Bangladesh Journal of Medical Science最新文献

{"title":"Systemic mastocytosis associated with acute myeloid leukaemia","authors":"Mohd Nasiruddin Dhamirah Nazihah, Wan Suriana, Hussain Faezahtul Arbaeyah, Husin Azlan, Saidin Nur Ilyia Syazwani, H. M. Nazri, Z. Zefarina, M. Y. Shafini, Iberahim Salfarina, Mohd Noor Noor Haslina","doi":"10.3329/bjms.v22i4.67129","DOIUrl":"https://doi.org/10.3329/bjms.v22i4.67129","url":null,"abstract":"Bacground: The pathogenesis of systemic mastocytosis with associated haematological neoplasm (SMAHN) is not well understood. Both diagnoses heavily rely on morphological evaluation because SM is rarely suspected in clinical practise.\u0000Objective: This case highlighted a possible delay in diagnosis due to underlying conditions or diseases.\u0000Case Report: We present a case of a patient with acute myeloid leukaemia (AML), acute myelomonocytic subtype, and concurrent mastocytosis according to World Health Organization (WHO) classification. Due to an extensive accumulation of AML blast cells that obscured the mast cell infiltrates, mastocytosis was not evident at the first diagnosis.\u0000Discussion and conclusion: The diagnosis, in this case, was established only in the third bone marrow biopsy after chemotherapy. A high index of suspicion with morphological and immunohistochemical evaluations for neoplastic mast cell populations should be considered. The optimal treatment approach should be chosen based on these two disease entities.\u0000Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 937-941","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"171 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85421452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between the prevalence of dental space infections in Pediatric patient and parents’ awareness","authors":"F. Akhter, M. Afroz, Leena Abdullah Alamri, Asma Naeem Alshami, T. Haque, Rawa Kamal Abdelrahim","doi":"10.3329/bjms.v22i4.67107","DOIUrl":"https://doi.org/10.3329/bjms.v22i4.67107","url":null,"abstract":"Background: The facial spaces in head and neck are the potential spaces between the various layers of fascia normally filled with loose connective tissue and bounded by anatomical barriers, usually of bone, muscle or facial layers.\u0000Objective: To evaluate the level of knowledge and awareness about space infection among pediatric patients and their parents in Riyadh, KSA which can lead to seeking early help.\u0000Results: A total of 102 children (56 girls, 46 boys; mean age from 2-12 years) visited Dar al Uloom hospital since January 2019. Most of the patients (51 cases) were children aged 6–9 years. It has been observed that majority of 10- 12 years old children noticed pain first (58.3%) followed by abscess drainage (25%) whereas, large number of 2-5 years old children noticed pain as the first option (66.7%) followed by swelling (26.7%). Further, a greater number of 6-9 years old children noticed pain (80.4%) followed by swelling (7.8%). These results suggest that the association of the first symptom observed by the child with different age groups was found to be significant.\u0000Conclusion: In our study, the most common age group of pediatric patient infected with space infection was from 6-9 years, and the most common source of infection was caries. The level of education does not affect the awareness. It was observed that the symptoms of space infection were first noticed by the child, and it was due to the lack of early visits to the dentist. Hence, there is a need of increased awareness of the parents towards space infection and its potential risk.\u0000Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 773-777","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"33 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83056823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Men with Undescended Testis on Fertility and Hormonal Function Promoting Hypogonadism","authors":"Prahara Yuri, Supriyatiningsih Wenang, Magister Midwifery, Lidia Febrianti, Arlina Dewi, Dicky Moch Rizal, Ralph J Lelle","doi":"10.3329/bjms.v22i4.67125","DOIUrl":"https://doi.org/10.3329/bjms.v22i4.67125","url":null,"abstract":"Objectives: Undescended testes or cryptorchidism is a disorder in men and is associated with hypogonadism and infertility. UDT is the majority factor in male adults. Studies on the effects of UDT on hormoneassociated hypogonadism are limited.\u0000Materials and Methods: This study aimed to assess the effects of UDT on fertility and testicular hormonal function in adult men. Data from medical records were gathered, laboratory tests, and retrospective interviews from 2018 to 2020. The independent variable was men with UDT, while the dependent variable was fertility and reproductive hormones that trigger hypogonadism. Data on infertility, reproductive hormones, semen analysis, and symptoms of hypogonadism from 20 patients with and without UDT. ANOVA, Kruskal-Wallis test, Pearson chi-square test, and Fisher’s exact test helped perform the analysis.