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Polymerization of Acrylamide N-methylene Lactic and Glycolic Acid 丙烯酰胺 N-亚甲基乳酸和乙醇酸的聚合反应
IF 0.6 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-12-05 DOI: 10.21123/bsj.2023.9076
Sevara Khazratkulova, Nodira T. Zokirova, Busora Mukhamedova, Basant Lal, Orifjon Khamidov, E. Berdimurodov, Guloy K Alieva, Ahmad Hosseini-Bandegharaei, Nizomiddin Aliev
In this research work, the novel polymer base on acrylamide N-methylene lactic and glycolic acid was synthesized and its structural performances were identified by the IR, 1H NMR and 13C NMR spectroscopic investigations. The influencing factors and kinetics of polymerization, viscosity performance were studied and quantum chemical calculations were used to identify the correlation between the structure and properties. It was determined that the polymerization rate of the examined monomers in an aqueous solution, in the presence of DAA, adheres to the standard rules for radical polymerization of acrylamide monomers in solution. An investigation into the pH solution's impact on the kinetics of radical polymerization of acrylamido-N-methylene glycolic and acrylamido-N-methylene lactic acids revealed an extreme dependence with a minimum in a neutral medium. It was found the linear correlation between pH and viscosity. The physical and chemical performance of this polymer depends on the structural parameters related the results of quantum chemical calculation. Biological tests conducted on polyacrylamido-N-methylene lactic acid indicated its potential as a plant growth stimulator. The polymeric form of lactic acid was found to enhance the growth of Dustlik variety wheat seedlings by 40% more efficiently than lactic acid alone.
本研究合成了以丙烯酰胺n -亚甲基乳酸和乙醇酸为基料的新型聚合物,并通过IR、1H NMR和13C NMR对其结构性能进行了表征。研究了聚合动力学、粘度性能的影响因素,并利用量子化学计算确定了结构与性能之间的相关性。经测定,在DAA存在的情况下,所测单体在水溶液中的聚合速率符合丙烯酰胺单体在溶液中自由基聚合的标准规则。对pH溶液对丙烯酰胺- n -亚甲基乙醇酸和丙烯酰胺- n -亚甲基乳酸自由基聚合动力学影响的研究表明,在中性介质中,pH溶液对丙烯酰胺- n -亚甲基乳酸自由基聚合动力学的影响极小。发现pH值与粘度呈线性相关。该聚合物的物理和化学性能取决于与量子化学计算结果相关的结构参数。对聚丙烯酰胺- n -亚甲基乳酸进行的生物学试验表明,聚丙烯酰胺- n -亚甲基乳酸具有促进植物生长的潜力。研究发现,与单独使用乳酸相比,聚合物形式的乳酸对Dustlik品种小麦幼苗的生长促进效率提高了40%。
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引用次数: 0
Red Ginger's Anti-Anxiety Effect on BALB/c Strain Mice (Mus musculus) Pro-Inflammatory and Anti-Inflammatory Measurements as Anxiety Model 红姜对作为焦虑模型的 BALB/c 株小鼠(麝香猫)前炎症和抗炎症测量的抗焦虑作用
IF 0.6 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-12-05 DOI: 10.21123/bsj.2023.9035
Ira Aini Dania, A. Rambe, Urip Harahap, E. Effendy, Tuti Wahmurti, Syafruddin Ilyas, M. Rusda, M. Amin
There is a correlation between the occurrence of anxiety and the production of inflammatory mediators, and red ginger rhizome is a well-known herbal product with a high content of phenolic and flavonoid compounds that can be used as anti-inflammatories and antioxidants. The aim of study to evaluate the effect of red ginger as antianxiety in mice (Mus musculus) BALB/c strain by measuring levels of TNF-α, IL-6 and IL-10.  Anxiety model mice were carried out by giving treatment with the Forced Swimming Test (FST) for 7 days then assessed by carrying out the Elevated Plus Maze for Mice (EPM) test for one day. After the treatment, the anxiety mice model was made, followed by administration of red ginger ethanol extract therapy for 14 days. The distribution of the experimental animal model groups was divided into control groups (KN, K-, K+) and treatment groups (P, P2, P3).There was a significant difference the decreased of the TNF-α levels at the all of treatment groups with red ginger rhizome extract (P1, P2, P3) compared with the control groups (KN, K-) (p<0.05), the significantly decreased of IL-6 levels in the three doses treatment group (P1, P2, P3) compared to the control group (K-, K+) (p <0.05) and an increase in IL-10 levels in the 50 mg treatment group compared to group K -, statistically not significant (p>0.05).In overall, this study suggests that FST stimulation will create anxiety symptoms and behavior as well as impact cytokine levels, namely elevated levels of TNF-α and IL-6. Giving red ginger ethanol extract has the potential to be researched further for reducing anxiety symptoms because it can block pro-inflammatory cytokines by significantly decreased levels of TNF-α, IL-6, and increased IL-10 cytokines a brief abstract about your paper’s subject of study.
