Pub Date : 2023-06-16DOI: 10.3329/bjms.v22i3.66963
Ziad Kh. Al Enizi, Waleed Fouad Mahameed
Objective. The technology of in vitro fertilization (IVF) opened a new era in the treatment of infertility but at the same time it created new challenges for civil and international private law. This concerns the issues of determining and/or acquiring child citizenship and legal conflicts associated with this. Materials and methods. This study examines the aspects of obtaining UAE citizenship through the study of the UAE Citizenship Law and the principle of jus sanguinis (right of blood) when citizenship is acquired by a parent’s nationality. The research aims to identify whether the current legislative regulation of the UAE meets the current challenges in the field of family relations against the backdrop of new medical advances in IVF. The paper considers the aspects of the UAE legal regulation in the scope of family law relationships. The above issues were considered from the critical evaluation prospects taking into account the potential ways for their improvement. Results and Discussion. The problems associated with determining the citizenship for those born as a result of IVF are the subject of discussion, while, as practice shows, the law often does not keep pace with the development of reproductive technologies. Based on the analysis of legal regulation and practice, the study summarizes the grounds for obtaining UAE citizenship by children conceived through IVF and refusals to obtain it. Conclusion. The paper recommends mitigating the requirement of proof of paternity as a condition to grant the nationality to an IVF child, especially in the case of purely medical errors in which father has no responsibility. Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 676-686
{"title":"IVF Children Acquiring Emirati Citizenship by the Nationality of a Parent (Jus Sanguinis)","authors":"Ziad Kh. Al Enizi, Waleed Fouad Mahameed","doi":"10.3329/bjms.v22i3.66963","DOIUrl":"https://doi.org/10.3329/bjms.v22i3.66963","url":null,"abstract":"Objective. The technology of in vitro fertilization (IVF) opened a new era in the treatment of infertility but at the same time it created new challenges for civil and international private law. This concerns the issues of determining and/or acquiring child citizenship and legal conflicts associated with this. \u0000Materials and methods. This study examines the aspects of obtaining UAE citizenship through the study of the UAE Citizenship Law and the principle of jus sanguinis (right of blood) when citizenship is acquired by a parent’s nationality. The research aims to identify whether the current legislative regulation of the UAE meets the current challenges in the field of family relations against the backdrop of new medical advances in IVF. The paper considers the aspects of the UAE legal regulation in the scope of family law relationships. The above issues were considered from the critical evaluation prospects taking into account the potential ways for their improvement. \u0000Results and Discussion. The problems associated with determining the citizenship for those born as a result of IVF are the subject of discussion, while, as practice shows, the law often does not keep pace with the development of reproductive technologies. Based on the analysis of legal regulation and practice, the study summarizes the grounds for obtaining UAE citizenship by children conceived through IVF and refusals to obtain it. \u0000Conclusion. The paper recommends mitigating the requirement of proof of paternity as a condition to grant the nationality to an IVF child, especially in the case of purely medical errors in which father has no responsibility. \u0000Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 676-686","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"31 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86031263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.3329/bjms.v22i3.65317
Erika Martining Wardani, Riezky Faisal Nugroho, Eppy Setiyowati, N. Ainiyah, Difran Nobel Bistara, Siti Nur Hasina
