in Bangladesh, particularly as children are increasingly accessing the internet and social media. This paper examines the prevalence and impact of online sexual abuse on children in Bangladesh, and provides policy recommendations to protect children from this type of abuse.\u0000Methods: This policy brief was prepared after reviewing findings of the research works conducted on online child sexual abuse.\u0000Results: Around 86% female and 91% male children of Bangladesh use the internet. Among the internet users, about one in two children are sexually abused. In addition to the Children Act 2013, the government of Bangladesh enacted the ICT Act 2006 and the Digital Security Act 2018 to address cybercrimes. However, these acts do not specifically address the issue of online child sexual abuse. In addition, the legal provisions lack strict enforcement and the media at times discloses the identities of child victims including images.\u0000Policy recommendations: The government, civil society organizations, and other stakeholders need to take a comprehensive approach to protect children from online sexual abuse including improving the legal framework, strengthening child protection mechanisms, increasing awareness and education on safe internet use, and empowering children and their families to report incidents of online sexual abuse. Anonymous reporting system needs to be developed and strict legal measures must be enforced.\u0000Conclusion: Protecting children from online sexual abuse requires a sustained multi-stakeholder approach that involves the government, civil society organizations, parents, educators, and children themselves.\u0000Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 111-117","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46219105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of imbalanced diet with dental caries: A casecontrol study","authors":"Md Ali Asgor Moral, R. Akter","doi":"10.3329/bsmmuj.v16i2.67240","DOIUrl":"https://doi.org/10.3329/bsmmuj.v16i2.67240","url":null,"abstract":"Abstract not available\u0000Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 126-127","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45418871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-25DOI: 10.3329/bsmmuj.v16i2.67202
Md Badrul Alam, U. K. Saha, S. Mashreky, A. Hussain, Md Atiqul Haque, A. Rahman, K. Dalal, Q. Mohammad
Background: Improper health-seeking behaviours (HSB) have been correlated with detrimental health outcomes, elevated rates of illness and mortality. The study aimed to investigate how stroke patients in a rural community of Bangladesh seek health care. Methods: A cross-sectional survey was conducted in the Raiganj sub-district of Sirajganj district from January to June 2016, using a validated screening tool to identify stroke patients at the household level. Neurologists confirmed the diagnosis after examining all suspected cases. Out of the 419 suspected cases identified during the screening process, 186 cases were officially reported after undergoing a confirmed diagnosis. Information on health-seeking behaviour was collected through face-to-face interviews with patients or their attendants. Results: After experiencing a stroke, approximately 35% of patients received treatment from unregistered care providers and over 40% received treatment outside of a hospital setting. Males were significantly more likely than females to receive treatment from registered physicians or hospitals (P<.05 and P<.01). A significantly higher proportion of educated individuals sought healthcare from registered physicians or hospitals (P<.05). Although better health-seeking behaviour was observed among higher-income groups, the findings were not statistically significant. Around 67% of patients were found to be hypertensive, with about one-third of them not taking any medication for their elevated blood pressure. Approximately 37% of patients had elevated blood glucose levels but only 22% were taking medication. Conclusion: A notable proportion of stroke patients in rural Bangladesh sought treatment from unqualified service providers. Health-seeking behaviour was associated with factors such as gender, education, and economic condition. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 75-80
{"title":"Health-seeking behaviour of stroke patients in a rural area of Bangladesh","authors":"Md Badrul Alam, U. K. Saha, S. Mashreky, A. Hussain, Md Atiqul Haque, A. Rahman, K. Dalal, Q. Mohammad","doi":"10.3329/bsmmuj.v16i2.67202","DOIUrl":"https://doi.org/10.3329/bsmmuj.v16i2.67202","url":null,"abstract":"Background: Improper health-seeking behaviours (HSB) have been correlated with detrimental health outcomes, elevated rates of illness and mortality. The study aimed to investigate how stroke patients in a rural community of Bangladesh seek health care.\u0000Methods: A cross-sectional survey was conducted in the Raiganj sub-district of Sirajganj district from January to June 2016, using a validated screening tool to identify stroke patients at the household level. Neurologists confirmed the diagnosis after examining all suspected cases. Out of the 419 suspected cases identified during the screening process, 186 cases were officially reported after undergoing a confirmed diagnosis. Information on health-seeking behaviour was collected through face-to-face interviews with patients or their attendants.\u0000Results: After experiencing a stroke, approximately 35% of patients received treatment from unregistered care providers and over 40% received treatment outside of a hospital setting. Males were significantly more likely than females to receive treatment from registered physicians or hospitals (P<.05 and P<.01). A significantly higher proportion of educated individuals sought healthcare from registered physicians or hospitals (P<.05). Although better health-seeking behaviour was observed among higher-income groups, the findings were not statistically significant. Around 67% of patients were found to be hypertensive, with about one-third of them not taking any medication for their elevated blood pressure. Approximately 37% of patients had elevated blood glucose levels but only 22% were taking medication.