Pub Date : 2023-10-13DOI: 10.3329/bsmmcj.v1i2.68872
Mohammad Jahidur Rahman Khan, Ruksana Raihan, Arifa Akram, Sumon Roy, Md Shahidul Islam, Mahjabin Alam, Md Sabir Hossain, Nurul Karim, Farha Matin Juliana, Mohammad Rezaul Quader, Farhana Khatoon Khatoon, Ashikuzzaman Suzan, Farzana Mim, Sharmin Rahman, Md Hanif Howlader, Selim Reza
The tests providing high sensitivity and specificity are essential to identify and manage COVID-19 patients.There is aheavy demand for low-cost rapid antigen tests (RATs) for COVID-19 with a decent diagnostic value. Globally,several RATs for COVID-19 have been developed, but their clinical efficacy has not been well recognized.Thepurpose of the study was to evaluate the performance of RATs. We conducted this prospective observational study atShaheed Suhrawardy Medical College hospital from February 2021 to April 2021 in Dhaka, Bangladesh. This studyincluded the patients admitted in this hospital at the COVID-19 isolation unit or referred from the triage facility of theoutdoor department of this hospital suspected as COVID-19 case. Two nasopharyngeal samples were collectedsimultaneously. We used one sample on the spot for the RATs and the other was sent to the adjacent ShaheedSuhrawardy Medical College COVID-19 RT-PCR laboratory for real-time reverse transcription PCR (RT-PCR). Theperformance of the RATs was evaluated by consuming the real-time RT-PCR results as a reference. In thisinvestigation, SARS-CoV-2 was identified in 84 (30.7%) of the 223 patients who participated. Of these 84 patients, 9(10.7%) were asymptomatic. The overall sensitivity and specificity of RATs were 78.6% and 99.3%, respectively. Thesensitivity was 81.3% in symptomatic cases and 55.6% in asymptomatic cases. There were 18 false-negativespatients,including 3 asymptomatic cases, who had a low viral load (cycle threshold(Ct) > 30). When the Ct value was up to24, the detection rate of RATs was 100%. The detection rate was 42.3% when the Ct was >29. When symptoms beganwithin three days, the detection rate was 92.3%. When the start of symptoms was over 7 days, the detection rate was33.3%. RATs for COVID-19 used in this study delivered an acceptable performance in patients with high viral loadand within the first week of the onset of symptoms. This method can be a supplementary method to RT- PCR for thediagnosis of symptomatic COVID-19 patients. Bangabandhu Sheikh Mujib Med. Coll. J. 2022;1(2):58-64
{"title":"Evaluation of the Performance of the COVID-19 Rapid Antigen Tests in a Tertiary Level Hospital in Bangladesh","authors":"Mohammad Jahidur Rahman Khan, Ruksana Raihan, Arifa Akram, Sumon Roy, Md Shahidul Islam, Mahjabin Alam, Md Sabir Hossain, Nurul Karim, Farha Matin Juliana, Mohammad Rezaul Quader, Farhana Khatoon Khatoon, Ashikuzzaman Suzan, Farzana Mim, Sharmin Rahman, Md Hanif Howlader, Selim Reza","doi":"10.3329/bsmmcj.v1i2.68872","DOIUrl":"https://doi.org/10.3329/bsmmcj.v1i2.68872","url":null,"abstract":"The tests providing high sensitivity and specificity are essential to identify and manage COVID-19 patients.There is aheavy demand for low-cost rapid antigen tests (RATs) for COVID-19 with a decent diagnostic value. Globally,several RATs for COVID-19 have been developed, but their clinical efficacy has not been well recognized.Thepurpose of the study was to evaluate the performance of RATs. We conducted this prospective observational study atShaheed Suhrawardy Medical College hospital from February 2021 to April 2021 in Dhaka, Bangladesh. This studyincluded the patients admitted in this hospital at the COVID-19 isolation unit or referred from the triage facility of theoutdoor department of this hospital suspected as COVID-19 case. Two nasopharyngeal samples were collectedsimultaneously. We used one sample on the spot for the RATs and the other was sent to the adjacent ShaheedSuhrawardy Medical College COVID-19 RT-PCR laboratory for real-time reverse transcription PCR (RT-PCR). Theperformance of the RATs was evaluated by consuming the real-time RT-PCR results as a reference. In thisinvestigation, SARS-CoV-2 was identified in 84 (30.7%) of the 223 patients who participated. Of these 84 patients, 9(10.7%) were asymptomatic. The