焦虑的发生与炎症介质的产生存在相关性,红姜是一种众所周知的草药产品,其酚类和类黄酮化合物含量高,可以用作抗炎和抗氧化剂。目的通过测定小鼠血清中TNF-α、IL-6、IL-10的水平,探讨红姜对小鼠BALB/c的抗焦虑作用。焦虑模型小鼠采用强迫游泳试验(FST)治疗7 d,然后采用小鼠高架+迷宫(EPM)试验评估1 d。治疗后造焦虑小鼠模型,给予红姜乙醇提取物治疗14 d。实验动物模型组分布分为对照组(KN、K-、K+)和治疗组(P、P2、P3)。红姜提取物(P1、P2、P3)各处理组与对照组(KN、K-)相比,TNF-α水平的降低有显著差异(p0.05)。总体而言,本研究提示FST刺激会产生焦虑症状和行为,并影响细胞因子水平,即TNF-α和IL-6水平升高。给予红姜乙醇提取物在减轻焦虑症状方面有进一步研究的潜力,因为它可以通过显著降低TNF-α, IL-6和IL-10细胞因子的水平来阻断促炎细胞因子。关于您论文的研究主题的简要摘要。
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引用次数: 0
Indoor/Outdoor Deep Learning Based Image Classification for Object Recognition Applications 基于深度学习的室内/室外物体识别图像分类应用
IF 0.6 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-12-05 DOI: 10.21123/bsj.2023.8177
Omar Abdullatif Jassim, Mohammed Jawad Abed, Zenah Hadi Saied Saied
With the rapid development of smart devices, people's lives have become easier, especially for visually disabled or special-needs people. The new achievements in the fields of machine learning and deep learning let people identify and recognise the surrounding environment. In this study, the efficiency and high performance of deep learning architecture are used to build an image classification system in both indoor and outdoor environments. The proposed methodology starts with collecting two datasets (indoor and outdoor) from different separate datasets. In the second step, the collected dataset is split into training, validation, and test sets. The pre-trained GoogleNet and MobileNet-V2 models are trained using the indoor and outdoor sets, resulting in four trained models. The test sets are used to evaluate the trained models using many evaluation metrics (accuracy, TPR, FNR, PPR, FDR). Results of Google Net model indicate the high performance of the designed models with 99.34% and 99.76% accuracies for indoor and outdoor datasets, respectively. For Mobile Net models, the result accuracies are 99.27% and 99.68% for indoor and outdoor sets, respectively. The proposed methodology is compared with similar ones in the field of object recognition and image classification, and the comparative study proves the transcendence of the propsed system.