\u0000Conclusion: A notable proportion of stroke patients in rural Bangladesh sought treatment from unqualified service providers. Health-seeking behaviour was associated with factors such as gender, education, and economic condition.\u0000Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 75-80","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45309567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Artificial intelligence and healthcare: An ethical dilemma","authors":"Z. A. Ratan, Md Atiqul Haque","doi":"10.3329/bsmmuj.v16i2.67237","DOIUrl":"https://doi.org/10.3329/bsmmuj.v16i2.67237","url":null,"abstract":"Abstract not available\u0000Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 73-74","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46297375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-25DOI: 10.3329/bsmmuj.v16i2.67235
Kaitlyn Wallace, Jakir Hossain Bhuiyan Masud
Background: The automatic coding of electronic medical records with ICD (International Classification of Diseases) codes is an area of interest due to its potential in improving efficiency and streamlining processes such as billing and outcome tracking. artificial intelligence (AI), and particularly convolutional neural networks (CNN), have been suggested as a possible mechanism for automatic coding. To this end, a rapid review has been undertaken in order to assess the current use of CNN in predicting ICD codes from electronic medical records. Methods: After screening PubMed, IEEE Xplore, Scopus, and Google Scholar, 11 studies were analyzed for the use of CNN in predicting ICD codes. We used artificial intelligence and ICD prediction as keywords in the search strategy. Results: The analysis yielded a recommendation to further explore and research CNN frameworks as a promising lead to automatic ICD coding when paired with word embedding and/or neural transfer learning, while keeping research open to a wide variety of AI techniques. Conclusion: CNN frameworks are promising for the prediction of ICD codes from clinical notes. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 118-123
{"title":"Artificial intelligence for prediction of International Classification of Disease codes","authors":"Kaitlyn Wallace, Jakir Hossain Bhuiyan Masud","doi":"10.3329/bsmmuj.v16i2.67235","DOIUrl":"https://doi.org/10.3329/bsmmuj.v16i2.67235","url":null,"abstract":"Background: The automatic coding of electronic medical records with ICD (International Classification of Diseases) codes is an area of interest due to its potential in improving efficiency and streamlining processes such as billing and outcome tracking. artificial intelligence (AI), and particularly convolutional neural networks (CNN), have been suggested as a possible mechanism for automatic coding. To this end, a rapid review has been undertaken in order to assess the current use of CNN in predicting ICD codes from electronic medical records.\u0000Methods: After screening PubMed, IEEE Xplore, Scopus, and Google Scholar, 11 studies were analyzed for the use of CNN in predicting ICD codes. We used artificial intelligence and ICD prediction as keywords in the search strategy.\u0000Results: The analysis yielded a recommendation to further explore and research CNN frameworks as a promising lead to automatic ICD coding when paired with word embedding and/or neural transfer learning, while keeping research open to a wide variety of AI techniques.\u0000Conclusion: CNN frameworks are promising for the prediction of ICD codes from clinical notes.\u0000Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 118-123","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45964388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-25DOI: 10.3329/bsmmuj.v16i2.67185
Joysree Das Joya, D. Paul, M. Ahsan, M. A. Bhuiyan, Rifat Mahbuba Rob, Sheuly Ferdousi, Md. Saiful Islam, Shaila Yesmin
Background: Bipolar disorder is one of the major neuropsychiatric illnesses. It is responsible for 6.8% of disability-adjusted life years among all mental disorders. Few studies have evaluated the biochemical basis of bipolar disorder. Prolidase is an enzyme that degrade extracellular matrix into proline. In stress condition, prolidase by releasing proline maintain ATP generation, redox state, apoptosis and cell proliferation. The relationship between serum prolidase with bipolar disorder was investigated in this study. Method: A case - control study was conducted at the Department of Laboratory Medicine in collaboration with the Department of Psychiatry of Bangabandhu Sheikh Mujib Medical University, Dhaka from March 2021 to February 2022. Thirty-five patients with bipolar disorder type I consisting of 15 euthymic and 20 manic patients were enrolled in the study according to the availability of patients as cases. Thirty-five age - and sex-matched healthy individuals were recruited from the Department of Laboratory Medicine as controls. Serum prolidase level was measured in cases and controls using venous blood. Result: Serum prolidase level was significantly higher in cases than controls (P=0.021). There was no significant differences between euthymic and manic patients (P=0.629). Significant positive correlation was found between Young Mania Rating Scale severity score and serum prolidase level (P=0.001). Conclusion: Serum prolidase activity may be associated with bipolar disorder. This needs further corroboration because our sample size was small. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 96-100