overall sensitivity and specificity of RATs were 78.6% and 99.3%, respectively. Thesensitivity was 81.3% in symptomatic cases and 55.6% in asymptomatic cases. There were 18 false-negativespatients,including 3 asymptomatic cases, who had a low viral load (cycle threshold(Ct) > 30). When the Ct value was up to24, the detection rate of RATs was 100%. The detection rate was 42.3% when the Ct was >29. When symptoms beganwithin three days, the detection rate was 92.3%. When the start of symptoms was over 7 days, the detection rate was33.3%. RATs for COVID-19 used in this study delivered an acceptable performance in patients with high viral loadand within the first week of the onset of symptoms. This method can be a supplementary method to RT- PCR for thediagnosis of symptomatic COVID-19 patients. Bangabandhu Sheikh Mujib Med. Coll. J. 2022;1(2):58-64","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135854240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-13DOI: 10.3329/bsmmcj.v1i2.69343
Abu Faisal Md Pervez, Khalid Ahmed Syfullah, Mohammod Neamat Hossain, Rajib Biswas, Shuvo Debnath
The initial six months of exclusive breastfeeding, followed by appropriate complementary feeding, are critical forchildren's optimal growth and development. Since the 1980s, numerous organizations in Bangladesh have beenpromoting breast feeding, yet age-old practices have not changed significantly. Still, approximately half of children inBangladesh are not breastfed exclusively for six months and do not receive adequate complementary food. This studysought to identify the barriers and facilitators to implementing proper Infant and Young Child Feeding (IYCF)practices. A cross-sectional descriptive study was conducted at the Department of Pediatrics at Bangabandhu SheikhMujib Medical College, Faridpur, from February to June 2021. This study included sixty-six mothers with infantsaged six to twenty-four months. Face-to-face in-depth interviews were used to collect qualitative data regarding thebarriers and facilitators. Transcripts of interviews were translated, transcribed, and examined to determine the primaryfactors. The most prevalent factor was a lack of knowledge and experience with breastfeeding and supplementalfeeding. In addition, contradictory feeding information from various sources and a lack of social support for pregnantand childbearing mothers with limited decision-making capabilities were significant obstacles. In contrast, motherswho received guidance from healthcare professionals before and after delivery and who were educated and receivedfamily support were more likely to follow the recommended practice. Interventions should be prioritized to encouragemothers to take timely antenatal and post-natal care and nutritional counseling during their visits. Educating andempowering them with adequate support from the family and society is essential. Bangabandhu Sheikh Mujib Med. Coll. J. 2022;1(2):70-75
{"title":"Breastfeeding and Weaning of Children: Identifying the Practice-relevant Issues in an Urban Area of Bangladesh","authors":"Abu Faisal Md Pervez, Khalid Ahmed Syfullah, Mohammod Neamat Hossain, Rajib Biswas, Shuvo Debnath","doi":"10.3329/bsmmcj.v1i2.69343","DOIUrl":"https://doi.org/10.3329/bsmmcj.v1i2.69343","url":null,"abstract":"The initial six months of exclusive breastfeeding, followed by appropriate complementary feeding, are critical forchildren's optimal growth and development. Since the 1980s, numerous organizations in Bangladesh have beenpromoting breast feeding, yet age-old practices have not changed significantly. Still, approximately half of children inBangladesh are not breastfed exclusively for six months and do not receive adequate complementary food. This studysought to identify the barriers and facilitators to implementing proper Infant and Young Child Feeding (IYCF)practices. A cross-sectional descriptive study was conducted at the Department of Pediatrics at Bangabandhu SheikhMujib Medical College, Faridpur, from February to June 2021. This study included sixty-six mothers with infantsaged six to twenty-four months. Face-to-face in-depth interviews were used to collect qualitative data regarding thebarriers and