Background : One of metabolic disease disorders is Diabetes Mellitus (DM) with signs of hyperglycemia due to impaired insulin secretion and/or cellular insulin resistance. Diabetic ulcers are a complication of DM on the skin, beginning with a feeling of numbness and tingling. Symptoms or signs and symptoms of DM cause symptoms that occur because these clinical symptoms are often on a daily basis so that this can interfere with sleep. Objective : analyzed the effect of diabetic foot spa, bueger’s allen exercise and music therapy on foot sensitivity, ankle brachial index and sleep quality. Methods : This study with quasy experiment pre-post control group design. The population in were DM type 2 with sample 150 respondents, who were divided to intervention and control group. Collecting data using the observation sheet for diabetic foot SPA; The tools used were hammer reflex and cotton swabs to assess foot sensitivity, sphygmomanometer to measure abi and PQSI questionnaire. Data were analyzed by wilcoxon and t test. Results : The test results showed that foot sensitivity with p value = 0.000 (p>0.05), ankle brachial index with p-value = 0.001 (p>0.05) and sleep quality with p value = 0.000 (p>0.05). Conclusion : Implementation of diabetic foot spa, bueger’s allen exercises and music therapy are effective to increase foot sensitivity, ankle brachial index and sleep quality in patients with diabetes mellitus type 2. Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 536-544
{"title":"Diabetic foot spa, bueger’s allen exercise and music therapy on foot sensitivity, the ankle brachial index and sleep quality for diabetes mellitus in Indonesia","authors":"Erika Martining Wardani, Riezky Faisal Nugroho, Eppy Setiyowati, N. Ainiyah, Difran Nobel Bistara, Siti Nur Hasina","doi":"10.3329/bjms.v22i3.65317","DOIUrl":"https://doi.org/10.3329/bjms.v22i3.65317","url":null,"abstract":"Background : One of metabolic disease disorders is Diabetes Mellitus (DM) with signs of hyperglycemia due to impaired insulin secretion and/or cellular insulin resistance. Diabetic ulcers are a complication of DM on the skin, beginning with a feeling of numbness and tingling. Symptoms or signs and symptoms of DM cause symptoms that occur because these clinical symptoms are often on a daily basis so that this can interfere with sleep.\u0000Objective : analyzed the effect of diabetic foot spa, bueger’s allen exercise and music therapy on foot sensitivity, ankle brachial index and sleep quality.\u0000Methods : This study with quasy experiment pre-post control group design. The population in were DM type 2 with sample 150 respondents, who were divided to intervention and control group. Collecting data using the observation sheet for diabetic foot SPA; The tools used were hammer reflex and cotton swabs to assess foot sensitivity, sphygmomanometer to measure abi and PQSI questionnaire. Data were analyzed by wilcoxon and t test.\u0000Results : The test results showed that foot sensitivity with p value = 0.000 (p>0.05), ankle brachial index with p-value = 0.001 (p>0.05) and sleep quality with p value = 0.000 (p>0.05).\u0000Conclusion : Implementation of diabetic foot spa, bueger’s allen exercises and music therapy are effective to increase foot sensitivity, ankle brachial index and sleep quality in patients with diabetes mellitus type 2.\u0000Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 536-544","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"60 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77104231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.3329/bjms.v22i3.65314
A. Lishnevska, M. Chemych, O. Chemych, I. Chernetsky
Method: Etiological, gender, age and laboratory characteristics of chronic viral hepatitis C (СVHC) were studied and analyzed. The distribution of patients depending on the virus genotype, the activity degree and the severity of liver fibrosis were found out. Indices of non-specific reactivity, endogenous intoxication and inflammation in the course of СVHC, their dependence on treatment were studied. Correlations between the values of non-specific reactivity, endogenous intoxication, inflammation and patients’ affiliation to the group of injecting drug users, the APRI score, the stage of liver fibrosis and the virus genotype were estimated. Significant increase in endogenous intoxication (LII, HII, ISS), non-specific immunoreactivity (IR, LMR, Ilymph, IA) and inflammation (ILG) at decrease in some endogenous intoxication indices (ISL, NRR) and inflammation (KI, ILESR) in patients with CHCV compared with healthy persons were established. Result: The decrease in endogenous intoxication indices (LII; HII; ISL; ISS; NRR) were observed during antiviral treatment. Such unambiguous reaction of non-specific immunoreactivity indices and inflammation indices were not observed: some of them increased (Ilymph, IA), some of them decreased (IR, NLR; ELR). KI decreased during the treatment, but ILG increased. Direct correlation between patients’ affiliation to a group of injecting drug patients and the values of HII, NRR (p<0.05), between the APRI score and Ilymph level (p<0.05) was identified. Conclusion: No correlation between the indices values and fibrosis severity (according to METAVIR) and virus genotype was found. Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 508-514