随着智能设备的快速发展,人们的生活变得更加方便,特别是对于视障人士或有特殊需要的人。机器学习和深度学习领域的新成就让人们能够识别和识别周围的环境。在本研究中,利用深度学习架构的高效化和高性能来构建室内和室外环境下的图像分类系统。提出的方法首先从不同的独立数据集中收集两个数据集(室内和室外)。第二步,将收集到的数据集分成训练集、验证集和测试集。使用室内集和室外集对预训练的GoogleNet和MobileNet-V2模型进行训练,得到4个训练模型。测试集用于使用许多评估指标(准确性、TPR、FNR、PPR、FDR)来评估训练好的模型。Google Net模型的结果表明,所设计的模型在室内和室外数据集上的准确率分别为99.34%和99.76%。对于Mobile Net模型,室内和室外集的结果准确率分别为99.27%和99.68%。将所提出的方法与目标识别和图像分类领域的同类方法进行了比较,对比研究证明了所提出系统的超越性。
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引用次数: 0
Classification of Diseases in Oil Palm Leaves Using the GoogLeNet Model 利用 GoogLeNet 模型对油棕榈树叶的病害进行分类
IF 0.6 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-12-05 DOI: 10.21123/bsj.2023.8547
Asmah Indrawati, Abdul Rahman, Erwin Pane, Muhathir
The general health of palm trees, encompassing the roots, stems, and leaves, significantly impacts palm oil production, therefore, meticulous attention is needed to achieve optimal yield. One of the challenges encountered in sustaining productive crops is the prevalence of pests and diseases afflicting oil palm plants. These diseases can detrimentally influence growth and development, leading to decreased productivity. Oil palm productivity is closely related to the conditions of its leaves, which play a vital role in photosynthesis. This research employed a comprehensive dataset of 1,230 images, consisting of 410 showing leaves, another 410 depicting bagworm infestations, and an additional 410 displaying caterpillar infestations. Furthermore, the major objective was to formulate a deep learning model for the identification of diseases and pests affecting oil palm leaves, using image analysis techniques to facilitate pest management practices. To address the core problem under investigation, the GoogLeNet deep learning approach was applied, alongside various hyperparameters. The classification experiments were executed across 16 trials, each capped at a computational timeframe of 10 minutes, and the predominant duration spanned from 2 to 7 minutes. The results, particularly derived from the superior performance in Model 4 (M4), showed evaluation accuracy, precision, recall, and F1-score rates of 93.22%, 93.33%, 93.95%, and 93.15%, respectively. These were highly satisfactory, warranting their application in oil palm companies to enhance the management of pest and disease attacks.
棕榈树的总体健康状况,包括根、茎和叶,对棕榈油产量有重大影响,因此,需要密切关注以达到最佳产量。在维持高产作物方面遇到的挑战之一是肆虐油棕植物的病虫害。这些疾病会对生长发育产生不利影响,导致生产力下降。油棕的产量与其叶片的状况密切相关,而叶片在光合作用中起着至关重要的作用。这项研究使用了一个由1230张图像组成的综合数据集,其中410张显示树叶,另外410张描绘了bagworm的侵扰,另外410张显示了毛虫的侵扰。此外,主要目标是制定一个深度学习模型,用于识别影响油棕叶片的病虫害,利用图像分析技术促进病虫害管理实践。为了解决正在调查的核心问题,应用了GoogLeNet深度学习方法以及各种超参数。分类实验在16个试验中执行,每个试验的计算时间范围为10分钟,主要持续时间为2到7分钟。结果显示,模型4 (M4)的评估正确率、精密度、召回率和f1得分率分别为93.22%、93.33%、93.95%和93.15%。这些结果非常令人满意,有理由将其应用于油棕公司,以加强病虫害的管理。
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引用次数: 0
A Numerical scheme to Solve Boundary Value Problems Involving Singular Perturbation 解决涉及奇异扰动的边值问题的数值方案
IF 0.6 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-12-05 DOI: 10.21123/bsj.2023.6409
Hussain A. Alaidroos, A. Kherd, Salim F. Bamsaoud
The Wang-Ball polynomials operational matrices of the derivatives are used in this study to solve singular perturbed second-order differential equations (SPSODEs) with boundary conditions. Using the matrix of Wang-Ball polynomials, the main singular perturbation problem is converted into linear algebraic equation systems. The coefficients of the required approximate solution are obtained from the solution of this system. The residual correction approach was also used to improve an error, and the results were compared to other reported numerical methods. Several examples are used to illustrate both the reliability and usefulness of the Wang-Ball operational matrices. The Wang Ball approach has the ability to improve the outcomes by minimizing the degree of error between approximate and exact solutions. The Wang-Ball series has shown its usefulness in solving any real-life scenario model as first- or second-order differential equations (DEs).