facilitators. Transcripts of interviews were translated, transcribed, and examined to determine the primaryfactors. The most prevalent factor was a lack of knowledge and experience with breastfeeding and supplementalfeeding. In addition, contradictory feeding information from various sources and a lack of social support for pregnantand childbearing mothers with limited decision-making capabilities were significant obstacles. In contrast, motherswho received guidance from healthcare professionals before and after delivery and who were educated and receivedfamily support were more likely to follow the recommended practice. Interventions should be prioritized to encouragemothers to take timely antenatal and post-natal care and nutritional counseling during their visits. Educating andempowering them with adequate support from the family and society is essential. Bangabandhu Sheikh Mujib Med. Coll. J. 2022;1(2):70-75","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135854419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-13DOI: 10.3329/bsmmcj.v1i2.69351
M M Shahin Ul Islam, Mst Naznin Sarker, Syeda Nur E Jannat, Nimai Das, Mohammad Iqbal Hossain, Swapan Kumar Mondal, ATM Ataur Rahman, Dewan Saifuddin Ahmed
Previously thought that, synchronous colonic cancers are relatively common but synchronous upper gastrointestinal cancers are relatively uncommon. But now a days, frequency of synchronous esophageal cancers, gastric cancers or duodenal cancers is increasing due to availability of the upper GI endoscopy, and the prolonged life span of the general population. Here we discussed anelderly malewho presented with features of gastric outlet obstruction and dysphagia and finally diagnosed as simultaneous esophageal squamous cell carcinoma and gastric adenocarcinoma.
Bangabandhu Sheikh Mujib Med. Coll. J. 2022;1(2):107-109
{"title":"Synchronous Upper GIT Malignancy in an Elderly Patient","authors":"M M Shahin Ul Islam, Mst Naznin Sarker, Syeda Nur E Jannat, Nimai Das, Mohammad Iqbal Hossain, Swapan Kumar Mondal, ATM Ataur Rahman, Dewan Saifuddin Ahmed","doi":"10.3329/bsmmcj.v1i2.69351","DOIUrl":"https://doi.org/10.3329/bsmmcj.v1i2.69351","url":null,"abstract":"Previously thought that, synchronous colonic cancers are relatively common but synchronous upper gastrointestinal cancers are relatively uncommon. But now a days, frequency of synchronous esophageal cancers, gastric cancers or duodenal cancers is increasing due to availability of the upper GI endoscopy, and the prolonged life span of the general population. Here we discussed anelderly malewho presented with features of gastric outlet obstruction and dysphagia and finally diagnosed as simultaneous esophageal squamous cell carcinoma and gastric adenocarcinoma.
 Bangabandhu Sheikh Mujib Med. Coll. J. 2022;1(2):107-109","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135855459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-13DOI: 10.3329/bsmmcj.v1i2.69350
Dilruba Zeba, Biswanath Roy, Rahul Biswash
Abdominal pregnancy is a rare form of ectopic pregnancy and a serious form of extrauterine pregnancy. Abdominal pregnancy account for almost 1% of ectopic pregnancies. Rarely,it may reach at advanced gestation and a viable fetal outcome is a rare event. Sometimes, the diagnosis is suspected only when repeated attempts of induction of abortion or labor are unsuccessful. Really it is difficult to diagnose and manage. Here we are reporting a case of secondary abdominal pregnancy in a 27 years old primi gravida at 39+ weeks of gestation. It was observed from her ultrasonography that a single live pregnancy with breech presentation with almost absent liquor with IUGR baby then decision was made for lower uterine cesarean section under sub-arachnoid block. But it was turned into laparotomy and diagnosed as a secondary abdominal pregnancy. A healthy female baby was delivered. The placenta was attached with the omentum and large bowel loop. After tying and cutting the cord flushed with it's placental attachment, placenta was kept in situ. Abdomen was closed in layers. The diagnosis of abdominal pregnancy was made peroperatively with successful management and delivery of a healthy female baby.