{"title":"Immunoreactivity and intoxication syndrome in patients with chronic viral hepatitis c","authors":"A. Lishnevska, M. Chemych, O. Chemych, I. Chernetsky","doi":"10.3329/bjms.v22i3.65314","DOIUrl":"https://doi.org/10.3329/bjms.v22i3.65314","url":null,"abstract":"Method: Etiological, gender, age and laboratory characteristics of chronic viral hepatitis C (СVHC) were studied and analyzed. The distribution of patients depending on the virus genotype, the activity degree and the severity of liver fibrosis were found out. Indices of non-specific reactivity, endogenous intoxication and inflammation in the course of СVHC, their dependence on treatment were studied. Correlations between the values of non-specific reactivity, endogenous intoxication, inflammation and patients’ affiliation to the group of injecting drug users, the APRI score, the stage of liver fibrosis and the virus genotype were estimated. Significant increase in endogenous intoxication (LII, HII, ISS), non-specific immunoreactivity (IR, LMR, Ilymph, IA) and inflammation (ILG) at decrease in some endogenous intoxication indices (ISL, NRR) and inflammation (KI, ILESR) in patients with CHCV compared with healthy persons were established.\u0000Result: The decrease in endogenous intoxication indices (LII; HII; ISL; ISS; NRR) were observed during antiviral treatment. Such unambiguous reaction of non-specific immunoreactivity indices and inflammation indices were not observed: some of them increased (Ilymph, IA), some of them decreased (IR, NLR; ELR). KI decreased during the treatment, but ILG increased. Direct correlation between patients’ affiliation to a group of injecting drug patients and the values of HII, NRR (p<0.05), between the APRI score and Ilymph level (p<0.05) was identified.\u0000Conclusion: No correlation between the indices values and fibrosis severity (according to METAVIR) and virus genotype was found.\u0000Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 508-514","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"1117 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80018587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Nutrient deficiency after malabsorptive bariatric procedure is a common phenomenon. The study aims to determine the prevalence of nutritional insufficiencies (specific with Ascorbic acid, Cobalamin, calciferol and calcium) in obese population opting for One Ananstomosis Gastric Bypass surgery (OAGB), and also to understand the association of these nutrients with change in Body Mass Index (BMI) after the surgery. Methods: One hundred fifty subjects comprising males and females aged 20-60 years were randomly selected at a bariatric center in India. Subjects belonged to both grade III and grade II obesity. Plasma aa, serum vitB12, serum VitD3 and serum calcium concentrations were prospectively assessed at 0m, 3m, and 6m of surgery through high-performance liquid chromatography. Result: The values of nutrients beyond the standard levels are considered as deficiency. Both follow up values showed a significant increase in cobalamin, Calciferol, and ascorbic acid levels compared to baseline data. Conclusion: Nutrition depletion and deficiency are often seen in post bariatric cases. The contributing factors included high BMI, food intolerance, and non-adherence to supplements and correct dietary regimens. With the correction of weight and comorbidities, the levels also showed a stable and positive level. Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 695-708
{"title":"One Anastomosis Gastric Bypass Surgery: Consequences Over Ascorbic Acid, Cobalamin, Calciferol, and Calcium","authors":"Arya Singh, Rahnuma Ahmad, Susmita Sinha, Md. Ahsanul Haq, M. Narwaria, Mainul Haque, Santosh Kumar, Nandita Sanghani","doi":"10.3329/bjms.v22i3.66965","DOIUrl":"https://doi.org/10.3329/bjms.v22i3.66965","url":null,"abstract":"Background: Nutrient deficiency after malabsorptive bariatric procedure is a common phenomenon. The study aims to determine the prevalence of nutritional insufficiencies (specific with Ascorbic acid, Cobalamin, calciferol and calcium) in obese population opting for One Ananstomosis Gastric Bypass surgery (OAGB), and also to understand the association of these nutrients with change in Body Mass Index (BMI) after the surgery. \u0000Methods: One hundred fifty subjects comprising males and females aged 