本文利用微分的Wang-Ball多项式运算矩阵求解具有边界条件的奇异摄动二阶微分方程(SPSODEs)。利用王球多项式矩阵,将主要的奇异摄动问题转化为线性代数方程组。由该系统的解得到所需近似解的系数。利用残差校正方法对误差进行了修正,并与已有的数值方法进行了比较。用几个例子说明了王球运算矩阵的可靠性和实用性。王球方法有能力通过最小化近似和精确解之间的误差程度来改善结果。Wang-Ball系列已经证明了它在解决任何现实生活场景模型作为一阶或二阶微分方程(DEs)时的有用性。
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引用次数: 0
Enhancing Smart Cities with IoT and Cloud Computing: A Study on Integrating Wireless Ad Hoc Networks for Efficient Communication 利用物联网和云计算提升智慧城市:关于整合无线 Ad Hoc 网络实现高效通信的研究
IF 0.6 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-12-05 DOI: 10.21123/bsj.2023.9277
H. M. Abdulhadi, Y. A. A. S. Aldeen, Maryam A. Yousif, Mays jalal Jaseem, Syed Hamid Hussain Madni
Smart cities have recently undergone a fundamental evolution that has greatly increased their potentials. In reality, recent advances in the Internet of Things (IoT) have created new opportunities by solving a number of critical issues that are allowing innovations for smart cities as well as the creation and computerization of cutting-edge services and applications for the many city partners. In order to further the development of smart cities toward compelling sharing and connection, this study will explore the information innovation in smart cities in light of the Internet of Things (IoT) and cloud computing (CC). IoT data is first collected in the context of smart cities. The data that is gathered is uniform. The Internet of Things, which enables gadgets to connect with one another mostly without human involvement, is made possible by AI. In line with this, The Ad Hoc Routing Function (ARF) AI computation is used for multi-rule simplification, the use of Adaptive Cloud Computing Virtual Machine Asset Allotment Technique (ACC-VMRA) is advised. To confirm its viability, the applied developments of IoT and CC in smart cities is examined and duplicated. The experiment results show that the recommended enhancement calculation is more productive than other currently used methods.
智慧城市最近经历了一场根本性的演变,极大地增加了它们的潜力。实际上,物联网(IoT)的最新进展通过解决一些关键问题创造了新的机会,这些问题使智慧城市能够创新,并为许多城市合作伙伴创建和计算机化尖端服务和应用程序。为了进一步推动智慧城市向共享和连接的方向发展,本研究将探讨物联网(IoT)和云计算(CC)在智慧城市中的信息创新。物联网数据首先是在智慧城市的背景下收集的。收集的数据是统一的。物联网(Internet of Things)是一种无需人工干预就能让设备相互连接的技术,它是由人工智能实现的。因此,采用Ad Hoc Routing Function (ARF) AI计算进行多规则简化,建议采用自适应云计算虚拟机资产分配技术(ACC-VMRA)。为了确认其可行性,对物联网和CC在智慧城市中的应用发展进行了检查和复制。实验结果表明,所推荐的增强计算比目前使用的其他方法效率更高。
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引用次数: 0
Processing of Polymers Stress Relaxation Curves Using Machine Learning Methods 利用机器学习方法处理聚合物应力松弛曲线
IF 0.6 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-12-05 DOI: 10.21123/bsj.2023.8819
Anton S. Chepurnenko, Tatiana N. Kondratieva, Ebrahim Al-Wali
Currently, one of the topical areas of application of machine learning methods is the prediction of material characteristics. The aim of this work is to develop machine learning models for determining the rheological properties of polymers from experimental stress relaxation curves. The paper presents an overview of the main directions of metaheuristic approaches (local search, evolutionary algorithms) to solving combinatorial optimization problems. Metaheuristic algorithms for solving some important combinatorial optimization problems are described, with special emphasis on the construction of decision trees. A comparative analysis of algorithms for solving the regression problem in CatBoost Regressor has been carried out. The object of the study is the generated data sets obtained on the basis of theoretical stress relaxation curves. Tables of initial data for training models for all samples are presented, a statistical analysis of the characteristics of the initial data sets is carried out. The total number of numerical experiments for all samples was 346020 variations. When developing the models, CatBoost artificial intelligence methods were used, regularization methods (Weight Decay, Decoupled Weight Decay Regularization, Augmentation) were used to improve the accuracy of the model, and the Z-Score method was used to normalize the data. As a result of the study, intelligent models were developed to determine the rheological parameters of polymers included in the generalized non-linear Maxwell-Gurevich equation (initial relaxation viscosity, velocity modulus) using generated data sets for the EDT-10 epoxy binder as an example. Based on the results of testing the models, the quality of the models was assessed, graphs of forecasts for trainees and test samples, graphs of forecast errors were plotted. Intelligent models are based on the CatBoost algorithm and implemented in the Jupyter Notebook environment in Python. The constructed models have passed the quality assessment according to the following metrics: MAE, MSE, RMSE, MAPE. The maximum value of model error predictions was 0.86 for the MAPE metric, and the minimum value of model error predictions was 0.001 for the MSE metric. Model performance estimates obtained during testing are valid.