\u0000Results and Discussion: Undescended testes were associated with infertility so that levels of FSH and LH were considerably greater than men without UDT (p < 0.05). Bilateral UDT men had the highest levels of FSH and LH but not significantly different from unilateral UDT (p > 0.05). Bilateral UDT men had the lowest mean estradiol, testosterone and sperm quality (p < 0.05). All men had prolactin and AMH levels within normal limits (p > 0.05). Men with UDT had more significant hypogonadal symptoms (p < 0.001)\u0000Conclusion: Infertility, FSH, and LH levels were highest in men with bilateral UDT, but testosterone and estradiol levels were lowest. It also has the worst sperm quality and the most hypogonadal symptoms. All of the men had normal prolactin and AMH levels.\u0000Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 859-868","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"11 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76228416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin enhances ovarian response in infertile women with polycystic ovary syndrome: A randomized controlled trial.","authors":"Sumaiya Akter, J. Banu, Shakeela Ishrat, Chalontika Rani, Shirin Jahan, Sohely Nazneen, N. Jahan","doi":"10.3329/bjms.v22i4.67124","DOIUrl":"https://doi.org/10.3329/bjms.v22i4.67124","url":null,"abstract":"Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. Anovulation, decreased Oocyte quality and low endometrial receptivity are the cause of infertility in women with PCOS. Anovulation is the consequence of hyperandrogenism, insulin resistance. Furthermore, the reactive oxygen species (ROS) induce oxidative stress which may be responsible for poor Oocyte quality. Melatonin is a documented powerful free radical scavenger and broad-spectrum antioxidant. Current evidence suggests that melatonin involves in ovarian physiology including follicular development, ovulation, and oocyte maturation. Present study was tried to evaluate the effects of melatonin on biochemical parameters as well as outcomes of ovulation induction by letrozole in infertile women with polycystic ovary syndrome.\u0000Method: This is a randomized controlled trial including 74 women of Polycystic Ovary Syndrome (PCOS) with infertility. Intervention group received melatonin 3 mg at bed time for 8 weeks as pretreatment. Serum luteinizing hormone (LH), testosterone, anti mullerian hormone (AMH), fasting insulin, oral glucose tolerance test (OGTT) were measured at baseline and after 8 weeks. Both intervention and controlled group were received ovulation induction for 3 cycles by Letrozole (5 mg from cycle days 2 to 6). Intervention group continued melatonin until mature follicle achieved. The primary outcomes were biochemical changes by serum luteinizing hormone (LH), testosterone, anti mullerian hormone (AMH), fasting insulin, oral glucose tolerance test (OGTT) and ovarian responses by number of mature follicles, endometrial thickness and ovulation rate. Secondary outcome was pregnancy rate.\u0000Result: Melatonin treatment for 8 weeks significantly decreased testosterone (P <0.01) serum luteinizing hormone (0.05). There was significant difference in number of mature follicles (< 0.01), mean endometrial thickness (P<0.01). The risk ratio (RR) of ovulation rate was 1.34(0.09-1.68) and pregnancy rate was 2.55 (.37-3.51). The risk ratio (RR) of pregnancy rate in relation to AMH level was 1.12(0.05-1.79) in ≤8ng/ ml group and 8.65(0.25-9.59) in ≥8ng/ml group which was significant.\u0000Conclusion: After 8 weeks pretreatment and 3 cycle’s co treatment with ovulation induction by letrozole, melatonin seems to provide improved biochemical and ovarian response. Based on these results, melatonin could be considered as a potential therapeutic agent for infertile women with polycystic ovary syndrome.\u0000Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 850-858","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"1 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87900210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical properties and antimicrobial susceptibility pattern of Rothia mucilaginosa isolated from patients with respiratory tract infections","authors":"Tania Rahman, Q. M. Haque, Abdullah Akhtar Ahmed","doi":"10.3329/bjms.v22i4.67120","DOIUrl":"https://doi.org/10.3329/bjms.v22i4.67120","url":null,"abstract":"Background: Rothia mucilaginosa is appearing as an alarming pathogen for respiratory tract infection, infection of prosthetic devices and endocarditis. Over the past few years, Rothia sp. are frequently identified in a tertiary hospital of northern Bangladesh. Biochemical properties and antibiotic susceptibility pattern of the isolates were determined.