20-60 years were randomly selected at a bariatric center in India. Subjects belonged to both grade III and grade II obesity. Plasma aa, serum vitB12, serum VitD3 and serum calcium concentrations were prospectively assessed at 0m, 3m, and 6m of surgery through high-performance liquid chromatography. \u0000Result: The values of nutrients beyond the standard levels are considered as deficiency. Both follow up values showed a significant increase in cobalamin, Calciferol, and ascorbic acid levels compared to baseline data. \u0000Conclusion: Nutrition depletion and deficiency are often seen in post bariatric cases. The contributing factors included high BMI, food intolerance, and non-adherence to supplements and correct dietary regimens. With the correction of weight and comorbidities, the levels also showed a stable and positive level. \u0000Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 695-708","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"312 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80428416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.3329/bjms.v22i3.65335
V. Rajalaxmi, S. Kotteswari, R. Nisha, Mohan Nallathambi
Objective: To investigate the intra – rater and inter – rater reliability of cranio cervical flexion test in symptomatic subjects. Background of study: Neck flexor muscles endurance was negatively correlated with cervical pain and dysfunction. Cranio cervical flexion test protocol has been advocated to train cranio cervical flexor muscle performance at present there is no consensus to the most effective method. The CCFT is a clinical test of neuromotor control of deep flexor of the cervical spine. Methodology: This was an observational study design with test-retest type and conducted in the ACS medical college and hospital. 50 samples were selected based on inclusion criteria. The CCFT was measured by one tester twice for intra rater reliability and two testers for inter-rater reliability were again tested after 24 Hours (Next day) by keeping time and environment optimal. In this CCFT, the activation pressure score and highest-pressure score was measured using Pressure Biofeedback unit. Result: The mean score for Activation Pressure by intra-rater tester one was found to be 2.24 (1.69) and 2.64 (1.48) in retest. The ICC intrarater score for Highest pressure value by tester one was 23.92 (2.17) and 24.32 (1.99) in retest. The mean score for activation pressure by Inter – rater examiners was found to be 2.92(1.15) by examiner - 1 and 2.72(1.19) by examiner - 2. The ICC Inter – rater score for highest pressure value by examiner - 1 was 24.32(1.95) and 24.4(2.33) by examiner - 2. The ICC value of the study indicated high reliability of the activation pressure and highest-pressure value among the intra and inter-raters. Conclusion: The CCFT has high inter-rater and intra-rater reliabilities in symptomatic subjects. Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 617-622
{"title":"Intra-rater and inter-rater reliability of cranio cervical flexion test in symptomatic subjects of neck pain using pressure biofeedback","authors":"V. Rajalaxmi, S. Kotteswari, R. Nisha, Mohan Nallathambi","doi":"10.3329/bjms.v22i3.65335","DOIUrl":"https://doi.org/10.3329/bjms.v22i3.65335","url":null,"abstract":"Objective: To investigate the intra – rater and inter – rater reliability of cranio cervical flexion test in symptomatic subjects.\u0000Background of study: Neck flexor muscles endurance was negatively correlated with cervical pain and dysfunction. Cranio cervical flexion test protocol has been advocated to train cranio cervical flexor muscle performance at present there is no consensus to the most effective method. The CCFT is a clinical test of neuromotor control of deep flexor of the cervical spine.\u0000Methodology: This was an observational study design with test-retest type and conducted in the ACS medical college and hospital. 50 samples were selected based on inclusion criteria. The CCFT was measured by one tester twice for intra rater reliability and two testers for inter-rater reliability were again tested after 24 Hours (Next day) by keeping time and environment optimal. In this CCFT, the activation pressure score and highest-pressure score was measured using Pressure Biofeedback unit.\u0000Result: The mean score for Activation Pressure by intra-rater tester one was found to be 2.24 (1.69) and 2.64 (1.48) in retest. The ICC intrarater score for Highest pressure value by tester one was 23.92 (2.17) and 24.32 (1.99) in retest. The mean score for activation pressure by Inter – rater examiners was found to be 2.92(1.15) by examiner - 1 and 2.72(1.19) by examiner - 2. The ICC Inter – rater score for highest pressure value by examiner - 1 was 24.32(1.95) and 24.4(2.33) by examiner - 2. The ICC value of the study indicated high reliability of the activation pressure and highest-pressure value among the intra and inter-raters.\u0000Conclusion: The CCFT has high inter-rater and intra-rater reliabilities in symptomatic subjects.\u0000Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 617-622","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"71 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74838277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.3329/bjms.v22i3.65315