{"title":"Prolidase activity in adult bipolar disorder patient: a case - control study","authors":"Joysree Das Joya, D. Paul, M. Ahsan, M. A. Bhuiyan, Rifat Mahbuba Rob, Sheuly Ferdousi, Md. Saiful Islam, Shaila Yesmin","doi":"10.3329/bsmmuj.v16i2.67185","DOIUrl":"https://doi.org/10.3329/bsmmuj.v16i2.67185","url":null,"abstract":"Background: Bipolar disorder is one of the major neuropsychiatric illnesses. It is responsible for 6.8% of disability-adjusted life years among all mental disorders. Few studies have evaluated the biochemical basis of bipolar disorder. Prolidase is an enzyme that degrade extracellular matrix into proline. In stress condition, prolidase by releasing proline maintain ATP generation, redox state, apoptosis and cell proliferation. The relationship between serum prolidase with bipolar disorder was investigated in this study.\u0000Method: A case - control study was conducted at the Department of Laboratory Medicine in collaboration with the Department of Psychiatry of Bangabandhu Sheikh Mujib Medical University, Dhaka from March 2021 to February 2022. Thirty-five patients with bipolar disorder type I consisting of 15 euthymic and 20 manic patients were enrolled in the study according to the availability of patients as cases. Thirty-five age - and sex-matched healthy individuals were recruited from the Department of Laboratory Medicine as controls. Serum prolidase level was measured in cases and controls using venous blood.\u0000Result: Serum prolidase level was significantly higher in cases than controls (P=0.021). There was no significant differences between euthymic and manic patients (P=0.629). Significant positive correlation was found between Young Mania Rating Scale severity score and serum prolidase level (P=0.001).\u0000Conclusion: Serum prolidase activity may be associated with bipolar disorder. This needs further corroboration because our sample size was small.\u0000Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 96-100\u0000 ","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47845158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-25DOI: 10.3329/bsmmuj.v16i2.67207
S. Rahman, M. Rukunuzzaman, R. Alam, K. Nahid
Background: We aimed to examine the persistence of anti-HBs in Bangladeshi children aged 5 and 10 years after primary vaccination, and this response to a booster dose. Methods: A total of 100 children were enrolled who were divided into two groups (A and B). Group A comprised of 50 children vaccinated 5 years ago, and group B had 50 children vaccinated 10 years ago. Hepatitis B surface antibody titer was measured, and a booster dose of the vaccine was administered to those who had anti-HBs less than 10 mlU/ml. Seventeen such children from group A and 27 from group B were vaccinated with a booster dose. After one month, 12 children from group A and 18 children from group B were retested for hepatitis B surface antibody levels. Results: After 5 and 10 years of primary vaccination, 66.0% and 46.0% children had protective antibody levels. After one month of booster dose, 91.6% children responded to the increased level of anti-HBs in group A. Among them, 66.6% showed an adequate response. In group B, 88.8% had an increased level of anti-HBs antibody where 83.3% had an adequate response. Geometric mean titre of anti-HBs antibody boosted by 35 and 75 times from pre-booster time to post-booster vaccination in group A and B, respectively. Conclusion: Children had protective levels of anti-HBs antibodies at 5 and 10 years after completion of the primary vaccinations. Anamnestic response to booster vaccination confirmed the persistence of an effective immunological memory in vaccines. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 101-105
{"title":"Persistence of anti-HBs and immunologic memory in children immunized with hepatitis B vaccine","authors":"S. Rahman, M. Rukunuzzaman, R. Alam, K. Nahid","doi":"10.3329/bsmmuj.v16i2.67207","DOIUrl":"https://doi.org/10.3329/bsmmuj.v16i2.67207","url":null,"abstract":"Background: We aimed to examine the persistence of anti-HBs in Bangladeshi children aged 5 and 10 years after primary vaccination, and this response to a booster dose.\u0000Methods: A total of 100 children were enrolled who were divided into two groups (A and B). Group A comprised of 50 children vaccinated 5 years ago, and group B had 50 children vaccinated 10 years ago. Hepatitis B surface antibody titer was measured, and a booster dose of the vaccine was administered to those who had anti-HBs less than 10 mlU/ml. Seventeen such children from group A and 27 from group B were vaccinated with a booster dose. After one month, 12 children from group A and 18 children from group B were retested for hepatitis B surface antibody levels.\u0000Results: After 5 and 10 years of primary vaccination, 66.0% and 46.0% children had protective antibody levels. After one month of booster dose, 91.6% children responded to the increased level of anti-HBs in group A. Among them, 66.6% showed an adequate response. In group B, 88.8% had an increased level of anti-HBs antibody where 83.3% had an adequate response. Geometric mean titre of anti-HBs antibody boosted by 35 and 75 times from pre-booster time to post-booster vaccination in group A and B, respectively.\u0000Conclusion: Children had protective levels of anti-HBs antibodies at 5 and 10 years after completion of the primary vaccinations. Anamnestic response to booster vaccination confirmed the persistence of an effective immunological memory in vaccines.\u0000Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 101-105","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44459784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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