\u0000Methods: A total 22 isolates of R. mucilaginosa were studied to observe the fermentation status of carbohydrate and protein substrates for identification by using BD Phoenix M50 system. Antibiotic susceptibility was tested by disk diffusion method.\u0000Results: All isolates of R. mucilaginosa showed variable reaction to almost 50% of the carbohydrate and around 50% of protein- amino acid substrates used. Amikacin, meropenem, imipenem and moxifloxacin showed maximum sensitivity in vitro.\u0000Conclusion: Biochemical characteristics of R. mucilaginosa can reveal the vital information necessary for accurately identifying the organism within a sample. This depends on production of various enzymes by the organism. Antibiotic susceptibility test is essential for proper management of patient.\u0000Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 827-832","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"45 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77228191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategy for the Implementation of Health Protocols on Mass Circumcision during a Pandemic in East Jakarta, Indonesia","authors":"B. Supartono, Dyah Utari, Prita Kusumaningsih, Sarah Primadani Kaurow, Dewi Fatimah Zahra","doi":"10.3329/bjms.v22i4.68676","DOIUrl":"https://doi.org/10.3329/bjms.v22i4.68676","url":null,"abstract":"Background: Circumcision, a religious obligation for Male Muslims in Indonesia, is conducted at a high cost using health facilities. Meanwhile, while wanting to circumcise their children the pandemic situation reduces the economic capacity of the people. Therefore, it is necessary to conduct community service activities in the form of free circumcision performed en masse to help the poor. However, due to the coronavirus pandemic which has spread rapidly since the beginning of 2020, it is necessary to adhere to health protocols. Mass circumcision during a pandemic requires a health protocol strategy to ensure that activities are performed in a safe, comfortable, and satisfying state. East Jakarta has 2,937,859 people, with 486,110 people being children of age 0-19 years. The majority of residents in this city, about 96%, are Muslims. Meanwhile 3% percent of them, or 91,610 people, are considered poor. There is still a high need for the people of East Jakarta to conduct circumcision for their children during the pandemic, even though there is a decrease in their income. \u0000Methods: A free, safe, and comfortable mass circumcision is required with the implementation of health protocols. Out of 170 participants registered for the circumcision, 163 of them passed the Covid-19 screening, while two did not fulfill the indications for circumcision; hence only 161 children were circumcised using the smart clamp. Furthermore, the youngest, oldest, and most circumcised participants were 1, 15, and 5 – 9 years old (60 %), respectively. \u0000Results: The commonly used smart clamps were 13 in numbers, and the average circumcision time for each participant was 6 minutes. Furthermore, there were mild complications among 7 participants (4%). The participants’ parents were satisfied and advised their relatives to partake in mass circumcision in the future. \u0000Conclusion: Meanwhile, there were no reports of participants, parents, health workers, and committee members being infected with the coronavirus after completing the activity. The health protocol implementation strategy was successfully conducted during the free mass circumcision in East Jakarta, which took place safely, comfortably, and satisfactorily. \u0000Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 785-796","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"168 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74706151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorative effect of Silk Fibroin against 5-Fluorouracil (5-FU)-induced gastrointestinal damage in rats","authors":"A. Sehirli, A. Aykaç, Hanife Özkayalar, G. Savtekin, S. Sayıner","doi":"10.3329/bjms.v22i4.68679","DOIUrl":"https://doi.org/10.3329/bjms.v22i4.68679","url":null,"abstract":"Objective: 5-Fluorouracil (5-FU), a widely administered anti-cancer drug, causes gastrointestinal damage through various mechanisms. This study aimed to investigate the ameliorative effect of silk fibroin (SF), which has anti-inflammatory and antioxidant properties, against 5 FU-induced gastrointestinal damage. \u0000Materials and methods: Wistar albino rats were divided into 3 