Jayashankar Bv, A. Aradya, R. Chowdhary
Objective: The study was designed to evaluate and compare stress distribution intrans cortical section of bone with titanium implant and zirconia implant model under vertical and oblique forces in anterior maxillary region. Materials and Methods: A three‑dimensional finite element model was designed using ANSYS 13.0 software. Around the prepared implant, bone was constructed with definitive differentiation of outer cortical and inner cancellous. Two straight abutment was constructed, crowns of 9mm mesiodistal width and 11mm cervicoincisal length were created and they were cemented with 50 micron meter cemental layer. The bone-implant interface for both the models was bonded, simulating complete osseointegration and the dental implant, abutment and crown were assumed to be connected as a single unit. Force application was performed in both oblique and vertical conditions using 100 N as a representative masticatory force. For oblique loading, a force of 100 N was applied at 45° from the vertical axis. Von Mises stress analysis was evaluated. Results: The results of the study showed cortical stress in the Titanium and Zirconia model under oblique forces were 81.317 MPa and 78.405 MPa, respectively. Cortical stress in the titanium and zirconia implant model under vertical forces was 46.161 MPa and 46.097 MPa, respectively. Conclusion: Results from this study showed the zirconia implant model led to relative decrease in von Mises stress in trans cortical section of bone compared to titanium under vertical and oblique forces in anterior maxillary region. Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 521-528
{"title":"Comparative Evaluation of Stress Distribution Around The Supporting Bone, Abutment, Prosthesis, Using Zirconia And Titanium Implants In The Anterior Maxilla: A Three Dimensional Finite Element Analysis","authors":"Jayashankar Bv, A. Aradya, R. Chowdhary","doi":"10.3329/bjms.v22i3.65315","DOIUrl":"https://doi.org/10.3329/bjms.v22i3.65315","url":null,"abstract":"Objective: The study was designed to evaluate and compare stress distribution intrans cortical section of bone with titanium implant and zirconia implant model under vertical and oblique forces in anterior maxillary region.\u0000Materials and Methods: A three‑dimensional finite element model was designed using ANSYS 13.0 software. Around the prepared implant, bone was constructed with definitive differentiation of outer cortical and inner cancellous. Two straight abutment was constructed, crowns of 9mm mesiodistal width and 11mm cervicoincisal length were created and they were cemented with 50 micron meter cemental layer. The bone-implant interface for both the models was bonded, simulating complete osseointegration and the dental implant, abutment and crown were assumed to be connected as a single unit. Force application was performed in both oblique and vertical conditions using 100 N as a representative masticatory force. For oblique loading, a force of 100 N was applied at 45° from the vertical axis. Von Mises stress analysis was evaluated.\u0000Results: The results of the study showed cortical stress in the Titanium and Zirconia model under oblique forces were 81.317 MPa and 78.405 MPa, respectively. Cortical stress in the titanium and zirconia implant model under vertical forces was 46.161 MPa and 46.097 MPa, respectively.\u0000Conclusion: Results from this study showed the zirconia implant model led to relative decrease in von Mises stress in trans cortical section of bone compared to titanium under vertical and oblique forces in anterior maxillary region.\u0000Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 521-528","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"4 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79153999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.3329/bjms.v22i3.65336
Huseyin Cagsin, E. Becer, R. Kalkan