Bangabandhu Sheikh Mujib Med. Coll. J. 2022;1(2):104-106
{"title":"Secondary Abdominal Pregnancy at term: a case report","authors":"Dilruba Zeba, Biswanath Roy, Rahul Biswash","doi":"10.3329/bsmmcj.v1i2.69350","DOIUrl":"https://doi.org/10.3329/bsmmcj.v1i2.69350","url":null,"abstract":"Abdominal pregnancy is a rare form of ectopic pregnancy and a serious form of extrauterine pregnancy. Abdominal pregnancy account for almost 1% of ectopic pregnancies. Rarely,it may reach at advanced gestation and a viable fetal outcome is a rare event. Sometimes, the diagnosis is suspected only when repeated attempts of induction of abortion or labor are unsuccessful. Really it is difficult to diagnose and manage. Here we are reporting a case of secondary abdominal pregnancy in a 27 years old primi gravida at 39+ weeks of gestation. It was observed from her ultrasonography that a single live pregnancy with breech presentation with almost absent liquor with IUGR baby then decision was made for lower uterine cesarean section under sub-arachnoid block. But it was turned into laparotomy and diagnosed as a secondary abdominal pregnancy. A healthy female baby was delivered. The placenta was attached with the omentum and large bowel loop. After tying and cutting the cord flushed with it's placental attachment, placenta was kept in situ. Abdomen was closed in layers. The diagnosis of abdominal pregnancy was made peroperatively with successful management and delivery of a healthy female baby.
 Bangabandhu Sheikh Mujib Med. Coll. J. 2022;1(2):104-106","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135853855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationship between COVID-19 and Diabetes Mellitus","authors":"Mohammad Rezaul Quader, Sharmin Rahman, Sabir Hossain, Selim Reza, Farzana Mim","doi":"10.3329/bsmmcj.v1i2.69337","DOIUrl":"https://doi.org/10.3329/bsmmcj.v1i2.69337","url":null,"abstract":"Abstract not available. Bangabandhu Sheikh Mujib Med. Coll. J. 2022;1(2):56-57","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135854173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-27DOI: 10.3329/bsmmuj.v16i3.67860
Evana Binthe Alam, Md Atiqul Haque, Muhammad Ibrahim Ibne Towhid, Md Maruf Haque Khan, Khandakar Fatema, Marium Salwa, Fariha Haseen, Bijoy Kumer Paul
Background: Over the last two decades, there has been a gender shift in undergraduate medical education in Bangladesh with different influencing factors in specialty choice as a career. We aimed to determine the trend and influencing factors in specialty choice among post-graduate medical students of Bangladesh. Methods: This cross-sectional study was carried out at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. Secondary data regarding students’ enrollment from 2016 to 2020 were acquired from the registry of the Information Technology Cell of BSMMU, and face-to-face interviews were conducted with 118 post-graduate medical students and asked them about the motivation behind their specialty selections. Results: From 2016 to 2020, 9,112 post-graduate medical students were enrolled in 73 post-graduate medical programs across the five faculties (Surgery, Medicine, Basic Science and Para Clinical Science, Pediatrics, and Preventive and Social Medicine) of BSMMU. There was a gradual increase in female students from 41.6% in 2016 to 49.3% in 2020. Male dominancy was found in the faculties of Surgery (61.2%) and Medicine (69.7%), whereas the faculties of Basic Science and Paraclinical Science (74.6%), Pediatrics (53.7%), and Preventive and Social Medicine (66.9%) were dominated by female students. Significant differences in the sex distribution among postgraduate medical students were observed in the faculties of Surgery and Pediatrics. The most frequently mentioned influencing factors for medical students' choice of specialization were 'personal interest' (86.3%), followed by 'future career potential' (74.6%) and 'demand for the specialty' (73.7%). Significant gender variations in these influencing factors existed. Conclusion: Over the years, the percentage of female postgraduate medical students has increased in all five faculties of BSMMU. Gender differences in specialty choice can assist policymakers in making equitable distributions of the healthcare workforce. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 152-159