目前,机器学习方法应用的热门领域之一是材料特性的预测。这项工作的目的是开发机器学习模型,用于从实验应力松弛曲线确定聚合物的流变特性。本文概述了解决组合优化问题的元启发式方法(局部搜索、进化算法)的主要方向。描述了用于解决一些重要组合优化问题的元启发式算法,特别强调了决策树的构造。对CatBoost regression中求解回归问题的几种算法进行了比较分析。研究对象是根据理论应力松弛曲线得到的生成数据集。给出了所有样本训练模型的初始数据表,并对初始数据集的特征进行了统计分析。所有样本的数值实验总数为346020次。在开发模型时,使用CatBoost人工智能方法,使用正则化方法(Weight Decay, decoupling Weight Decay regularization, Augmentation)提高模型的准确性,并使用Z-Score方法对数据进行归一化。研究结果表明,以EDT-10环氧粘合剂生成的数据集为例,开发了智能模型来确定包含在广义非线性Maxwell-Gurevich方程中的聚合物流变参数(初始松弛粘度、速度模量)。根据模型的测试结果,对模型的质量进行了评价,绘制了学员和测试样本的预测图和预测误差图。智能模型基于CatBoost算法,在Jupyter Notebook环境中使用Python实现。根据MAE、MSE、RMSE、MAPE等指标对构建的模型进行了质量评价。MAPE指标的模型误差预测最大值为0.86,MSE指标的模型误差预测最小值为0.001。在测试期间获得的模型性能估计是有效的。
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引用次数: 0
An Observation and Analysis the role of Convolutional Neural Network towards Lung Cancer Prediction 观察和分析卷积神经网络对肺癌预测的作用
IF 0.6 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-12-05 DOI: 10.21123/bsj.2023.9029
Suranjana Mitra, A. B. Majumder, Tanusree Saha
Lung cancer is one of the most serious and prevalent diseases, causing many deaths each year. Though CT scan images are mostly used in the diagnosis of cancer, the assessment of scans is an error-prone and time-consuming task. Machine learning and AI-based models can identify and classify types of lung cancer quite accurately, which helps in the early-stage detection of lung cancer that can increase the survival rate. In this paper, Convolutional Neural Network is used to classify Adenocarcinoma, squamous cell carcinoma and normal case CT scan images from the Chest CT Scan Images Dataset using different combinations of hidden layers and parameters in CNN models. The proposed model was trained on 1000 CT Scan Images of cancerous and non-cancerous cells to find the best combination of parameters in CNN to predict lung cancer accurately.  The proposed system recorded the highest accuracy of 92.79%. In addition to that, the paper addresses 192 observations made using the CNN model. 
肺癌是最严重和最普遍的疾病之一,每年造成许多人死亡。虽然CT扫描图像主要用于癌症的诊断,但对扫描结果的评估是一项容易出错且耗时的任务。机器学习和基于人工智能的模型可以非常准确地识别和分类肺癌的类型,这有助于肺癌的早期发现,从而提高生存率。本文利用卷积神经网络对胸部CT扫描图像数据集中的腺癌、鳞状细胞癌和正常病例CT扫描图像进行分类,在CNN模型中使用不同的隐藏层和参数组合。该模型在1000张癌细胞和非癌细胞的CT扫描图像上进行训练,寻找CNN中最佳的参数组合来准确预测肺癌。该系统的最高准确率为92.79%。除此之外,该论文还使用CNN模型进行了192次观察。
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引用次数: 0
Synthesis of Multifunctional Polymers Based on Tert-Butyl Acrylamide/Octyl Acrylate as Lubricant Additives and Adsorbents for Copper Ion from Aqueous Solution 合成基于丙烯酰胺叔丁酯/丙烯酸辛酯的多功能聚合物,作为润滑油添加剂和水溶液中铜离子的吸附剂
IF 0.6 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-12-05 DOI: 10.21123/bsj.2023.9095
A. Mohammed, Enaam Fadel Mousa, A. H. Hamed, Mansor Ahmad
Two homopolymeric and three copolymeric additives for base oil were synthesized using octyl acrylate (OA) and tert-butyl acrylamide (TBA) monomers. The two additives named P1 and P2 are the homopolymers of TBA and OA, respectively, whereas copolymeric additives named Co1, Co2, and Co3 were synthesized by varying the ratios of TBA:OA as 1:3, 3:1 and 1:1, respectively. The prepared polymers were characterized by Fourier Transform Infrared (FTIR). Based on the solubility of synthesized polymers in base oil and reactivity ratios of TBA/OA copolymer (0.222, 0.434) calculated by Fineman-Ross method, P2, Co1, Co2 and Co3 were selected to evaluate their performance as pour point depressant (PPD), viscosity improver (VII), and anticorrosion additives in base oil. Additives P2 and Co1 showed the best performance as (PPD) and (VII) whereas Co2 and Co3 revealed the best performance as anticorrosion additives. The flash point of base oil increased as a concentration of polymeric additives increased in the base oil. In addition to study the performance of synthesized polymers as lubricant additives, the capability of polymers for removing CuII from synthetic wastewater was also investigated. Different parameters such as pH of solution, contact time, and CuII concentration were changed in order to study their effect on adsorption capacity of polymers. Generally, polymers with high TBA content such as P1, Co2, and Co3 showed good performance in removing CuII.