groups; Control group, 5- FU group (30mg/kg/day on days 0, 2, 4), and 5-FU+SF (30 mg/kg/day 5-FU on days 0, 2, 4 + 600 mg/kg/day SF for 14 days). At the end of the experiment, stomach and intestinal tissue samples were collected and immunohistochemically iNOS, caspase-3, CD4+ and CD8+ were measured. Besides, structural damage was assessed with hematoxylin-eosin and caspase-3 and 9 activities were evaluated using western blot analysis. \u0000Results and Discussion: It was determined that iNOS, caspase-3, caspase-9 activities, CD4+ and CD8+ levels and structural damage significantly increased in both stomach and intestinal tissues. Furthermore, elevated markers were regressed almost to control levels in SF administrated group. \u0000Conclusion: SF may have an ameliorative effect, thus reducing the gastrointestinal damage caused by 5 FU. More clinical and scientific research should be conducted as the silk fibroin may be a suitable candidate against the adverse effects of chemotherapeuic agents. \u0000Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 907-915","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"21 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78713090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Image Findings in A Rare Case of Bilateral Knee Pain in A Small Patella Syndrome Patient","authors":"Faris Indra Prahasta Bin Didi Indra, Loo Wen Chen, Mohd Anuar Ramdhan Bin Ibrahim, O. Han","doi":"10.3329/bjms.v22i4.67111","DOIUrl":"https://doi.org/10.3329/bjms.v22i4.67111","url":null,"abstract":"Congenital aplasia or hypoplasia of the patella can manifest as an isolated disease or more commonly part of rare genetic disorders such as small patella syndrome (SPS). To our knowledge this is the first report of a patient with small patella syndrome who complained of bilateral knee pain with no preceding injury. Magnetic resonance imaging (MRI) revealed early degenerative changes of the knee joints which had not been mentioned in any literature. The MRI findings in our case are important as it would help in finding the cause of the pain and allow early treatment to be initiated thus delaying the progression of the arthritic changes.\u0000Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 926-931","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"142 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80425965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Miniature Biodevices with Mighty Impact: the Current Applications and Future Challenges of Organ-on-Chip Technology","authors":"Santosh Kumar, Namrata Dagli, Mainul Haque","doi":"10.3329/bjms.v22i4.68667","DOIUrl":"https://doi.org/10.3329/bjms.v22i4.68667","url":null,"abstract":"Abstract not available \u0000Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page :725-728","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"10 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80442619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of KatG Mutation in MDR Mycobacterium Tuberculosis Isolates by PCR-RFLP and DNA Sequencing","authors":"Muhammad Ilyas, Falak Niaz, Rafaqat Ishaq, Rafiullah, Azra Khanum","doi":"10.3329/bjms.v22i4.67114","DOIUrl":"https://doi.org/10.3329/bjms.v22i4.67114","url":null,"abstract":"Objective: Tuberculosis (TB) is among the widespread and rapidly growing infections in the world. Furthermore, TB is one of the major public health problems in Pakistan as every year 48,000 Pakistani dies due to this infection. Pakistan ranks fifth among high burden countries worldwide. As the TB has become most threatening because of the epidemics of human immune deficiency virus (HIV), Covid-19 and the emergence of multi-drug resistance (MDR) strains of Mycobacterium tuberculosis (M. tb). This study was aimed to understand the genetic mechanism of drug resistance in local TB isolates.\u0000Methodology: For the genetic studies of INH resistance, KatG (encoding catalase peroxidase) hotspot region was amplified through PCR followed by RFLP and sequencing.\u0000Results: The study of PCR-RFLP showed that forty-five out eighty INH resistant M. tb strains had mutations in KatG (codon 315) which is 56.2% of all cases. Sequencing results revealed that this is substitution mutation; AGC to ACC (Ser315Thr).\u0000Conclusion: It may be concluded that majority of INH resistance is due to the mutation in the codon 315 of KatG in local isolates. Furthermore, PCR-RFLP technique could be considered as a reliable method for the early detection of KatG mutations in MDR-TB.\u0000Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 804-808","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"77 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72857755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}