{"title":"Gender and other factors influencing the specialty choice among postgraduate medical students in Bangladesh, 2016-2020","authors":"Evana Binthe Alam, Md Atiqul Haque, Muhammad Ibrahim Ibne Towhid, Md Maruf Haque Khan, Khandakar Fatema, Marium Salwa, Fariha Haseen, Bijoy Kumer Paul","doi":"10.3329/bsmmuj.v16i3.67860","DOIUrl":"https://doi.org/10.3329/bsmmuj.v16i3.67860","url":null,"abstract":"Background: Over the last two decades, there has been a gender shift in undergraduate medical education in Bangladesh with different influencing factors in specialty choice as a career. We aimed to determine the trend and influencing factors in specialty choice among post-graduate medical students of Bangladesh. Methods: This cross-sectional study was carried out at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. Secondary data regarding students’ enrollment from 2016 to 2020 were acquired from the registry of the Information Technology Cell of BSMMU, and face-to-face interviews were conducted with 118 post-graduate medical students and asked them about the motivation behind their specialty selections. Results: From 2016 to 2020, 9,112 post-graduate medical students were enrolled in 73 post-graduate medical programs across the five faculties (Surgery, Medicine, Basic Science and Para Clinical Science, Pediatrics, and Preventive and Social Medicine) of BSMMU. There was a gradual increase in female students from 41.6% in 2016 to 49.3% in 2020. Male dominancy was found in the faculties of Surgery (61.2%) and Medicine (69.7%), whereas the faculties of Basic Science and Paraclinical Science (74.6%), Pediatrics (53.7%), and Preventive and Social Medicine (66.9%) were dominated by female students. Significant differences in the sex distribution among postgraduate medical students were observed in the faculties of Surgery and Pediatrics. The most frequently mentioned influencing factors for medical students' choice of specialization were 'personal interest' (86.3%), followed by 'future career potential' (74.6%) and 'demand for the specialty' (73.7%). Significant gender variations in these influencing factors existed. Conclusion: Over the years, the percentage of female postgraduate medical students has increased in all five faculties of BSMMU. Gender differences in specialty choice can assist policymakers in making equitable distributions of the healthcare workforce. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 152-159","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135586076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-27DOI: 10.3329/bsmmuj.v16i3.68154
Bijoy Kumer Paul
Abstract not available Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 182-183
[摘要]孟加拉谢赫穆吉布医科大学学报，2023;16(3):182-183
{"title":"Outcome based education: Shaping the future of learning","authors":"Bijoy Kumer Paul","doi":"10.3329/bsmmuj.v16i3.68154","DOIUrl":"https://doi.org/10.3329/bsmmuj.v16i3.68154","url":null,"abstract":"Abstract not available Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 182-183","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135586268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-27DOI: 10.3329/bsmmuj.v16i3.64496
Naomee Shareef, Ahmed Abu Saleh, Abu Naser Ibne Sattar, Shaheda Anwar
In this cross-sectional study, from March 2021 to February 2022, a total 53 RIF resistant MTB isolates in sputum samples, detected by Xpert-MTB RIF assay were enrolled. All samples were tested for mutation in katG (codon 315) and inhA promoter (-5, -8, -15 and -16) genes for detection of INH resistance by Real-time PCR. Statistical analysis was done using SPSS (version-26). Out of 53 RIF resistant samples, the proportion of newly diagnosed and previously treated cases were nearly equal and most of the previously treated cases (92.9%) received treatment regularly. 15.1% RIF resistant MTB isolates were sensitive to INH and rest had concomitant resistance to INH. INH resistant cases were mostly previously treated (55.5%), whereas sensitive cases were mostly newly diagnosed (62.5%). katG was found to be the prominent mutation, with or without in combination with inhA mutation. A considerable number of RIF resistant isolates did not show concomitant resistance to INH. Most of the INH resistant isolates were associated with katG mutation. Evaluation of INH resistance before using high dose INH will help to avoid dose dependent toxicity and to determine an appropriate treatment regimen timely. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 160-166