以丙烯酸辛酯(OA)和丙烯酰胺叔丁基(TBA)为单体,合成了2种均聚物和3种共聚物基础油添加剂。添加剂P1和P2分别是TBA和OA的均聚物,而共聚添加剂Co1、Co2和Co3分别是在TBA和OA的比例分别为1:3、3:1和1:1时合成的。用傅里叶红外(FTIR)对所制备的聚合物进行了表征。根据合成的聚合物在基础油中的溶解度和通过Fineman-Ross法计算的TBA/OA共聚物的反应性比(0.222,0.434),选择P2、Co1、Co2和Co3作为基础油中的降凝剂(PPD)、增粘剂(VII)和防腐添加剂,评价其在基础油中的性能。添加剂P2和Co1作为(PPD)和(VII)的防腐性能最好,而Co2和Co3作为防腐添加剂的防腐性能最好。随着基础油中聚合物添加剂浓度的增加,基础油闪点增大。除了研究合成的聚合物作为润滑剂添加剂的性能外,还研究了聚合物对合成废水中CuII的去除能力。研究了溶液pH、接触时间、CuII浓度等参数对聚合物吸附能力的影响。一般来说,TBA含量较高的聚合物如P1、Co2和Co3对CuII的去除效果较好。
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引用次数: 0
Synthesis and Antibacterial Evaluation for Some New Schiff-bases Derived from P-aminoacetanilide 由 P-氨基乙酰苯胺衍生的一些新希夫碱的合成与抗菌评价
IF 0.6 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-12-05 DOI: 10.21123/bsj.2023.8905
Eman M. Hussain
Derivatives of Schiff-bases possess a great importance in pharmaceutical chemistry. They can be used for synthesizing different types of bioactive compounds. In this paper, derivatives of new Schiff bases have been synthesized from several serial steps. The acid (I) was synthesized from the reaction of dichloroethanoic acid with 2 moles of p-aminoacetanilide. New acid (I) converted to its ester (II) via the reaction of (I) with dimethyl sulphate in the present of anhydrous of sodium carbonate and dry acetone. Acid hydrazide (III) has been synthesized by adding 80% of hydrazine hydrate  to the new ester using ethanol as a solvent. The last step included the preparation of new Schiff-bases (IV-VIII) by the reaction of acid hydrazide with appropriate aromatic aldehydes and using glacial acetic acid as a catalyst. New derivatives were diagnosed by FT-IR, and by mass and 1HNMR spectroscopy (some of them). Derivatives (IV-VIII) were screened for their antibacterial against E. Coli (G-) and staph. aureus (G+). All tested compounds were found to have activity against the two kinds of bacteria.
席夫碱衍生物在药物化学中占有重要地位。它们可用于合成不同类型的生物活性化合物。本文通过一系列步骤合成了新的席夫碱衍生物。以二氯乙醇酸和2mol对氨基乙酰苯胺为原料合成了酸(I)。在无水碳酸钠和干丙酮的存在下,通过(I)与硫酸二甲酯反应,将新酸(I)转化为其酯(II)。以乙醇为溶剂,在新酯中加入80%的水合肼,合成了酸性肼(III)。最后一步以冰醋酸为催化剂,通过酸性肼与合适的芳香醛反应制备新的希夫碱(IV-VIII)。新的衍生物是通过FT-IR,质量和1HNMR光谱(其中一些)诊断出来的。筛选衍生物IV-VIII对大肠杆菌(G-)和葡萄球菌的抑菌作用。葡萄球菌(G +)。所有被测试的化合物都被发现对这两种细菌有活性。
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引用次数: 0
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Baghdad Science Journal
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