Background: Obesity is a multifactorial disorder that is an important predisposing factor for a number of disorders. Genetic and epigenetic variations play important roles during the development of obesity. Method: DNA methylation is the most studied as one of the epigenetic modifications and is directly related to gene expression. Here, the methylation status of FSHR, PTH and ESRRA genes were investigated in obese patients to discover novel associations between DNA methylation and obesity phenotype. A total of 69 patients with obesity and 76 patients without obesity were enrolled in this study. DNA methylation in FSHR, PTH and ESRRA genes was analyzed. Result: There is a statistically significant association between the methylation status of ESRRA and fasting glucose (P=0.04) and BMI and methylation of the PTH gene (P=0.036) in obese subjects. In non-obese subjects, a statistically significant association was detected between adiponectin, resistin levels and FSHR methylation status. It is concluded that the methylation status of FSHR, PTH and ESRRA genes play an important role in obesity phenotype, adiponectin and resistin levels. These genes had previously been associated with obesity-related variables, but their methylation status was not highlighted. Conclusion: Our study will shed light on resolving the epigenetic contributions toward the development of obesity. Studies in the field of epigenetics will help discover predisposition markers for obesity. Based on the literature this was the first study that shows the interactions between FSHR, PTH and ESRRA methylation and obesity. Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 623-631
{"title":"Investigation of the relationship between DNA methylation of PTH, ESRRA, FSHR and obesity: A single center study","authors":"Huseyin Cagsin, E. Becer, R. Kalkan","doi":"10.3329/bjms.v22i3.65336","DOIUrl":"https://doi.org/10.3329/bjms.v22i3.65336","url":null,"abstract":"Background: Obesity is a multifactorial disorder that is an important predisposing factor for a number of disorders. Genetic and epigenetic variations play important roles during the development of obesity.\u0000Method: DNA methylation is the most studied as one of the epigenetic modifications and is directly related to gene expression. Here, the methylation status of FSHR, PTH and ESRRA genes were investigated in obese patients to discover novel associations between DNA methylation and obesity phenotype. A total of 69 patients with obesity and 76 patients without obesity were enrolled in this study. DNA methylation in FSHR, PTH and ESRRA genes was analyzed.\u0000Result: There is a statistically significant association between the methylation status of ESRRA and fasting glucose (P=0.04) and BMI and methylation of the PTH gene (P=0.036) in obese subjects. In non-obese subjects, a statistically significant association was detected between adiponectin, resistin levels and FSHR methylation status. It is concluded that the methylation status of FSHR, PTH and ESRRA genes play an important role in obesity phenotype, adiponectin and resistin levels. These genes had previously been associated with obesity-related variables, but their methylation status was not highlighted.\u0000Conclusion: Our study will shed light on resolving the epigenetic contributions toward the development of obesity. Studies in the field of epigenetics will help discover predisposition markers for obesity. Based on the literature this was the first study that shows the interactions between FSHR, PTH and ESRRA methylation and obesity.\u0000Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 623-631","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"49 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91204061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.3329/bjms.v22i3.66964
Alla Philippova, O. Malkina, Vladilena L. Korotun, Evgeniya Shatova
Objective. This study aimed to establish practical evidence of the leading role of somatic factors in psychosomatic health disorders in the early stages of the mental development of children and adolescents. Materials and methods. An interview method was used to obtain complete and reliable historical data for children and youth who applied for primary medical care. In addition, an anonymous questioning method was implemented. It allowed gathering of a reliable database of basic information on the psychosomatic health of children and adolescents in the Western European region. A study enrolled a sample of 1000 children, including 498 girls and 502 boys, aged 13 to 18 years. Results and Discussion. Psychosomatic pathologies were detected in 54% of cases, of which 63% were female. The influence of somatic factors on psychosomatic pathology progression was found to be greater in the early stages of mental development. Conclusion. The study’s findings may serve as a primary basis for understanding the role of somatization factors on psychosomatic disorders in children and adolescents in the early stages of mental development. The study also highlights the need to enhance the methodological basis for preventing psychosomatic disorders in children and adolescents. Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 687-694