{"title":"Isoniazid resistance profile in rifampicin resistant Mycobacterium tuberculosis","authors":"Naomee Shareef, Ahmed Abu Saleh, Abu Naser Ibne Sattar, Shaheda Anwar","doi":"10.3329/bsmmuj.v16i3.64496","DOIUrl":"https://doi.org/10.3329/bsmmuj.v16i3.64496","url":null,"abstract":"In this cross-sectional study, from March 2021 to February 2022, a total 53 RIF resistant MTB isolates in sputum samples, detected by Xpert-MTB RIF assay were enrolled. All samples were tested for mutation in katG (codon 315) and inhA promoter (-5, -8, -15 and -16) genes for detection of INH resistance by Real-time PCR. Statistical analysis was done using SPSS (version-26). Out of 53 RIF resistant samples, the proportion of newly diagnosed and previously treated cases were nearly equal and most of the previously treated cases (92.9%) received treatment regularly. 15.1% RIF resistant MTB isolates were sensitive to INH and rest had concomitant resistance to INH. INH resistant cases were mostly previously treated (55.5%), whereas sensitive cases were mostly newly diagnosed (62.5%). katG was found to be the prominent mutation, with or without in combination with inhA mutation. A considerable number of RIF resistant isolates did not show concomitant resistance to INH. Most of the INH resistant isolates were associated with katG mutation. Evaluation of INH resistance before using high dose INH will help to avoid dose dependent toxicity and to determine an appropriate treatment regimen timely. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 160-166","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135586256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-27DOI: 10.3329/bsmmuj.v16i3.68478
Samina Masud Santa, Tahmina Akter Diba, Abdullah Al Mamun, Afroza Begum, Syed Saimul Haque
We report a 3 year 10 month old girl with Pierson syndrome. Kidney biopsy showed features suggestive of Alport syndrome. Genetic study report showed LAMB2 mutation which are considered to (Nephrotic syndrome, type 5 with or without ocular abnormalities and Pierson syndrome), TRIM8 mutation which are considered to (FSGS and neurodevelopmental syndrome). The patient is getting supportive therapy. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 178-181
{"title":"Pierson syndrome presenting as Alport syndrome: A case report","authors":"Samina Masud Santa, Tahmina Akter Diba, Abdullah Al Mamun, Afroza Begum, Syed Saimul Haque","doi":"10.3329/bsmmuj.v16i3.68478","DOIUrl":"https://doi.org/10.3329/bsmmuj.v16i3.68478","url":null,"abstract":"We report a 3 year 10 month old girl with Pierson syndrome. Kidney biopsy showed features suggestive of Alport syndrome. Genetic study report showed LAMB2 mutation which are considered to (Nephrotic syndrome, type 5 with or without ocular abnormalities and Pierson syndrome), TRIM8 mutation which are considered to (FSGS and neurodevelopmental syndrome). The patient is getting supportive therapy. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 178-181","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135586260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-27DOI: 10.3329/bsmmuj.v16i3.68020
Shahjada Selim
Abastract not available. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 131-132
摘要不可用。孟加拉谢赫穆吉布医科大学学报;2023;16(3):131-132
{"title":"Endocrine disruptors: emerging health concerns","authors":"Shahjada Selim","doi":"10.3329/bsmmuj.v16i3.68020","DOIUrl":"https://doi.org/10.3329/bsmmuj.v16i3.68020","url":null,"abstract":"Abastract not available. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 131-132","PeriodicalId":8681,"journal":{"name":"Bangabandhu Sheikh Mujib Medical University Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135586266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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