{"title":"The role of somatic factors in early childhood and adolescent psychosomatic disorders","authors":"Alla Philippova, O. Malkina, Vladilena L. Korotun, Evgeniya Shatova","doi":"10.3329/bjms.v22i3.66964","DOIUrl":"https://doi.org/10.3329/bjms.v22i3.66964","url":null,"abstract":"Objective. This study aimed to establish practical evidence of the leading role of somatic factors in psychosomatic health disorders in the early stages of the mental development of children and adolescents. \u0000Materials and methods. An interview method was used to obtain complete and reliable historical data for children and youth who applied for primary medical care. In addition, an anonymous questioning method was implemented. It allowed gathering of a reliable database of basic information on the psychosomatic health of children and adolescents in the Western European region. A study enrolled a sample of 1000 children, including 498 girls and 502 boys, aged 13 to 18 years. \u0000Results and Discussion. Psychosomatic pathologies were detected in 54% of cases, of which 63% were female. The influence of somatic factors on psychosomatic pathology progression was found to be greater in the early stages of mental development. \u0000Conclusion. The study’s findings may serve as a primary basis for understanding the role of somatization factors on psychosomatic disorders in children and adolescents in the early stages of mental development. The study also highlights the need to enhance the methodological basis for preventing psychosomatic disorders in children and adolescents. \u0000Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 687-694","PeriodicalId":8696,"journal":{"name":"Bangladesh Journal of Medical Science","volume":"178 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79251505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-16DOI: 10.3329/bjms.v22i3.65332
Naveen Kumar, R. Bhaskar, A. S, S. Ks, Surekha Shetty D, A. Aithal P.
Introduction: Supraorbital neuralgia is manifested with pain and tenderness at the distribution of the supraorbital nerve (SN). Explicit knowledge of the location of SN is vital for clinicians performing regional nerve blocks to relieve the pain. In the present study, detailed measurements of the supraorbital foramen (SOF) and supraorbital notch (SON) of South Indian skulls are presented, and the data are compared with those from other populations. Methodology: One hundred SON/SOF were assessed morphometrically from 50 dried adult human skull. Relevant morphometric measurements were performed using Vernier caliper. The parameters used were horizontal and vertical diameters of SON/SOF, distance between SON/SOF from the supraorbital rim; SOF to the nasal skeletal midline; SOF to the temporal crest of the frontal bone, and SOF to the superior wall of the IOF. Data was analyzed using SPSSv16.0. Results: SON was more frequently found than SOF. The mean distance of SON/SOF to the nasal midline was 24.77 mm on right side and 23.36 mm on left side. The mean distance of SON/SOF to the temporal crest of frontal bone was 30.22 mm on both sides. Mean distance between SON/SOF to infraorbital foramen was 39.71 mm on right side and 40.41 mm on left side. Mean height of SOF was 1.38 mm on the right side and 1.31 mm on the left side. Mean transverse diameter of SON was 3.93 mm. Conclusion: Differences exist in the dimensions and position of SOF/SON among different races and people of other regions. Anatomical knowledge of SON/ SOF is essential in facilitating craniofacial surgical procedures and in the treatment of neuralgia. Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 598-603
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Pub Date : 2023-06-16DOI: 10.3329/bjms.v22i3.66959
Santosh Kumar, Namrata Dagli, Mainul Haque
Abstract not available Bangladesh Journal of Medical Science Vol. 22 No. 03 July’23 Page : 472-474
《孟加拉国医学科学杂志》第22卷第23期7月3日第472-474页
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